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The map label for this gene is nuoE1 [H]

Identifier: 13471403

GI number: 13471403

Start: 1143537

End: 1144811

Strand: Reverse

Name: nuoE1 [H]

Synonym: mll1366

Alternate gene names: 13471403

Gene position: 1144811-1143537 (Counterclockwise)

Preceding gene: 13471404

Following gene: 13471402

Centisome position: 16.27

GC content: 64.63

Gene sequence:

>1275_bases
ATGTCAGTCCGCCGTCTCGCAGAAGCCAGCGTCCAGCCAGTATCCTTCGCCTTCAACCGGGCGAACGCGGCAGCGGCGAA
GCAATGGATCAAGAAGTACCCGAAGGGCCGCGAGCAGTCGGCGATCATTCCGCTGCTGATGCTGGCGCAGGAACAGGAAG
GCTGGGTCACCAAGGCAGCGATCGAGACGATTTCGGACATGCTCGGCATGCCGCGCATCCGTGGGCTCGAGGTCGCGACC
TTCTACACGCAGTACCAGCTCAATCCCGTCGGCACCCGCGCGCACATCCAGGTCTGCGGCACCACGCCCTGCATGCTGCG
CGGCTCGGAAGCACTGATGGATGTCTGCCGCTCGAAAATCCATCACGACCAGTTCCACACCAATGACAAGGGCACCTTGT
CGTGGGAAGAGGTCGAGTGTCTTGGCGCCTGCGTCAACGCGCCGATGGTGATGATTTTCAAGGACACGTTCGAGGATTTG
ACACCGGAGCGGCTGGCTGAAATCATCGACCTCTATGATGCGGGCAAGGGCGCCTCGGTGGCGCCGGGACCGCAGAATGG
CCGCACCGGCTCGGAGCCGGCTTCCGGCCTGACGACGCTGAAAAGCGAAAAGGCGATCCTCAAGTCGACCCGCGATCGGG
AGGCCAGGGAGGCCGCAAAGGCCGCCAAGGCGGCACCCGACGCGATCATCGCCGCGCCCGTTCCGACACCTGCTCCTGTC
GCACCGTCCAATGCCAGCAAGCCGAAGACCGACGCGCCTGAAACCAGCCCGGCCTTGAAGACACCGTCAAAGACCAAGGT
GGCGCCGGCGGCTGAGAAGGCGGCTAGCGTTTCGGCGCCGCTGCATTCGGCCGCCAATGCCAACAAGGCAGCGCCGGAAG
TCGAGAAGGTCTCCAAACAGCGCAATGGGCCGAAGGCCAATGCCGAGCCGGCTGCTGCCTTCAAGGCGCTGGAAGCCAAG
GCGCCGGCGGCAAAGCCGGCAAAAACGTCGCTGGAGGACAAGAACCGTCCGGCCGGTATCGATAGGCCGGCCGCGGTCGA
CGATCTCAAGCTGATCTCCGGCGTCGGCCCGAAGATCGAGGGCGTCCTGCATACGCTGGGCATCTTCACCTTCGCGCAGG
TCGCTTCCTGGAAGAAGGCCGAGCGCGACTGGGTCGACGGCTATCTCTCCTTCCACGGCCGCATCGAGCGCGACGACTGG
GTCAAGCAGGCCAAGGCGCTCGCCAAGGGCGGCGTCGCCGAATACATCCGCGTCTTCGGCAAGAAGCCGGTCTGA

Upstream 100 bases:

>100_bases
TCTGCAAGCCATGGATTTCCTGTGCCGCGGCCACCTGCTGGCCGACGTCACCGCCGTCCTCGGCTCCCTCGACATCGTGT
TTGGTGAGGTCGATCGCTAA

Downstream 100 bases:

>100_bases
GGGACGAAAAATGCTTCAGGATAAAGACCGCATCTTCACCAACATCTACGGCCTCTTCGACAAGTCGCTGGCCGGCGCCA
TGGCTCGCGGCGCCTGGGAC

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E 1; NDH-1 subunit E 1 [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSVRRLAEASVQPVSFAFNRANAAAAKQWIKKYPKGREQSAIIPLLMLAQEQEGWVTKAAIETISDMLGMPRIRGLEVAT
FYTQYQLNPVGTRAHIQVCGTTPCMLRGSEALMDVCRSKIHHDQFHTNDKGTLSWEEVECLGACVNAPMVMIFKDTFEDL
TPERLAEIIDLYDAGKGASVAPGPQNGRTGSEPASGLTTLKSEKAILKSTRDREAREAAKAAKAAPDAIIAAPVPTPAPV
APSNASKPKTDAPETSPALKTPSKTKVAPAAEKAASVSAPLHSAANANKAAPEVEKVSKQRNGPKANAEPAAAFKALEAK
APAAKPAKTSLEDKNRPAGIDRPAAVDDLKLISGVGPKIEGVLHTLGIFTFAQVASWKKAERDWVDGYLSFHGRIERDDW
VKQAKALAKGGVAEYIRVFGKKPV

Sequences:

>Translated_424_residues
MSVRRLAEASVQPVSFAFNRANAAAAKQWIKKYPKGREQSAIIPLLMLAQEQEGWVTKAAIETISDMLGMPRIRGLEVAT
FYTQYQLNPVGTRAHIQVCGTTPCMLRGSEALMDVCRSKIHHDQFHTNDKGTLSWEEVECLGACVNAPMVMIFKDTFEDL
TPERLAEIIDLYDAGKGASVAPGPQNGRTGSEPASGLTTLKSEKAILKSTRDREAREAAKAAKAAPDAIIAAPVPTPAPV
APSNASKPKTDAPETSPALKTPSKTKVAPAAEKAASVSAPLHSAANANKAAPEVEKVSKQRNGPKANAEPAAAFKALEAK
APAAKPAKTSLEDKNRPAGIDRPAAVDDLKLISGVGPKIEGVLHTLGIFTFAQVASWKKAERDWVDGYLSFHGRIERDDW
VKQAKALAKGGVAEYIRVFGKKPV
>Mature_423_residues
SVRRLAEASVQPVSFAFNRANAAAAKQWIKKYPKGREQSAIIPLLMLAQEQEGWVTKAAIETISDMLGMPRIRGLEVATF
YTQYQLNPVGTRAHIQVCGTTPCMLRGSEALMDVCRSKIHHDQFHTNDKGTLSWEEVECLGACVNAPMVMIFKDTFEDLT
PERLAEIIDLYDAGKGASVAPGPQNGRTGSEPASGLTTLKSEKAILKSTRDREAREAAKAAKAAPDAIIAAPVPTPAPVA
PSNASKPKTDAPETSPALKTPSKTKVAPAAEKAASVSAPLHSAANANKAAPEVEKVSKQRNGPKANAEPAAAFKALEAKA
PAAKPAKTSLEDKNRPAGIDRPAAVDDLKLISGVGPKIEGVLHTLGIFTFAQVASWKKAERDWVDGYLSFHGRIERDDWV
KQAKALAKGGVAEYIRVFGKKPV

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG3743

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=185, Percent_Identity=45.4054054054054, Blast_Score=163, Evalue=3e-40,
Organism=Escherichia coli, GI1788621, Length=161, Percent_Identity=32.9192546583851, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17561328, Length=201, Percent_Identity=43.7810945273632, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI18859877, Length=190, Percent_Identity=42.1052631578947, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI21355353, Length=190, Percent_Identity=34.2105263157895, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 45310; Mature: 45179

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRRLAEASVQPVSFAFNRANAAAAKQWIKKYPKGREQSAIIPLLMLAQEQEGWVTKAA
CCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHH
IETISDMLGMPRIRGLEVATFYTQYQLNPVGTRAHIQVCGTTPCMLRGSEALMDVCRSKI
HHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHH
HHDQFHTNDKGTLSWEEVECLGACVNAPMVMIFKDTFEDLTPERLAEIIDLYDAGKGASV
HHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCC
APGPQNGRTGSEPASGLTTLKSEKAILKSTRDREAREAAKAAKAAPDAIIAAPVPTPAPV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
APSNASKPKTDAPETSPALKTPSKTKVAPAAEKAASVSAPLHSAANANKAAPEVEKVSKQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
RNGPKANAEPAAAFKALEAKAPAAKPAKTSLEDKNRPAGIDRPAAVDDLKLISGVGPKIE
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
GVLHTLGIFTFAQVASWKKAERDWVDGYLSFHGRIERDDWVKQAKALAKGGVAEYIRVFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHC
KKPV
CCCC
>Mature Secondary Structure 
SVRRLAEASVQPVSFAFNRANAAAAKQWIKKYPKGREQSAIIPLLMLAQEQEGWVTKAA
CHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHH
IETISDMLGMPRIRGLEVATFYTQYQLNPVGTRAHIQVCGTTPCMLRGSEALMDVCRSKI
HHHHHHHHCCCCCCCEEEEEEEEEEECCCCCCEEEEEECCCCCHHCCCCHHHHHHHHHHH
HHDQFHTNDKGTLSWEEVECLGACVNAPMVMIFKDTFEDLTPERLAEIIDLYDAGKGASV
HHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEHHHHHHCCHHHHHHHHHHHHCCCCCCC
APGPQNGRTGSEPASGLTTLKSEKAILKSTRDREAREAAKAAKAAPDAIIAAPVPTPAPV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCC
APSNASKPKTDAPETSPALKTPSKTKVAPAAEKAASVSAPLHSAANANKAAPEVEKVSKQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHH
RNGPKANAEPAAAFKALEAKAPAAKPAKTSLEDKNRPAGIDRPAAVDDLKLISGVGPKIE
CCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHH
GVLHTLGIFTFAQVASWKKAERDWVDGYLSFHGRIERDDWVKQAKALAKGGVAEYIRVFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHC
KKPV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]