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The map label for this gene is nuoD [H]

Identifier: 13471404

GI number: 13471404

Start: 1144812

End: 1146002

Strand: Reverse

Name: nuoD [H]

Synonym: mll1367

Alternate gene names: 13471404

Gene position: 1146002-1144812 (Counterclockwise)

Preceding gene: 13471405

Following gene: 13471403

Centisome position: 16.29

GC content: 62.3

Gene sequence:

>1191_bases
ATGGCTGAGACCTCCGTCCGCAATTTCAACATCAACTTCGGCCCGCAACACCCTGCGGCGCACGGCGTTTTGCGCCTCGT
TCTGGAGCTCGACGGCGAAGTCGTCGATCGCGTCGATCCACATATCGGGCTGCTGCATCGCGGCACCGAAAAGCTGATCG
AGGCAAAAACCTATCTGCAGGCTGTGCCTTATCTCGATCGGCTCGACTATTGCGCGCCGATGAACCAGGAGCATGCCTTC
GCGCTCGCCGCCGAGCGCCTGCTTGGCATCGAAGTGCCGAAACGCGGCCAGTTGATCCGCGTGCTCTATTGCGAGATCGG
CCGCATCATGTCGCACATCCTCAATGTGACGACGCAAGCCATGGACGTCGGAGCGCTGACGCCGCCGCTGTGGGGTTTCG
TCGAGCGCGAAAAGCTGATGGTGTTTTATGAGCGCGCCTCCGGCTCGCGCATGCATGCAGCCTATTTCCGCCCCGGCGGC
GTCCATCAGGATCTGCCGCGCCAGCTGGTCGAGGACATCGGCAAGTGGATCGACCCGTTCCTGAAGTCGATCGACGACCT
CGATCGTCTGCTGACCGGCAATCGCATCTTCAAGCAGCGCAATGTCGATATCGGCATTGTTTCGCTGGCCGATGCCTGGG
CCTGGGGCTTTTCGGGCGTCATGGTGCGTGGTTCTGGCGCGGCCTGGGACCTGCGCAAGTCGCAGCCCTATGAGTGCTAT
TCGGAAATGGATTTCGACATTCCGATCGGCAAGAACGGCGACTGCTACGACCGCTATCTCGTGCGCATGGAAGAAATGCG
CCAGTCGGCCAGGATCATGCGCCAGTGCGTCGACCTGCTGCTTGGCAAGGAAAGCACCGGTCCGGTGTCGAACCTCGACG
GCAAGGTGGTGCCGCCCAAGCGCGCGGCGATGAAGCGTTCGATGGAAGCGCTGATCCACCACTTCAAGCTTTACACCGAG
GGTTATCGCGTGCCGGCCGGCGAGGTCTACGCGGCCGTCGAGGCGCCGAAGGGCGAGTTCGGCGTCTATCTGGTCTCCGA
CGGCACCAATAAGCCCTACCGCTGCAAGCTGCGCGCGCCCGGTTTCGCGCATCTGCAAGCCATGGATTTCCTGTGCCGCG
GCCACCTGCTGGCCGACGTCACCGCCGTCCTCGGCTCCCTCGACATCGTGTTTGGTGAGGTCGATCGCTAA

Upstream 100 bases:

>100_bases
CAAGCAGGAATTCCGCAATTTCGATTTTCTCTCGCCATGGGAAGGGACGGATTACGTTCTGCCTGGCGATGAAAAAGCCA
AGACGAATTGAGGCGCCACA

Downstream 100 bases:

>100_bases
ATGTCAGTCCGCCGTCTCGCAGAAGCCAGCGTCCAGCCAGTATCCTTCGCCTTCAACCGGGCGAACGCGGCAGCGGCGAA
GCAATGGATCAAGAAGTACC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MAETSVRNFNINFGPQHPAAHGVLRLVLELDGEVVDRVDPHIGLLHRGTEKLIEAKTYLQAVPYLDRLDYCAPMNQEHAF
ALAAERLLGIEVPKRGQLIRVLYCEIGRIMSHILNVTTQAMDVGALTPPLWGFVEREKLMVFYERASGSRMHAAYFRPGG
VHQDLPRQLVEDIGKWIDPFLKSIDDLDRLLTGNRIFKQRNVDIGIVSLADAWAWGFSGVMVRGSGAAWDLRKSQPYECY
SEMDFDIPIGKNGDCYDRYLVRMEEMRQSARIMRQCVDLLLGKESTGPVSNLDGKVVPPKRAAMKRSMEALIHHFKLYTE
GYRVPAGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKLRAPGFAHLQAMDFLCRGHLLADVTAVLGSLDIVFGEVDR

Sequences:

>Translated_396_residues
MAETSVRNFNINFGPQHPAAHGVLRLVLELDGEVVDRVDPHIGLLHRGTEKLIEAKTYLQAVPYLDRLDYCAPMNQEHAF
ALAAERLLGIEVPKRGQLIRVLYCEIGRIMSHILNVTTQAMDVGALTPPLWGFVEREKLMVFYERASGSRMHAAYFRPGG
VHQDLPRQLVEDIGKWIDPFLKSIDDLDRLLTGNRIFKQRNVDIGIVSLADAWAWGFSGVMVRGSGAAWDLRKSQPYECY
SEMDFDIPIGKNGDCYDRYLVRMEEMRQSARIMRQCVDLLLGKESTGPVSNLDGKVVPPKRAAMKRSMEALIHHFKLYTE
GYRVPAGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKLRAPGFAHLQAMDFLCRGHLLADVTAVLGSLDIVFGEVDR
>Mature_395_residues
AETSVRNFNINFGPQHPAAHGVLRLVLELDGEVVDRVDPHIGLLHRGTEKLIEAKTYLQAVPYLDRLDYCAPMNQEHAFA
LAAERLLGIEVPKRGQLIRVLYCEIGRIMSHILNVTTQAMDVGALTPPLWGFVEREKLMVFYERASGSRMHAAYFRPGGV
HQDLPRQLVEDIGKWIDPFLKSIDDLDRLLTGNRIFKQRNVDIGIVSLADAWAWGFSGVMVRGSGAAWDLRKSQPYECYS
EMDFDIPIGKNGDCYDRYLVRMEEMRQSARIMRQCVDLLLGKESTGPVSNLDGKVVPPKRAAMKRSMEALIHHFKLYTEG
YRVPAGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKLRAPGFAHLQAMDFLCRGHLLADVTAVLGSLDIVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=394, Percent_Identity=63.1979695431472, Blast_Score=519, Evalue=1e-147,
Organism=Homo sapiens, GI260898743, Length=388, Percent_Identity=62.3711340206186, Blast_Score=504, Evalue=1e-143,
Organism=Escherichia coli, GI145693162, Length=387, Percent_Identity=39.5348837209302, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1789076, Length=391, Percent_Identity=25.5754475703325, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788832, Length=388, Percent_Identity=26.0309278350515, Blast_Score=109, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=394, Percent_Identity=62.1827411167513, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17568379, Length=394, Percent_Identity=61.4213197969543, Blast_Score=506, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24638644, Length=394, Percent_Identity=62.1827411167513, Blast_Score=524, Evalue=1e-149,
Organism=Drosophila melanogaster, GI221459469, Length=394, Percent_Identity=54.3147208121827, Blast_Score=467, Evalue=1e-132,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 44507; Mature: 44376

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00535 COMPLEX1_49K ; PS00503 PECTINESTERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETSVRNFNINFGPQHPAAHGVLRLVLELDGEVVDRVDPHIGLLHRGTEKLIEAKTYLQ
CCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AVPYLDRLDYCAPMNQEHAFALAAERLLGIEVPKRGQLIRVLYCEIGRIMSHILNVTTQA
HCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFVEREKLMVFYERASGSRMHAAYFRPGGVHQDLPRQLVEDIGKWIDPF
HHCCCCCCCHHHHHHHCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LKSIDDLDRLLTGNRIFKQRNVDIGIVSLADAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHHHCCHHHHHCCCCEEEEEHHHHHHCCCCCEEEECCCCEEECCCCCCCHHH
SEMDFDIPIGKNGDCYDRYLVRMEEMRQSARIMRQCVDLLLGKESTGPVSNLDGKVVPPK
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
RAAMKRSMEALIHHFKLYTEGYRVPAGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKLRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFLCRGHLLADVTAVLGSLDIVFGEVDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
>Mature Secondary Structure 
AETSVRNFNINFGPQHPAAHGVLRLVLELDGEVVDRVDPHIGLLHRGTEKLIEAKTYLQ
CCCCCEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHCCCCHHHHHCCHHHHHHHHHHHH
AVPYLDRLDYCAPMNQEHAFALAAERLLGIEVPKRGQLIRVLYCEIGRIMSHILNVTTQA
HCCHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MDVGALTPPLWGFVEREKLMVFYERASGSRMHAAYFRPGGVHQDLPRQLVEDIGKWIDPF
HHCCCCCCCHHHHHHHCEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
LKSIDDLDRLLTGNRIFKQRNVDIGIVSLADAWAWGFSGVMVRGSGAAWDLRKSQPYECY
HHHHHHHHHHHHCCHHHHHCCCCEEEEEHHHHHHCCCCCEEEECCCCEEECCCCCCCHHH
SEMDFDIPIGKNGDCYDRYLVRMEEMRQSARIMRQCVDLLLGKESTGPVSNLDGKVVPPK
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
RAAMKRSMEALIHHFKLYTEGYRVPAGEVYAAVEAPKGEFGVYLVSDGTNKPYRCKLRAP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCEEEEECCC
GFAHLQAMDFLCRGHLLADVTAVLGSLDIVFGEVDR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA