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The map label for this gene is nuoF1 [H]

Identifier: 13471402

GI number: 13471402

Start: 1142222

End: 1143526

Strand: Reverse

Name: nuoF1 [H]

Synonym: mll1365

Alternate gene names: 13471402

Gene position: 1143526-1142222 (Counterclockwise)

Preceding gene: 13471403

Following gene: 13471401

Centisome position: 16.25

GC content: 65.9

Gene sequence:

>1305_bases
ATGCTTCAGGATAAAGACCGCATCTTCACCAACATCTACGGCCTCTTCGACAAGTCGCTGGCCGGCGCCATGGCTCGCGG
CGCCTGGGACAACACGCCCGGCATCGTCGCCAAGGGGCGCGAGTGGATCGTCAACGAGATGAAGGCGTCCGGCCTGCGCG
GCCGTGGCGGCGCAGGCTTCCCGACGGGCCTCAAATGGTCGTTCATGCCCAAGCAGAGCGACGGCCGGCCAAGCTACCTC
GTCATCAATGCCGACGAATCCGAGCCTGGCACCTGCAAGGACCGCGACATCCTGCGCAACGACCCGCACACGCTGGTCGA
GGGCGCGCTGCTCGCCGGCTTCGCCATGGGCGCGATTGCCGCCTACATCTATGTGCGCGGCGAATTCATCCGCGAGCGCG
AGGCGCTGCAGCGTGCCATCGACGAGGCCTATGAGGCCAAGCTGATCGGCAAGGGCAACACGTCAGGCTACGATTTCGAC
GTCTACATGCATCACGGCGCCGGCGCCTATATCTGCGGCGAGGAGACGGCGCTGCTCGAAAGCCTGGAAGGCAAGAAGGG
CCAGCCCAGGCTGAAGCCGCCATTCCCGGCCAATGTCGGCCTCTATGGCTGCCCGACCACCGTCAACAATGTCGAGTCGA
TCGCAGTGGCGCCAACCATCCTGCGCCGGGGCGCGGCCTGGTTCTCGTCCTTCGGCCGGCCCAACAATGTCGGCACCAAG
CTGTTCTGCGTCTCCGGCCACGTCAACAATCCGTGCACCGTCGAAGAGGCGATGTCGATCCCGTTCCGCGAGCTGATCGA
GACGCATTGCGGCGGCATTCGCGGCGGCTGGGACAATCTGCTGGCGGTCATTCCCGGCGGTGCCTCGGTGCCGCTGGTGC
CGGCCGAGCAGATCATCGACACGCCGATGGATTTCGACGCGCTGCGCGACCTCAAATCCGGCCTCGGCACCGCGGCCGTC
ATCGTCATGGACAAGTCGACCGATGTCGTGAAGGCGATCGCGCGGCTGTCCTACTTCTACAAGCATGAGAGCTGCGGCCA
GTGCACGCCGTGCCGCGAAGGCACCGGATGGATGTGGCGGGTGATGGAACGGCTGGTGCGCGGCGAGGCGCAGAAGCGCG
AGATCGACATGCTGCTCGACGTCACCAAGCAGGTCGAGGGCCACACGATCTGCGCGCTGGGCGATGCGGCGGCATGGCCG
ATCCAGGGCCTGATGCGGCATTTCCGCGGCGAGGTGGAGCGGCGCATCGACGAGTTTTCGCGCAACGCGCATCGGGCCGA
ACCGGTGATGGTGGCGGCGGAATAA

Upstream 100 bases:

>100_bases
GAGCGCGACGACTGGGTCAAGCAGGCCAAGGCGCTCGCCAAGGGCGGCGTCGCCGAATACATCCGCGTCTTCGGCAAGAA
GCCGGTCTGAGGGACGAAAA

Downstream 100 bases:

>100_bases
AGGAATTGTGAGTGCGGGTGAAAGCCCGAAGCGAAAATAACGGGGCGGGCGAACGAAGAAACGACCGGGAGAATTCTATG
GCGCCGTATTCGACACCCTA

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MLQDKDRIFTNIYGLFDKSLAGAMARGAWDNTPGIVAKGREWIVNEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPSYL
VINADESEPGTCKDRDILRNDPHTLVEGALLAGFAMGAIAAYIYVRGEFIREREALQRAIDEAYEAKLIGKGNTSGYDFD
VYMHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRPNNVGTK
LFCVSGHVNNPCTVEEAMSIPFRELIETHCGGIRGGWDNLLAVIPGGASVPLVPAEQIIDTPMDFDALRDLKSGLGTAAV
IVMDKSTDVVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAQKREIDMLLDVTKQVEGHTICALGDAAAWP
IQGLMRHFRGEVERRIDEFSRNAHRAEPVMVAAE

Sequences:

>Translated_434_residues
MLQDKDRIFTNIYGLFDKSLAGAMARGAWDNTPGIVAKGREWIVNEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPSYL
VINADESEPGTCKDRDILRNDPHTLVEGALLAGFAMGAIAAYIYVRGEFIREREALQRAIDEAYEAKLIGKGNTSGYDFD
VYMHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRPNNVGTK
LFCVSGHVNNPCTVEEAMSIPFRELIETHCGGIRGGWDNLLAVIPGGASVPLVPAEQIIDTPMDFDALRDLKSGLGTAAV
IVMDKSTDVVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAQKREIDMLLDVTKQVEGHTICALGDAAAWP
IQGLMRHFRGEVERRIDEFSRNAHRAEPVMVAAE
>Mature_434_residues
MLQDKDRIFTNIYGLFDKSLAGAMARGAWDNTPGIVAKGREWIVNEMKASGLRGRGGAGFPTGLKWSFMPKQSDGRPSYL
VINADESEPGTCKDRDILRNDPHTLVEGALLAGFAMGAIAAYIYVRGEFIREREALQRAIDEAYEAKLIGKGNTSGYDFD
VYMHHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRPNNVGTK
LFCVSGHVNNPCTVEEAMSIPFRELIETHCGGIRGGWDNLLAVIPGGASVPLVPAEQIIDTPMDFDALRDLKSGLGTAAV
IVMDKSTDVVKAIARLSYFYKHESCGQCTPCREGTGWMWRVMERLVRGEAQKREIDMLLDVTKQVEGHTICALGDAAAWP
IQGLMRHFRGEVERRIDEFSRNAHRAEPVMVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=419, Percent_Identity=68.9737470167064, Blast_Score=608, Evalue=1e-174,
Organism=Homo sapiens, GI260656005, Length=419, Percent_Identity=68.9737470167064, Blast_Score=607, Evalue=1e-174,
Organism=Escherichia coli, GI1788620, Length=384, Percent_Identity=44.7916666666667, Blast_Score=327, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=422, Percent_Identity=68.0094786729858, Blast_Score=618, Evalue=1e-177,
Organism=Drosophila melanogaster, GI19920794, Length=417, Percent_Identity=70.0239808153477, Blast_Score=624, Evalue=1e-179,
Organism=Drosophila melanogaster, GI45550452, Length=418, Percent_Identity=64.8325358851675, Blast_Score=575, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24653819, Length=425, Percent_Identity=46.3529411764706, Blast_Score=390, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24653817, Length=425, Percent_Identity=43.0588235294118, Blast_Score=353, Evalue=2e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47513; Mature: 47513

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQDKDRIFTNIYGLFDKSLAGAMARGAWDNTPGIVAKGREWIVNEMKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKQSDGRPSYLVINADESEPGTCKDRDILRNDPHTLVEGALLAGFAMGAIA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
AYIYVRGEFIREREALQRAIDEAYEAKLIGKGNTSGYDFDVYMHHGAGAYICGEETALLE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LFCVSGHVNNPCTVEEAMSIPFRELIETHCGGIRGGWDNLLAVIPGGASVPLVPAEQIID
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
TPMDFDALRDLKSGLGTAAVIVMDKSTDVVKAIARLSYFYKHESCGQCTPCREGTGWMWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERLVRGEAQKREIDMLLDVTKQVEGHTICALGDAAAWPIQGLMRHFRGEVERRIDEFS
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RNAHRAEPVMVAAE
HCCCCCCCEEEEEC
>Mature Secondary Structure
MLQDKDRIFTNIYGLFDKSLAGAMARGAWDNTPGIVAKGREWIVNEMKASGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKQSDGRPSYLVINADESEPGTCKDRDILRNDPHTLVEGALLAGFAMGAIA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHH
AYIYVRGEFIREREALQRAIDEAYEAKLIGKGNTSGYDFDVYMHHGAGAYICGEETALLE
HHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEEEEECCCCEEEECCHHHHHH
SLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPTILRRGAAWFSSFGRPNNVGTK
HHCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
LFCVSGHVNNPCTVEEAMSIPFRELIETHCGGIRGGWDNLLAVIPGGASVPLVPAEQIID
EEEEECCCCCCCCHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHHC
TPMDFDALRDLKSGLGTAAVIVMDKSTDVVKAIARLSYFYKHESCGQCTPCREGTGWMWR
CCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHH
VMERLVRGEAQKREIDMLLDVTKQVEGHTICALGDAAAWPIQGLMRHFRGEVERRIDEFS
HHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
RNAHRAEPVMVAAE
HCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]