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The map label for this gene is nuoH

Identifier: 13471399

GI number: 13471399

Start: 1138248

End: 1139291

Strand: Reverse

Name: nuoH

Synonym: mll1361

Alternate gene names: 13471399

Gene position: 1139291-1138248 (Counterclockwise)

Preceding gene: 13471400

Following gene: 13471398

Centisome position: 16.19

GC content: 61.02

Gene sequence:

>1044_bases
ATGGACACCTTCTTCTCCTTCTACGTGCTGCCGGCGCTGCTGATCCTTCTGAAGTCGGTCGTGCTGATCGTGGTGCTGCT
GATCTTCGTGGCCTACATCCTCTACGCCGACCGCAAGATCTGGGCGGCGGTGCAGTTGCGCCGTGGCCCGAACGTTGTCG
GCCCCTGGGGTACGCTGCAGGCCTTCGCCGATCTGTTGAAATTCGTCTTCAAGGAACCGGTCATCCCGTCCGGCGCCAAC
AAGGGCGTGTTCCTTCTGGCGCCGCTGGTGTCGGCGGTGCTGGCGATTTCGGCCTGGGCGGTCATTCCGGTCAACCAAGG
CTGGGCGATCGCCAACGTCAATGTCGGCATCCTCTATGTCTTCGCCATCTCCTCGCTTGAGGTCTATGGCGTGATCATGG
GCGGCTGGGCATCGAACTCGAAATATCCGTTCCTCGGCGCGCTGCGTTCGGCCGCGCAAATGGTGTCCTACGAAGTCTCG
ATCGGCTTCGTCATCGTCACCGTGCTGCTCACCGCCGGCTCGCTCAATTTGTCCGACATTGTGCTGTCGCAGCATGATGG
AATCGGCACCAGGCTTGGCTTGCCCAACACCTTCCTCGACTGGAACTGGCTGGCGCTGTTTCCGATGTTCATCATCTTCT
TCATCTCGGCCCTGGCCGAGACGAACCGGCCGCCCTTCGACCTGGTCGAAGCCGAATCGGAACTGGTCGCCGGCCATATG
GTCGAATATTCGTCGACGCCGTTCCTGTTGTTCTTCCTCGGCGAGTATGTCGCCATCGTCCTGATGTGCGCGCTGGCCAC
CATCCTGTTCCTTGGCGGCTGGCTGCCGCCCTTCGACTTCGTGCCCTTCACCTGGGTGCCCGGCGTCATCTGGTTCGTGC
TGAAGGTCTGCTTCGTGTTCTTCGGCATTTCGATGGTGAAGGCCTTCGTGCCGCGCTACCGCTACGACCAGCTGATGCGG
CTGGGCTGGAAGGTGTTCCTGCCGATCTCGCTGTTCATGGTGGTCGCCACTGCAGCGTTCCTCAAGATCACGGGGTTTGC
GTGA

Upstream 100 bases:

>100_bases
AGGATTTCTATCTGACCAACCCGATCGCGCGGGCATCGGCCGTGATGGCGGAATGCTCGGCACTGGCCAAGAGCGGCTTC
AAGCAGGCGGCGGAATAAGC

Downstream 100 bases:

>100_bases
TGTCCGCTTTGTCCCAGGCCGCAAAATCGCTGCTTCTGCAGGATTTCGTCAGCGCGTTCTTCCTGTCGATGCGCCAGTTC
TTCGCGCCGAAGGAGACGAT

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDTFFSFYVLPALLILLKSVVLIVVLLIFVAYILYADRKIWAAVQLRRGPNVVGPWGTLQAFADLLKFVFKEPVIPSGAN
KGVFLLAPLVSAVLAISAWAVIPVNQGWAIANVNVGILYVFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTAGSLNLSDIVLSQHDGIGTRLGLPNTFLDWNWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
VEYSSTPFLLFFLGEYVAIVLMCALATILFLGGWLPPFDFVPFTWVPGVIWFVLKVCFVFFGISMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKITGFA

Sequences:

>Translated_347_residues
MDTFFSFYVLPALLILLKSVVLIVVLLIFVAYILYADRKIWAAVQLRRGPNVVGPWGTLQAFADLLKFVFKEPVIPSGAN
KGVFLLAPLVSAVLAISAWAVIPVNQGWAIANVNVGILYVFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTAGSLNLSDIVLSQHDGIGTRLGLPNTFLDWNWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
VEYSSTPFLLFFLGEYVAIVLMCALATILFLGGWLPPFDFVPFTWVPGVIWFVLKVCFVFFGISMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKITGFA
>Mature_347_residues
MDTFFSFYVLPALLILLKSVVLIVVLLIFVAYILYADRKIWAAVQLRRGPNVVGPWGTLQAFADLLKFVFKEPVIPSGAN
KGVFLLAPLVSAVLAISAWAVIPVNQGWAIANVNVGILYVFAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGFVIVTVLLTAGSLNLSDIVLSQHDGIGTRLGLPNTFLDWNWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
VEYSSTPFLLFFLGEYVAIVLMCALATILFLGGWLPPFDFVPFTWVPGVIWFVLKVCFVFFGISMVKAFVPRYRYDQLMR
LGWKVFLPISLFMVVATAAFLKITGFA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=39.5424836601307, Blast_Score=227, Evalue=1e-59,
Organism=Escherichia coli, GI1788618, Length=327, Percent_Identity=41.2844036697248, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789077, Length=298, Percent_Identity=26.8456375838926, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_RHILO (Q98KR3)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102965.1
- GeneID:   1225628
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1361
- NMPDR:   fig|266835.1.peg.1070
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   PRK06076
- BRENDA:   1.6.99.5
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38371; Mature: 38371

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc79a4d0)-; HASH(0xe4972b8)-; HASH(0xb5de9c4)-; HASH(0xe49c0cc)-; HASH(0xe49ccf0)-; HASH(0xe499644)-; HASH(0xe49cea0)-; HASH(0xdf23cc0)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTFFSFYVLPALLILLKSVVLIVVLLIFVAYILYADRKIWAAVQLRRGPNVVGPWGTLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
AFADLLKFVFKEPVIPSGANKGVFLLAPLVSAVLAISAWAVIPVNQGWAIANVNVGILYV
HHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHH
FAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLTAGSLNLSDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VLSQHDGIGTRLGLPNTFLDWNWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VEYSSTPFLLFFLGEYVAIVLMCALATILFLGGWLPPFDFVPFTWVPGVIWFVLKVCFVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGISMVKAFVPRYRYDQLMRLGWKVFLPISLFMVVATAAFLKITGFA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MDTFFSFYVLPALLILLKSVVLIVVLLIFVAYILYADRKIWAAVQLRRGPNVVGPWGTLQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHH
AFADLLKFVFKEPVIPSGANKGVFLLAPLVSAVLAISAWAVIPVNQGWAIANVNVGILYV
HHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHHHHHEEEECCCCEEEEECCHHHHHH
FAISSLEVYGVIMGGWASNSKYPFLGALRSAAQMVSYEVSIGFVIVTVLLTAGSLNLSDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VLSQHDGIGTRLGLPNTFLDWNWLALFPMFIIFFISALAETNRPPFDLVEAESELVAGHM
HHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VEYSSTPFLLFFLGEYVAIVLMCALATILFLGGWLPPFDFVPFTWVPGVIWFVLKVCFVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
FGISMVKAFVPRYRYDQLMRLGWKVFLPISLFMVVATAAFLKITGFA
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968