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The map label for this gene is nqo3 [H]

Identifier: 13471400

GI number: 13471400

Start: 1139294

End: 1141375

Strand: Reverse

Name: nqo3 [H]

Synonym: mll1362

Alternate gene names: 13471400

Gene position: 1141375-1139294 (Counterclockwise)

Preceding gene: 13471401

Following gene: 13471399

Centisome position: 16.22

GC content: 65.18

Gene sequence:

>2082_bases
ATGGCAAAGCTCAAGGTCGACGGGAAAGAGATCACTGTACCCGACCACTACACGCTGCTGCAGGCGGCGGAAGACGCGGG
CGCGGAAGTGCCGCGCTTCTGCTTCCATGAGCGGCTGTCGATCGCCGGCAATTGCCGCATGTGCCTGATCGAGGTGAAGG
GCGGGCCGCCCAAGCCGCAGGCCTCCTGCGCCATGGGCGTGCGCGATTTGCGCCCCGGCCCCAATGGCGAGCCGCCGGAA
ATCTTCACCAACACGCCGATGGTCAAGAAGGCCCGGGAAGGCGTGATGGAGTTCCTGCTGATCAACCATCCGCTGGATTG
CCCGATCTGCGACCAGGGCGGCGAGTGCGACCTGCAGGACCAGGCGATGGCCTTCGGCGTCGATTCCTCGCGCTATCACG
AGAACAAGCGGGCGGTCGAAGACAAGTATATCGGCCCGCTGGTCAAGACGGTGATGAACCGCTGCATCCATTGCACGCGC
TGCGTCCGCTTCACCACGGAAGTCGCCGGCATTTCCGAACTCGGCCTGATCGGCCGTGGCGAGGATGCGGAGATCACCAC
CTATCTCGAACAGGCGATGACCTCGGAATTGCAGGGCAATGTCATCGATCTCTGCCCAGTCGGCGCGCTGACCTCCAAAC
CCTTCGCCTTCCAGGCGCGGCCGTGGGAACTGACCAAGACCGAATCCATCGACGTCATGGACGCCGTCGGCTCGGCGATC
CGCATCGACAGCCGTGGCCGCGAAGTGATGCGCATCCTGCCGCGCGTCAACGAGCAGGTGAACGAGGAGTGGATTTCCGA
CAAGACCCGCTTCATCTGGGACGGGTTGCGCACGCAGCGCCTCGACCGTCCCTATGTGCGCAAGGACGGCAGGCTGGTTG
CGGCAAGCTGGGCCGAAGCGTTCGCGACAATCAAGGACGCGGTGTCGAAGACGACGCCAGAGAAGATCGGTGCCATTGCC
GGAGATCTCGCGGCTGTCGAGGAAATCTATGCGCTCAAGTTGCTGATGGCTTCGCTCGGCTCCAAGAATGTCGATTGCCG
CCAGGATGGCGCCGCACTCGATCCGGAGCTTGGACGCGCCAGCTACATCTTCAACCCGACCATCGAAGGTATCGAGCAGG
CCGACGCGGTGCTGATCATTGGCGCCAATCCGCGTTTCGAAGCCTCGGTGCTCAACGCCCGCATCCGTAAGCGCTGGCGG
GTCGGCAACCTGCCGGTCGGCGTCATCGGCGATGTCGGCGACACGCGCTACGAATATGAATTGCTCGGCGCCGGGCCGGA
TTCGCTCAAGGATCTGGCCGACGGCAACGGCAAGTTCTTCCAGACGCTGAAGAAGGCGACGCATCCGCTGATCATCGTCG
GCCAGGGCGCGCTGGCGCGCGCCGACGGCGCGGCCGTGCTCGGCCAGGCGGCGAAGCTCGCCACTGCCGTGAATGCCGCC
CGCGCCGACTGGAACGGCTTTGCCGTGCTGCACAATGCGGCGGCCAGGGTCGGCGGCCTCGATCTCGGTTTCGTGCCGGG
CGAGGGCGGCAAGGATGTCGCCGGCATGCTGGGCGAAACGGACGTGCTGTTCCTGCTCGGCGCCGACGAGATCGACATGG
GCAAGACCGGCGGTGCCTTCGTCGTCTACATCGGCACGCATGGCGACCACGGCGCGCATCGCGCCAATGTCATCCTGCCG
GCAGCTGCCTACACGGAAAAGTCGGGCACCTACGTCAACACCGAAGGGCGCGTGCAGCAGACCAACCGCGCCGGCTTCGC
CCCGGGCGACGCGCGCGAGGACTGGGCGATTCTGCGGGCCCTGTCCGACGTGCTGGGCAAGAAACTGCCATTCGATTCGC
TGCCGCAACTGCGCGCCAAACTCTATGGCGAGTACCCGCATCTGGCCCGCATCGATCAGGTCGCGGCCGGCAATGCCGAG
GACATCGCCGGCGTGGCGAAGCTCGGTGGGCGGCTGAACAAAGGCACCTTCACCTCCCCGGTCAAGGATTTCTATCTGAC
CAACCCGATCGCGCGGGCATCGGCCGTGATGGCGGAATGCTCGGCACTGGCCAAGAGCGGCTTCAAGCAGGCGGCGGAAT
AA

Upstream 100 bases:

>100_bases
GCGGCTGTGCTGGCCGCGAAGAAGTGAATGAAATGCCGGGTGCCGCGTCTGTCGCGCCCGGGAAATGAGATTGCGGGAAA
TCCGCAGGGGTTTGAAGCGA

Downstream 100 bases:

>100_bases
GCATGGACACCTTCTTCTCCTTCTACGTGCTGCCGGCGCTGCTGATCCTTCTGAAGTCGGTCGTGCTGATCGTGGTGCTG
CTGATCTTCGTGGCCTACAT

Product: NADH dehydrogenase subunit G

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 3; NDH-1, chain 3 [H]

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MAKLKVDGKEITVPDHYTLLQAAEDAGAEVPRFCFHERLSIAGNCRMCLIEVKGGPPKPQASCAMGVRDLRPGPNGEPPE
IFTNTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGVDSSRYHENKRAVEDKYIGPLVKTVMNRCIHCTR
CVRFTTEVAGISELGLIGRGEDAEITTYLEQAMTSELQGNVIDLCPVGALTSKPFAFQARPWELTKTESIDVMDAVGSAI
RIDSRGREVMRILPRVNEQVNEEWISDKTRFIWDGLRTQRLDRPYVRKDGRLVAASWAEAFATIKDAVSKTTPEKIGAIA
GDLAAVEEIYALKLLMASLGSKNVDCRQDGAALDPELGRASYIFNPTIEGIEQADAVLIIGANPRFEASVLNARIRKRWR
VGNLPVGVIGDVGDTRYEYELLGAGPDSLKDLADGNGKFFQTLKKATHPLIIVGQGALARADGAAVLGQAAKLATAVNAA
RADWNGFAVLHNAAARVGGLDLGFVPGEGGKDVAGMLGETDVLFLLGADEIDMGKTGGAFVVYIGTHGDHGAHRANVILP
AAAYTEKSGTYVNTEGRVQQTNRAGFAPGDAREDWAILRALSDVLGKKLPFDSLPQLRAKLYGEYPHLARIDQVAAGNAE
DIAGVAKLGGRLNKGTFTSPVKDFYLTNPIARASAVMAECSALAKSGFKQAAE

Sequences:

>Translated_693_residues
MAKLKVDGKEITVPDHYTLLQAAEDAGAEVPRFCFHERLSIAGNCRMCLIEVKGGPPKPQASCAMGVRDLRPGPNGEPPE
IFTNTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGVDSSRYHENKRAVEDKYIGPLVKTVMNRCIHCTR
CVRFTTEVAGISELGLIGRGEDAEITTYLEQAMTSELQGNVIDLCPVGALTSKPFAFQARPWELTKTESIDVMDAVGSAI
RIDSRGREVMRILPRVNEQVNEEWISDKTRFIWDGLRTQRLDRPYVRKDGRLVAASWAEAFATIKDAVSKTTPEKIGAIA
GDLAAVEEIYALKLLMASLGSKNVDCRQDGAALDPELGRASYIFNPTIEGIEQADAVLIIGANPRFEASVLNARIRKRWR
VGNLPVGVIGDVGDTRYEYELLGAGPDSLKDLADGNGKFFQTLKKATHPLIIVGQGALARADGAAVLGQAAKLATAVNAA
RADWNGFAVLHNAAARVGGLDLGFVPGEGGKDVAGMLGETDVLFLLGADEIDMGKTGGAFVVYIGTHGDHGAHRANVILP
AAAYTEKSGTYVNTEGRVQQTNRAGFAPGDAREDWAILRALSDVLGKKLPFDSLPQLRAKLYGEYPHLARIDQVAAGNAE
DIAGVAKLGGRLNKGTFTSPVKDFYLTNPIARASAVMAECSALAKSGFKQAAE
>Mature_692_residues
AKLKVDGKEITVPDHYTLLQAAEDAGAEVPRFCFHERLSIAGNCRMCLIEVKGGPPKPQASCAMGVRDLRPGPNGEPPEI
FTNTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQDQAMAFGVDSSRYHENKRAVEDKYIGPLVKTVMNRCIHCTRC
VRFTTEVAGISELGLIGRGEDAEITTYLEQAMTSELQGNVIDLCPVGALTSKPFAFQARPWELTKTESIDVMDAVGSAIR
IDSRGREVMRILPRVNEQVNEEWISDKTRFIWDGLRTQRLDRPYVRKDGRLVAASWAEAFATIKDAVSKTTPEKIGAIAG
DLAAVEEIYALKLLMASLGSKNVDCRQDGAALDPELGRASYIFNPTIEGIEQADAVLIIGANPRFEASVLNARIRKRWRV
GNLPVGVIGDVGDTRYEYELLGAGPDSLKDLADGNGKFFQTLKKATHPLIIVGQGALARADGAAVLGQAAKLATAVNAAR
ADWNGFAVLHNAAARVGGLDLGFVPGEGGKDVAGMLGETDVLFLLGADEIDMGKTGGAFVVYIGTHGDHGAHRANVILPA
AAYTEKSGTYVNTEGRVQQTNRAGFAPGDAREDWAILRALSDVLGKKLPFDSLPQLRAKLYGEYPHLARIDQVAAGNAED
IAGVAKLGGRLNKGTFTSPVKDFYLTNPIARASAVMAECSALAKSGFKQAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=709, Percent_Identity=50.2115655853314, Blast_Score=671, Evalue=0.0,
Organism=Escherichia coli, GI145693161, Length=708, Percent_Identity=26.1299435028249, Blast_Score=201, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17565758, Length=694, Percent_Identity=48.9913544668588, Blast_Score=615, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI32566231, Length=590, Percent_Identity=50.8474576271186, Blast_Score=559, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI193209088, Length=256, Percent_Identity=60.15625, Blast_Score=318, Evalue=9e-87,
Organism=Drosophila melanogaster, GI24640559, Length=684, Percent_Identity=50.2923976608187, Blast_Score=629, Evalue=1e-180,
Organism=Drosophila melanogaster, GI24640557, Length=684, Percent_Identity=50.2923976608187, Blast_Score=629, Evalue=1e-180,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR006656
- InterPro:   IPR000283
- InterPro:   IPR010228
- InterPro:   IPR019574
- InterPro:   IPR015405 [H]

Pfam domain/function: PF09326 DUF1982; PF00111 Fer2; PF00384 Molybdopterin; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 74546; Mature: 74415

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLKVDGKEITVPDHYTLLQAAEDAGAEVPRFCFHERLSIAGNCRMCLIEVKGGPPKPQ
CCEEEECCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
ASCAMGVRDLRPGPNGEPPEIFTNTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHCHHHCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGVDSSRYHENKRAVEDKYIGPLVKTVMNRCIHCTRCVRFTTEVAGISELGLIGRG
CHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
EDAEITTYLEQAMTSELQGNVIDLCPVGALTSKPFAFQARPWELTKTESIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCEE
RIDSRGREVMRILPRVNEQVNEEWISDKTRFIWDGLRTQRLDRPYVRKDGRLVAASWAEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
FATIKDAVSKTTPEKIGAIAGDLAAVEEIYALKLLMASLGSKNVDCRQDGAALDPELGRA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
SYIFNPTIEGIEQADAVLIIGANPRFEASVLNARIRKRWRVGNLPVGVIGDVGDTRYEYE
EEEECCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEE
LLGAGPDSLKDLADGNGKFFQTLKKATHPLIIVGQGALARADGAAVLGQAAKLATAVNAA
EECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
RADWNGFAVLHNAAARVGGLDLGFVPGEGGKDVAGMLGETDVLFLLGADEIDMGKTGGAF
HCCCCCEEHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCEE
VVYIGTHGDHGAHRANVILPAAAYTEKSGTYVNTEGRVQQTNRAGFAPGDAREDWAILRA
EEEEECCCCCCCCCCCEEEEEHHEECCCCCEECCCCCEEECCCCCCCCCCCCHHHHHHHH
LSDVLGKKLPFDSLPQLRAKLYGEYPHLARIDQVAAGNAEDIAGVAKLGGRLNKGTFTSP
HHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
VKDFYLTNPIARASAVMAECSALAKSGFKQAAE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKLKVDGKEITVPDHYTLLQAAEDAGAEVPRFCFHERLSIAGNCRMCLIEVKGGPPKPQ
CEEEECCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCC
ASCAMGVRDLRPGPNGEPPEIFTNTPMVKKAREGVMEFLLINHPLDCPICDQGGECDLQD
HHHHHCHHHCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
QAMAFGVDSSRYHENKRAVEDKYIGPLVKTVMNRCIHCTRCVRFTTEVAGISELGLIGRG
CHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCC
EDAEITTYLEQAMTSELQGNVIDLCPVGALTSKPFAFQARPWELTKTESIDVMDAVGSAI
CCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCEECCCCCCCCCCCCCHHHHHCCCEE
RIDSRGREVMRILPRVNEQVNEEWISDKTRFIWDGLRTQRLDRPYVRKDGRLVAASWAEA
EECCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
FATIKDAVSKTTPEKIGAIAGDLAAVEEIYALKLLMASLGSKNVDCRQDGAALDPELGRA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCE
SYIFNPTIEGIEQADAVLIIGANPRFEASVLNARIRKRWRVGNLPVGVIGDVGDTRYEYE
EEEECCCHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEE
LLGAGPDSLKDLADGNGKFFQTLKKATHPLIIVGQGALARADGAAVLGQAAKLATAVNAA
EECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
RADWNGFAVLHNAAARVGGLDLGFVPGEGGKDVAGMLGETDVLFLLGADEIDMGKTGGAF
HCCCCCEEHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCCEEEEECCCCCCCCCCCCEE
VVYIGTHGDHGAHRANVILPAAAYTEKSGTYVNTEGRVQQTNRAGFAPGDAREDWAILRA
EEEEECCCCCCCCCCCEEEEEHHEECCCCCEECCCCCEEECCCCCCCCCCCCHHHHHHHH
LSDVLGKKLPFDSLPQLRAKLYGEYPHLARIDQVAAGNAEDIAGVAKLGGRLNKGTFTSP
HHHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCC
VKDFYLTNPIARASAVMAECSALAKSGFKQAAE
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1605643; 8422400 [H]