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The map label for this gene is nuoI

Identifier: 13471398

GI number: 13471398

Start: 1137757

End: 1138251

Strand: Reverse

Name: nuoI

Synonym: mll1359

Alternate gene names: 13471398

Gene position: 1138251-1137757 (Counterclockwise)

Preceding gene: 13471399

Following gene: 13471397

Centisome position: 16.18

GC content: 63.84

Gene sequence:

>495_bases
GTGATGTCCGCTTTGTCCCAGGCCGCAAAATCGCTGCTTCTGCAGGATTTCGTCAGCGCGTTCTTCCTGTCGATGCGCCA
GTTCTTCGCGCCGAAGGAGACGATCAACTACCCGCACGAGAAGGGGCCGGTCAGCCCGCGCTTCCGGGGCGAGCACGCGC
TGCGCCGCTACCCCAATGGCGAGGAACGCTGCATCGCCTGCAAACTGTGCGAGGCGATCTGCCCGGCGCAAGCCATCACC
ATCGAGGCCGGCCCGCGCCGCAATGACGGCACGCGCCGTACGGTGCGTTACGACATCGACATGGTGAAGTGCATCTATTG
CGGCTTCTGCCAGGAAGCCTGCCCGGTCGATGCCATCGTCGAGGGGCCGAATTTCGAGTTCGCGACGGAAACGCGCGAGG
AGCTCTATTACGACAAGGACAAGCTGCTGGCGAATGGCGACCGGTGGGAGCGTGAGCTGGCGCGCAACATCTCGTTGGAT
GCGCCGTACCGCTGA

Upstream 100 bases:

>100_bases
GCTACGACCAGCTGATGCGGCTGGGCTGGAAGGTGTTCCTGCCGATCTCGCTGTTCATGGTGGTCGCCACTGCAGCGTTC
CTCAAGATCACGGGGTTTGC

Downstream 100 bases:

>100_bases
TATTTGACGCATGGACGAGGCGAGGGGCCTCGTCTAAGGAACACGCAACTTGACGACCGGAGGCGGTCGCAGAAATCAAA
CAGGACGAGCGTCCTGTTTG

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAIT
IEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLD
APYR

Sequences:

>Translated_164_residues
MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAIT
IEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLD
APYR
>Mature_164_residues
MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNGEERCIACKLCEAICPAQAIT
IEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIVEGPNFEFATETREELYYDKDKLLANGDRWERELARNISLD
APYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=164, Percent_Identity=70.1219512195122, Blast_Score=240, Evalue=3e-64,
Organism=Escherichia coli, GI1788617, Length=129, Percent_Identity=39.5348837209302, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555194, Length=160, Percent_Identity=66.875, Blast_Score=225, Evalue=8e-60,
Organism=Drosophila melanogaster, GI17864306, Length=158, Percent_Identity=69.620253164557, Blast_Score=237, Evalue=2e-63,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_RHILO (Q98KR4)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102964.1
- HSSP:   P00198
- ProteinModelPortal:   Q98KR4
- SMR:   Q98KR4
- GeneID:   1225627
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll1359
- NMPDR:   fig|266835.1.peg.1069
- HOGENOM:   HBG724359
- OMA:   NYPYEKG
- ProtClustDB:   PRK05888
- BRENDA:   1.6.99.5
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18813; Mature: 18813

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHCCCC
EERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIV
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEE
EGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDAPYR
CCCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMSALSQAAKSLLLQDFVSAFFLSMRQFFAPKETINYPHEKGPVSPRFRGEHALRRYPNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHHHCCCC
EERCIACKLCEAICPAQAITIEAGPRRNDGTRRTVRYDIDMVKCIYCGFCQEACPVDAIV
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCEEE
EGPNFEFATETREELYYDKDKLLANGDRWERELARNISLDAPYR
CCCCCCCHHHHHHHHHHCHHHHHCCCHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11214968