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The map label for this gene is cobC [H]

Identifier: 13471357

GI number: 13471357

Start: 1096714

End: 1097760

Strand: Reverse

Name: cobC [H]

Synonym: mll1303

Alternate gene names: 13471357

Gene position: 1097760-1096714 (Counterclockwise)

Preceding gene: 13471359

Following gene: 13471356

Centisome position: 15.6

GC content: 66.19

Gene sequence:

>1047_bases
ATGAAGCTTCTTGAAGGAGCGGTGGACCATGGTGGAAGTCTTGGCCGGGCGAGGGCGCTTTTCCCCAACGCTCTTCAGCC
TTTCGTCGACCTTTCGACCGGTATCAACCCGCACTCCTACCCGCTTTTCGAGCTGCCCGCCACCTCGCTGTGGCGATTGC
CGGAAGCGGCACGGGCGCGTGAACTGACGGAGATCGCGGCCGGCACCTATGGCGCGCCGTCGCCGGCCAATGTCGTCGCG
GCGCCCGGCACGCAGATCCTGCTGCCGCGCGTGGCATCGCTGGTCAGGCCCGGCAAGGCATTGGTGCTGGGGCCGACCTA
TGCCGAACATGCACGTGCAGCGGCGATTGCCGGGCATCAGGTGACCGAAGTCAGCGATTTTGCGGCGCTGGCGGATGCCG
ACCTTGCTATCATCGTCAATCCGAACAATCCCGACGGTCGCGTCATCGAGCGCGACCGGCTGCTGGCACTGGCCGCCGGG
CTACGCGCCAGAGGCGGGCTGCTGGTCGTCGACGAGGCCTTCATGGATGTCGGCCCGCGTGAACACAGCCTCGCCGGTGA
TGTCGATCAGCGCGGGCTCGTCGTGCTGCGTTCCTTCGGCAAGTTCTTTGGGTTGGCCGGCCTGCGGCTTGGCTTCGCGC
TTTCCGATGCAGCGACGGTTGGCTGGCTGGAAACGCAATTCGGGCCGTGGGCCGTCGCCGGTCCAGCGCTGGACTATGGC
ATTCGCGCGCTTGCCGATATTGGCTGGCAGGATGCGATGCGCGCGTCCCTGGCCGAGGGCGCGGCGCGGCTCGATGCACT
CTTCGGCCGTTTCGGCGTGCCTGTAGCGGGCGGCACCACATTGTTCCGCTATTTCAGCCTGCCGGATGCCGCCAGCCTGT
TTTCAGCGCTTGGCAAACGCGGCGTCCTGCTTCGGCATTTCTGCGATCGGCCGCATGTCCTGCGCGCCGGCCTGCCGGGG
TGTCAGGAGGAATGGCGGCGGCTCGAATCGGCCCTTGCCGAATGGGCGACGCGGCGCGAGGATCGACAAAAAGGTTCAAA
ACAATGA

Upstream 100 bases:

>100_bases
GCCGAACCACGTCACCGGATGGCCGATGGCGCGGAACAGCCAGTCCGGGTAACCCAGGACGAATTCGACGGCCAATGACA
GGAAAGCGATCAGGACTGAC

Downstream 100 bases:

>100_bases
TCCATGTCTGCTCATTGGCGAAGATCGAGGAAACGGTGGCCAGGACCGGCGCCGACCGCATGCTGTCGCTGCTCTCCATC
GGAACCGAGGTGACGCGTCC

Product: cobalamin biosynthetic protein cobC

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MKLLEGAVDHGGSLGRARALFPNALQPFVDLSTGINPHSYPLFELPATSLWRLPEAARARELTEIAAGTYGAPSPANVVA
APGTQILLPRVASLVRPGKALVLGPTYAEHARAAAIAGHQVTEVSDFAALADADLAIIVNPNNPDGRVIERDRLLALAAG
LRARGGLLVVDEAFMDVGPREHSLAGDVDQRGLVVLRSFGKFFGLAGLRLGFALSDAATVGWLETQFGPWAVAGPALDYG
IRALADIGWQDAMRASLAEGAARLDALFGRFGVPVAGGTTLFRYFSLPDAASLFSALGKRGVLLRHFCDRPHVLRAGLPG
CQEEWRRLESALAEWATRREDRQKGSKQ

Sequences:

>Translated_348_residues
MKLLEGAVDHGGSLGRARALFPNALQPFVDLSTGINPHSYPLFELPATSLWRLPEAARARELTEIAAGTYGAPSPANVVA
APGTQILLPRVASLVRPGKALVLGPTYAEHARAAAIAGHQVTEVSDFAALADADLAIIVNPNNPDGRVIERDRLLALAAG
LRARGGLLVVDEAFMDVGPREHSLAGDVDQRGLVVLRSFGKFFGLAGLRLGFALSDAATVGWLETQFGPWAVAGPALDYG
IRALADIGWQDAMRASLAEGAARLDALFGRFGVPVAGGTTLFRYFSLPDAASLFSALGKRGVLLRHFCDRPHVLRAGLPG
CQEEWRRLESALAEWATRREDRQKGSKQ
>Mature_348_residues
MKLLEGAVDHGGSLGRARALFPNALQPFVDLSTGINPHSYPLFELPATSLWRLPEAARARELTEIAAGTYGAPSPANVVA
APGTQILLPRVASLVRPGKALVLGPTYAEHARAAAIAGHQVTEVSDFAALADADLAIIVNPNNPDGRVIERDRLLALAAG
LRARGGLLVVDEAFMDVGPREHSLAGDVDQRGLVVLRSFGKFFGLAGLRLGFALSDAATVGWLETQFGPWAVAGPALDYG
IRALADIGWQDAMRASLAEGAARLDALFGRFGVPVAGGTTLFRYFSLPDAASLFSALGKRGVLLRHFCDRPHVLRAGLPG
CQEEWRRLESALAEWATRREDRQKGSKQ

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=327, Percent_Identity=26.9113149847095, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 37051; Mature: 37051

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLEGAVDHGGSLGRARALFPNALQPFVDLSTGINPHSYPLFELPATSLWRLPEAARAR
CCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHCCCHHHHHH
ELTEIAAGTYGAPSPANVVAAPGTQILLPRVASLVRPGKALVLGPTYAEHARAAAIAGHQ
HHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCC
VTEVSDFAALADADLAIIVNPNNPDGRVIERDRLLALAAGLRARGGLLVVDEAFMDVGPR
HHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCC
EHSLAGDVDQRGLVVLRSFGKFFGLAGLRLGFALSDAATVGWLETQFGPWAVAGPALDYG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEECCHHHHH
IRALADIGWQDAMRASLAEGAARLDALFGRFGVPVAGGTTLFRYFSLPDAASLFSALGKR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCHHHHHHHHCCC
GVLLRHFCDRPHVLRAGLPGCQEEWRRLESALAEWATRREDRQKGSKQ
CHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKLLEGAVDHGGSLGRARALFPNALQPFVDLSTGINPHSYPLFELPATSLWRLPEAARAR
CCCHHHHHHCCCCCCHHHHHCCHHHHHHHHHHCCCCCCCCCEEECCCHHHHCCCHHHHHH
ELTEIAAGTYGAPSPANVVAAPGTQILLPRVASLVRPGKALVLGPTYAEHARAAAIAGHQ
HHHHHHCCCCCCCCCCCEEECCCCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHCCCC
VTEVSDFAALADADLAIIVNPNNPDGRVIERDRLLALAAGLRARGGLLVVDEAFMDVGPR
HHHHHHHHHHCCCCEEEEECCCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCC
EHSLAGDVDQRGLVVLRSFGKFFGLAGLRLGFALSDAATVGWLETQFGPWAVAGPALDYG
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCEEECCHHHHH
IRALADIGWQDAMRASLAEGAARLDALFGRFGVPVAGGTTLFRYFSLPDAASLFSALGKR
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEECCCCHHHHHHHHCCC
GVLLRHFCDRPHVLRAGLPGCQEEWRRLESALAEWATRREDRQKGSKQ
CHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]