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The map label for this gene is dppA [H]

Identifier: 13471266

GI number: 13471266

Start: 998056

End: 999549

Strand: Direct

Name: dppA [H]

Synonym: mlr1186

Alternate gene names: 13471266

Gene position: 998056-999549 (Clockwise)

Preceding gene: 13471265

Following gene: 13471267

Centisome position: 14.18

GC content: 61.24

Gene sequence:

>1494_bases
ATGGGGAGTTCAGCGATGAAACTTTGGAAGACCCTTCTGGCCGCTGCCGTGCTGGCGGTCGCGACCGCCACTTCGGCGTT
TGCCGCCCGGACCGATCTTATCATCGGCATTCCGCTTGAACCCCCGCATCTCGACCCGACGGCGGGAGCGGCCGCGGCAA
TCAGGGAGGTCACCTACGCCAATGTGTTCGAGGGCCTGACCCGGATCGGCCCCAATGGCGAAGTCTTGCCGGATCTCGCC
GAAAGCTGGACCATTTCCGATGACGGCAAGGTCTACACCTTCAAGCTGCACACCGGCGTGAAATTCCACGACGGCGCCGA
TTTCAGCGCCGACGACGTAAAGTTCTCACTCGACCGTGCCCGCGCGGAAAACTCCATCAACGCGCAAAAGCAGCTCTTTG
CCGCCATCGACAAGGTCGAAGTGGCCGACCCCGCCACCGTGAAGGTGACGCTGACCCACCCGCAAGGCTCGTTCCTCTAC
AATATGGGCTGGGGCGACGCGGTGATCGTGTCGCCGAAATCCGCCGACACCAACAAGGAAAAACCTGTTGGCACCGGCCC
CTTCAAGTTCGGGAGCTGGGCCAAGGGTTCATCGATCACCCTGCTCAAATCGGATCATTACTGGGGCGCCCCTGTCTTCC
TCGAAAAGGTCGAGTTCCGCATCGTTCCCGATGCCGCGGCGGCAGTGCCGGCGCTGCTTTCCGGCGACATACAGGCCTTC
CCCTTCTTCGATCCCGACAGCGTCGCGCAGGTCAAGGATGATCCGCGCTTCAAGGTGGTGGTCGGCGCGACCGAAGGCGA
GACCATACTGTCGATCAACAACAAGAAGCCGCCCTTCGACAAATTGCAGGTGAGGCAGGCAATTTCCTATGCGCTCGACC
GCAAGGCGATCATCGACGGCGCCTCGGCCGGGCTCGGCCTGCCGATCGGCTCGCATATGTCGCCGGCTAACAAATACTAT
GTCGACCTCACCGGCCGCTATCCGCACGACGTGGCCAAGGCCAAGGAACTGCTTAAGGAGGCGGGACTGGAGAACGGCTT
CAAGGCCACGCTGAAGCTGCCGCCGACGACCTATGCGCGGCTCGGCGGCGAGATCATCGCCTCGCAACTCCGCGACGTCG
GCATCAACCTCGAGATCATCCCCGTCGAGTGGGCGCAGTGGCTGGACCAGGTGTTCACCAAGAAGGACTACGACCTGACC
ATCGTGTCCCATACCGAGCCGAACGACATCGATATCTACGCGCGCAAGGACTACTACTTCAACTACGACAACCCTGCCTT
CAAAAAGGTCATCGCCGATCTGGAACTGACGTCCGACGAGGCCAAACGCAAAGAACTGTATGCCCAGGCGCAAAAGATCC
TGGCCGACGATGCCGTGGTCGGCTTCCTCTACGAACTGCCCAAGGTCGGAGTCTGGGACGCCAAGCTGCAAGGGTTGTGG
GAAAGCGCACCGATCCCTGCCAACGACCTGACCAAGGTGAAGTGGAGCGAGTGA

Upstream 100 bases:

>100_bases
GGCGCAAAAACATTTCTCCTGGCGCGGCGCGACAGCACGAAACGCAATTTACTCCCGAGCGAAATCACGCTTCTATCCCC
GGGCTTGAGCATTTGAGCAC

Downstream 100 bases:

>100_bases
GGTTCGTTTCGTCATCCTAGGGCGAAGCAGGCGCGCAGCGACTGCGCAGACCCTGGGATCCATTCCGTGAGTTACGAGCG
CACCCCGTGGTGCAGAATCT

Product: dipeptide-binding protein of ABC transporter

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MGSSAMKLWKTLLAAAVLAVATATSAFAARTDLIIGIPLEPPHLDPTAGAAAAIREVTYANVFEGLTRIGPNGEVLPDLA
ESWTISDDGKVYTFKLHTGVKFHDGADFSADDVKFSLDRARAENSINAQKQLFAAIDKVEVADPATVKVTLTHPQGSFLY
NMGWGDAVIVSPKSADTNKEKPVGTGPFKFGSWAKGSSITLLKSDHYWGAPVFLEKVEFRIVPDAAAAVPALLSGDIQAF
PFFDPDSVAQVKDDPRFKVVVGATEGETILSINNKKPPFDKLQVRQAISYALDRKAIIDGASAGLGLPIGSHMSPANKYY
VDLTGRYPHDVAKAKELLKEAGLENGFKATLKLPPTTYARLGGEIIASQLRDVGINLEIIPVEWAQWLDQVFTKKDYDLT
IVSHTEPNDIDIYARKDYYFNYDNPAFKKVIADLELTSDEAKRKELYAQAQKILADDAVVGFLYELPKVGVWDAKLQGLW
ESAPIPANDLTKVKWSE

Sequences:

>Translated_497_residues
MGSSAMKLWKTLLAAAVLAVATATSAFAARTDLIIGIPLEPPHLDPTAGAAAAIREVTYANVFEGLTRIGPNGEVLPDLA
ESWTISDDGKVYTFKLHTGVKFHDGADFSADDVKFSLDRARAENSINAQKQLFAAIDKVEVADPATVKVTLTHPQGSFLY
NMGWGDAVIVSPKSADTNKEKPVGTGPFKFGSWAKGSSITLLKSDHYWGAPVFLEKVEFRIVPDAAAAVPALLSGDIQAF
PFFDPDSVAQVKDDPRFKVVVGATEGETILSINNKKPPFDKLQVRQAISYALDRKAIIDGASAGLGLPIGSHMSPANKYY
VDLTGRYPHDVAKAKELLKEAGLENGFKATLKLPPTTYARLGGEIIASQLRDVGINLEIIPVEWAQWLDQVFTKKDYDLT
IVSHTEPNDIDIYARKDYYFNYDNPAFKKVIADLELTSDEAKRKELYAQAQKILADDAVVGFLYELPKVGVWDAKLQGLW
ESAPIPANDLTKVKWSE
>Mature_496_residues
GSSAMKLWKTLLAAAVLAVATATSAFAARTDLIIGIPLEPPHLDPTAGAAAAIREVTYANVFEGLTRIGPNGEVLPDLAE
SWTISDDGKVYTFKLHTGVKFHDGADFSADDVKFSLDRARAENSINAQKQLFAAIDKVEVADPATVKVTLTHPQGSFLYN
MGWGDAVIVSPKSADTNKEKPVGTGPFKFGSWAKGSSITLLKSDHYWGAPVFLEKVEFRIVPDAAAAVPALLSGDIQAFP
FFDPDSVAQVKDDPRFKVVVGATEGETILSINNKKPPFDKLQVRQAISYALDRKAIIDGASAGLGLPIGSHMSPANKYYV
DLTGRYPHDVAKAKELLKEAGLENGFKATLKLPPTTYARLGGEIIASQLRDVGINLEIIPVEWAQWLDQVFTKKDYDLTI
VSHTEPNDIDIYARKDYYFNYDNPAFKKVIADLELTSDEAKRKELYAQAQKILADDAVVGFLYELPKVGVWDAKLQGLWE
SAPIPANDLTKVKWSE

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=499, Percent_Identity=30.060120240481, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1787052, Length=467, Percent_Identity=29.1220556745182, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787762, Length=492, Percent_Identity=29.2682926829268, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789887, Length=488, Percent_Identity=25.2049180327869, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1787551, Length=508, Percent_Identity=24.6062992125984, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787495, Length=513, Percent_Identity=25.7309941520468, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87081878, Length=502, Percent_Identity=24.1035856573705, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1789397, Length=511, Percent_Identity=23.4833659491194, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 54199; Mature: 54068

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSAMKLWKTLLAAAVLAVATATSAFAARTDLIIGIPLEPPHLDPTAGAAAAIREVTYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
NVFEGLTRIGPNGEVLPDLAESWTISDDGKVYTFKLHTGVKFHDGADFSADDVKFSLDRA
HHHHHHHHCCCCCCCCCCHHHCCEECCCCEEEEEEEECCEEEECCCCCCCCCEEEEHHHH
RAENSINAQKQLFAAIDKVEVADPATVKVTLTHPQGSFLYNMGWGDAVIVSPKSADTNKE
HCCCCCCHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCC
KPVGTGPFKFGSWAKGSSITLLKSDHYWGAPVFLEKVEFRIVPDAAAAVPALLSGDIQAF
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCEEE
PFFDPDSVAQVKDDPRFKVVVGATEGETILSINNKKPPFDKLQVRQAISYALDRKAIIDG
CCCCCCCHHHCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCC
ASAGLGLPIGSHMSPANKYYVDLTGRYPHDVAKAKELLKEAGLENGFKATLKLPPTTYAR
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
LGGEIIASQLRDVGINLEIIPVEWAQWLDQVFTKKDYDLTIVSHTEPNDIDIYARKDYYF
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCEEE
NYDNPAFKKVIADLELTSDEAKRKELYAQAQKILADDAVVGFLYELPKVGVWDAKLQGLW
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCC
ESAPIPANDLTKVKWSE
CCCCCCCCCCCEEEECC
>Mature Secondary Structure 
GSSAMKLWKTLLAAAVLAVATATSAFAARTDLIIGIPLEPPHLDPTAGAAAAIREVTYA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHH
NVFEGLTRIGPNGEVLPDLAESWTISDDGKVYTFKLHTGVKFHDGADFSADDVKFSLDRA
HHHHHHHHCCCCCCCCCCHHHCCEECCCCEEEEEEEECCEEEECCCCCCCCCEEEEHHHH
RAENSINAQKQLFAAIDKVEVADPATVKVTLTHPQGSFLYNMGWGDAVIVSPKSADTNKE
HCCCCCCHHHHHHHHHHHEECCCCCEEEEEEECCCCCEEEECCCCCEEEECCCCCCCCCC
KPVGTGPFKFGSWAKGSSITLLKSDHYWGAPVFLEKVEFRIVPDAAAAVPALLSGDIQAF
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEEEECCCHHHHHHHHHCCCCEEE
PFFDPDSVAQVKDDPRFKVVVGATEGETILSINNKKPPFDKLQVRQAISYALDRKAIIDG
CCCCCCCHHHCCCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHCCC
ASAGLGLPIGSHMSPANKYYVDLTGRYPHDVAKAKELLKEAGLENGFKATLKLPPTTYAR
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHH
LGGEIIASQLRDVGINLEIIPVEWAQWLDQVFTKKDYDLTIVSHTEPNDIDIYARKDYYF
HHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEECCEEE
NYDNPAFKKVIADLELTSDEAKRKELYAQAQKILADDAVVGFLYELPKVGVWDAKLQGLW
ECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCC
ESAPIPANDLTKVKWSE
CCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]