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The map label for this gene is hemR [H]

Identifier: 13471238

GI number: 13471238

Start: 966369

End: 968612

Strand: Direct

Name: hemR [H]

Synonym: mlr1155

Alternate gene names: 13471238

Gene position: 966369-968612 (Clockwise)

Preceding gene: 13471232

Following gene: 13471239

Centisome position: 13.73

GC content: 62.39

Gene sequence:

>2244_bases
ATGCCAGCGAGCCCGAGGCCAGCCAGCAAGAAACCTGGAATCTGGAGTTGGGGCATGGGGTTTTTGAACTGGGAATTGCG
CGGCCGGTCGGCGGCGAACGGTGTGGCGGCTTTGTTGGCGAGCGTGGCGGCGATCGCCCTGTCCGCGCCATCGGCGCATG
CCCAACAGGCAACGCAGCCGGCGGGCGAGCAGACAGATCAATCGAAGAAGGCTGACCAGGAAAAAGCCGCCACCGCGGGC
GCGACGCTGCTCGACAAGATTCTGGTCATCAGCCGCACCGGCGAAACGGCGATCGAATCACTGGCCTCGGCCAGCCATGT
CGACCAAGAGCAACTCGCCCACCGCATGGCGACGACGCCGAACGAGATGCTGCTGGGTGTGCCCGGTGTCGCGACACAGG
CTGACGCCAGGCGCGTCAGCACCAGCATCAACATACGCGGCCTGCAGGATTTCGGCCGCGTCGCGGTTATCGTCGATGGC
GCACGCCAGGATTTCCAGCGTTCAGACCATGGCACCCAGTCGACCTTCTATATCGACCCCGAGCTCGTCAAATCCGTCGA
TGTGATCCGCGGTCCGGTCGCCAACACCTATGGTTCGGGCGCCATCGGCGGCGTCGTCTTCTTCGACACCAAGGACGCCG
CCGACTTCCTCAAGCCGGAGGAAACATGGGGCGCTTCGGTGACCGGACGCTATGAGAGCAACGGCAAGGGCTGGACCACC
AGCGCCACCGGCGCCTACCGTTTCAACGAGAACTGGGACGCGCTCGGCAACATCGTCTACCGCAACTACGACAACTACAA
GGATGGCGGCGGCGACACCGTCAACGGCACCGGCTTCGACGTGCTGAGCGGTCTGCTCAAGACCAGCATACGGCCGACCG
AGAACAGCGAGTTGAAGCTGGGCTGGGTCGGCTCAAGCGACGGCTGGGACGAAACCAGCGGCGGCATGCCGGTCAACGAC
GTCGACCTGAAGTCGAACACCTTCACCGCCCGTTACAACATCACGGATGAGGACAAGAGCTGGCTCGATCTCCACATCAA
CACCTCGTACAACAAGACCAATCTCGACCTGACCAGCCTTGTCCCGCAAAAGCGGTTTGATCCCATAACGGGTCTTCCCA
CTGTCCTGCCGGCGGGGTCGCAATCGACTTTCGACGTCGGCACCACGGGTATCGACATCTGGAACACGTCGCGCTTCGAA
ACAGGCGGGATCGCCCACGAATTGACCTATGGCGGCGACTGGGTCGGCGACGATGTGAAGACGGGCGGCACGGCCGGCGG
CGACAGTTTTTACACGCCTTCGGGCAAGCGCAACGTCTCCGGCGCCTATGTCCAGGACAAGCTCACCTGGGACTGGCTCG
AGGTCATCGCTGGGCTGCGCTACGACAATTACAGCCTGAAGGACAGCACCCGCGAGACCTCGGGCGACCGGCTGTCGCCG
CGCATCACCGTCGGCGTCTCGCCGTTCGAGAGCGCCGGCCTTGCGGGTCTGCAATTCTACGGCACCTACGCCGAAGGCTA
TCGGTCGCCGTCGCTGACGGAAACGCTGATCAGCGGCAACCACCCGGCGGGCGTCACCTTCCCGTTCCTGCCCAATCCCA
ATCTGCGGCCCGAGACCGGCAAGACGACGGAATTCGGCATCAACTACAGGCAGAACGACATCTTCGAACCCGGCGACGCG
CTTCGCGTCAAGGCGGCCTACTTCCACAACAATGTCGACGATTATATCGATGGTGTGACCCTGTCGCCGTTCGCTCCGGG
CAGCGGCTGCCCGTTCGGACCCGGCATTCCGATCTGCTTCCAGTATCAGAATTTCGCCCAGGCCAAGATCGACGGCTTTG
AGCTGGAAGGCGTCTACGACGCCGGATGGGGCTATGCCGGGCTTTCGGCTTCGATCACCAATGGCCACACCATTTCCTAC
AAGGGTGTGGAAGCCGATCTCGCCACCATCCCCTCTTCGCAAGTCACCGCCCAGCTCGGGCTGCGCTTCCTCGAGGACAA
GCTGACCGTCGGTGGCGAGGTTCAGTACAATGGCAAACCAAAGGGCAATGCTGTGGCCGAGGACTATACGTTGGTCAATG
CCTTCGCCAGCTATCAGGCGACCGACAATCTGAAGGTCGATTTCCGCGCCGACAATCTGTTCGACGTCAAATACGCCAAC
CCGCTGAACGGCAGCACGACAGTCGCGGTCTATGAGCCGGGCATAACGCTGAAACTGGCGGCAACCATGCGGTTTGGAGG
TTGA

Upstream 100 bases:

>100_bases
AAATTGCCGATTCATTTCTTGACTTGAATAATCATGTTTACTAGTCAGTGCAATACCGGAGTAAACGAGTCAACATTTAA
GACACCGGACACGATGAAAA

Downstream 100 bases:

>100_bases
TGGCATGACGAGCTCGACGACATCCCTTCGTCTGCTGACCTCGACGCTGGCGATGTCGCTTGCGATGGTTCCGGCGCGGG
GTGAAGGATCCGCGCCGGCC

Product: heme acquisition protein hasR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MPASPRPASKKPGIWSWGMGFLNWELRGRSAANGVAALLASVAAIALSAPSAHAQQATQPAGEQTDQSKKADQEKAATAG
ATLLDKILVISRTGETAIESLASASHVDQEQLAHRMATTPNEMLLGVPGVATQADARRVSTSINIRGLQDFGRVAVIVDG
ARQDFQRSDHGTQSTFYIDPELVKSVDVIRGPVANTYGSGAIGGVVFFDTKDAADFLKPEETWGASVTGRYESNGKGWTT
SATGAYRFNENWDALGNIVYRNYDNYKDGGGDTVNGTGFDVLSGLLKTSIRPTENSELKLGWVGSSDGWDETSGGMPVND
VDLKSNTFTARYNITDEDKSWLDLHINTSYNKTNLDLTSLVPQKRFDPITGLPTVLPAGSQSTFDVGTTGIDIWNTSRFE
TGGIAHELTYGGDWVGDDVKTGGTAGGDSFYTPSGKRNVSGAYVQDKLTWDWLEVIAGLRYDNYSLKDSTRETSGDRLSP
RITVGVSPFESAGLAGLQFYGTYAEGYRSPSLTETLISGNHPAGVTFPFLPNPNLRPETGKTTEFGINYRQNDIFEPGDA
LRVKAAYFHNNVDDYIDGVTLSPFAPGSGCPFGPGIPICFQYQNFAQAKIDGFELEGVYDAGWGYAGLSASITNGHTISY
KGVEADLATIPSSQVTAQLGLRFLEDKLTVGGEVQYNGKPKGNAVAEDYTLVNAFASYQATDNLKVDFRADNLFDVKYAN
PLNGSTTVAVYEPGITLKLAATMRFGG

Sequences:

>Translated_747_residues
MPASPRPASKKPGIWSWGMGFLNWELRGRSAANGVAALLASVAAIALSAPSAHAQQATQPAGEQTDQSKKADQEKAATAG
ATLLDKILVISRTGETAIESLASASHVDQEQLAHRMATTPNEMLLGVPGVATQADARRVSTSINIRGLQDFGRVAVIVDG
ARQDFQRSDHGTQSTFYIDPELVKSVDVIRGPVANTYGSGAIGGVVFFDTKDAADFLKPEETWGASVTGRYESNGKGWTT
SATGAYRFNENWDALGNIVYRNYDNYKDGGGDTVNGTGFDVLSGLLKTSIRPTENSELKLGWVGSSDGWDETSGGMPVND
VDLKSNTFTARYNITDEDKSWLDLHINTSYNKTNLDLTSLVPQKRFDPITGLPTVLPAGSQSTFDVGTTGIDIWNTSRFE
TGGIAHELTYGGDWVGDDVKTGGTAGGDSFYTPSGKRNVSGAYVQDKLTWDWLEVIAGLRYDNYSLKDSTRETSGDRLSP
RITVGVSPFESAGLAGLQFYGTYAEGYRSPSLTETLISGNHPAGVTFPFLPNPNLRPETGKTTEFGINYRQNDIFEPGDA
LRVKAAYFHNNVDDYIDGVTLSPFAPGSGCPFGPGIPICFQYQNFAQAKIDGFELEGVYDAGWGYAGLSASITNGHTISY
KGVEADLATIPSSQVTAQLGLRFLEDKLTVGGEVQYNGKPKGNAVAEDYTLVNAFASYQATDNLKVDFRADNLFDVKYAN
PLNGSTTVAVYEPGITLKLAATMRFGG
>Mature_746_residues
PASPRPASKKPGIWSWGMGFLNWELRGRSAANGVAALLASVAAIALSAPSAHAQQATQPAGEQTDQSKKADQEKAATAGA
TLLDKILVISRTGETAIESLASASHVDQEQLAHRMATTPNEMLLGVPGVATQADARRVSTSINIRGLQDFGRVAVIVDGA
RQDFQRSDHGTQSTFYIDPELVKSVDVIRGPVANTYGSGAIGGVVFFDTKDAADFLKPEETWGASVTGRYESNGKGWTTS
ATGAYRFNENWDALGNIVYRNYDNYKDGGGDTVNGTGFDVLSGLLKTSIRPTENSELKLGWVGSSDGWDETSGGMPVNDV
DLKSNTFTARYNITDEDKSWLDLHINTSYNKTNLDLTSLVPQKRFDPITGLPTVLPAGSQSTFDVGTTGIDIWNTSRFET
GGIAHELTYGGDWVGDDVKTGGTAGGDSFYTPSGKRNVSGAYVQDKLTWDWLEVIAGLRYDNYSLKDSTRETSGDRLSPR
ITVGVSPFESAGLAGLQFYGTYAEGYRSPSLTETLISGNHPAGVTFPFLPNPNLRPETGKTTEFGINYRQNDIFEPGDAL
RVKAAYFHNNVDDYIDGVTLSPFAPGSGCPFGPGIPICFQYQNFAQAKIDGFELEGVYDAGWGYAGLSASITNGHTISYK
GVEADLATIPSSQVTAQLGLRFLEDKLTVGGEVQYNGKPKGNAVAEDYTLVNAFASYQATDNLKVDFRADNLFDVKYANP
LNGSTTVAVYEPGITLKLAATMRFGG

Specific function: This protein is involved in the initial step of iron uptake by binding hemin, an iron chelatin siderophore that allows the bacteria to extract iron from the environment [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR011276
- InterPro:   IPR010949 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 80103; Mature: 79972

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASPRPASKKPGIWSWGMGFLNWELRGRSAANGVAALLASVAAIALSAPSAHAQQATQP
CCCCCCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
AGEQTDQSKKADQEKAATAGATLLDKILVISRTGETAIESLASASHVDQEQLAHRMATTP
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCC
NEMLLGVPGVATQADARRVSTSINIRGLQDFGRVAVIVDGARQDFQRSDHGTQSTFYIDP
CCEEEECCCCCCCCHHHHHEEEEEEEECCCCCCEEEEECCCHHHHHHCCCCCCEEEEECH
ELVKSVDVIRGPVANTYGSGAIGGVVFFDTKDAADFLKPEETWGASVTGRYESNGKGWTT
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHCCCCEEEEEECCCCCEEE
SATGAYRFNENWDALGNIVYRNYDNYKDGGGDTVNGTGFDVLSGLLKTSIRPTENSELKL
CCCEEEEECCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
GWVGSSDGWDETSGGMPVNDVDLKSNTFTARYNITDEDKSWLDLHINTSYNKTNLDLTSL
EEECCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHH
VPQKRFDPITGLPTVLPAGSQSTFDVGTTGIDIWNTSRFETGGIAHELTYGGDWVGDDVK
CCHHHCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCC
TGGTAGGDSFYTPSGKRNVSGAYVQDKLTWDWLEVIAGLRYDNYSLKDSTRETSGDRLSP
CCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
RITVGVSPFESAGLAGLQFYGTYAEGYRSPSLTETLISGNHPAGVTFPFLPNPNLRPETG
EEEEECCCCCCCCCCEEEEEEEHHHCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCC
KTTEFGINYRQNDIFEPGDALRVKAAYFHNNVDDYIDGVTLSPFAPGSGCPFGPGIPICF
CCEEEECCCCCCCCCCCCCCEEEEEEHHHCCHHHHHCCEEECCCCCCCCCCCCCCCCEEE
QYQNFAQAKIDGFELEGVYDAGWGYAGLSASITNGHTISYKGVEADLATIPSSQVTAQLG
EECCCCHHCCCCEEEEEEEECCCCCCCCEEEECCCEEEEECCCCCHHHHCCCHHHHHHHH
LRFLEDKLTVGGEVQYNGKPKGNAVAEDYTLVNAFASYQATDNLKVDFRADNLFDVKYAN
HHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEECC
PLNGSTTVAVYEPGITLKLAATMRFGG
CCCCCEEEEEECCCEEEEEEEEEECCC
>Mature Secondary Structure 
PASPRPASKKPGIWSWGMGFLNWELRGRSAANGVAALLASVAAIALSAPSAHAQQATQP
CCCCCCCCCCCCCEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCC
AGEQTDQSKKADQEKAATAGATLLDKILVISRTGETAIESLASASHVDQEQLAHRMATTP
CCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHHCCC
NEMLLGVPGVATQADARRVSTSINIRGLQDFGRVAVIVDGARQDFQRSDHGTQSTFYIDP
CCEEEECCCCCCCCHHHHHEEEEEEEECCCCCCEEEEECCCHHHHHHCCCCCCEEEEECH
ELVKSVDVIRGPVANTYGSGAIGGVVFFDTKDAADFLKPEETWGASVTGRYESNGKGWTT
HHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHCCCCHHCCCCEEEEEECCCCCEEE
SATGAYRFNENWDALGNIVYRNYDNYKDGGGDTVNGTGFDVLSGLLKTSIRPTENSELKL
CCCEEEEECCCHHHHCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEE
GWVGSSDGWDETSGGMPVNDVDLKSNTFTARYNITDEDKSWLDLHINTSYNKTNLDLTSL
EEECCCCCCCCCCCCCCCCCEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCHHHH
VPQKRFDPITGLPTVLPAGSQSTFDVGTTGIDIWNTSRFETGGIAHELTYGGDWVGDDVK
CCHHHCCCCCCCCCCCCCCCCCCEECCCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCC
TGGTAGGDSFYTPSGKRNVSGAYVQDKLTWDWLEVIAGLRYDNYSLKDSTRETSGDRLSP
CCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
RITVGVSPFESAGLAGLQFYGTYAEGYRSPSLTETLISGNHPAGVTFPFLPNPNLRPETG
EEEEECCCCCCCCCCEEEEEEEHHHCCCCCCHHHHHHCCCCCCCEEECCCCCCCCCCCCC
KTTEFGINYRQNDIFEPGDALRVKAAYFHNNVDDYIDGVTLSPFAPGSGCPFGPGIPICF
CCEEEECCCCCCCCCCCCCCEEEEEEHHHCCHHHHHCCEEECCCCCCCCCCCCCCCCEEE
QYQNFAQAKIDGFELEGVYDAGWGYAGLSASITNGHTISYKGVEADLATIPSSQVTAQLG
EECCCCHHCCCCEEEEEEEECCCCCCCCEEEECCCEEEEECCCCCHHHHCCCHHHHHHHH
LRFLEDKLTVGGEVQYNGKPKGNAVAEDYTLVNAFASYQATDNLKVDFRADNLFDVKYAN
HHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEECC
PLNGSTTVAVYEPGITLKLAATMRFGG
CCCCCEEEEEECCCEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1425573 [H]