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The map label for this gene is lpxD

Identifier: 13470834

GI number: 13470834

Start: 501594

End: 502649

Strand: Reverse

Name: lpxD

Synonym: mll0635

Alternate gene names: 13470834

Gene position: 502649-501594 (Counterclockwise)

Preceding gene: 13470835

Following gene: 13470833

Centisome position: 7.14

GC content: 64.39

Gene sequence:

>1056_bases
ATGACCGATCCGGTGTTCTTCGCGCCATCACGCCGGTATACGGCGGCCGAAGTCGCGAATCTGACCGGCTCGGTGCTTGT
CGATTCCGGCCAATCCGACGTTTCGATCGAGGCGCTGGCGCCGGCCAGCGAAGGCGGCGCCAATGCGCTCGTCTTCGTCG
ACGGCAGGCGTAATTCCGCGCTGATGCCGTCGCTGCGCGCGGCAGCGGTCCTGTGTCCGGCGGAATTCGCCAACAAGGCG
CCGTCGAGCGTCGCCGTTTTGATCCATCCGCGTCCGCAACAGGCATTCGCGCTGGTGGGCCGACTGCTGTTTCCGACAGC
CGCCACGCCGGGGCCAATGACCAGTGAGACCGGTGTTTCAGCGCATGCCCATATCGATCCGACCGCGCATGTCGAAGCCG
GCGCCATCATCGAGGCCGGTGTGGTCATCGGACCAGGCGTCTCGATCGGCAGCGGCACCGTCATCGCGCCAAACGCGGTC
ATTGGACAATCCTGCCAGATCGGCCGTGACGGCTATGTCGGCCCGGGCGCCAGCATCCAGTATGCGCTGATCGGCAATCG
GGTCATCATCCATGGCGGCGCCAGGATCGGCCAGGACGGCTTCGGCTTCGTCGGCGGCGCCAAGGGCCCGGAACGCGTTC
CCCAGATCGGACGGGTCGTCATCCAGGACGATGTCGAGATCGGCTCCAATTCCACCGTCGATCGCGGCGCCATGTCCGAT
ACGATCATCGGCCAGGGCACCAAGATCGACAATCTCGTGCAGATCGCCCATAACGTCCGCATCGGTCGCAATTGTATCGT
GGCGGGACTTTCGGGTATTTCCGGTTCCGTGGTCGTGGGTGACAACGTTACGATGGGCGGCGGTGTCGGGCTTGCCGATC
ACCTGACCATCGGGTCCGGTGCCAAGCTTGCCGCCAGAAGTGGATTTATGAGCAATGTCCCGGCCGGCGAGATCTGGGGC
GGTTATCCGGCACAGCCGATGGCGGAAGCCATGCGGGAGATAGCCATGTTGCGCACGATGGCAAGGGCACGCAAGCAGGG
CAAGGACAATGGCTGA

Upstream 100 bases:

>100_bases
CTTCGGCATATCGACCCGCTTCTGATCGGCGGCCAACGATGCTCCCGGATTTTTTGGATCCGGGAGAAATGTTTCGACCT
AGCTGGATATAGCTTCTGGA

Downstream 100 bases:

>100_bases
TATGGTGGCGGCGACGACGCTGGAAGCGGTCGACATAATGGGGCTGATGAAGCTCCTGCCACACCGCTATCCCTTCCTGA
TGATCGACCGCATCATCGAC

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MTDPVFFAPSRRYTAAEVANLTGSVLVDSGQSDVSIEALAPASEGGANALVFVDGRRNSALMPSLRAAAVLCPAEFANKA
PSSVAVLIHPRPQQAFALVGRLLFPTAATPGPMTSETGVSAHAHIDPTAHVEAGAIIEAGVVIGPGVSIGSGTVIAPNAV
IGQSCQIGRDGYVGPGASIQYALIGNRVIIHGGARIGQDGFGFVGGAKGPERVPQIGRVVIQDDVEIGSNSTVDRGAMSD
TIIGQGTKIDNLVQIAHNVRIGRNCIVAGLSGISGSVVVGDNVTMGGGVGLADHLTIGSGAKLAARSGFMSNVPAGEIWG
GYPAQPMAEAMREIAMLRTMARARKQGKDNG

Sequences:

>Translated_351_residues
MTDPVFFAPSRRYTAAEVANLTGSVLVDSGQSDVSIEALAPASEGGANALVFVDGRRNSALMPSLRAAAVLCPAEFANKA
PSSVAVLIHPRPQQAFALVGRLLFPTAATPGPMTSETGVSAHAHIDPTAHVEAGAIIEAGVVIGPGVSIGSGTVIAPNAV
IGQSCQIGRDGYVGPGASIQYALIGNRVIIHGGARIGQDGFGFVGGAKGPERVPQIGRVVIQDDVEIGSNSTVDRGAMSD
TIIGQGTKIDNLVQIAHNVRIGRNCIVAGLSGISGSVVVGDNVTMGGGVGLADHLTIGSGAKLAARSGFMSNVPAGEIWG
GYPAQPMAEAMREIAMLRTMARARKQGKDNG
>Mature_350_residues
TDPVFFAPSRRYTAAEVANLTGSVLVDSGQSDVSIEALAPASEGGANALVFVDGRRNSALMPSLRAAAVLCPAEFANKAP
SSVAVLIHPRPQQAFALVGRLLFPTAATPGPMTSETGVSAHAHIDPTAHVEAGAIIEAGVVIGPGVSIGSGTVIAPNAVI
GQSCQIGRDGYVGPGASIQYALIGNRVIIHGGARIGQDGFGFVGGAKGPERVPQIGRVVIQDDVEIGSNSTVDRGAMSDT
IIGQGTKIDNLVQIAHNVRIGRNCIVAGLSGISGSVVVGDNVTMGGGVGLADHLTIGSGAKLAARSGFMSNVPAGEIWGG
YPAQPMAEAMREIAMLRTMARARKQGKDNG

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=327, Percent_Identity=29.9694189602446, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786378, Length=222, Percent_Identity=31.5315315315315, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_RHILO (Q98MC4)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102403.1
- ProteinModelPortal:   Q98MC4
- SMR:   Q98MC4
- GeneID:   1225066
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0635
- NMPDR:   fig|266835.1.peg.508
- HOGENOM:   HBG469615
- OMA:   VQIGRVI
- ProtClustDB:   PRK00892
- HAMAP:   MF_00523
- InterPro:   IPR001451
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 35585; Mature: 35454

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPVFFAPSRRYTAAEVANLTGSVLVDSGQSDVSIEALAPASEGGANALVFVDGRRNSA
CCCCEEECCCCCCCHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCC
LMPSLRAAAVLCPAEFANKAPSSVAVLIHPRPQQAFALVGRLLFPTAATPGPMTSETGVS
CCCCHHHHEEECCHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AHAHIDPTAHVEAGAIIEAGVVIGPGVSIGSGTVIAPNAVIGQSCQIGRDGYVGPGASIQ
EEEECCCCCCCCCCCEEECCEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEE
YALIGNRVIIHGGARIGQDGFGFVGGAKGPERVPQIGRVVIQDDVEIGSNSTVDRGAMSD
EEEECCEEEEECCCEECCCCCCCCCCCCCHHHHHHHCEEEEECCCCCCCCCCCCCCCCCC
TIIGQGTKIDNLVQIAHNVRIGRNCIVAGLSGISGSVVVGDNVTMGGGVGLADHLTIGSG
CEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCEEECCCCCCHHEEEECCC
AKLAARSGFMSNVPAGEIWGGYPAQPMAEAMREIAMLRTMARARKQGKDNG
CCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TDPVFFAPSRRYTAAEVANLTGSVLVDSGQSDVSIEALAPASEGGANALVFVDGRRNSA
CCCEEECCCCCCCHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCEEEEEEECCCCCC
LMPSLRAAAVLCPAEFANKAPSSVAVLIHPRPQQAFALVGRLLFPTAATPGPMTSETGVS
CCCCHHHHEEECCHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
AHAHIDPTAHVEAGAIIEAGVVIGPGVSIGSGTVIAPNAVIGQSCQIGRDGYVGPGASIQ
EEEECCCCCCCCCCCEEECCEEEECCCCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEE
YALIGNRVIIHGGARIGQDGFGFVGGAKGPERVPQIGRVVIQDDVEIGSNSTVDRGAMSD
EEEECCEEEEECCCEECCCCCCCCCCCCCHHHHHHHCEEEEECCCCCCCCCCCCCCCCCC
TIIGQGTKIDNLVQIAHNVRIGRNCIVAGLSGISGSVVVGDNVTMGGGVGLADHLTIGSG
CEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCEEECCCEEECCCCCCHHEEEECCC
AKLAARSGFMSNVPAGEIWGGYPAQPMAEAMREIAMLRTMARARKQGKDNG
CCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968