Click here to switch to the map view.

The map label for this gene is glsA

Identifier: 13470489

GI number: 13470489

Start: 143624

End: 144571

Strand: Direct

Name: glsA

Synonym: mlr0211

Alternate gene names: 13470489

Gene position: 143624-144571 (Clockwise)

Preceding gene: 13470488

Following gene: 13470491

Centisome position: 2.04

GC content: 62.87

Gene sequence:

>948_bases
ATGCCGGAACTCGAACGGGCCCCCAAACTTGATCAAGCATTGGCCGAAGTCGCCGCCGAAATGGCCGAACGCACCGATCG
CGGCGATGTCGCCACCTACATTCCTCAGCTGGGCAAGGTCGATCCAAGGAAATTCGGCATTGCCGCCGTCACCAATGACG
GCCGCGTCCTGGTGGCCGGCGATGCCGACCAGGCTTTTTCGATCCAGAGCATCTCCAAGGTGTTCACCTTGACGCTGGCG
CTCGGCAATGTCGGCGACGCGCTGTGGCAGAGGGTCGGGCGCGAGCCGTCGGGCAATCCGTTCAATTCGATCGTCCAGCT
CGAACACGAGAACGGCATTCCGCGCAATCCGTTCATCAATGCCGGCGCCATCGTCATTTCCGACATCCTGCTTGCCGGTC
ATCAGCCGCGCGAGGCGATCGGCGAGATCCTGCGCTTCATCCAGTTCCTGGCCGACGACGACACCATCATCATCGACCGC
GAGGTCGCTGCCTCCGAGCGCGCCACCGGCTATCGCAACTTCGCGCTCGCCAACTACATGAAATCCTTCGGCAATCTTCA
TCATGCACCGGAACTGGCGCTGGGCGTCTATTTCCACCATTGCGCCATCGCCATGAGCTGCCGGCAACTGGCGATGGCCG
GCCGCTTCCTCGCCAATGGCGGCAAGAACCCGGCCACCGGTCATTCCGTGGTATCGGCGGAGCGAGCGCGGCGCATCGGC
GCCATGATGCTGACCTGCGGCCACTATGATGGCTCCGGCGATTTCGCCTTCCGCGTCGGCATTCCGGGAAAAAGCGGCGT
CGGTGGCGGCATATTGGGCATTGTGCCGGGTGTGGCGTCGCTTGCGGTGTGGTCGCCCGGGCTCAACGCCAACGGCAATT
CCAAGCTGGGTTCGATCGCGCTGGAGAAGCTGGCCAGGATGATGAACTGGTCGATCTTCGCGCCATAA

Upstream 100 bases:

>100_bases
ACCCAGGCCGGACATCGCACGATGCGGTTTTCCTACGCCGGCAGCCATGACGACATGGTCGAGGCGATGGCGCGCATCGA
ACGCTGGTTGAGGTAGCGCC

Downstream 100 bases:

>100_bases
ATTTTTGCAGCCTGCCGCACGTGAAAAATCCCGCGCCGTCTTTCGATCGGCGCGGGATTTTCTTATTAAAAAGTCACATC
AACCAGTTGAAAGGCTTAGA

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MPELERAPKLDQALAEVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTNDGRVLVAGDADQAFSIQSISKVFTLTLA
LGNVGDALWQRVGREPSGNPFNSIVQLEHENGIPRNPFINAGAIVISDILLAGHQPREAIGEILRFIQFLADDDTIIIDR
EVAASERATGYRNFALANYMKSFGNLHHAPELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSAERARRIG
AMMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVPGVASLAVWSPGLNANGNSKLGSIALEKLARMMNWSIFAP

Sequences:

>Translated_315_residues
MPELERAPKLDQALAEVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTNDGRVLVAGDADQAFSIQSISKVFTLTLA
LGNVGDALWQRVGREPSGNPFNSIVQLEHENGIPRNPFINAGAIVISDILLAGHQPREAIGEILRFIQFLADDDTIIIDR
EVAASERATGYRNFALANYMKSFGNLHHAPELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSAERARRIG
AMMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVPGVASLAVWSPGLNANGNSKLGSIALEKLARMMNWSIFAP
>Mature_314_residues
PELERAPKLDQALAEVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTNDGRVLVAGDADQAFSIQSISKVFTLTLAL
GNVGDALWQRVGREPSGNPFNSIVQLEHENGIPRNPFINAGAIVISDILLAGHQPREAIGEILRFIQFLADDDTIIIDRE
VAASERATGYRNFALANYMKSFGNLHHAPELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSAERARRIGA
MMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVPGVASLAVWSPGLNANGNSKLGSIALEKLARMMNWSIFAP

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=294, Percent_Identity=37.0748299319728, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI20336214, Length=286, Percent_Identity=37.0629370629371, Blast_Score=190, Evalue=1e-48,
Organism=Escherichia coli, GI1787804, Length=310, Percent_Identity=47.741935483871, Blast_Score=268, Evalue=2e-73,
Organism=Escherichia coli, GI1786693, Length=308, Percent_Identity=40.2597402597403, Blast_Score=199, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17507019, Length=288, Percent_Identity=38.8888888888889, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI193204073, Length=308, Percent_Identity=35.0649350649351, Blast_Score=190, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI193204075, Length=310, Percent_Identity=34.8387096774194, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17532727, Length=287, Percent_Identity=36.5853658536585, Blast_Score=189, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24653166, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24653164, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI281363239, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI281363241, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24653162, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24653156, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24653158, Length=294, Percent_Identity=36.734693877551, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI116008307, Length=291, Percent_Identity=37.1134020618557, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_RHILO (Q98NB7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102058.1
- ProteinModelPortal:   Q98NB7
- SMR:   Q98NB7
- GeneID:   1224721
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0211
- NMPDR:   fig|266835.1.peg.163
- HOGENOM:   HBG512335
- OMA:   NALMLTC
- ProtClustDB:   PRK00971
- BRENDA:   3.5.1.2
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33517; Mature: 33386

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELERAPKLDQALAEVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTNDGRVLVAG
CCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHCCEEEEECCCEEEEEC
DADQAFSIQSISKVFTLTLALGNVGDALWQRVGREPSGNPFNSIVQLEHENGIPRNPFIN
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCCCCCCC
AGAIVISDILLAGHQPREAIGEILRFIQFLADDDTIIIDREVAASERATGYRNFALANYM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHHH
KSFGNLHHAPELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSAERARRIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AMMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVPGVASLAVWSPGLNANGNSKLGSIA
HHEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LEKLARMMNWSIFAP
HHHHHHHHCCCCCCC
>Mature Secondary Structure 
PELERAPKLDQALAEVAAEMAERTDRGDVATYIPQLGKVDPRKFGIAAVTNDGRVLVAG
CCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCHHCCEEEEECCCEEEEEC
DADQAFSIQSISKVFTLTLALGNVGDALWQRVGREPSGNPFNSIVQLEHENGIPRNPFIN
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCCCCCCC
AGAIVISDILLAGHQPREAIGEILRFIQFLADDDTIIIDREVAASERATGYRNFALANYM
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCHHHHHHHHHH
KSFGNLHHAPELALGVYFHHCAIAMSCRQLAMAGRFLANGGKNPATGHSVVSAERARRIG
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AMMLTCGHYDGSGDFAFRVGIPGKSGVGGGILGIVPGVASLAVWSPGLNANGNSKLGSIA
HHEEEECCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
LEKLARMMNWSIFAP
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968