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The map label for this gene is prlC [H]

Identifier: 134302210

GI number: 134302210

Start: 1211996

End: 1214017

Strand: Direct

Name: prlC [H]

Synonym: FTW_1280

Alternate gene names: 134302210

Gene position: 1211996-1214017 (Clockwise)

Preceding gene: 134302203

Following gene: 134302211

Centisome position: 63.84

GC content: 33.78

Gene sequence:

>2022_bases
ATGAATTCGATAATTGAAGACTCTAAATTACCTAAACTTGCAGAATTTAAAGTAGACGAAGTAAAGCCTGCTATAGATAA
ACTCTTTAGCCTAGCTCAAAGCAACCTTGAAAATGCTCTACAAACTCAAAATCCCAATTGGCAGACGTTACTAAAACTAG
AGGAAGATGACGAGAAAATAAGTCAAGCTTTTTCAACAATCTCACATATGAATGCTGTTTGTAATTCTAAAGAACTGCGC
GAAAGTTATGAATATGCGATAGCTAAACTTACTGACTACTATACCAAATTAGGACAAAATAAAGATTTATATAACCTCTA
CAAACAAATTCAAAAAGATAATTTAACTAATGAACAAGCTCAAGCAGTACGTAAAGCTATTATTGGCTTTGAGCAATCAG
GGGTAAATCTTGATGAAGCTAAGAGAAAGAGACTACAACAAATCTCTCAAGAACTTGCTCAACTAAGCACTAAATTTGAA
AATAATGTTCTAGATGCAACTATGGATTGGCTATATACTACCGATGATGAGAAAGAACTCAAAGGTTTATCACAACATAC
TATAGAATCAGCAAAAGCTAAAGCCAATCAAAAGAATATCGCTGAAAAATATGCTCTAGGTATAGACATCCCAACGTACT
TGGCAGTAATGCAGCAAGCAGACAATCGAAAACTTCGTGAAAAATTCTACAAAGCATATTGCACAAAAGCGTCAAAAGAA
GCTGATAATAAAAATTTTGTTAATGATGAAAATATTGAAAAAATTCTAAAATTACGTATTGAAAAATCTCAAATACTTGG
CTTTGATAATTATGCTGAAAATTCTCTCTTTACAAAAATGGCTGAAACACCAGAACAAGTCTTAGAGCTATTAAATAAAC
TCCTAGAAAAATCTTTACCACAAGCTAAAAAAGAACTTAATGAATTACGTAGATTTGCAGAGGATGCTGGCCTTGTCGAT
GCGCTACAACCATGGGATAGCGCATACTACTCTGAGAAACTCAAAAAAGCTAAATTCGACTTCACAGAAGAAGAACTTAG
AGAATACTTTCCATTAGAAAAAGTACAAGATGGATTATTTAAAATACTCAAGCAAATCTATAATTTAGATGTAAAAGAAA
ATACTCAATATACAAAATATGTACCCGAACAACAGACATTTGACTTTTTCAAAAATGATCAATATGTCGGTAGTATAATC
TGTGATTTTTTTGCTCGTGATAACAAACGCGGTGGTGCATGGATGGATGATTCACGTACTGCTTTTACCACTTCTAGTGG
TTCAAAACAAAATCCAGTAGCTTATGTAAACTGCAATTTCCTACCACCCTCAAAAGATGGTGCAAATCTAACCCATAATG
ATGTTGTGACACTATTTCATGAGTTTGGTCATGCATTGCATCATATATTATCACAAGTAACTATTCCTTCTATCTCCGGT
ACAAATGGTGTTGAGTGGGATGCTATTGAGTTGCCGAGTCAATTTATGGAGAATTTCTGTTGGTGTCAGGAAGGTCTAGC
AGTTATATCTGGATCACGAGATGGTAAGGTACTCAGTAGCAAACAGATAGATAAGCTTGTAGGTACTAGACACTTTCATT
CAGCTCTAATGATGGTTAGACAACTTGAGTTTGGAATATTTGATATGAATATCCACTATAAAAAACTAACATCTGCAACA
GAAGTACAAAAAGAGCTAGACAGTATTAGAGAAAAAATTAATTTAATTAAAACGCCAAGTTATAATAAATTCCAAAATGG
CTTTTCACATATTTTTGCTGGTGGCTATGCTGCGGGTTACTATAGCTATAAATGGGCAGAAATCTTATCTTCAGATGTAT
TCTCACGCTTTGAGCAAGAAGGGATACTTAGTCATAAAGTTGGTAATGAGTTGTTAGAAAATATTATTTCTAAAGGGTCA
TCACGTGATGCTATGGATAACTTTGTCGCATTTATGGGACGCAAACCAAACGAAGATGCGCTACTTAGACATAGTGGCAT
TAACTATAAGATTTACATTTAA

Upstream 100 bases:

>100_bases
AGTCATCATAGCAAAAAAACCTTGATTATAATAACATAGTTAACTATATATAAGATTATAACTTATTAACAACATATCTA
AACAATATTTTGAGGCGACT

Downstream 100 bases:

>100_bases
GAAACTACCCTTCAAATTATTGAAACGGTGGCAACCAAAAACTGACAGGACAGCACAATAAAGAAAATGCAAACAATAGA
AATAGGTAACAAAGCAGAAC

Product: M3 family peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 673

Protein sequence:

>673_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYAIAKLTDYYTKLGQNKDLYNLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFVNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLPQAKKELNELRRFAEDAGLVD
ALQPWDSAYYSEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDDSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGINYKIYI

Sequences:

>Translated_673_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYAIAKLTDYYTKLGQNKDLYNLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFVNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLPQAKKELNELRRFAEDAGLVD
ALQPWDSAYYSEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDDSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGINYKIYI
>Mature_673_residues
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKISQAFSTISHMNAVCNSKELR
ESYEYAIAKLTDYYTKLGQNKDLYNLYKQIQKDNLTNEQAQAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFE
NNVLDATMDWLYTTDDEKELKGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
ADNKNFVNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLPQAKKELNELRRFAEDAGLVD
ALQPWDSAYYSEKLKKAKFDFTEEELREYFPLEKVQDGLFKILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSII
CDFFARDNKRGGAWMDDSRTAFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVRQLEFGIFDMNIHYKKLTSAT
EVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGYYSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGS
SRDAMDNFVAFMGRKPNEDALLRHSGINYKIYI

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=612, Percent_Identity=28.921568627451, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI14149738, Length=614, Percent_Identity=27.0358306188925, Blast_Score=199, Evalue=1e-50,
Organism=Homo sapiens, GI156105687, Length=646, Percent_Identity=23.5294117647059, Blast_Score=126, Evalue=7e-29,
Organism=Escherichia coli, GI1789913, Length=677, Percent_Identity=43.5745937961595, Blast_Score=580, Evalue=1e-166,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=28.2199710564399, Blast_Score=242, Evalue=5e-65,
Organism=Caenorhabditis elegans, GI71999758, Length=583, Percent_Identity=24.0137221269297, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI32565901, Length=527, Percent_Identity=21.8216318785579, Blast_Score=87, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6319793, Length=644, Percent_Identity=28.7267080745342, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322715, Length=558, Percent_Identity=22.9390681003584, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356111, Length=577, Percent_Identity=24.7833622183709, Blast_Score=176, Evalue=4e-44,
Organism=Drosophila melanogaster, GI20129717, Length=598, Percent_Identity=22.5752508361204, Blast_Score=124, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77170; Mature: 77170

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKI
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCHHHHH
SQAFSTISHMNAVCNSKELRESYEYAIAKLTDYYTKLGQNKDLYNLYKQIQKDNLTNEQA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFENNVLDATMDWLYTTDDEKEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
KGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADNKNFVNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCH
QAKKELNELRRFAEDAGLVDALQPWDSAYYSEKLKKAKFDFTEEELREYFPLEKVQDGLF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
KILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSIICDFFARDNKRGGAWMDDSRT
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVR
CCCCCCCHHHHHHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLEFGIFDMNIHYKKLTSATEVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGY
HHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
YSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGSSRDAMDNFVAFMGRKPNEDA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCH
LLRHSGINYKIYI
HHHCCCCCEEEEC
>Mature Secondary Structure
MNSIIEDSKLPKLAEFKVDEVKPAIDKLFSLAQSNLENALQTQNPNWQTLLKLEEDDEKI
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEECCHHHHH
SQAFSTISHMNAVCNSKELRESYEYAIAKLTDYYTKLGQNKDLYNLYKQIQKDNLTNEQA
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHH
QAVRKAIIGFEQSGVNLDEAKRKRLQQISQELAQLSTKFENNVLDATMDWLYTTDDEKEL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHH
KGLSQHTIESAKAKANQKNIAEKYALGIDIPTYLAVMQQADNRKLREKFYKAYCTKASKE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
ADNKNFVNDENIEKILKLRIEKSQILGFDNYAENSLFTKMAETPEQVLELLNKLLEKSLP
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCH
QAKKELNELRRFAEDAGLVDALQPWDSAYYSEKLKKAKFDFTEEELREYFPLEKVQDGLF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHH
KILKQIYNLDVKENTQYTKYVPEQQTFDFFKNDQYVGSIICDFFARDNKRGGAWMDDSRT
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
AFTTSSGSKQNPVAYVNCNFLPPSKDGANLTHNDVVTLFHEFGHALHHILSQVTIPSISG
EEEECCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TNGVEWDAIELPSQFMENFCWCQEGLAVISGSRDGKVLSSKQIDKLVGTRHFHSALMMVR
CCCCCCCHHHHHHHHHHHHHHHHHCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLEFGIFDMNIHYKKLTSATEVQKELDSIREKINLIKTPSYNKFQNGFSHIFAGGYAAGY
HHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHH
YSYKWAEILSSDVFSRFEQEGILSHKVGNELLENIISKGSSRDAMDNFVAFMGRKPNEDA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCH
LLRHSGINYKIYI
HHHCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]