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The map label for this gene is ribD [H]

Identifier: 134299939

GI number: 134299939

Start: 2288555

End: 2289685

Strand: Reverse

Name: ribD [H]

Synonym: Dred_2093

Alternate gene names: 134299939

Gene position: 2289685-2288555 (Counterclockwise)

Preceding gene: 134299940

Following gene: 134299938

Centisome position: 63.46

GC content: 47.13

Gene sequence:

>1131_bases
ATGGATCAGGACAGGCACTATATGAACATGGCCCTTGAACTGGCAGCCAAGGCTAGAGGACGCACCAGCCCTAATCCTAT
GGTGGGAGCTGTTTTGGTTAAGGATGGGGAAGTGGTTGGCAAAGGTTTTCATGCCAAAGCAGGCGGTGCCCATGCAGAAG
TAGTGGCGTTGGCCGATGCTGGTGATCGGGCAAAGGGAGCCACAGTGTATGTAACATTGGAACCTTGTTGTCATCATGGG
AAAACCGGACCTTGTACAGAGGCATTGAAAAAAGCAGGGGTTAAAAGGGTTGTGGCCGCCATGACTGACCCGAACCCTTT
GGTTGCAGGTAAGGGCTTAAATATTTTAAAGGATGCCGGTATAGAAGTGGTATCCGGTTTGTTGGAGGAAGAAGCAAAGG
AATTAAATGAGGTTTTTATTAAATATATAACAACAAAAATACCCTTTATTGTCTTAAAGGCTGCCACCAGCTTGGATGGT
AAAATAGCAACAGCCAGTGGGGAATCTAAGTGGATTACCGGTGATACAGCCAGAAATTATGGACACAGATTAAGGGATGC
CTACGATGCCATATTGGTGGGGGTTAATACTGTATTAGCTGATGATCCATCTTTAACTGCCAGATTGCCCGAAGGCAGGG
GCAAAGATCCCCTGCGGATTATTGTAGACAGCATGTCCCGTACCCCTACCAGTGCAAAGATACTAACCCAGGAGTCTGCT
GCCCATACCATCATTGCAACGACCCAAGCGGCACCAGTGGAGCGTCGTGCAAGTTTAATGGCCGCTGGCGCAGAGGTTAT
AGTAGTACCGGGCGAAGGTCCAGGGGTTGACCTGAAAAAATTAATGGTTCTGCTGGGGGAAAAGCAAATATCCAGTGTGC
TCATTGAAGGCGGCGGTAAAATTAGCGGTTCTGCTTTGAATGCAGGTATTGTTGATAAAGTTGCTTGGTTTATTGCCCCT
AAAATCATCGGCGGGGACCTCGCTCCGGGACCTGTTCGGGGTGAAGGAATTCAATTCTTAAAAGATGCTACAAAACTATA
TAAGGTAACAGTGCAAAACTTAGGAGCAGATATTCTCATCACTGGTTATACCTCGAAAGGGGGGGACAAGATATCTTTAC
TGGAATTGTAG

Upstream 100 bases:

>100_bases
TGTCAAAAACCTGCAAAAGAGTACTTTTGTAAGGTTTAATAACTGTGTCTAAAACCCTGGTTTTGTCAGGGTTTTATTTA
TTTTCTTGGGGGATGAAGGA

Downstream 100 bases:

>100_bases
AAGAGATTGGCACCATTAGAGGGATTTCCAAGGGCCCGGATTCAGCCAGGCTTCATATATTAGGGTCAAAGGTGTTGCAG
GATACAAGAATTGGTGACAG

Product: riboflavin biosynthesis protein RibD

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MDQDRHYMNMALELAAKARGRTSPNPMVGAVLVKDGEVVGKGFHAKAGGAHAEVVALADAGDRAKGATVYVTLEPCCHHG
KTGPCTEALKKAGVKRVVAAMTDPNPLVAGKGLNILKDAGIEVVSGLLEEEAKELNEVFIKYITTKIPFIVLKAATSLDG
KIATASGESKWITGDTARNYGHRLRDAYDAILVGVNTVLADDPSLTARLPEGRGKDPLRIIVDSMSRTPTSAKILTQESA
AHTIIATTQAAPVERRASLMAAGAEVIVVPGEGPGVDLKKLMVLLGEKQISSVLIEGGGKISGSALNAGIVDKVAWFIAP
KIIGGDLAPGPVRGEGIQFLKDATKLYKVTVQNLGADILITGYTSKGGDKISLLEL

Sequences:

>Translated_376_residues
MDQDRHYMNMALELAAKARGRTSPNPMVGAVLVKDGEVVGKGFHAKAGGAHAEVVALADAGDRAKGATVYVTLEPCCHHG
KTGPCTEALKKAGVKRVVAAMTDPNPLVAGKGLNILKDAGIEVVSGLLEEEAKELNEVFIKYITTKIPFIVLKAATSLDG
KIATASGESKWITGDTARNYGHRLRDAYDAILVGVNTVLADDPSLTARLPEGRGKDPLRIIVDSMSRTPTSAKILTQESA
AHTIIATTQAAPVERRASLMAAGAEVIVVPGEGPGVDLKKLMVLLGEKQISSVLIEGGGKISGSALNAGIVDKVAWFIAP
KIIGGDLAPGPVRGEGIQFLKDATKLYKVTVQNLGADILITGYTSKGGDKISLLEL
>Mature_376_residues
MDQDRHYMNMALELAAKARGRTSPNPMVGAVLVKDGEVVGKGFHAKAGGAHAEVVALADAGDRAKGATVYVTLEPCCHHG
KTGPCTEALKKAGVKRVVAAMTDPNPLVAGKGLNILKDAGIEVVSGLLEEEAKELNEVFIKYITTKIPFIVLKAATSLDG
KIATASGESKWITGDTARNYGHRLRDAYDAILVGVNTVLADDPSLTARLPEGRGKDPLRIIVDSMSRTPTSAKILTQESA
AHTIIATTQAAPVERRASLMAAGAEVIVVPGEGPGVDLKKLMVLLGEKQISSVLIEGGGKISGSALNAGIVDKVAWFIAP
KIIGGDLAPGPVRGEGIQFLKDATKLYKVTVQNLGADILITGYTSKGGDKISLLEL

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=369, Percent_Identity=44.9864498644986, Blast_Score=301, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6319629, Length=190, Percent_Identity=29.4736842105263, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 39282; Mature: 39282

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQDRHYMNMALELAAKARGRTSPNPMVGAVLVKDGEVVGKGFHAKAGGAHAEVVALADA
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEEEECC
GDRAKGATVYVTLEPCCHHGKTGPCTEALKKAGVKRVVAAMTDPNPLVAGKGLNILKDAG
CCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHCHHHHHHHCCCCCCEEECCCCHHHHHCC
IEVVSGLLEEEAKELNEVFIKYITTKIPFIVLKAATSLDGKIATASGESKWITGDTARNY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCCCEEECCHHHHH
GHRLRDAYDAILVGVNTVLADDPSLTARLPEGRGKDPLRIIVDSMSRTPTSAKILTQESA
HHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCHHHHEEEHHCCCCCCCEEEECCCC
AHTIIATTQAAPVERRASLMAAGAEVIVVPGEGPGVDLKKLMVLLGEKQISSVLIEGGGK
CEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHEEECCCE
ISGSALNAGIVDKVAWFIAPKIIGGDLAPGPVRGEGIQFLKDATKLYKVTVQNLGADILI
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
TGYTSKGGDKISLLEL
EEECCCCCCEEEEEEC
>Mature Secondary Structure
MDQDRHYMNMALELAAKARGRTSPNPMVGAVLVKDGEVVGKGFHAKAGGAHAEVVALADA
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCEEEEEEECC
GDRAKGATVYVTLEPCCHHGKTGPCTEALKKAGVKRVVAAMTDPNPLVAGKGLNILKDAG
CCCCCCCEEEEEECHHHCCCCCCCHHHHHHHHCHHHHHHHCCCCCCEEECCCCHHHHHCC
IEVVSGLLEEEAKELNEVFIKYITTKIPFIVLKAATSLDGKIATASGESKWITGDTARNY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCCCEEECCHHHHH
GHRLRDAYDAILVGVNTVLADDPSLTARLPEGRGKDPLRIIVDSMSRTPTSAKILTQESA
HHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCHHHHEEEHHCCCCCCCEEEECCCC
AHTIIATTQAAPVERRASLMAAGAEVIVVPGEGPGVDLKKLMVLLGEKQISSVLIEGGGK
CEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHCCHHHHHHEEECCCE
ISGSALNAGIVDKVAWFIAPKIIGGDLAPGPVRGEGIQFLKDATKLYKVTVQNLGADILI
ECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEE
TGYTSKGGDKISLLEL
EEECCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8522537 [H]