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The map label for this gene is mtnA

Identifier: 134299910

GI number: 134299910

Start: 2260293

End: 2261333

Strand: Reverse

Name: mtnA

Synonym: Dred_2064

Alternate gene names: 134299910

Gene position: 2261333-2260293 (Counterclockwise)

Preceding gene: 134299911

Following gene: 134299909

Centisome position: 62.67

GC content: 48.8

Gene sequence:

>1041_bases
TTGAACGCAATTATATGGGAAAATAACCAACTGCAGCTGCTGGATCAGACCAAGCTGCCCCGTACCATTGAATATATCCA
GTGTACAGATTATCATACTGTTGGTAAGGCAATAAAAAAATTATCTGTTCGAGGAGCCCCGGCCATTGGAGCGGCTGCTG
CCTATGGTCTGGTGGTGGGAGCGCAACAAGTGGATGCCACGGATCGGAAAACCTTTCTGGAAAAATTGGAAGCCATTGCT
GGTGAATTGGGGGCAACCAGACCAACGGCGGTCAATCTCCGGTGGGCCTTGGATCGGATGATGATGCGTCTAAGTACTGC
CCCAGAGCAGAATGTCGAAGACCTACGCAAAATCATGTTGGAAGAAGCCCATGCCATCTATAACGAAGATGTTGAAAGCA
ATCGAAAGATGGGCGAATATGGACAGGAGTTATTACCGGAGGAAGCCCGTGTACTGACCCACTGCAACGCTGGAGCCCTG
GCAACGGCGGGTTATGGAACAGCCTTGGGGGTTGTGCGGGCTGCCCATGAAAAGGGTAAGAAGGTGCATGTTTATGCGGA
TGAAACCAGACCCCTTTTGCAAGGAGCCAGATTAACTTCCTGGGAAATGGTGCAGGAGGGAATTCCAGTGACCCTCATTA
CCGATAATATGGCTGGTTATCTAATGTCCAAAAAAATGGTTGATTGTATCGTGGTTGGTGCAGATCGGATTACTGCCAAC
GGCGATGTGGCAAACAAAATTGGTACTTATGGTGTGGCGGTACTGGCTAATCATCATAACATTCCCTTTTATGTGGCGGC
TCCTCTGTCAACCATTGACATGAGTCTTTCATCCGGGGAGGAAATTCCCATTGAGGAAAGGGACCCCCAAGAGGTGACCC
ATCATGGTGGGCAGCCCATGGCTCCAGAAGGGGTTCAGGTATGGAACCCTGCCTTTGATGTGACACCAAATTCACTGGTA
AAAGCGATTATTACGGAGAGGGGTGTTGTTTTACCGCCCTTTGCTGAAAACCTTGCTAAAATATGCTGTAATAAAAAGTA
G

Upstream 100 bases:

>100_bases
TTTAAAGAAGCTTGCCATGAAGGCCATCAGCTTAATTGACCCCGAAAGGGGTTGCCTGTGTCAGGAGGCATTGGAAAGGC
TGAATAAGGAGTGATCATAA

Downstream 100 bases:

>100_bases
GAGGAGTACTATGCCTGACTACATTGTACGAGATATTAACCTGGCCCCTGCGGGTCGTTTAAAGATTGACTGGGTTCGCC
AACATATGCCGGTATTGAAT

Product: aIF-2BI family translation initiation factor

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MNAIIWENNQLQLLDQTKLPRTIEYIQCTDYHTVGKAIKKLSVRGAPAIGAAAAYGLVVGAQQVDATDRKTFLEKLEAIA
GELGATRPTAVNLRWALDRMMMRLSTAPEQNVEDLRKIMLEEAHAIYNEDVESNRKMGEYGQELLPEEARVLTHCNAGAL
ATAGYGTALGVVRAAHEKGKKVHVYADETRPLLQGARLTSWEMVQEGIPVTLITDNMAGYLMSKKMVDCIVVGADRITAN
GDVANKIGTYGVAVLANHHNIPFYVAAPLSTIDMSLSSGEEIPIEERDPQEVTHHGGQPMAPEGVQVWNPAFDVTPNSLV
KAIITERGVVLPPFAENLAKICCNKK

Sequences:

>Translated_346_residues
MNAIIWENNQLQLLDQTKLPRTIEYIQCTDYHTVGKAIKKLSVRGAPAIGAAAAYGLVVGAQQVDATDRKTFLEKLEAIA
GELGATRPTAVNLRWALDRMMMRLSTAPEQNVEDLRKIMLEEAHAIYNEDVESNRKMGEYGQELLPEEARVLTHCNAGAL
ATAGYGTALGVVRAAHEKGKKVHVYADETRPLLQGARLTSWEMVQEGIPVTLITDNMAGYLMSKKMVDCIVVGADRITAN
GDVANKIGTYGVAVLANHHNIPFYVAAPLSTIDMSLSSGEEIPIEERDPQEVTHHGGQPMAPEGVQVWNPAFDVTPNSLV
KAIITERGVVLPPFAENLAKICCNKK
>Mature_346_residues
MNAIIWENNQLQLLDQTKLPRTIEYIQCTDYHTVGKAIKKLSVRGAPAIGAAAAYGLVVGAQQVDATDRKTFLEKLEAIA
GELGATRPTAVNLRWALDRMMMRLSTAPEQNVEDLRKIMLEEAHAIYNEDVESNRKMGEYGQELLPEEARVLTHCNAGAL
ATAGYGTALGVVRAAHEKGKKVHVYADETRPLLQGARLTSWEMVQEGIPVTLITDNMAGYLMSKKMVDCIVVGADRITAN
GDVANKIGTYGVAVLANHHNIPFYVAAPLSTIDMSLSSGEEIPIEERDPQEVTHHGGQPMAPEGVQVWNPAFDVTPNSLV
KAIITERGVVLPPFAENLAKICCNKK

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=354, Percent_Identity=43.5028248587571, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI23943880, Length=350, Percent_Identity=38, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4503503, Length=264, Percent_Identity=27.2727272727273, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI78000156, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI78000158, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI187607323, Length=175, Percent_Identity=28, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI7657058, Length=263, Percent_Identity=25.8555133079848, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17557462, Length=333, Percent_Identity=39.039039039039, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17557123, Length=273, Percent_Identity=24.9084249084249, Blast_Score=88, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6325375, Length=388, Percent_Identity=35.5670103092784, Blast_Score=202, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6322878, Length=275, Percent_Identity=28.3636363636364, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21357667, Length=349, Percent_Identity=43.5530085959885, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24651647, Length=349, Percent_Identity=43.5530085959885, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI21358605, Length=229, Percent_Identity=27.0742358078603, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_DESRM (A4J678)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113406.1
- ProteinModelPortal:   A4J678
- SMR:   A4J678
- STRING:   A4J678
- GeneID:   4955467
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2064
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   A4J678
- ProtClustDB:   CLSK853635
- BioCyc:   DRED349161:DRED_2064-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 37722; Mature: 37722

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: ACT_SITE 235-235 BINDING 87-87 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIIWENNQLQLLDQTKLPRTIEYIQCTDYHTVGKAIKKLSVRGAPAIGAAAAYGLVVG
CCCEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
AQQVDATDRKTFLEKLEAIAGELGATRPTAVNLRWALDRMMMRLSTAPEQNVEDLRKIML
CHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EEAHAIYNEDVESNRKMGEYGQELLPEEARVLTHCNAGALATAGYGTALGVVRAAHEKGK
HHHHHHHCCCHHHCCHHHHHHHHHCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCC
KVHVYADETRPLLQGARLTSWEMVQEGIPVTLITDNMAGYLMSKKMVDCIVVGADRITAN
EEEEEECCCCHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHEEEEEECCCEEECC
GDVANKIGTYGVAVLANHHNIPFYVAAPLSTIDMSLSSGEEIPIEERDPQEVTHHGGQPM
CCHHHHHHCCEEEEEEECCCCCEEEECCCHHHEECCCCCCCCCCCCCCHHHHHHCCCCCC
APEGVQVWNPAFDVTPNSLVKAIITERGVVLPPFAENLAKICCNKK
CCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MNAIIWENNQLQLLDQTKLPRTIEYIQCTDYHTVGKAIKKLSVRGAPAIGAAAAYGLVVG
CCCEEECCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
AQQVDATDRKTFLEKLEAIAGELGATRPTAVNLRWALDRMMMRLSTAPEQNVEDLRKIML
CHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHH
EEAHAIYNEDVESNRKMGEYGQELLPEEARVLTHCNAGALATAGYGTALGVVRAAHEKGK
HHHHHHHCCCHHHCCHHHHHHHHHCCHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCC
KVHVYADETRPLLQGARLTSWEMVQEGIPVTLITDNMAGYLMSKKMVDCIVVGADRITAN
EEEEEECCCCHHHHCCCCCHHHHHHCCCCEEEEECCHHHHHHHHHHEEEEEECCCEEECC
GDVANKIGTYGVAVLANHHNIPFYVAAPLSTIDMSLSSGEEIPIEERDPQEVTHHGGQPM
CCHHHHHHCCEEEEEEECCCCCEEEECCCHHHEECCCCCCCCCCCCCCHHHHHHCCCCCC
APEGVQVWNPAFDVTPNSLVKAIITERGVVLPPFAENLAKICCNKK
CCCCCEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA