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The map label for this gene is xapA [C]

Identifier: 134299911

GI number: 134299911

Start: 2261340

End: 2262131

Strand: Reverse

Name: xapA [C]

Synonym: Dred_2065

Alternate gene names: 134299911

Gene position: 2262131-2261340 (Counterclockwise)

Preceding gene: 134299912

Following gene: 134299910

Centisome position: 62.7

GC content: 46.21

Gene sequence:

>792_bases
GTGAGCGTCCGAATAGCGATCATTGGTGGAACCGGAGTTTATGACCCGAATATCTTAGATAACATAAGGGATGAAAAAGT
GAGCACTGCCTACGGGGAAGTGGGTATGAAAATCGGCGACTATCAGGGGAAATCGGTGGCTTTCTTGAATCGTCACGGGG
TAGGACATTCTGTGCCGCCGCATCTGGTAAATTATCGTGCAAATATTGCAGCTCTGAAGGAATTGGGTGTCAAGAGTATT
TTTGCCACCGCAGCAGTGGGTTCTTTGAATAGAAACATGGCCCCGGGTCATTTCGTTTTTTCAGATCAATTTCTTGATTT
TACGAAGGTAAGAAAGAATACTTTCTTTGAAGGCGGGGAGCAAGGGGTTGTACATATTGATATGACAGACCCCTATTGCC
CGGAACTACGTAAAGTGTTAACTTCGGCTGCGGAAGACTTAGGGTTAACCTATCACCGCTACGGAACCTATGTTACCTGT
GAGGGACCCCGCTTTGAAACTCCAGCAGAGATTAAAATGTATCAATTGCTTGGGGGGGACCTGGTGGGTATGACCAGTGT
GCCAGAGGTTGTGCTGGCCCGTGAAAAAGAAATGTGTTATGCCAATATTTCTATGGTTACGAATTATGCGGCGGGTATTT
CGCCAACCAAATTAACTCATCAGGAAGTATTGGATGTAATGGCAGAGAATGCTGGGAATTTAAAGAAGCTTGCCATGAAG
GCCATCAGCTTAATTGACCCCGAAAGGGGTTGCCTGTGTCAGGAGGCATTGGAAAGGCTGAATAAGGAGTGA

Upstream 100 bases:

>100_bases
AATTAACCTGTTTTAGAGGAAAACATAACCAAGAAGGAGAATATTTGAAGTTTGTATAAACCATGCTAATCTTATATTTT
GAGGAAAGGAAGGATCCATT

Downstream 100 bases:

>100_bases
TCATAATTGAACGCAATTATATGGGAAAATAACCAACTGCAGCTGCTGGATCAGACCAAGCTGCCCCGTACCATTGAATA
TATCCAGTGTACAGATTATC

Product: 5'-methylthioadenosine phosphorylase

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSVRIAIIGGTGVYDPNILDNIRDEKVSTAYGEVGMKIGDYQGKSVAFLNRHGVGHSVPPHLVNYRANIAALKELGVKSI
FATAAVGSLNRNMAPGHFVFSDQFLDFTKVRKNTFFEGGEQGVVHIDMTDPYCPELRKVLTSAAEDLGLTYHRYGTYVTC
EGPRFETPAEIKMYQLLGGDLVGMTSVPEVVLAREKEMCYANISMVTNYAAGISPTKLTHQEVLDVMAENAGNLKKLAMK
AISLIDPERGCLCQEALERLNKE

Sequences:

>Translated_263_residues
MSVRIAIIGGTGVYDPNILDNIRDEKVSTAYGEVGMKIGDYQGKSVAFLNRHGVGHSVPPHLVNYRANIAALKELGVKSI
FATAAVGSLNRNMAPGHFVFSDQFLDFTKVRKNTFFEGGEQGVVHIDMTDPYCPELRKVLTSAAEDLGLTYHRYGTYVTC
EGPRFETPAEIKMYQLLGGDLVGMTSVPEVVLAREKEMCYANISMVTNYAAGISPTKLTHQEVLDVMAENAGNLKKLAMK
AISLIDPERGCLCQEALERLNKE
>Mature_262_residues
SVRIAIIGGTGVYDPNILDNIRDEKVSTAYGEVGMKIGDYQGKSVAFLNRHGVGHSVPPHLVNYRANIAALKELGVKSIF
ATAAVGSLNRNMAPGHFVFSDQFLDFTKVRKNTFFEGGEQGVVHIDMTDPYCPELRKVLTSAAEDLGLTYHRYGTYVTCE
GPRFETPAEIKMYQLLGGDLVGMTSVPEVVLAREKEMCYANISMVTNYAAGISPTKLTHQEVLDVMAENAGNLKKLAMKA
ISLIDPERGCLCQEALERLNKE

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=42, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI157168362, Length=263, Percent_Identity=28.1368821292776, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1788746, Length=200, Percent_Identity=32.5, Blast_Score=91, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=40.3225806451613, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17541190, Length=169, Percent_Identity=24.8520710059172, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323045, Length=260, Percent_Identity=34.6153846153846, Blast_Score=134, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6323238, Length=221, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20130079, Length=272, Percent_Identity=36.0294117647059, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221459247, Length=249, Percent_Identity=34.9397590361446, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45552887, Length=262, Percent_Identity=27.8625954198473, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45552885, Length=262, Percent_Identity=27.8625954198473, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24656093, Length=262, Percent_Identity=27.8625954198473, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24656090, Length=262, Percent_Identity=27.8625954198473, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 28839; Mature: 28707

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVRIAIIGGTGVYDPNILDNIRDEKVSTAYGEVGMKIGDYQGKSVAFLNRHGVGHSVPP
CEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCH
HLVNYRANIAALKELGVKSIFATAAVGSLNRNMAPGHFVFSDQFLDFTKVRKNTFFEGGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCC
QGVVHIDMTDPYCPELRKVLTSAAEDLGLTYHRYGTYVTCEGPRFETPAEIKMYQLLGGD
CCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCCCCHHHHHHHHHCCC
LVGMTSVPEVVLAREKEMCYANISMVTNYAAGISPTKLTHQEVLDVMAENAGNLKKLAMK
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
AISLIDPERGCLCQEALERLNKE
HHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SVRIAIIGGTGVYDPNILDNIRDEKVSTAYGEVGMKIGDYQGKSVAFLNRHGVGHSVPP
EEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCEECCCCCCEEEEEECCCCCCCCCH
HLVNYRANIAALKELGVKSIFATAAVGSLNRNMAPGHFVFSDQFLDFTKVRKNTFFEGGE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHCCCCCC
QGVVHIDMTDPYCPELRKVLTSAAEDLGLTYHRYGTYVTCEGPRFETPAEIKMYQLLGGD
CCEEEEECCCCCCHHHHHHHHHHHHHHCCEEECCCCEEEECCCCCCCCHHHHHHHHHCCC
LVGMTSVPEVVLAREKEMCYANISMVTNYAAGISPTKLTHQEVLDVMAENAGNLKKLAMK
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
AISLIDPERGCLCQEALERLNKE
HHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]