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The map label for this gene is ahcY [H]

Identifier: 134299909

GI number: 134299909

Start: 2259026

End: 2260282

Strand: Reverse

Name: ahcY [H]

Synonym: Dred_2063

Alternate gene names: 134299909

Gene position: 2260282-2259026 (Counterclockwise)

Preceding gene: 134299910

Following gene: 134299908

Centisome position: 62.64

GC content: 46.94

Gene sequence:

>1257_bases
ATGCCTGACTACATTGTACGAGATATTAACCTGGCCCCTGCGGGTCGTTTAAAGATTGACTGGGTTCGCCAACATATGCC
GGTATTGAATGAAATCCGTGCACAGTTTGAAAAGGAGCAACCCTTTAAAGGGTACCGGGTGGCGGTATGCATTCACTTAG
AGGCTAAAACCGCTTATTTGGCAGAAGTTTTGAGGGCCGGTGGTGCGGAGGTTTCCATTGCTGGTTCAAATCCGTTGTCT
ACCCAGGATGATGTTGCCGCAGCTCTGGCAGCGGCAGGACTGAATGTTTATTCCTGGTACAATGCTACCGATGAAGAGTA
TAAAGAACATCTACTGCATTTAATAGATGACCAGCCGGACATTGTCATTGATGATGGCGGTGATGTTGTTCAGTTGTTGC
ATACCGAAAGAACAGAAGCTGCTTCCCGGGTGCTGGGAGGTTGCGAGGAGACCACCACCGGGGTATTGCGCCTACGCTCC
CTAGCCAAACAGGGGGAATTGAAATTTCCCATGATTGCCGTAAATGATGCCTATTGTAAGTATCTTTTTGATAATCGCTA
TGGCACAGGGGAGTCGGTATGGTCCGGTATAATGCGTACCACAAACCTGATTACTGCGGGGAAAACTGTAGTAGTAGCGG
GTTACGGCTGGTGCGGTAAAGGTATCGCCATGCGTGCCAAGGGAATGGGGGCCAAGGTGATTGTTACAGAGGTCGATCCC
GTAAAGGCCATCGAAGCTTATATGGATGGATTCCATCCCATGAATAGCTTAGAAGCTGCTAAACTGGGGGATATTTTTAT
TACAGTTACTGGATGCAAGGATGTGTTCACTGGCGTACACTATGAACGTATGAAAGACGGGGCTATTCTCTGTAATGCTG
GACATTTTGATGTGGAGGTTAACAAACCAGATTTGCTAGCCTTAGCAACCTCCCGGAGGATTGTTAGAAAGGACATTGAG
GAGTTTACCATGAAAGATGGCCGGAAAATTTACTTATTAGCAGAGGGGCGTCTAGTTAACCTTGCTGCGGGTGACGGACA
TCCGGCAGAGATCATGGATATGTCCTTTGCTCTTCAAGCCCTAAGCGCTAGATATGTGTTGGAGAATGCTAAAAAGTTAT
CTAATGAAGTATACGTGGTACCGAAGGAAATTGATGACCGAGTGGCCAATCTAAAACTAAAATCTTTGGGAGTGGATATT
GATTCCCTCACGCCTGAGCAAGAAGCCTATATTAACGAGTGGAACCATGGTACCTAA

Upstream 100 bases:

>100_bases
TCACTGGTAAAAGCGATTATTACGGAGAGGGGTGTTGTTTTACCGCCCTTTGCTGAAAACCTTGCTAAAATATGCTGTAA
TAAAAAGTAGGAGGAGTACT

Downstream 100 bases:

>100_bases
GCAGGAGTTAGTAATGGTAAAGGCAACTGAAAAAGTAAGAGAAACGGTGGCCCGGCTGGGGAGAAAAATGTTGGAGTCTG
GTTTGGTTGCAGGAACCTGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPDYIVRDINLAPAGRLKIDWVRQHMPVLNEIRAQFEKEQPFKGYRVAVCIHLEAKTAYLAEVLRAGGAEVSIAGSNPLS
TQDDVAAALAAAGLNVYSWYNATDEEYKEHLLHLIDDQPDIVIDDGGDVVQLLHTERTEAASRVLGGCEETTTGVLRLRS
LAKQGELKFPMIAVNDAYCKYLFDNRYGTGESVWSGIMRTTNLITAGKTVVVAGYGWCGKGIAMRAKGMGAKVIVTEVDP
VKAIEAYMDGFHPMNSLEAAKLGDIFITVTGCKDVFTGVHYERMKDGAILCNAGHFDVEVNKPDLLALATSRRIVRKDIE
EFTMKDGRKIYLLAEGRLVNLAAGDGHPAEIMDMSFALQALSARYVLENAKKLSNEVYVVPKEIDDRVANLKLKSLGVDI
DSLTPEQEAYINEWNHGT

Sequences:

>Translated_418_residues
MPDYIVRDINLAPAGRLKIDWVRQHMPVLNEIRAQFEKEQPFKGYRVAVCIHLEAKTAYLAEVLRAGGAEVSIAGSNPLS
TQDDVAAALAAAGLNVYSWYNATDEEYKEHLLHLIDDQPDIVIDDGGDVVQLLHTERTEAASRVLGGCEETTTGVLRLRS
LAKQGELKFPMIAVNDAYCKYLFDNRYGTGESVWSGIMRTTNLITAGKTVVVAGYGWCGKGIAMRAKGMGAKVIVTEVDP
VKAIEAYMDGFHPMNSLEAAKLGDIFITVTGCKDVFTGVHYERMKDGAILCNAGHFDVEVNKPDLLALATSRRIVRKDIE
EFTMKDGRKIYLLAEGRLVNLAAGDGHPAEIMDMSFALQALSARYVLENAKKLSNEVYVVPKEIDDRVANLKLKSLGVDI
DSLTPEQEAYINEWNHGT
>Mature_417_residues
PDYIVRDINLAPAGRLKIDWVRQHMPVLNEIRAQFEKEQPFKGYRVAVCIHLEAKTAYLAEVLRAGGAEVSIAGSNPLST
QDDVAAALAAAGLNVYSWYNATDEEYKEHLLHLIDDQPDIVIDDGGDVVQLLHTERTEAASRVLGGCEETTTGVLRLRSL
AKQGELKFPMIAVNDAYCKYLFDNRYGTGESVWSGIMRTTNLITAGKTVVVAGYGWCGKGIAMRAKGMGAKVIVTEVDPV
KAIEAYMDGFHPMNSLEAAKLGDIFITVTGCKDVFTGVHYERMKDGAILCNAGHFDVEVNKPDLLALATSRRIVRKDIEE
FTMKDGRKIYLLAEGRLVNLAAGDGHPAEIMDMSFALQALSARYVLENAKKLSNEVYVVPKEIDDRVANLKLKSLGVDID
SLTPEQEAYINEWNHGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=411, Percent_Identity=43.0656934306569, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=43.1876606683805, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI195539349, Length=414, Percent_Identity=37.6811594202899, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI298286489, Length=414, Percent_Identity=37.6811594202899, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI195539337, Length=414, Percent_Identity=37.6811594202899, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI24308043, Length=414, Percent_Identity=37.6811594202899, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI21361647, Length=414, Percent_Identity=36.4734299516908, Blast_Score=250, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17506425, Length=419, Percent_Identity=43.436754176611, Blast_Score=337, Evalue=7e-93,
Organism=Saccharomyces cerevisiae, GI6320882, Length=428, Percent_Identity=40.1869158878505, Blast_Score=310, Evalue=3e-85,
Organism=Drosophila melanogaster, GI24642172, Length=414, Percent_Identity=43.9613526570048, Blast_Score=329, Evalue=2e-90,
Organism=Drosophila melanogaster, GI24656245, Length=415, Percent_Identity=37.1084337349398, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI45553385, Length=412, Percent_Identity=37.621359223301, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI45553387, Length=412, Percent_Identity=37.621359223301, Blast_Score=252, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 46026; Mature: 45895

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2 ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYIVRDINLAPAGRLKIDWVRQHMPVLNEIRAQFEKEQPFKGYRVAVCIHLEAKTAYL
CCCCEEEECCCCCCCCEEHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHH
AEVLRAGGAEVSIAGSNPLSTQDDVAAALAAAGLNVYSWYNATDEEYKEHLLHLIDDQPD
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCC
IVIDDGGDVVQLLHTERTEAASRVLGGCEETTTGVLRLRSLAKQGELKFPMIAVNDAYCK
EEEECCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
YLFDNRYGTGESVWSGIMRTTNLITAGKTVVVAGYGWCGKGIAMRAKGMGAKVIVTEVDP
HHCCCCCCCHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCH
VKAIEAYMDGFHPMNSLEAAKLGDIFITVTGCKDVFTGVHYERMKDGAILCNAGHFDVEV
HHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCHHHHHCCCHHHCCCCEEEEECCCEEEEE
NKPDLLALATSRRIVRKDIEEFTMKDGRKIYLLAEGRLVNLAAGDGHPAEIMDMSFALQA
CCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
LSARYVLENAKKLSNEVYVVPKEIDDRVANLKLKSLGVDIDSLTPEQEAYINEWNHGT
HHHHHHHHHHHHCCCCEEEECCHHCCHHHCEEEHHHCCCHHCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
PDYIVRDINLAPAGRLKIDWVRQHMPVLNEIRAQFEKEQPFKGYRVAVCIHLEAKTAYL
CCCEEEECCCCCCCCEEHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEEEEECCHHHHH
AEVLRAGGAEVSIAGSNPLSTQDDVAAALAAAGLNVYSWYNATDEEYKEHLLHLIDDQPD
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCC
IVIDDGGDVVQLLHTERTEAASRVLGGCEETTTGVLRLRSLAKQGELKFPMIAVNDAYCK
EEEECCCCEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
YLFDNRYGTGESVWSGIMRTTNLITAGKTVVVAGYGWCGKGIAMRAKGMGAKVIVTEVDP
HHCCCCCCCHHHHHHHHHHHHHEEECCCEEEEEECCCCCCCCEEEECCCCCEEEEEECCH
VKAIEAYMDGFHPMNSLEAAKLGDIFITVTGCKDVFTGVHYERMKDGAILCNAGHFDVEV
HHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCHHHHHCCCHHHCCCCEEEEECCCEEEEE
NKPDLLALATSRRIVRKDIEEFTMKDGRKIYLLAEGRLVNLAAGDGHPAEIMDMSFALQA
CCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
LSARYVLENAKKLSNEVYVVPKEIDDRVANLKLKSLGVDIDSLTPEQEAYINEWNHGT
HHHHHHHHHHHHCCCCEEEECCHHCCHHHCEEEHHHCCCHHCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]