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The map label for this gene is nuoD

Identifier: 134299889

GI number: 134299889

Start: 2242941

End: 2244041

Strand: Reverse

Name: nuoD

Synonym: Dred_2043

Alternate gene names: 134299889

Gene position: 2244041-2242941 (Counterclockwise)

Preceding gene: 134299890

Following gene: 134299888

Centisome position: 62.19

GC content: 43.78

Gene sequence:

>1101_bases
TTGACCATTAAAACCGAAGAATTTTTATTAAATTTAGGTCCGCAGCATCCCAGTACCCACGGTGTTTTTAGAATTGTTTT
AACCCTGGATGGTGAGACTGTAGTAAAGGCTGTACCGGTTCCGGGATATCTGCACAGGGGTATTGAAAAATTACTTGAGT
CCAGAACCTATACTCAAGTTATTCCCTATACAGATCGTCTTGATTACTTGGCAGGTATGTTAATGAACTGGGGCTATGTA
CATGCTGTTGAAAAGCTAATGGAGGTTGAAATACCGGAAAGGGCTGAATATATTCGGGTTATTGTTGGGGAATTATCCCG
AATTGCCAGCCACCTGGTGGCCACCGGTGCCTACGCAGCGGATATTGGAGGACTGACAGGCTTTATTTACACTTTCCGGG
ATCGTGAAGAAATTATGGACCTGTTTGAAATGATCTCCGGTGCCAGGCTAACTCCAAGTTTTATGCGGATAGGTGGTGTA
GCCTATGATATTCCTGATGGTTTTATGGAGCGGTGCAAAAAGTTTGTAGATTACCTGCCTGAGGCCATTAAAGAATATAA
CACCCTAATTACCGGAAATGAAATCTTTCAAGCCAGGACAAAGAATGTTGCCATCTTATCGGCGGAAAAGGCCATTGATA
TGAGTCTGTCGGGTCCGGTCCTGAGGGCTACTGGTGTTAATTATGATCTTAGGAAGGTTAGGCCCTACAGTGTGTACGAG
AGATTTGAGTTTGAGGTTCCCCTCGGTACTAAGGGTGACTGCTTTGATCGGTATTATATTCGCTTATTAGAAATGGAACA
GTCAGCGAGGATTATTCAACAGGCCATGGATCAAATACCCGAAGGACCCATAAGGGCAAAAATACCAAAGATGATAAAAC
CTCCTGTGGGAGAAGCCTATGCAGAGATTGAAAGTTCTAAAGGGATTATGGGTACCTATGTTGTTAGTGACGGCAGTACC
AAACCTTATCGGGTACACTTCCGCCGCCCATCCTTTGTAAACTTGGGTTATTTAAATGAAATGCTACGGGGCTGGAAGAT
AGCGGATGTTATTGCCATTCTTGGCAGCATTGATATCGTGTTAGGTGAAGTTGATGCTTAG

Upstream 100 bases:

>100_bases
AGGAGAATCTTACTGGCCGATGATTGGGAAGGTCATCCTCTCCGCAGGGATTATCAGTGGGAGGGTGGCCGAGAATAGGC
CCTATGAGAGGTGATACACG

Downstream 100 bases:

>100_bases
ATTGTAGGAGTGAGGCAAAGTGGAGAACTTATTTGTTAATTTAGCCAGCGGGTCTCGGACCCTGCTGGGGTCCGCTGGCC
TACCCGGTGCGGCAACTGAT

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MTIKTEEFLLNLGPQHPSTHGVFRIVLTLDGETVVKAVPVPGYLHRGIEKLLESRTYTQVIPYTDRLDYLAGMLMNWGYV
HAVEKLMEVEIPERAEYIRVIVGELSRIASHLVATGAYAADIGGLTGFIYTFRDREEIMDLFEMISGARLTPSFMRIGGV
AYDIPDGFMERCKKFVDYLPEAIKEYNTLITGNEIFQARTKNVAILSAEKAIDMSLSGPVLRATGVNYDLRKVRPYSVYE
RFEFEVPLGTKGDCFDRYYIRLLEMEQSARIIQQAMDQIPEGPIRAKIPKMIKPPVGEAYAEIESSKGIMGTYVVSDGST
KPYRVHFRRPSFVNLGYLNEMLRGWKIADVIAILGSIDIVLGEVDA

Sequences:

>Translated_366_residues
MTIKTEEFLLNLGPQHPSTHGVFRIVLTLDGETVVKAVPVPGYLHRGIEKLLESRTYTQVIPYTDRLDYLAGMLMNWGYV
HAVEKLMEVEIPERAEYIRVIVGELSRIASHLVATGAYAADIGGLTGFIYTFRDREEIMDLFEMISGARLTPSFMRIGGV
AYDIPDGFMERCKKFVDYLPEAIKEYNTLITGNEIFQARTKNVAILSAEKAIDMSLSGPVLRATGVNYDLRKVRPYSVYE
RFEFEVPLGTKGDCFDRYYIRLLEMEQSARIIQQAMDQIPEGPIRAKIPKMIKPPVGEAYAEIESSKGIMGTYVVSDGST
KPYRVHFRRPSFVNLGYLNEMLRGWKIADVIAILGSIDIVLGEVDA
>Mature_365_residues
TIKTEEFLLNLGPQHPSTHGVFRIVLTLDGETVVKAVPVPGYLHRGIEKLLESRTYTQVIPYTDRLDYLAGMLMNWGYVH
AVEKLMEVEIPERAEYIRVIVGELSRIASHLVATGAYAADIGGLTGFIYTFRDREEIMDLFEMISGARLTPSFMRIGGVA
YDIPDGFMERCKKFVDYLPEAIKEYNTLITGNEIFQARTKNVAILSAEKAIDMSLSGPVLRATGVNYDLRKVRPYSVYER
FEFEVPLGTKGDCFDRYYIRLLEMEQSARIIQQAMDQIPEGPIRAKIPKMIKPPVGEAYAEIESSKGIMGTYVVSDGSTK
PYRVHFRRPSFVNLGYLNEMLRGWKIADVIAILGSIDIVLGEVDA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=381, Percent_Identity=42.257217847769, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI260898743, Length=376, Percent_Identity=41.4893617021277, Blast_Score=318, Evalue=3e-87,
Organism=Escherichia coli, GI145693162, Length=389, Percent_Identity=41.6452442159383, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI1789076, Length=355, Percent_Identity=29.5774647887324, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI1788832, Length=348, Percent_Identity=29.3103448275862, Blast_Score=137, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17568379, Length=385, Percent_Identity=41.5584415584416, Blast_Score=340, Evalue=5e-94,
Organism=Caenorhabditis elegans, GI17555284, Length=385, Percent_Identity=40.7792207792208, Blast_Score=337, Evalue=4e-93,
Organism=Drosophila melanogaster, GI24638644, Length=381, Percent_Identity=43.3070866141732, Blast_Score=348, Evalue=3e-96,
Organism=Drosophila melanogaster, GI221459469, Length=382, Percent_Identity=41.8848167539267, Blast_Score=332, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_DESRM (A4J657)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113385.1
- STRING:   A4J657
- GeneID:   4958013
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2043
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   WIQNIPL
- PhylomeDB:   A4J657
- ProtClustDB:   PRK12322
- BioCyc:   DRED349161:DRED_2043-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 41271; Mature: 41140

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKTEEFLLNLGPQHPSTHGVFRIVLTLDGETVVKAVPVPGYLHRGIEKLLESRTYTQV
CCCCHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCEEE
IPYTDRLDYLAGMLMNWGYVHAVEKLMEVEIPERAEYIRVIVGELSRIASHLVATGAYAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIGGLTGFIYTFRDREEIMDLFEMISGARLTPSFMRIGGVAYDIPDGFMERCKKFVDYLP
HHCCHHEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHCCEEEECCHHHHHHHHHHHHHHH
EAIKEYNTLITGNEIFQARTKNVAILSAEKAIDMSLSGPVLRATGVNYDLRKVRPYSVYE
HHHHHHHCEECCCHHHHHHCCCEEEEECCHHHCCCCCCCEEEECCCCCHHHHCCCHHHHH
RFEFEVPLGTKGDCFDRYYIRLLEMEQSARIIQQAMDQIPEGPIRAKIPKMIKPPVGEAY
HEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHCCCCCHHH
AEIESSKGIMGTYVVSDGSTKPYRVHFRRPSFVNLGYLNEMLRGWKIADVIAILGSIDIV
HHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHEE
LGEVDA
EECCCC
>Mature Secondary Structure 
TIKTEEFLLNLGPQHPSTHGVFRIVLTLDGETVVKAVPVPGYLHRGIEKLLESRTYTQV
CCCHHHHHHCCCCCCCCCCCEEEEEEEECCCEEEEEECCCHHHHHHHHHHHHCCCCEEE
IPYTDRLDYLAGMLMNWGYVHAVEKLMEVEIPERAEYIRVIVGELSRIASHLVATGAYAA
CCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DIGGLTGFIYTFRDREEIMDLFEMISGARLTPSFMRIGGVAYDIPDGFMERCKKFVDYLP
HHCCHHEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHCCEEEECCHHHHHHHHHHHHHHH
EAIKEYNTLITGNEIFQARTKNVAILSAEKAIDMSLSGPVLRATGVNYDLRKVRPYSVYE
HHHHHHHCEECCCHHHHHHCCCEEEEECCHHHCCCCCCCEEEECCCCCHHHHCCCHHHHH
RFEFEVPLGTKGDCFDRYYIRLLEMEQSARIIQQAMDQIPEGPIRAKIPKMIKPPVGEAY
HEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCHHHCCCCCHHH
AEIESSKGIMGTYVVSDGSTKPYRVHFRRPSFVNLGYLNEMLRGWKIADVIAILGSIDIV
HHHHCCCCEEEEEEEECCCCCCEEEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHEE
LGEVDA
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA