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The map label for this gene is citT [C]

Identifier: 134299835

GI number: 134299835

Start: 2184038

End: 2185486

Strand: Reverse

Name: citT [C]

Synonym: Dred_1988

Alternate gene names: 134299835

Gene position: 2185486-2184038 (Counterclockwise)

Preceding gene: 134299836

Following gene: 134299834

Centisome position: 60.57

GC content: 40.37

Gene sequence:

>1449_bases
ATGAGTAAAGAGACAAAAAGATACTTTTTTATATTTCTTGGCTTTGCAGTATTGCTTTTATTTTATTTTATGCCCCAGGT
AGCTCCGGCCATTGACCCTATGGGGAAATCCTTTGAATTAACACAATCTGGTAAAGCTGGTATTGGACTTTTCCTACTGG
CAGGTATCTTTTGGGTTTTTGAAGTAATACCCATTGGAGTAACAAGTATTGCTATTGGTGTATTACAGCCAGTTTTTGGT
ATCCGTGAAGCAAAGGATGCATTTAGGGATTTTATGGATCCCACTGTAATGTTTATTTTAGGCTCCCTACTTGTGGGTAT
TGCTTTTACCCAATGTGGAATCACCAAAAGAGTCGCTTATAAAATGCTTGTTTTAGTTGGAGAAGATACAAGAAAGATTT
TACTGGGAGTATTTGTACTTACGGCACTTTTAACACACGTTATGGCACACACTGCTGTGGCTGGTGCCATGTTCCCAATT
ATGATGTCAATACTTGCACTATACGGAGGAGATCCTACTAAACCAAGTAAATTTGGAAAAGCATTGTTTATGGGAATGGC
TTTCTCAGCTGGTGCTGGTAGTATCTGTACCATGATGGGCGGTGCCCGTAACCCTGCGGCAGTAGGTTTTTTCAAAGAAT
TTACGGGCCAAGATATTGGTTTTCTTGAATTTTCTGCTGCCCTAGCACCCTTTGGCTGGATTACTGTTTTCCTTGTTTTC
TTTTTAATGATTACAATCTATAAGCCAGAAAAGTTAAAAGTACAGGGGCTACGGCAGCGAGCTCAAGTAGAATTAGATAA
GTTAGGTCCAATTACTAAACAGGAAATCTTTGTATTAGCTGTAGTAGGTATTGCTCTTTGTACCCTTATCTTTAAACAGT
ACATTCCTGCCTTAAAAAGTATGGATCGTTCCATTCCGTTGTTGGCAGCGGGGCTGGTATTCTTCATAACAAACATACTC
ACTGTTAAAGAACTGGAGAAATCCATTCCCTGGAATATTGTATTACTGTTCTCTGGCGCAATGAGTATTGGTTTTGCTCT
ATGGCAAACTGGTGCTGCGGAGTGGATGGCGGTAAGCTGGCTTTCCTTTATCAAAGATGCGCCCTGGTTAGTTTTCTTAT
TAGGTATATCATTCTTGGTATTGATACTAACCAACTTTATCATGAACGTAGCGGCCATTTCTATCTGTTTACCAGTTGCT
CTTGTTATTGCTAAATATTTGGGCGTAAATCCTGAAGTGGTATTGTATGCCTCGGTAGCTATGTCGGGGATGCCCTTCCT
TTTATTAATAGGAGCAGCTCCCAATGCTATCGCCTATGAATCAAAACAATTTACCACAGGAGAGTTTTTTGTGACGGGAA
TTCCAGCAAGTTTAGCGATTCTGGCAATGGTAGCCATCCTCTCCTTAACTTTCTGGCCTTTAATTGGTATTCCTGCGGTG
CTAAGCTGA

Upstream 100 bases:

>100_bases
AAGCACCACTACTAATTAGCACCTTGGTAACCAGTTTATGATCAAAATGCTGAAAGTTAAAAATTATTAAGCACCTTAAT
TTAAACGAGAGGTGATTTGG

Downstream 100 bases:

>100_bases
TTTAATTTAGATACCCTGGTTTGCAAAACCAGGGTATCTAAATTAAAATAAATATTTCGACAACATTCTTGTAAAGGGAT
ATTGATAGGATTATAATATT

Product: anion transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MSKETKRYFFIFLGFAVLLLFYFMPQVAPAIDPMGKSFELTQSGKAGIGLFLLAGIFWVFEVIPIGVTSIAIGVLQPVFG
IREAKDAFRDFMDPTVMFILGSLLVGIAFTQCGITKRVAYKMLVLVGEDTRKILLGVFVLTALLTHVMAHTAVAGAMFPI
MMSILALYGGDPTKPSKFGKALFMGMAFSAGAGSICTMMGGARNPAAVGFFKEFTGQDIGFLEFSAALAPFGWITVFLVF
FLMITIYKPEKLKVQGLRQRAQVELDKLGPITKQEIFVLAVVGIALCTLIFKQYIPALKSMDRSIPLLAAGLVFFITNIL
TVKELEKSIPWNIVLLFSGAMSIGFALWQTGAAEWMAVSWLSFIKDAPWLVFLLGISFLVLILTNFIMNVAAISICLPVA
LVIAKYLGVNPEVVLYASVAMSGMPFLLLIGAAPNAIAYESKQFTTGEFFVTGIPASLAILAMVAILSLTFWPLIGIPAV
LS

Sequences:

>Translated_482_residues
MSKETKRYFFIFLGFAVLLLFYFMPQVAPAIDPMGKSFELTQSGKAGIGLFLLAGIFWVFEVIPIGVTSIAIGVLQPVFG
IREAKDAFRDFMDPTVMFILGSLLVGIAFTQCGITKRVAYKMLVLVGEDTRKILLGVFVLTALLTHVMAHTAVAGAMFPI
MMSILALYGGDPTKPSKFGKALFMGMAFSAGAGSICTMMGGARNPAAVGFFKEFTGQDIGFLEFSAALAPFGWITVFLVF
FLMITIYKPEKLKVQGLRQRAQVELDKLGPITKQEIFVLAVVGIALCTLIFKQYIPALKSMDRSIPLLAAGLVFFITNIL
TVKELEKSIPWNIVLLFSGAMSIGFALWQTGAAEWMAVSWLSFIKDAPWLVFLLGISFLVLILTNFIMNVAAISICLPVA
LVIAKYLGVNPEVVLYASVAMSGMPFLLLIGAAPNAIAYESKQFTTGEFFVTGIPASLAILAMVAILSLTFWPLIGIPAV
LS
>Mature_481_residues
SKETKRYFFIFLGFAVLLLFYFMPQVAPAIDPMGKSFELTQSGKAGIGLFLLAGIFWVFEVIPIGVTSIAIGVLQPVFGI
REAKDAFRDFMDPTVMFILGSLLVGIAFTQCGITKRVAYKMLVLVGEDTRKILLGVFVLTALLTHVMAHTAVAGAMFPIM
MSILALYGGDPTKPSKFGKALFMGMAFSAGAGSICTMMGGARNPAAVGFFKEFTGQDIGFLEFSAALAPFGWITVFLVFF
LMITIYKPEKLKVQGLRQRAQVELDKLGPITKQEIFVLAVVGIALCTLIFKQYIPALKSMDRSIPLLAAGLVFFITNILT
VKELEKSIPWNIVLLFSGAMSIGFALWQTGAAEWMAVSWLSFIKDAPWLVFLLGISFLVLILTNFIMNVAAISICLPVAL
VIAKYLGVNPEVVLYASVAMSGMPFLLLIGAAPNAIAYESKQFTTGEFFVTGIPASLAILAMVAILSLTFWPLIGIPAVL
S

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CitM (TC 2.A.11) transporter family [H]

Homologues:

Organism=Homo sapiens, GI301069346, Length=472, Percent_Identity=24.5762711864407, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI301069349, Length=480, Percent_Identity=23.9583333333333, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI29171306, Length=500, Percent_Identity=23.2, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI31377715, Length=524, Percent_Identity=23.6641221374046, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI58761541, Length=512, Percent_Identity=23.046875, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI219802232, Length=445, Percent_Identity=23.5955056179775, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI301069353, Length=459, Percent_Identity=22.8758169934641, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI31795546, Length=340, Percent_Identity=23.5294117647059, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI4506979, Length=114, Percent_Identity=30.7017543859649, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786829, Length=290, Percent_Identity=22.4137931034483, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988385, Length=475, Percent_Identity=23.1578947368421, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI32565804, Length=468, Percent_Identity=23.2905982905983, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17551790, Length=544, Percent_Identity=25, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71989118, Length=497, Percent_Identity=21.1267605633803, Blast_Score=92, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6322263, Length=443, Percent_Identity=23.4762979683973, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319885, Length=450, Percent_Identity=24.4444444444444, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI45551633, Length=478, Percent_Identity=24.0585774058577, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281366409, Length=478, Percent_Identity=24.0585774058577, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17737623, Length=478, Percent_Identity=24.0585774058577, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24666468, Length=478, Percent_Identity=24.0585774058577, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362116, Length=493, Percent_Identity=22.3123732251521, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI281362114, Length=496, Percent_Identity=22.9838709677419, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362112, Length=496, Percent_Identity=22.9838709677419, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 52276; Mature: 52145

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKETKRYFFIFLGFAVLLLFYFMPQVAPAIDPMGKSFELTQSGKAGIGLFLLAGIFWVF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHH
EVIPIGVTSIAIGVLQPVFGIREAKDAFRDFMDPTVMFILGSLLVGIAFTQCGITKRVAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHHHH
KMLVLVGEDTRKILLGVFVLTALLTHVMAHTAVAGAMFPIMMSILALYGGDPTKPSKFGK
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
ALFMGMAFSAGAGSICTMMGGARNPAAVGFFKEFTGQDIGFLEFSAALAPFGWITVFLVF
HHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHH
FLMITIYKPEKLKVQGLRQRAQVELDKLGPITKQEIFVLAVVGIALCTLIFKQYIPALKS
HHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MDRSIPLLAAGLVFFITNILTVKELEKSIPWNIVLLFSGAMSIGFALWQTGAAEWMAVSW
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHH
LSFIKDAPWLVFLLGISFLVLILTNFIMNVAAISICLPVALVIAKYLGVNPEVVLYASVA
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHH
MSGMPFLLLIGAAPNAIAYESKQFTTGEFFVTGIPASLAILAMVAILSLTFWPLIGIPAV
HCCCCEEEEEECCCCCCEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHH
LS
CC
>Mature Secondary Structure 
SKETKRYFFIFLGFAVLLLFYFMPQVAPAIDPMGKSFELTQSGKAGIGLFLLAGIFWVF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHH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CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]