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The map label for this gene is dapA

Identifier: 134299787

GI number: 134299787

Start: 2130524

End: 2131414

Strand: Reverse

Name: dapA

Synonym: Dred_1939

Alternate gene names: 134299787

Gene position: 2131414-2130524 (Counterclockwise)

Preceding gene: 134299788

Following gene: 134299786

Centisome position: 59.07

GC content: 44.0

Gene sequence:

>891_bases
ATGTCAACAGTGGATTTTGGCAGGGTTATTACGGCCATGGTGACACCTTTTCATCCAGATATGTCCGTGAATTATACCCA
GGCTAAAAAACTAAGCAGATATCTGGTGGAAAATGGTTCAGATGGTTTGGTTGTTAGTGGAACCACTGGAGAATCTCCTA
CCCTGAACAAGGATGAAAAGATTCAATTATTTAAAGCAGTGGTAGAAGAAGTTGGAGGGCAGGCAACGGTTATTGCTGGG
ACCGGAAGTTATGATACCGCCAGCAGTATTATCCTAACCAAAGAAGCTGAAAAGGTTGGTTGTGATGGAGTTATGCTGGT
GGCTCCCTATTACAACAAACCATCCCAGGAAGGACTCTATCAGCATTTTCGCACTATCGCTGAATGTACCAGCTTGCCAG
TAATGCTTTACAATATTCCGGGGCGGACTGGAATTAATGTTTTGCCCGCCACAGTGGAAAGACTGGCCAAGGATGTACCA
AACATTGTGGCCATTAAAGAAGCGGCTGGGGATATCAATCAGGTATCTGAATTACGTCGCATCCTACCTGAGGATTTTAT
CATCTTTAGCGGAGATGACTCTTTGACACTACCAATGCTGTCCTTAGGATGCAAGGGGATTGTTAGTGTGGCGGCTCATA
TTGCCGGTAAGCAAATACAGGAGATGATTGATGCCTTTACTTCTGGGAATACAACCCTTGCGGCTAATCTCCATAAAGAA
CTTTTCCCGATCTTTAAGGGGTTGTTTATAACATCCAATCCAGTTCCGGTCAAAGCAGCCTTAAACCTAAAGGGGCTTGC
GGTAGGTGGTGTGAGATTACCCTTAGTTGAGGCGACGGCCAAGGAAATCGAAACTGTAAAAAATATTATGAATAACCTCC
ATTTATTGTAA

Upstream 100 bases:

>100_bases
TTAGTTGAAAAGGAAAACATGAAGAAAGCCATACGTGCCTTGCATCGAAAGTTTAAGTTAGGTCAAAGGGAATAAGGTTA
TTGAGGGGATGTGAAAGTCA

Downstream 100 bases:

>100_bases
GAATAAAGGATACACTTTTTGTGTATCCTTTTGTATTATTTTGGCACTTACGGGTAATTATATTGCCGTTAGGGATTAAT
TTGAGTATAATTTATTGCGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MSTVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEKIQLFKAVVEEVGGQATVIAG
TGSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLYQHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVP
NIVAIKEAAGDINQVSELRRILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKE
LFPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL

Sequences:

>Translated_296_residues
MSTVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEKIQLFKAVVEEVGGQATVIAG
TGSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLYQHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVP
NIVAIKEAAGDINQVSELRRILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKE
LFPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL
>Mature_295_residues
STVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEKIQLFKAVVEEVGGQATVIAGT
GSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLYQHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVPN
IVAIKEAAGDINQVSELRRILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKEL
FPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=25.4355400696864, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI13540533, Length=301, Percent_Identity=25.5813953488372, Blast_Score=86, Evalue=3e-17,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=42.1232876712329, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI87082415, Length=294, Percent_Identity=29.5918367346939, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=30.2040816326531, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789620, Length=233, Percent_Identity=30.4721030042918, Blast_Score=120, Evalue=8e-29,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_DESRM (A4J5V5)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113283.1
- ProteinModelPortal:   A4J5V5
- SMR:   A4J5V5
- STRING:   A4J5V5
- GeneID:   4956292
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1939
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- PhylomeDB:   A4J5V5
- ProtClustDB:   PRK03170
- BioCyc:   DRED349161:DRED_1939-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31730; Mature: 31599

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEK
CCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHH
IQLFKAVVEEVGGQATVIAGTGSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLY
HHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECHHHCCCCCEEEEECCCCCCCHHHHH
QHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVPNIVAIKEAAGDINQVSELRR
HHHHHHHHHHCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHH
ILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKE
HCCCCEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
LFPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL
HHHHHHHHEEECCCCCEEEECCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STVDFGRVITAMVTPFHPDMSVNYTQAKKLSRYLVENGSDGLVVSGTTGESPTLNKDEK
CCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHH
IQLFKAVVEEVGGQATVIAGTGSYDTASSIILTKEAEKVGCDGVMLVAPYYNKPSQEGLY
HHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEEECHHHCCCCCEEEEECCCCCCCHHHHH
QHFRTIAECTSLPVMLYNIPGRTGINVLPATVERLAKDVPNIVAIKEAAGDINQVSELRR
HHHHHHHHHHCCCEEEEECCCCCCCEEHHHHHHHHHHHCCCEEEEHHHCCCHHHHHHHHH
ILPEDFIIFSGDDSLTLPMLSLGCKGIVSVAAHIAGKQIQEMIDAFTSGNTTLAANLHKE
HCCCCEEEECCCCCCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHH
LFPIFKGLFITSNPVPVKAALNLKGLAVGGVRLPLVEATAKEIETVKNIMNNLHLL
HHHHHHHHEEECCCCCEEEECCCCEEEECCEEEHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA