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The map label for this gene is mutL

Identifier: 134299735

GI number: 134299735

Start: 2067779

End: 2069701

Strand: Reverse

Name: mutL

Synonym: Dred_1884

Alternate gene names: 134299735

Gene position: 2069701-2067779 (Counterclockwise)

Preceding gene: 134299736

Following gene: 134299734

Centisome position: 57.36

GC content: 45.29

Gene sequence:

>1923_bases
TTGTCAAACATTACTATATTGGATGAAGCCACGGCTAACAAAATAGCAGCTGGAGAAGTGGTGGAACGTCCGGTTTCTGT
TGTTAAAGAATTAGTGGAAAACAGCTTGGATGCCGGTGCCAATAGAATAAGTGTTGAGTTAACACAGGGTGGCATAACTG
GCATTAAAGTGGTGGATAATGGCTACGGAATGCCAGCAGAGGATGTTCAGCTTTGCTTTCTGCGCCATGCCACTAGTAAA
ATAAAAAGGGCAGAGGATTTAAATAGTATTTTAACCTTAGGGTTTCGAGGAGAAGCACTACCCAGTATTGCTGCAGTCTC
TAAGGTAACCCTAACCACTCGAACAGAAGATGAACTGGCCGGTACAACCATGCAAATTGAAGGTGGCTATATGCAAAATG
TTGTGCCAACGGGGTGTCCCGTTGGCACAATCATTGAGATAAAGGATTTATTTTTTAATACTCCGGCCAGAAGAAAGTTC
CTTAAAACAGCCAATGCAGAGACCAGTCAGGTAAGTGATTTAATAACCAGGCTGGCCATGGCTCGTCCAGACGTTCGTTT
TGAATTACGCAGCGGTAACAGGGTGCTATTCTCAAGTCCGGGCACCGGGTCGTTAAAAGACACGGCGGCGGTGATCTTTG
GGCTGGATAATGTGAGAAGCATGTTGGAGATAGGCTATCAGGGGAAACTGCTTTCAGTAGCTGGACTGATTTCAAAACCT
GTTCTAACTAGAGCCTCCCGGCATTATCAAAATTTCTTTATCAATGGACGATATATTCGAAGTGGTTTTCTTTCCTCTAT
ATTACAGCAGGCCTACGATACCTTGATTCCCGCGGGGCGTTTTCCCATTGCCATATTACACATAGATATTGATCCTACCC
AGGTTGATGTCAATGTACATCCTACCAAAATGGAGATTCGTATGGCAAGGGAAGGGGAGATTCAGGAAGAGTTGTTGGCA
GCCCTCAGTGACTCCCTCAATGTACCGACAGCTATTACCGGGTTATGGGAAATCATGCCCGGCAGGACAAAGAACACAGC
AACGGATCAAAGGGCAGAAAATCTGGAGGTTAAACCGGATAGTAAGGAAAAGGAACTTCAACCAAAAGAGTCCCAGCATC
CAAGATTGGTTGCCTGTGATTTACCCAGCGGCAAAATAATGCCCCCCCGGCATGACCAGGAACAGCTTCATTTTTCTTCC
CGAAGGATTGCTCCTGTCAGGGGAAAAAATAGCCTTCTACCCGATGAAGGAAGTTCTATCAATAGAGAAGAGATCCCTCC
GGTAGTGGATGTTAAAGAACAGCAATTGAAAGAAAACCCGAACACTTACCAACCCGCAGAGACACTGGGTTTTCCTGTCT
TAGTACCCGCTGGTCAGGTACCGCCAACCTATGTTTTAGCCCACGGAGAAGGTGGCTTGTATATCATTGATCAGCATGCG
GCACATGAACGGGTGCTTTACGAGAAATATCTTTATCTTTTAGGCAATTATGTAGAAGCGCAAATGCTTCTGGAACCCCT
GACCCTTGAAATTCCCCATCATGAGGCTCAATTGATTATCAAGCATATTGTGGACTTTAATGAACTTGGCTTTATACTGG
AGCACTTTGGTGGAGATACTTTTTTGTTGAGGGGTGTTCCCACAAACGCTATAACAGAACCCAAAGAGGTATTTTTGGAC
TTGTTGGCAAGATTGCAAGAAAATCCTTCCCAAAAAGTCGAAAAGAATCTGGTTTTGGATCATCTGGCAGCAGCCATGGC
CTGTCGGGATGCGGTTAAGTCCGGACAGCACTTTAGTGCTGTCGAAACGAAAGCGTTGCTGGATGGCTTGGCGAGGTGTC
AAAAGCCCTATACTTGTCCCCATGGTAGACCAACTTTGATTCAGATTAGTCAAGAGGAGTTGAAGAAAAGGTTCAAACGA
TGA

Upstream 100 bases:

>100_bases
TTTGATTACATTTATCTGCAAGATAAATCTACTGATACCTTTATGATTTATCAACGGCTGGGCAACAGAGAAATACGCTC
AGACGGTTAGGGGTGACAAC

Downstream 100 bases:

>100_bases
ATGATTCCCTTGTTATCACCACTGGAATTAGAAGCAGGAAAAACCTGGAGGAAAAGGCCCTGGAATTAAGTAGAGAGTGG
AAGATACCCTATCAACCAAG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSNITILDEATANKIAAGEVVERPVSVVKELVENSLDAGANRISVELTQGGITGIKVVDNGYGMPAEDVQLCFLRHATSK
IKRAEDLNSILTLGFRGEALPSIAAVSKVTLTTRTEDELAGTTMQIEGGYMQNVVPTGCPVGTIIEIKDLFFNTPARRKF
LKTANAETSQVSDLITRLAMARPDVRFELRSGNRVLFSSPGTGSLKDTAAVIFGLDNVRSMLEIGYQGKLLSVAGLISKP
VLTRASRHYQNFFINGRYIRSGFLSSILQQAYDTLIPAGRFPIAILHIDIDPTQVDVNVHPTKMEIRMAREGEIQEELLA
ALSDSLNVPTAITGLWEIMPGRTKNTATDQRAENLEVKPDSKEKELQPKESQHPRLVACDLPSGKIMPPRHDQEQLHFSS
RRIAPVRGKNSLLPDEGSSINREEIPPVVDVKEQQLKENPNTYQPAETLGFPVLVPAGQVPPTYVLAHGEGGLYIIDQHA
AHERVLYEKYLYLLGNYVEAQMLLEPLTLEIPHHEAQLIIKHIVDFNELGFILEHFGGDTFLLRGVPTNAITEPKEVFLD
LLARLQENPSQKVEKNLVLDHLAAAMACRDAVKSGQHFSAVETKALLDGLARCQKPYTCPHGRPTLIQISQEELKKRFKR

Sequences:

>Translated_640_residues
MSNITILDEATANKIAAGEVVERPVSVVKELVENSLDAGANRISVELTQGGITGIKVVDNGYGMPAEDVQLCFLRHATSK
IKRAEDLNSILTLGFRGEALPSIAAVSKVTLTTRTEDELAGTTMQIEGGYMQNVVPTGCPVGTIIEIKDLFFNTPARRKF
LKTANAETSQVSDLITRLAMARPDVRFELRSGNRVLFSSPGTGSLKDTAAVIFGLDNVRSMLEIGYQGKLLSVAGLISKP
VLTRASRHYQNFFINGRYIRSGFLSSILQQAYDTLIPAGRFPIAILHIDIDPTQVDVNVHPTKMEIRMAREGEIQEELLA
ALSDSLNVPTAITGLWEIMPGRTKNTATDQRAENLEVKPDSKEKELQPKESQHPRLVACDLPSGKIMPPRHDQEQLHFSS
RRIAPVRGKNSLLPDEGSSINREEIPPVVDVKEQQLKENPNTYQPAETLGFPVLVPAGQVPPTYVLAHGEGGLYIIDQHA
AHERVLYEKYLYLLGNYVEAQMLLEPLTLEIPHHEAQLIIKHIVDFNELGFILEHFGGDTFLLRGVPTNAITEPKEVFLD
LLARLQENPSQKVEKNLVLDHLAAAMACRDAVKSGQHFSAVETKALLDGLARCQKPYTCPHGRPTLIQISQEELKKRFKR
>Mature_639_residues
SNITILDEATANKIAAGEVVERPVSVVKELVENSLDAGANRISVELTQGGITGIKVVDNGYGMPAEDVQLCFLRHATSKI
KRAEDLNSILTLGFRGEALPSIAAVSKVTLTTRTEDELAGTTMQIEGGYMQNVVPTGCPVGTIIEIKDLFFNTPARRKFL
KTANAETSQVSDLITRLAMARPDVRFELRSGNRVLFSSPGTGSLKDTAAVIFGLDNVRSMLEIGYQGKLLSVAGLISKPV
LTRASRHYQNFFINGRYIRSGFLSSILQQAYDTLIPAGRFPIAILHIDIDPTQVDVNVHPTKMEIRMAREGEIQEELLAA
LSDSLNVPTAITGLWEIMPGRTKNTATDQRAENLEVKPDSKEKELQPKESQHPRLVACDLPSGKIMPPRHDQEQLHFSSR
RIAPVRGKNSLLPDEGSSINREEIPPVVDVKEQQLKENPNTYQPAETLGFPVLVPAGQVPPTYVLAHGEGGLYIIDQHAA
HERVLYEKYLYLLGNYVEAQMLLEPLTLEIPHHEAQLIIKHIVDFNELGFILEHFGGDTFLLRGVPTNAITEPKEVFLDL
LARLQENPSQKVEKNLVLDHLAAAMACRDAVKSGQHFSAVETKALLDGLARCQKPYTCPHGRPTLIQISQEELKKRFKR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=318, Percent_Identity=35.5345911949685, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI310128478, Length=350, Percent_Identity=30.8571428571429, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4505911, Length=329, Percent_Identity=30.6990881458967, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI4505913, Length=350, Percent_Identity=30.8571428571429, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI189458898, Length=329, Percent_Identity=30.6990881458967, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI189458896, Length=322, Percent_Identity=30.4347826086957, Blast_Score=134, Evalue=4e-31,
Organism=Homo sapiens, GI310128480, Length=307, Percent_Identity=28.6644951140065, Blast_Score=110, Evalue=5e-24,
Organism=Homo sapiens, GI91992162, Length=263, Percent_Identity=28.5171102661597, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI263191589, Length=227, Percent_Identity=30.3964757709251, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI91992160, Length=253, Percent_Identity=28.8537549407115, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1790612, Length=310, Percent_Identity=43.2258064516129, Blast_Score=246, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=37.5, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17562796, Length=355, Percent_Identity=26.1971830985915, Blast_Score=121, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323819, Length=461, Percent_Identity=31.8872017353579, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6324247, Length=358, Percent_Identity=26.2569832402235, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6325093, Length=310, Percent_Identity=26.1290322580645, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6323063, Length=184, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136968, Length=315, Percent_Identity=35.5555555555556, Blast_Score=195, Evalue=8e-50,
Organism=Drosophila melanogaster, GI17136970, Length=355, Percent_Identity=25.0704225352113, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_DESRM (A4J5Q3)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113231.1
- ProteinModelPortal:   A4J5Q3
- SMR:   A4J5Q3
- STRING:   A4J5Q3
- GeneID:   4958264
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1884
- eggNOG:   COG0323
- HOGENOM:   HBG520262
- OMA:   MACKAAV
- PhylomeDB:   A4J5Q3
- ProtClustDB:   PRK00095
- BioCyc:   DRED349161:DRED_1884-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70736; Mature: 70605

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNITILDEATANKIAAGEVVERPVSVVKELVENSLDAGANRISVELTQGGITGIKVVDN
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
GYGMPAEDVQLCFLRHATSKIKRAEDLNSILTLGFRGEALPSIAAVSKVTLTTRTEDELA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHEEEEEECCCHHHC
GTTMQIEGGYMQNVVPTGCPVGTIIEIKDLFFNTPARRKFLKTANAETSQVSDLITRLAM
CCEEEECCCHHHCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ARPDVRFELRSGNRVLFSSPGTGSLKDTAAVIFGLDNVRSMLEIGYQGKLLSVAGLISKP
CCCCCEEEECCCCEEEEECCCCCCCHHHHEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHH
VLTRASRHYQNFFINGRYIRSGFLSSILQQAYDTLIPAGRFPIAILHIDIDPTQVDVNVH
HHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEC
PTKMEIRMAREGEIQEELLAALSDSLNVPTAITGLWEIMPGRTKNTATDQRAENLEVKPD
CCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCC
SKEKELQPKESQHPRLVACDLPSGKIMPPRHDQEQLHFSSRRIAPVRGKNSLLPDEGSSI
CCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NREEIPPVVDVKEQQLKENPNTYQPAETLGFPVLVPAGQVPPTYVLAHGEGGLYIIDQHA
CHHHCCCCCCCCHHHHHCCCCCCCCHHHCCCEEEECCCCCCCCEEEEECCCCEEEEECCC
AHERVLYEKYLYLLGNYVEAQMLLEPLTLEIPHHEAQLIIKHIVDFNELGFILEHFGGDT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCE
FLLRGVPTNAITEPKEVFLDLLARLQENPSQKVEKNLVLDHLAAAMACRDAVKSGQHFSA
EEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VETKALLDGLARCQKPYTCPHGRPTLIQISQEELKKRFKR
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHCC
>Mature Secondary Structure 
SNITILDEATANKIAAGEVVERPVSVVKELVENSLDAGANRISVELTQGGITGIKVVDN
CCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEC
GYGMPAEDVQLCFLRHATSKIKRAEDLNSILTLGFRGEALPSIAAVSKVTLTTRTEDELA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHEEEEEECCCHHHC
GTTMQIEGGYMQNVVPTGCPVGTIIEIKDLFFNTPARRKFLKTANAETSQVSDLITRLAM
CCEEEECCCHHHCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHH
ARPDVRFELRSGNRVLFSSPGTGSLKDTAAVIFGLDNVRSMLEIGYQGKLLSVAGLISKP
CCCCCEEEECCCCEEEEECCCCCCCHHHHEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHH
VLTRASRHYQNFFINGRYIRSGFLSSILQQAYDTLIPAGRFPIAILHIDIDPTQVDVNVH
HHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEC
PTKMEIRMAREGEIQEELLAALSDSLNVPTAITGLWEIMPGRTKNTATDQRAENLEVKPD
CCEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCC
SKEKELQPKESQHPRLVACDLPSGKIMPPRHDQEQLHFSSRRIAPVRGKNSLLPDEGSSI
CCHHCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NREEIPPVVDVKEQQLKENPNTYQPAETLGFPVLVPAGQVPPTYVLAHGEGGLYIIDQHA
CHHHCCCCCCCCHHHHHCCCCCCCCHHHCCCEEEECCCCCCCCEEEEECCCCEEEEECCC
AHERVLYEKYLYLLGNYVEAQMLLEPLTLEIPHHEAQLIIKHIVDFNELGFILEHFGGDT
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHCHHHHHHHHHHCCCCE
FLLRGVPTNAITEPKEVFLDLLARLQENPSQKVEKNLVLDHLAAAMACRDAVKSGQHFSA
EEEECCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VETKALLDGLARCQKPYTCPHGRPTLIQISQEELKKRFKR
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA