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The map label for this gene is 134299736

Identifier: 134299736

GI number: 134299736

Start: 2069712

End: 2071067

Strand: Reverse

Name: 134299736

Synonym: Dred_1885

Alternate gene names: NA

Gene position: 2071067-2069712 (Counterclockwise)

Preceding gene: 134299737

Following gene: 134299735

Centisome position: 57.4

GC content: 45.8

Gene sequence:

>1356_bases
ATGAGCAAAAAAACCGGCGTTATCTTTTTTCCTGCCTTCGATTGGGCAATTTCGCCAACGCACCCCGAACGGGAGGAGCG
CCTCCTTTATACCAGGGATCAAATGTTTGAAGAGGGTATTTTAGATCTGCCGGAAATCCAGCAATATGCTCCACGCATGG
CTTCAAAACATGACATCGCCCGGGTTCATTTCTGTGTGCCCAATGTAGAGGAGCAAGTTTTAGATGCACATCGGATTGCA
GCCGGAGCGGCCATTGACTTAGGCGATAGAGTGATGGCTGGGGAAATTGCCAATGGGTTTGCCCTAGTGCGACCCCCAGG
ACACCATGCCATGCGGGTTGTTCACGGAAATCGGGGATTTTGCAATATTAATAATGAAGCTGTTCTCGTCGAATATCTTA
GAAAAACCTACGGGGTTAAAAAAATCGCCATTGTGGATACGGATGTTCATCACGGAGACGGTACCCAGGATATTTTTTAC
CATGATCCCGATGTGCTTTTTATTTCCTTTCATCAAGATGGTCGCACCATTTATCCGGGCACTGGTTTTACCTATGAGTT
AGGGGGTCCTGGCGCATACGCATCTACCATCAACATACCCCTACCACCCGGTGTAACGGATTCCGGTCTGCACTATGTGA
TGGATCATCTGATACTTCCTATCTTGAAGGATTTCCAACCGGATTTTGTTGTCAATTCGGCAGGACAGGATAATCACTTC
ACTGATCCTCTGGGACGAATGAAAATCACTGCCCAGGGGTACGCAAGGTTAACGGAAAAATTAAAACCAAATCTTGCAGT
CCTCGAAGGGGGTTATGCCATTGAAACGGCGTTGCCCTATGTAAATCTAGCAATCCTGCTGGCCCTGGCAGGGAAGGATT
ATACGTCTGTAGTTGAGCCGGAATATAACCCTGCCAAATTTAAAGAAAGCCCTAAGGTGACCTCGGAAATTGGTCGTGTC
GTAGAGGAACTGCAAGAAATTTGGGCTAAACGTCACCAGTTTGATAAATACACCCTAGCTAAGGGAACTGGTTTTTATCA
GAGAACAAAGCCCATTTTTTACGATACACATTATATAGAAGAAAAACAAATTGAAAAGGTTCGGGTCTGTGATCAGTGCT
CTGGGTTTATTAGTTTAGATTCGCAGGCATACCATCCCAATGGTAAGCACTATAGGATTTGTGCCATCAGCATCCCCTTC
CAGTCATGCAAATCATGTCAGGCAGAGGCGTGGGAAAGTTATGAGCAGGCCAAAGGGGACCCTCACTTTGATTACATTTA
TCTGCAAGATAAATCTACTGATACCTTTATGATTTATCAACGGCTGGGCAACAGAGAAATACGCTCAGACGGTTAG

Upstream 100 bases:

>100_bases
TGGTTCGAGATTGGCAAACCACTGGCAGATTATTTCACATTTCGGTGCAAACACCCAGGGGGATTCTGGCTCATATCGGA
ACCGGGGGGAGGTTTTTACC

Downstream 100 bases:

>100_bases
GGGTGACAACTTGTCAAACATTACTATATTGGATGAAGCCACGGCTAACAAAATAGCAGCTGGAGAAGTGGTGGAACGTC
CGGTTTCTGTTGTTAAAGAA

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSKKTGVIFFPAFDWAISPTHPEREERLLYTRDQMFEEGILDLPEIQQYAPRMASKHDIARVHFCVPNVEEQVLDAHRIA
AGAAIDLGDRVMAGEIANGFALVRPPGHHAMRVVHGNRGFCNINNEAVLVEYLRKTYGVKKIAIVDTDVHHGDGTQDIFY
HDPDVLFISFHQDGRTIYPGTGFTYELGGPGAYASTINIPLPPGVTDSGLHYVMDHLILPILKDFQPDFVVNSAGQDNHF
TDPLGRMKITAQGYARLTEKLKPNLAVLEGGYAIETALPYVNLAILLALAGKDYTSVVEPEYNPAKFKESPKVTSEIGRV
VEELQEIWAKRHQFDKYTLAKGTGFYQRTKPIFYDTHYIEEKQIEKVRVCDQCSGFISLDSQAYHPNGKHYRICAISIPF
QSCKSCQAEAWESYEQAKGDPHFDYIYLQDKSTDTFMIYQRLGNREIRSDG

Sequences:

>Translated_451_residues
MSKKTGVIFFPAFDWAISPTHPEREERLLYTRDQMFEEGILDLPEIQQYAPRMASKHDIARVHFCVPNVEEQVLDAHRIA
AGAAIDLGDRVMAGEIANGFALVRPPGHHAMRVVHGNRGFCNINNEAVLVEYLRKTYGVKKIAIVDTDVHHGDGTQDIFY
HDPDVLFISFHQDGRTIYPGTGFTYELGGPGAYASTINIPLPPGVTDSGLHYVMDHLILPILKDFQPDFVVNSAGQDNHF
TDPLGRMKITAQGYARLTEKLKPNLAVLEGGYAIETALPYVNLAILLALAGKDYTSVVEPEYNPAKFKESPKVTSEIGRV
VEELQEIWAKRHQFDKYTLAKGTGFYQRTKPIFYDTHYIEEKQIEKVRVCDQCSGFISLDSQAYHPNGKHYRICAISIPF
QSCKSCQAEAWESYEQAKGDPHFDYIYLQDKSTDTFMIYQRLGNREIRSDG
>Mature_450_residues
SKKTGVIFFPAFDWAISPTHPEREERLLYTRDQMFEEGILDLPEIQQYAPRMASKHDIARVHFCVPNVEEQVLDAHRIAA
GAAIDLGDRVMAGEIANGFALVRPPGHHAMRVVHGNRGFCNINNEAVLVEYLRKTYGVKKIAIVDTDVHHGDGTQDIFYH
DPDVLFISFHQDGRTIYPGTGFTYELGGPGAYASTINIPLPPGVTDSGLHYVMDHLILPILKDFQPDFVVNSAGQDNHFT
DPLGRMKITAQGYARLTEKLKPNLAVLEGGYAIETALPYVNLAILLALAGKDYTSVVEPEYNPAKFKESPKVTSEIGRVV
EELQEIWAKRHQFDKYTLAKGTGFYQRTKPIFYDTHYIEEKQIEKVRVCDQCSGFISLDSQAYHPNGKHYRICAISIPFQ
SCKSCQAEAWESYEQAKGDPHFDYIYLQDKSTDTFMIYQRLGNREIRSDG

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI30795204, Length=237, Percent_Identity=40.084388185654, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI30795202, Length=237, Percent_Identity=40.084388185654, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI17158039, Length=237, Percent_Identity=40.084388185654, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI20070354, Length=307, Percent_Identity=31.5960912052117, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI153085395, Length=270, Percent_Identity=36.6666666666667, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI148539870, Length=238, Percent_Identity=37.3949579831933, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI169234807, Length=238, Percent_Identity=37.3949579831933, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI62750347, Length=276, Percent_Identity=34.0579710144928, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI62750349, Length=276, Percent_Identity=34.0579710144928, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI13128864, Length=352, Percent_Identity=29.8295454545455, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI226529806, Length=307, Percent_Identity=28.6644951140065, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI13128862, Length=223, Percent_Identity=29.5964125560538, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI13128860, Length=287, Percent_Identity=26.1324041811847, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI293336691, Length=268, Percent_Identity=25.7462686567164, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI8923769, Length=172, Percent_Identity=31.3953488372093, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI262073088, Length=161, Percent_Identity=31.6770186335404, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193209491, Length=213, Percent_Identity=40.8450704225352, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17540334, Length=291, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17540332, Length=325, Percent_Identity=32, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI193206283, Length=327, Percent_Identity=31.4984709480122, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17537347, Length=338, Percent_Identity=32.5443786982249, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25154020, Length=210, Percent_Identity=36.1904761904762, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25154022, Length=212, Percent_Identity=35.377358490566, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=208, Percent_Identity=31.7307692307692, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=211, Percent_Identity=28.436018957346, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17561978, Length=170, Percent_Identity=31.1764705882353, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324307, Length=269, Percent_Identity=33.8289962825279, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6321244, Length=208, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323999, Length=174, Percent_Identity=31.6091954022989, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6325325, Length=180, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325141, Length=84, Percent_Identity=44.047619047619, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24642144, Length=342, Percent_Identity=31.2865497076023, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24642146, Length=342, Percent_Identity=31.2865497076023, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24642142, Length=342, Percent_Identity=31.2865497076023, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281360899, Length=341, Percent_Identity=31.3782991202346, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641720, Length=217, Percent_Identity=38.2488479262673, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI281360801, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI281360799, Length=217, Percent_Identity=38.2488479262673, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24644244, Length=174, Percent_Identity=31.6091954022989, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657891, Length=188, Percent_Identity=33.5106382978723, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 50928; Mature: 50797

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKTGVIFFPAFDWAISPTHPEREERLLYTRDQMFEEGILDLPEIQQYAPRMASKHDIA
CCCCCCEEEEEEECCEECCCCCCHHHHEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
RVHFCVPNVEEQVLDAHRIAAGAAIDLGDRVMAGEIANGFALVRPPGHHAMRVVHGNRGF
EEEEECCCHHHHHHHHHHHHCCCEECCCCEEEECHHCCCEEEECCCCCCEEEEEECCCCE
CNINNEAVLVEYLRKTYGVKKIAIVDTDVHHGDGTQDIFYHDPDVLFISFHQDGRTIYPG
EEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCCCEECCC
TGFTYELGGPGAYASTINIPLPPGVTDSGLHYVMDHLILPILKDFQPDFVVNSAGQDNHF
CCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
TDPLGRMKITAQGYARLTEKLKPNLAVLEGGYAIETALPYVNLAILLALAGKDYTSVVEP
CCCCCCEEEEHHHHHHHHHHHCCCEEEEECCEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
EYNPAKFKESPKVTSEIGRVVEELQEIWAKRHQFDKYTLAKGTGFYQRTKPIFYDTHYIE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCEEEECCCCC
EKQIEKVRVCDQCSGFISLDSQAYHPNGKHYRICAISIPFQSCKSCQAEAWESYEQAKGD
HHHHHHHHHHHHCCCCEEECCCEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCC
PHFDYIYLQDKSTDTFMIYQRLGNREIRSDG
CCEEEEEEECCCCCEEEEEHHHCCCCCCCCC
>Mature Secondary Structure 
SKKTGVIFFPAFDWAISPTHPEREERLLYTRDQMFEEGILDLPEIQQYAPRMASKHDIA
CCCCCEEEEEEECCEECCCCCCHHHHEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCE
RVHFCVPNVEEQVLDAHRIAAGAAIDLGDRVMAGEIANGFALVRPPGHHAMRVVHGNRGF
EEEEECCCHHHHHHHHHHHHCCCEECCCCEEEECHHCCCEEEECCCCCCEEEEEECCCCE
CNINNEAVLVEYLRKTYGVKKIAIVDTDVHHGDGTQDIFYHDPDVLFISFHQDGRTIYPG
EEECCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCEEEECCCEEEEEEECCCCEECCC
TGFTYELGGPGAYASTINIPLPPGVTDSGLHYVMDHLILPILKDFQPDFVVNSAGQDNHF
CCEEEECCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCC
TDPLGRMKITAQGYARLTEKLKPNLAVLEGGYAIETALPYVNLAILLALAGKDYTSVVEP
CCCCCCEEEEHHHHHHHHHHHCCCEEEEECCEEEEHHHHHHHHHHHHHCCCCCCCCCCCC
EYNPAKFKESPKVTSEIGRVVEELQEIWAKRHQFDKYTLAKGTGFYQRTKPIFYDTHYIE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHCCCEEEECCCCC
EKQIEKVRVCDQCSGFISLDSQAYHPNGKHYRICAISIPFQSCKSCQAEAWESYEQAKGD
HHHHHHHHHHHHCCCCEEECCCEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHCCCC
PHFDYIYLQDKSTDTFMIYQRLGNREIRSDG
CCEEEEEEECCCCCEEEEEHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]