Click here to switch to the map view.

The map label for this gene is nuoF2 [H]

Identifier: 134299512

GI number: 134299512

Start: 1812550

End: 1814433

Strand: Reverse

Name: nuoF2 [H]

Synonym: Dred_1655

Alternate gene names: 134299512

Gene position: 1814433-1812550 (Counterclockwise)

Preceding gene: 134299513

Following gene: 134299511

Centisome position: 50.29

GC content: 45.06

Gene sequence:

>1884_bases
ATGCTAATAAAAAGTCATGATGATCTAAAACAACTTAGACAGAAGGTAAAGGCTGCCCTTGATCAAGAAAAGATGCGCAT
CTTAGTCTGTGCTGGTACAGGATGTGTGGCCAACGGCTCTTTAAAGGTATACGCAGCATTAAAAAGAATGATTGAAGAAA
AGGGACTTCTAACCAGTGTTGAGCTAGTAGAAGAAGTAAGTCACGAAGGGATAGCTGTAAACATAAGTGGTTGTCACGGT
TTTTGTCAGATGGGACCTCTGGTTCGTTTTGAACCATCTGGACTACTTTACTGCAAGGTAAAAGAAGAAGATGCGGAAGA
AATCGTTAATACAACCGTTCTAAATAACGGTATTGTGGAACGTTTATTATATGAGGATCCTAATACCGGTGAAAAAATTA
AAACACAGGATGAAAACCCTTTCTATAAACGCCAAGAACGCGTGACTTTACGTTATTGTGGCCGTATTGATCCCGATGAT
ATCTATGATTATATTGCGCACCGCGGCTATCGGGCCATCAGCAAGATACTACAGGAAATGAACCCAGAAGAAGTTATTAA
GGAAGTTAACGATTCCGGTTTAAGGGGTCGGGGCGGCGGTGGATTCCCCACTGGTCGCAAATGGTCCTTTGCTGCTTCGC
AACCTGGACCCAAGAAATATATCATTTGTAACGGAGATGAGGGTGATCCGGGCGCCTTCATGGATCGTTCTGTAATGGAG
GGCAACCCACACTCCGTATTAGAGGGCATGATGATTGCTGGATACGCCATAGGGGCTAATGAGGGTTATATCTATGCTAG
AGCCGAATATCCCCTGGCAATTAAACGCATGCGTAAGGCTATTGCAGACGCCGAAGCACATGGATTATTGGGCAACAATA
TTTTAGGCAGTGATTTTAATTTCAAAATTAATATCAAAGAAGGTGCCGGAGCCTTTGTATGCGGTGAGGAAACTGCTCTT
ATCGCCTCCATTGAAGGTGAACGCGGTATGCCTCGTCCACGTCCTCCCTTCCCGGCTGTTAAAGGTTTATGGGGATGTCC
CACCATTATTAACAACGTAGAAACCTTGGCAAACCTACGCTACATTATCAACAATGGAGCTGGCGAGTTCAAAAAATATG
GTACTGCCGGCAGCTCTGGAACCAAAACCTTTGCCCTGGCTGGTCAGGTGCAAAATACGGGTCTAGTAGAAGTGCCCATG
GGCGTTACCCTGCGTGAAGTGGTATTTGACATTGGTGGTGGTCTCAGGGATGGAAAAAAATATAAATCTGTTCAAATTGG
TGGCCCCTCCGGTGGTTGTCTAACAGAAGATAAATTAGATTTGCCCCTAGATTATGATGAATTAATGAAAGTGGGCGCCA
TGATTGGTTCCGGTGGCTTGGTTGTTATGGGTGATGACACCTGCATGGTCGAAACCGCCAAGTTCTTTATGGGCTTCGTG
CAAAACGAATCCTGCGGCAAATGTGTCCCCTGCCGCGAGGGAACCAAACAATTACTGGCCCTTTTAACCAAGATAACTGA
GGGAAAAGGAACTGAAGCAGATCTTGATCTTTTGGAAGAATTGGCACAAAACGTTAAGGACGGGTCTTTATGCGGACTAG
GAAAAACTGCACCGAACCCGGTTCTGACCACTCTCCGTTACTTCCGTGACGAATATATTGCGCACGTACGTGACAAAAAA
TGTCCTGCAGGTGCCTGTCAAGCCTTAAAGGAATACTACATTAATCCTGAAAAATGCAAGGGTTGTACTGTATGTTCCAG
AGTATGTCCCGCCGGTGCCATCACCGGAGAAAAGAAGCAACCCCATGTCATTAATGTAGATCTCTGCTTGAAGTGCGGTG
CTTGTATGGAAAAATGTAAGTTTGGCTCTATAGAGATCAGGTAG

Upstream 100 bases:

>100_bases
TGCCGATGAGGAAGTTCATGGTCAAATGACCCCGGATGGGATCTTAGAAATAGTAAGAAAATTGGCACCTGCTGCCAGTG
AAAATTAGGGGGGACTATAG

Downstream 100 bases:

>100_bases
CTGGTTATCTGAGAAAGGGTGTGACGTAATGAGTGGAAAAATTACCATTAATGGTCAAATTATAGATTTTACCGATGAAA
AGAATATTCTGGCTGTTGCA

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MLIKSHDDLKQLRQKVKAALDQEKMRILVCAGTGCVANGSLKVYAALKRMIEEKGLLTSVELVEEVSHEGIAVNISGCHG
FCQMGPLVRFEPSGLLYCKVKEEDAEEIVNTTVLNNGIVERLLYEDPNTGEKIKTQDENPFYKRQERVTLRYCGRIDPDD
IYDYIAHRGYRAISKILQEMNPEEVIKEVNDSGLRGRGGGGFPTGRKWSFAASQPGPKKYIICNGDEGDPGAFMDRSVME
GNPHSVLEGMMIAGYAIGANEGYIYARAEYPLAIKRMRKAIADAEAHGLLGNNILGSDFNFKINIKEGAGAFVCGEETAL
IASIEGERGMPRPRPPFPAVKGLWGCPTIINNVETLANLRYIINNGAGEFKKYGTAGSSGTKTFALAGQVQNTGLVEVPM
GVTLREVVFDIGGGLRDGKKYKSVQIGGPSGGCLTEDKLDLPLDYDELMKVGAMIGSGGLVVMGDDTCMVETAKFFMGFV
QNESCGKCVPCREGTKQLLALLTKITEGKGTEADLDLLEELAQNVKDGSLCGLGKTAPNPVLTTLRYFRDEYIAHVRDKK
CPAGACQALKEYYINPEKCKGCTVCSRVCPAGAITGEKKQPHVINVDLCLKCGACMEKCKFGSIEIR

Sequences:

>Translated_627_residues
MLIKSHDDLKQLRQKVKAALDQEKMRILVCAGTGCVANGSLKVYAALKRMIEEKGLLTSVELVEEVSHEGIAVNISGCHG
FCQMGPLVRFEPSGLLYCKVKEEDAEEIVNTTVLNNGIVERLLYEDPNTGEKIKTQDENPFYKRQERVTLRYCGRIDPDD
IYDYIAHRGYRAISKILQEMNPEEVIKEVNDSGLRGRGGGGFPTGRKWSFAASQPGPKKYIICNGDEGDPGAFMDRSVME
GNPHSVLEGMMIAGYAIGANEGYIYARAEYPLAIKRMRKAIADAEAHGLLGNNILGSDFNFKINIKEGAGAFVCGEETAL
IASIEGERGMPRPRPPFPAVKGLWGCPTIINNVETLANLRYIINNGAGEFKKYGTAGSSGTKTFALAGQVQNTGLVEVPM
GVTLREVVFDIGGGLRDGKKYKSVQIGGPSGGCLTEDKLDLPLDYDELMKVGAMIGSGGLVVMGDDTCMVETAKFFMGFV
QNESCGKCVPCREGTKQLLALLTKITEGKGTEADLDLLEELAQNVKDGSLCGLGKTAPNPVLTTLRYFRDEYIAHVRDKK
CPAGACQALKEYYINPEKCKGCTVCSRVCPAGAITGEKKQPHVINVDLCLKCGACMEKCKFGSIEIR
>Mature_627_residues
MLIKSHDDLKQLRQKVKAALDQEKMRILVCAGTGCVANGSLKVYAALKRMIEEKGLLTSVELVEEVSHEGIAVNISGCHG
FCQMGPLVRFEPSGLLYCKVKEEDAEEIVNTTVLNNGIVERLLYEDPNTGEKIKTQDENPFYKRQERVTLRYCGRIDPDD
IYDYIAHRGYRAISKILQEMNPEEVIKEVNDSGLRGRGGGGFPTGRKWSFAASQPGPKKYIICNGDEGDPGAFMDRSVME
GNPHSVLEGMMIAGYAIGANEGYIYARAEYPLAIKRMRKAIADAEAHGLLGNNILGSDFNFKINIKEGAGAFVCGEETAL
IASIEGERGMPRPRPPFPAVKGLWGCPTIINNVETLANLRYIINNGAGEFKKYGTAGSSGTKTFALAGQVQNTGLVEVPM
GVTLREVVFDIGGGLRDGKKYKSVQIGGPSGGCLTEDKLDLPLDYDELMKVGAMIGSGGLVVMGDDTCMVETAKFFMGFV
QNESCGKCVPCREGTKQLLALLTKITEGKGTEADLDLLEELAQNVKDGSLCGLGKTAPNPVLTTLRYFRDEYIAHVRDKK
CPAGACQALKEYYINPEKCKGCTVCSRVCPAGAITGEKKQPHVINVDLCLKCGACMEKCKFGSIEIR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=387, Percent_Identity=38.5012919896641, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI20149568, Length=373, Percent_Identity=39.142091152815, Blast_Score=278, Evalue=1e-74,
Organism=Escherichia coli, GI1788620, Length=428, Percent_Identity=39.2523364485981, Blast_Score=337, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17531727, Length=373, Percent_Identity=39.4101876675603, Blast_Score=278, Evalue=6e-75,
Organism=Drosophila melanogaster, GI45550452, Length=368, Percent_Identity=40.4891304347826, Blast_Score=288, Evalue=7e-78,
Organism=Drosophila melanogaster, GI19920794, Length=373, Percent_Identity=39.4101876675603, Blast_Score=284, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24653819, Length=400, Percent_Identity=31, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24653817, Length=352, Percent_Identity=28.9772727272727, Blast_Score=171, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68143; Mature: 68143

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKSHDDLKQLRQKVKAALDQEKMRILVCAGTGCVANGSLKVYAALKRMIEEKGLLTSV
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHH
ELVEEVSHEGIAVNISGCHGFCQMGPLVRFEPSGLLYCKVKEEDAEEIVNTTVLNNGIVE
HHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHH
RLLYEDPNTGEKIKTQDENPFYKRQERVTLRYCGRIDPDDIYDYIAHRGYRAISKILQEM
HHHHCCCCCCCCCCCCCCCCHHHHHHHEEHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHC
NPEEVIKEVNDSGLRGRGGGGFPTGRKWSFAASQPGPKKYIICNGDEGDPGAFMDRSVME
CHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHCCHHHC
GNPHSVLEGMMIAGYAIGANEGYIYARAEYPLAIKRMRKAIADAEAHGLLGNNILGSDFN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCE
FKINIKEGAGAFVCGEETALIASIEGERGMPRPRPPFPAVKGLWGCPTIINNVETLANLR
EEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHH
YIINNGAGEFKKYGTAGSSGTKTFALAGQVQNTGLVEVPMGVTLREVVFDIGGGLRDGKK
HHHCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCC
YKSVQIGGPSGGCLTEDKLDLPLDYDELMKVGAMIGSGGLVVMGDDTCMVETAKFFMGFV
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
QNESCGKCVPCREGTKQLLALLTKITEGKGTEADLDLLEELAQNVKDGSLCGLGKTAPNP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCH
VLTTLRYFRDEYIAHVRDKKCPAGACQALKEYYINPEKCKGCTVCSRVCPAGAITGEKKQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCCCCCCCC
PHVINVDLCLKCGACMEKCKFGSIEIR
CCEEEHHHHHHHHHHHHHCCCCCEEEC
>Mature Secondary Structure
MLIKSHDDLKQLRQKVKAALDQEKMRILVCAGTGCVANGSLKVYAALKRMIEEKGLLTSV
CCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCEEECCCCHHHHHHHHHHHHCCCHHHH
ELVEEVSHEGIAVNISGCHGFCQMGPLVRFEPSGLLYCKVKEEDAEEIVNTTVLNNGIVE
HHHHHHCCCCEEEEECCCCCHHHCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHH
RLLYEDPNTGEKIKTQDENPFYKRQERVTLRYCGRIDPDDIYDYIAHRGYRAISKILQEM
HHHHCCCCCCCCCCCCCCCCHHHHHHHEEHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHC
NPEEVIKEVNDSGLRGRGGGGFPTGRKWSFAASQPGPKKYIICNGDEGDPGAFMDRSVME
CHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCCHHCCHHHC
GNPHSVLEGMMIAGYAIGANEGYIYARAEYPLAIKRMRKAIADAEAHGLLGNNILGSDFN
CCHHHHHHHHHHEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCEECCCCE
FKINIKEGAGAFVCGEETALIASIEGERGMPRPRPPFPAVKGLWGCPTIINNVETLANLR
EEEEEECCCCEEEECCCCEEEEEECCCCCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHH
YIINNGAGEFKKYGTAGSSGTKTFALAGQVQNTGLVEVPMGVTLREVVFDIGGGLRDGKK
HHHCCCCHHHHHCCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHHHCCCCCCCCC
YKSVQIGGPSGGCLTEDKLDLPLDYDELMKVGAMIGSGGLVVMGDDTCMVETAKFFMGFV
CCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHH
QNESCGKCVPCREGTKQLLALLTKITEGKGTEADLDLLEELAQNVKDGSLCGLGKTAPNP
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCH
VLTTLRYFRDEYIAHVRDKKCPAGACQALKEYYINPEKCKGCTVCSRVCPAGAITGEKKQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHCCCHHHHHHHCCCCCCCCCCCC
PHVINVDLCLKCGACMEKCKFGSIEIR
CCEEEHHHHHHHHHHHHHCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]