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The map label for this gene is hbd [H]

Identifier: 134299352

GI number: 134299352

Start: 1616022

End: 1616876

Strand: Reverse

Name: hbd [H]

Synonym: Dred_1493

Alternate gene names: 134299352

Gene position: 1616876-1616022 (Counterclockwise)

Preceding gene: 134299353

Following gene: 134299351

Centisome position: 44.81

GC content: 43.98

Gene sequence:

>855_bases
ATGAACATTAAAAAAATAGCAGTGCTTGGTAGTGGTACCATGGGTTCCGGTATTGCTCAAGTGGCGGCTCAGTCAGGCTA
TGAGGTTCTTTTAATCGATGTGGACCAAAAGTTTATTGACCGGGCCTTAGCCGGTATTAGTAAAGGTTTTCAAAAGGCCG
TTGATAAAGGCAAAATGACCGCCGAAGACAAAGAGCAGGTATTTGGTCGCATTAAAGGTAGCATCTCTTATGAAGATTGT
AAAGACGTGGATTTGGTTATTGAAGCTATCCTTGAAAACATGGATCTGAAAAAACAAGTTTATAAGCAACTGGATGAAAA
GTGTCCCGACCATGCCATTTTAGCCAGCAACACCTCCTCTCTTTCCATTACTGAAATGGCGGCTGCCACCAAAAGATCTG
ACAAGGTTGTTGGTATGCACTTCTTTAATCCAGCCCAGGTAATGAAGCTAGTAGAGGTTATTCCTGGCTTAGATACCTCT
GAAGAGACCATAGCCGCCATTACAGAAGTCGCTAAAAAAATGAATAAGGTACCGGTAAATGCTAAGGAGTCTCCAGGTTT
TATTGTGAACCGTATTTTGGTTCCCATGATTAACGAGGCTGTTATTGCCTTAGGCGAAGGAATTGGCACCATTGAAGAAA
TTGATACAGCCATGAAGTTAGGTGCTGGTATGCCCATGGGACCACTGGCCCTGGCTGATATGGTGGGAATCGATATCGTG
CTAGCCGTGGCCGAGGTTTTCTATAAGGAATTTGCCGACAGTAAATATCGTCCAGCCTTGTTGTTAAAGCAGATGGTTAG
AGCCGGGCATTTGGGTGTTAAAACCGGAAGGGGCTTCTACAGTTACCAGAAATAG

Upstream 100 bases:

>100_bases
GCTTTTTTCTTTATTTTTCTCATTAATTAACACGTTATCAATTTTATGGCACGATCTATGCTTTGAGAAATAATTACTCA
TTAAAATAGGGGGGAAATCA

Downstream 100 bases:

>100_bases
ATGGGGGTGAAACAATGGATTACAAAAACTTACTATACAGCAAGGAAGAGAACATTGCCATCATTACTTTGAACAGACCC
AAGGTGCTTAATGCTCTAAA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MNIKKIAVLGSGTMGSGIAQVAAQSGYEVLLIDVDQKFIDRALAGISKGFQKAVDKGKMTAEDKEQVFGRIKGSISYEDC
KDVDLVIEAILENMDLKKQVYKQLDEKCPDHAILASNTSSLSITEMAAATKRSDKVVGMHFFNPAQVMKLVEVIPGLDTS
EETIAAITEVAKKMNKVPVNAKESPGFIVNRILVPMINEAVIALGEGIGTIEEIDTAMKLGAGMPMGPLALADMVGIDIV
LAVAEVFYKEFADSKYRPALLLKQMVRAGHLGVKTGRGFYSYQK

Sequences:

>Translated_284_residues
MNIKKIAVLGSGTMGSGIAQVAAQSGYEVLLIDVDQKFIDRALAGISKGFQKAVDKGKMTAEDKEQVFGRIKGSISYEDC
KDVDLVIEAILENMDLKKQVYKQLDEKCPDHAILASNTSSLSITEMAAATKRSDKVVGMHFFNPAQVMKLVEVIPGLDTS
EETIAAITEVAKKMNKVPVNAKESPGFIVNRILVPMINEAVIALGEGIGTIEEIDTAMKLGAGMPMGPLALADMVGIDIV
LAVAEVFYKEFADSKYRPALLLKQMVRAGHLGVKTGRGFYSYQK
>Mature_284_residues
MNIKKIAVLGSGTMGSGIAQVAAQSGYEVLLIDVDQKFIDRALAGISKGFQKAVDKGKMTAEDKEQVFGRIKGSISYEDC
KDVDLVIEAILENMDLKKQVYKQLDEKCPDHAILASNTSSLSITEMAAATKRSDKVVGMHFFNPAQVMKLVEVIPGLDTS
EETIAAITEVAKKMNKVPVNAKESPGFIVNRILVPMINEAVIALGEGIGTIEEIDTAMKLGAGMPMGPLALADMVGIDIV
LAVAEVFYKEFADSKYRPALLLKQMVRAGHLGVKTGRGFYSYQK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.0138888888889, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI296179427, Length=305, Percent_Identity=40.327868852459, Blast_Score=216, Evalue=1e-56,
Organism=Homo sapiens, GI20127408, Length=287, Percent_Identity=39.0243902439024, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI261878539, Length=294, Percent_Identity=33.6734693877551, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI68989263, Length=294, Percent_Identity=33.6734693877551, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI115430219, Length=242, Percent_Identity=29.7520661157025, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=43.3098591549296, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI1788682, Length=262, Percent_Identity=37.0229007633588, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1790281, Length=284, Percent_Identity=36.6197183098592, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=42.560553633218, Blast_Score=230, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=37.2413793103448, Blast_Score=205, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=37.8472222222222, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17558304, Length=283, Percent_Identity=36.0424028268551, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI25144276, Length=288, Percent_Identity=37.5, Blast_Score=187, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17508953, Length=288, Percent_Identity=37.5, Blast_Score=187, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17508951, Length=288, Percent_Identity=37.5, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71985923, Length=280, Percent_Identity=32.5, Blast_Score=163, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71985930, Length=284, Percent_Identity=29.9295774647887, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193203623, Length=199, Percent_Identity=25.1256281407035, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115533614, Length=199, Percent_Identity=25.1256281407035, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921000, Length=284, Percent_Identity=36.2676056338028, Blast_Score=195, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24583077, Length=284, Percent_Identity=36.2676056338028, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24583079, Length=284, Percent_Identity=36.2676056338028, Blast_Score=194, Evalue=4e-50,
Organism=Drosophila melanogaster, GI45549573, Length=241, Percent_Identity=31.9502074688797, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20129993, Length=255, Percent_Identity=25.8823529411765, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30674; Mature: 30674

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKKIAVLGSGTMGSGIAQVAAQSGYEVLLIDVDQKFIDRALAGISKGFQKAVDKGKMT
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
AEDKEQVFGRIKGSISYEDCKDVDLVIEAILENMDLKKQVYKQLDEKCPDHAILASNTSS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCC
LSITEMAAATKRSDKVVGMHFFNPAQVMKLVEVIPGLDTSEETIAAITEVAKKMNKVPVN
CHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
AKESPGFIVNRILVPMINEAVIALGEGIGTIEEIDTAMKLGAGMPMGPLALADMVGIDIV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAVAEVFYKEFADSKYRPALLLKQMVRAGHLGVKTGRGFYSYQK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNIKKIAVLGSGTMGSGIAQVAAQSGYEVLLIDVDQKFIDRALAGISKGFQKAVDKGKMT
CCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
AEDKEQVFGRIKGSISYEDCKDVDLVIEAILENMDLKKQVYKQLDEKCPDHAILASNTSS
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCC
LSITEMAAATKRSDKVVGMHFFNPAQVMKLVEVIPGLDTSEETIAAITEVAKKMNKVPVN
CHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCC
AKESPGFIVNRILVPMINEAVIALGEGIGTIEEIDTAMKLGAGMPMGPLALADMVGIDIV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LAVAEVFYKEFADSKYRPALLLKQMVRAGHLGVKTGRGFYSYQK
HHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA