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The map label for this gene is thlA [H]

Identifier: 134299350

GI number: 134299350

Start: 1614024

End: 1615205

Strand: Reverse

Name: thlA [H]

Synonym: Dred_1491

Alternate gene names: 134299350

Gene position: 1615205-1614024 (Counterclockwise)

Preceding gene: 134299351

Following gene: 134299349

Centisome position: 44.77

GC content: 45.09

Gene sequence:

>1182_bases
TTGAGAAATGTTGTTATTGTTGGGGCCGCCAGGACACCCATAGGAGATTACCTGGGTTCCCTCAAAGATATTTCAGCTGT
TGACTTAGGCGTTACAGCCGTAACTGGTGCCTTAAATAAAGCAGGCTTAAAGCCAGAACAGGTAAATGAAGTATTAATAG
GTATGTGTATGCAGGGTGCTGCTAAGGGTAACCCGGCCCGCCAAGTGCAGCTTAATTCCAAAATACCCGTTGAAGCTCCG
GCAGCCACCATTAACCAGCAGTGTGGTTCTGCCATGCGGGCCACAGAAATCGCAGCCCAACAAATCATGTTAGGCAAAGA
GGATGTCATAGTGGCCGGTGGTATTGAGTCCATGTCCAAAGCACCCTACTATCTGCTTAATGTTCGGGAAGGACTTCGGA
TGGGTGACGGCAAGGTTTATGATGCTCTTACCTATGACGGCCTTAATGATGCATTTTATGGCTATCATATGGGAATTACC
ACTGAAAACCTGGTAGAAAAGTATAATATTTCTCGCCAAGAACAGGATGAACTAGCTATTTTAAGTCATCAACGGTCCAC
GGCAGCCATCCAAGCAGGTAAATTTAAAGAAGAAATCATCCCCGTGGAGATTAAGACCAGAAAAGGAACTAAAATTGTAG
ATACCGACGAGCATCCCCGTTCCGATATATCTATAGAAAAACTCGCCAGTTTGAAAGCGGTCTTTAAAAAAGATGGTACA
GTTACAGCGGGTAACGCCTCCGGTATTAACGACGGTGCAGCTGCACTTGTTTTAATGGCTGAAGACAAAGCGAAGGAACT
GGGCATTAAACCACTGGCCCGAATTTTGAATACCGCTTCCTTTGGCGTAGACCCATCCATCATGGGTATCGGACCCGTAT
ACGCCATACCCAAAGCATTAAACTTTGTTAATCTTAAATTGTCAGACATTGATCTTTTCGAATTAAATGAAGCCTTTGCC
GGACAGTTTTTGGCTTGTAATCGCGAACTGAAAATTCCCATGGATAAGGTCAATATCAACGGTTCAGGTATTTCCTTAGG
CCACCCGGTGGGTGCCACCGGTGTCAGAATCATTGTTAGTCTTATCTATGAAATGAAGCGTCAGGGATCCCGGTTAGGTG
TAGCGTCTTTATGCTGCGGTGGTGGCCCAGGTATTGCTGCAGTAATTGAAAACATTGATTAA

Upstream 100 bases:

>100_bases
CTATTCTCCACCCAAGATCAAAAAGAGGGTATGAATGCCTTTTTAGAAAAACGTAAAGCGGAATTTAAAGGAAATTAACA
CTTACGAGGAGGTAAAAGGT

Downstream 100 bases:

>100_bases
AAATATAAGGAGGCTTGTATTATGAATTTCTTATTAACTGAAGAACAAGAAACCATGAGACAAATGGCTCGTAAATTTGC
AGAGCAGGAAATTGCCCCTG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRNVVIVGAARTPIGDYLGSLKDISAVDLGVTAVTGALNKAGLKPEQVNEVLIGMCMQGAAKGNPARQVQLNSKIPVEAP
AATINQQCGSAMRATEIAAQQIMLGKEDVIVAGGIESMSKAPYYLLNVREGLRMGDGKVYDALTYDGLNDAFYGYHMGIT
TENLVEKYNISRQEQDELAILSHQRSTAAIQAGKFKEEIIPVEIKTRKGTKIVDTDEHPRSDISIEKLASLKAVFKKDGT
VTAGNASGINDGAAALVLMAEDKAKELGIKPLARILNTASFGVDPSIMGIGPVYAIPKALNFVNLKLSDIDLFELNEAFA
GQFLACNRELKIPMDKVNINGSGISLGHPVGATGVRIIVSLIYEMKRQGSRLGVASLCCGGGPGIAAVIENID

Sequences:

>Translated_393_residues
MRNVVIVGAARTPIGDYLGSLKDISAVDLGVTAVTGALNKAGLKPEQVNEVLIGMCMQGAAKGNPARQVQLNSKIPVEAP
AATINQQCGSAMRATEIAAQQIMLGKEDVIVAGGIESMSKAPYYLLNVREGLRMGDGKVYDALTYDGLNDAFYGYHMGIT
TENLVEKYNISRQEQDELAILSHQRSTAAIQAGKFKEEIIPVEIKTRKGTKIVDTDEHPRSDISIEKLASLKAVFKKDGT
VTAGNASGINDGAAALVLMAEDKAKELGIKPLARILNTASFGVDPSIMGIGPVYAIPKALNFVNLKLSDIDLFELNEAFA
GQFLACNRELKIPMDKVNINGSGISLGHPVGATGVRIIVSLIYEMKRQGSRLGVASLCCGGGPGIAAVIENID
>Mature_393_residues
MRNVVIVGAARTPIGDYLGSLKDISAVDLGVTAVTGALNKAGLKPEQVNEVLIGMCMQGAAKGNPARQVQLNSKIPVEAP
AATINQQCGSAMRATEIAAQQIMLGKEDVIVAGGIESMSKAPYYLLNVREGLRMGDGKVYDALTYDGLNDAFYGYHMGIT
TENLVEKYNISRQEQDELAILSHQRSTAAIQAGKFKEEIIPVEIKTRKGTKIVDTDEHPRSDISIEKLASLKAVFKKDGT
VTAGNASGINDGAAALVLMAEDKAKELGIKPLARILNTASFGVDPSIMGIGPVYAIPKALNFVNLKLSDIDLFELNEAFA
GQFLACNRELKIPMDKVNINGSGISLGHPVGATGVRIIVSLIYEMKRQGSRLGVASLCCGGGPGIAAVIENID

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=46.7866323907455, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI167614485, Length=393, Percent_Identity=46.3104325699746, Blast_Score=344, Evalue=8e-95,
Organism=Homo sapiens, GI4557237, Length=395, Percent_Identity=46.3291139240506, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=41.5189873417722, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI4504327, Length=425, Percent_Identity=33.4117647058824, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=29.7435897435897, Blast_Score=150, Evalue=1e-36,
Organism=Escherichia coli, GI87082165, Length=390, Percent_Identity=48.7179487179487, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1788554, Length=394, Percent_Identity=50.253807106599, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=38.9027431421446, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=38.75, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=31.0513447432763, Blast_Score=183, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=44.6428571428571, Blast_Score=333, Evalue=8e-92,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=38.3631713554987, Blast_Score=288, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=38.4223918575064, Blast_Score=261, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17551802, Length=425, Percent_Identity=34.5882352941176, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17535917, Length=400, Percent_Identity=29.25, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=400, Percent_Identity=41.75, Blast_Score=294, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6322031, Length=402, Percent_Identity=37.3134328358209, Blast_Score=227, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=46.1734693877551, Blast_Score=380, Evalue=1e-106,
Organism=Drosophila melanogaster, GI17648125, Length=393, Percent_Identity=42.2391857506361, Blast_Score=305, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=40.2564102564103, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=32.7830188679245, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41655; Mature: 41655

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNVVIVGAARTPIGDYLGSLKDISAVDLGVTAVTGALNKAGLKPEQVNEVLIGMCMQGA
CCCEEEEECCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AKGNPARQVQLNSKIPVEAPAATINQQCGSAMRATEIAAQQIMLGKEDVIVAGGIESMSK
CCCCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
APYYLLNVREGLRMGDGKVYDALTYDGLNDAFYGYHMGITTENLVEKYNISRQEQDELAI
CCEEEEEEHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHH
LSHQRSTAAIQAGKFKEEIIPVEIKTRKGTKIVDTDEHPRSDISIEKLASLKAVFKKDGT
HHCCCCHHHHCCCCCHHCEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
VTAGNASGINDGAAALVLMAEDKAKELGIKPLARILNTASFGVDPSIMGIGPVYAIPKAL
EEECCCCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHC
NFVNLKLSDIDLFELNEAFAGQFLACNRELKIPMDKVNINGSGISLGHPVGATGVRIIVS
CEEEEEECCCCCEECCHHHCCCEEEECCCEECCCEEEEECCCCEECCCCCCHHHHHHHHH
LIYEMKRQGSRLGVASLCCGGGPGIAAVIENID
HHHHHHHCCCCCCHHHHCCCCCCCHHHHEECCC
>Mature Secondary Structure
MRNVVIVGAARTPIGDYLGSLKDISAVDLGVTAVTGALNKAGLKPEQVNEVLIGMCMQGA
CCCEEEEECCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
AKGNPARQVQLNSKIPVEAPAATINQQCGSAMRATEIAAQQIMLGKEDVIVAGGIESMSK
CCCCCCEEEEECCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
APYYLLNVREGLRMGDGKVYDALTYDGLNDAFYGYHMGITTENLVEKYNISRQEQDELAI
CCEEEEEEHHCCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHCCCCCCCCHHHH
LSHQRSTAAIQAGKFKEEIIPVEIKTRKGTKIVDTDEHPRSDISIEKLASLKAVFKKDGT
HHCCCCHHHHCCCCCHHCEEEEEEECCCCCEEECCCCCCCCCCCHHHHHHHHHHHHCCCC
VTAGNASGINDGAAALVLMAEDKAKELGIKPLARILNTASFGVDPSIMGIGPVYAIPKAL
EEECCCCCCCCCCEEEEEEECCCHHHCCHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHC
NFVNLKLSDIDLFELNEAFAGQFLACNRELKIPMDKVNINGSGISLGHPVGATGVRIIVS
CEEEEEECCCCCEECCHHHCCCEEEECCCEECCCEEEEECCCCEECCCCCCHHHHHHHHH
LIYEMKRQGSRLGVASLCCGGGPGIAAVIENID
HHHHHHHCCCCCCHHHHCCCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]