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The map label for this gene is acdA [H]

Identifier: 134299349

GI number: 134299349

Start: 1612866

End: 1614002

Strand: Reverse

Name: acdA [H]

Synonym: Dred_1490

Alternate gene names: 134299349

Gene position: 1614002-1612866 (Counterclockwise)

Preceding gene: 134299350

Following gene: 134299348

Centisome position: 44.73

GC content: 45.82

Gene sequence:

>1137_bases
ATGAATTTCTTATTAACTGAAGAACAAGAAACCATGAGACAAATGGCTCGTAAATTTGCAGAGCAGGAAATTGCCCCTGT
GGCCCTGGAATATGATGAAAAGAATGAATTTCACGCCGAGTTAATTCCTAAATTGTTTGAAACAGGACTTCTAACTGTAG
GTGTGCCAGAAGAATACGGTGGCCCTGGTATTGATACCGTTGGTCAAGCAGTGGTTATGGAAGAGTTGGCCCGGGGTTGT
GCAGCTGTTGCCACAACCGTTGCAGCATCTTGCCTTTTGGCTGCTGACCCGGTGGTAATTGCCGCCAATCACGAACAAAA
ACAACGCTTCTTTAACGTACTCAATGAAGGAAAACTAGCTGCCTTTTGTCTGACCGAACCTGGAGCTGGTTCCGATGTTG
CAGCTCTTAAAACCACTGCAAAACTAGAAGGCGACGAGTATGTCATCAACGGTTCCAAATGCTTTATCACCAACGGAGGT
GTAGCGGATATTTTCACAGTCTGCGCTTCTGTGGATCGCAGCAAAGGACACAAGGGTCTATGCTTCTTCATAGTTGAAAA
GGATCGTCCCGGCGTTTCAGTAGGTAAGAAGGAAAACAAACTTGGTATTCGTTCCTCCAGTACCACCGATGTAATTTTTG
AAGATGTACGCATCCCCAAAGAAAATCTACTGGGTAAAGAGGGTGACGGCTTTAAAATTGCTATGAAAGCCCTAGATATG
TCCCGTCCGATGGTTGCCGCTCTGGCAGTGGGTGTCGCCCAGGCCGCCATGGAATATGCAACCAATTATGCTAAAGAAAG
AATGGCCTTTGGCAAACCCATTGCTGCTCTGCAAGGCATCCAGTTCATGCTGGCAGACATGGCTATGCAAATTGAAGCAG
CCCGTCTTTTGGTTCATAAGGCCTGCTGGCTTAAAGATGCTGGTTTACCGTACAGCGTACTATCTTCTCTGTCCAAGGGC
TTTGCCGGCGATATGTGCATGAAGGTAACTACGGATGCCGTTCAAGTTTTAGGTGGATATGGTTATATCAAGGAATATCC
CGTTGAGAAATACATGCGTGATGCTAAAATCATGCAAATTTATGAAGGCACCAGTCAAGTTCAACGGGTTGTTATTGCCG
GCAATATGTTGAAATAG

Upstream 100 bases:

>100_bases
GGGATCCCGGTTAGGTGTAGCGTCTTTATGCTGCGGTGGTGGCCCAGGTATTGCTGCAGTAATTGAAAACATTGATTAAA
AATATAAGGAGGCTTGTATT

Downstream 100 bases:

>100_bases
TTCTGTCTAATGAAAGGAGGAAAACCGGGTGGCAAATTTTTCTGATTTGTATAAGAGTAAGTTAACAACGCCCGACCAAG
CAGTCAGCGTTGTTAAATCC

Product: butyryl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNFLLTEEQETMRQMARKFAEQEIAPVALEYDEKNEFHAELIPKLFETGLLTVGVPEEYGGPGIDTVGQAVVMEELARGC
AAVATTVAASCLLAADPVVIAANHEQKQRFFNVLNEGKLAAFCLTEPGAGSDVAALKTTAKLEGDEYVINGSKCFITNGG
VADIFTVCASVDRSKGHKGLCFFIVEKDRPGVSVGKKENKLGIRSSSTTDVIFEDVRIPKENLLGKEGDGFKIAMKALDM
SRPMVAALAVGVAQAAMEYATNYAKERMAFGKPIAALQGIQFMLADMAMQIEAARLLVHKACWLKDAGLPYSVLSSLSKG
FAGDMCMKVTTDAVQVLGGYGYIKEYPVEKYMRDAKIMQIYEGTSQVQRVVIAGNMLK

Sequences:

>Translated_378_residues
MNFLLTEEQETMRQMARKFAEQEIAPVALEYDEKNEFHAELIPKLFETGLLTVGVPEEYGGPGIDTVGQAVVMEELARGC
AAVATTVAASCLLAADPVVIAANHEQKQRFFNVLNEGKLAAFCLTEPGAGSDVAALKTTAKLEGDEYVINGSKCFITNGG
VADIFTVCASVDRSKGHKGLCFFIVEKDRPGVSVGKKENKLGIRSSSTTDVIFEDVRIPKENLLGKEGDGFKIAMKALDM
SRPMVAALAVGVAQAAMEYATNYAKERMAFGKPIAALQGIQFMLADMAMQIEAARLLVHKACWLKDAGLPYSVLSSLSKG
FAGDMCMKVTTDAVQVLGGYGYIKEYPVEKYMRDAKIMQIYEGTSQVQRVVIAGNMLK
>Mature_378_residues
MNFLLTEEQETMRQMARKFAEQEIAPVALEYDEKNEFHAELIPKLFETGLLTVGVPEEYGGPGIDTVGQAVVMEELARGC
AAVATTVAASCLLAADPVVIAANHEQKQRFFNVLNEGKLAAFCLTEPGAGSDVAALKTTAKLEGDEYVINGSKCFITNGG
VADIFTVCASVDRSKGHKGLCFFIVEKDRPGVSVGKKENKLGIRSSSTTDVIFEDVRIPKENLLGKEGDGFKIAMKALDM
SRPMVAALAVGVAQAAMEYATNYAKERMAFGKPIAALQGIQFMLADMAMQIEAARLLVHKACWLKDAGLPYSVLSSLSKG
FAGDMCMKVTTDAVQVLGGYGYIKEYPVEKYMRDAKIMQIYEGTSQVQRVVIAGNMLK

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=48.5411140583554, Blast_Score=364, Evalue=1e-101,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=48.5411140583554, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=46.1333333333333, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=41.6666666666667, Blast_Score=299, Evalue=3e-81,
Organism=Homo sapiens, GI7656849, Length=378, Percent_Identity=38.8888888888889, Blast_Score=269, Evalue=3e-72,
Organism=Homo sapiens, GI226958412, Length=374, Percent_Identity=36.6310160427808, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=34.1333333333333, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI21361497, Length=370, Percent_Identity=36.7567567567568, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI226958414, Length=363, Percent_Identity=34.7107438016529, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI76496475, Length=388, Percent_Identity=32.9896907216495, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557235, Length=388, Percent_Identity=32.9896907216495, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4503943, Length=375, Percent_Identity=28.5333333333333, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI7669494, Length=364, Percent_Identity=28.8461538461538, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI48976061, Length=376, Percent_Identity=30.5851063829787, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI211971008, Length=376, Percent_Identity=30.5851063829787, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=27.7777777777778, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI218563752, Length=239, Percent_Identity=28.8702928870293, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=31.5104166666667, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=30, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=26.9372693726937, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=47.244094488189, Blast_Score=347, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=45.0261780104712, Blast_Score=340, Evalue=9e-94,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.6692913385827, Blast_Score=335, Evalue=3e-92,
Organism=Caenorhabditis elegans, GI17508101, Length=369, Percent_Identity=42.0054200542005, Blast_Score=302, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=40, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17538396, Length=378, Percent_Identity=36.7724867724868, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=35.2, Blast_Score=243, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI71990804, Length=291, Percent_Identity=40.2061855670103, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI71985184, Length=380, Percent_Identity=33.6842105263158, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=30.4, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=239, Percent_Identity=39.3305439330544, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=375, Percent_Identity=29.3333333333333, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=374, Percent_Identity=30.7486631016043, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=267, Percent_Identity=32.5842696629214, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=315, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=34.8739495798319, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17531913, Length=176, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=329, Percent_Identity=27.0516717325228, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI86563383, Length=266, Percent_Identity=24.812030075188, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI86563381, Length=266, Percent_Identity=24.812030075188, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=48.5488126649077, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=45.0666666666667, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=43.2, Blast_Score=325, Evalue=3e-89,
Organism=Drosophila melanogaster, GI24666513, Length=370, Percent_Identity=37.8378378378378, Blast_Score=269, Evalue=2e-72,
Organism=Drosophila melanogaster, GI21355753, Length=376, Percent_Identity=35.6382978723404, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281363737, Length=345, Percent_Identity=36.8115942028986, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI19920834, Length=373, Percent_Identity=29.7587131367292, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40901; Mature: 40901

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFLLTEEQETMRQMARKFAEQEIAPVALEYDEKNEFHAELIPKLFETGLLTVGVPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCEEECCCHHCC
GPGIDTVGQAVVMEELARGCAAVATTVAASCLLAADPVVIAANHEQKQRFFNVLNEGKLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEE
AFCLTEPGAGSDVAALKTTAKLEGDEYVINGSKCFITNGGVADIFTVCASVDRSKGHKGL
EEEECCCCCCCCHHHHHHHHEECCCEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCE
CFFIVEKDRPGVSVGKKENKLGIRSSSTTDVIFEDVRIPKENLLGKEGDGFKIAMKALDM
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEEHHHHHHC
SRPMVAALAVGVAQAAMEYATNYAKERMAFGKPIAALQGIQFMLADMAMQIEAARLLVHK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACWLKDAGLPYSVLSSLSKGFAGDMCMKVTTDAVQVLGGYGYIKEYPVEKYMRDAKIMQI
HHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHH
YEGTSQVQRVVIAGNMLK
HHCHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNFLLTEEQETMRQMARKFAEQEIAPVALEYDEKNEFHAELIPKLFETGLLTVGVPEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCCEEECCCHHCC
GPGIDTVGQAVVMEELARGCAAVATTVAASCLLAADPVVIAANHEQKQRFFNVLNEGKLA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCEE
AFCLTEPGAGSDVAALKTTAKLEGDEYVINGSKCFITNGGVADIFTVCASVDRSKGHKGL
EEEECCCCCCCCHHHHHHHHEECCCEEEEECCEEEEECCCHHHHHHHHHHHHHCCCCCCE
CFFIVEKDRPGVSVGKKENKLGIRSSSTTDVIFEDVRIPKENLLGKEGDGFKIAMKALDM
EEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHCCCCCCCCCEEHHHHHHC
SRPMVAALAVGVAQAAMEYATNYAKERMAFGKPIAALQGIQFMLADMAMQIEAARLLVHK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ACWLKDAGLPYSVLSSLSKGFAGDMCMKVTTDAVQVLGGYGYIKEYPVEKYMRDAKIMQI
HHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHH
YEGTSQVQRVVIAGNMLK
HHCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]