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The map label for this gene is hymC [C]

Identifier: 126701030

GI number: 126701030

Start: 3986410

End: 3988191

Strand: Direct

Name: hymC [C]

Synonym: CD3407

Alternate gene names: 126701030

Gene position: 3986410-3988191 (Clockwise)

Preceding gene: 126701029

Following gene: 126701063

Centisome position: 92.92

GC content: 33.95

Gene sequence:

>1782_bases
ATGAGTTTAGTTAATTTAACTATTAATGGCAAACACGTTTCAGCACCTAGTGGAACTTCTATCTTAGATGCTGCGAAATT
AATAAATATAAAAATACACAACCTTTGTCATTTACATATGAATGAAATAGATAAGCTTGACACTTGTGCTTCTTGTCGTG
TTTGTATGGTTGAGACAGAGAGAGGATTAGTTCCAGCTTGTGGAACAGTTATAAAGGAAGGTATGAAAGTTCAGACTAAT
AGTGCTAAAGCATTAAATGCTCGTAGAACTATTGTTGAATTATTGTTATCAGACCATCCACAAGATTGTTTTGTCTGTGA
AAAAAATGGAGATTGTGAATTACAGACTATAGCTGCTGATTTAGGAGTAAGAAAAATAAGATATCAAGGTTCTAAATCTT
TTGCAGGTAAAGATACTTCTACTAAATCTTTAGTTAAAGACCATTCTAAGTGTATATTATGTAGAAGATGTGAGACTGTA
TGTAATGACATACAAACAGTAGGAGCATTATCTGGAGTTAATCGTGGATTTAATACTTTAGTTAGTACATTCTTTAACTC
TGATATGGTTGAAACAGAGTGTACATTCTGTGGTCAATGTATATCTGTCTGTCCAACTGGAGCATTAACAGAAGTAGATA
ATGTACCTAAACTTTGGGATGTTTTAAATAAAAAAGAAAAGACTATAGTAGTGCAAGTTGCTCCTGCTGTAAGAGTTGCT
ATTGGTGAAGAGTTTGGATTAGAACCAGGGTCAATCTCTACAGGGAAAATGGTAGCTGCTTTAAAAGCACTTGGATTTGA
ACATGTATTTGATACAAACTTTGGTGCAGATTTTACTATAATGGAAGAAGCTACTGAATTTATAGAAAGAATCCAAAAAG
GTGAAAATCTTCCTATATTAACAAGTTGTTGTCCTGCATGGGTAAACTTCTTAGAGCACAATTATCCAGACAAGTTAAAC
TTAGCATCTAGCTGTAAGTCTCCTCAAGGTATGTTTGGTTCTATAGCTAAAAACTACTATGCACCTAAAATATTAGGAAT
CAATCCTGAAGAACTTTATGTTGTATCTGTAATGCCTTGTGTAGCTAAAAAATATGAAGCTTCAAGAGAAGAATTAAGTG
AATCTGGAATACTAGATGTTGACCTTTCTATAACTACTAGAGAGTTAGCTAAGATGATAAAAGAAGCTGCAATCGATTTA
CCTAATCTTCAAGACCAAGATTTTGATAATCCTCTAGGAAAATCTACAGGTGCTGCATCTATATTTGGAGCAAGTGGTGG
AGTTTTAGAAGCTGCCCTACGTACTTCATATGAGAAGATAACTAATAAGACTTTAGATAATGTAAACTTCACTAATGTTA
GAGGTCTTAAAGGAATTAGGGAAGCAAGTATAGATGTTGATGGAACTACAGTTAATGTGTGTATTGTAAATACACTTAAA
AACGCTAGAAAGATTATGGATAAGGTCAGAAGTGGAGAATGTAAATACCATATCATAGAAGTTATGGCATGTCCTGGTGG
ATGTGTTGGAGGTGCTGGTCAACCTTATCACCATGGTAATACTGAAATAGTTGATAGACGTGCAAATGCGTTATATGAAA
TAGATAGAAATAAGGCTATTCGTAAATCTCATGAGAATCCTGATTTACAAGCTATTTATAAAGACTTCTTTGGAGAACCA
AATAGTGATGTAGCCCATAAATACCTTCATACTCATTACTTTGATAAGAGTTGTGTCTATGGAGAGTGTCCACAAGAATG
TGCTTGTGAAGAAGCTAAGTAG

Upstream 100 bases:

>100_bases
ACAATAGATACTTCTAAGTGTCTAAAATGTGGTGCTTGTATAGATAATTGTACATTTAACGCTATAATCAAGAAATAACT
TATTTGGAGGAGGAATAACA

Downstream 100 bases:

>100_bases
TCATAACAAAATATAAAATTTATTCTTAAAAAAGGATTGTCTTAAAATACTTTTACGTAATTTAAGACAATCCTTATTAA
TTTCACAAATTAAATTATAT

Product: iron-only hydrogenase, catalytic subunit

Products: NA

Alternate protein names: CpI; Fe-only hydrogenase; [Fe] hydrogenase [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEIDKLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTN
SAKALNARRTIVELLLSDHPQDCFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETV
CNDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKLWDVLNKKEKTIVVQVAPAVRVA
IGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGADFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLN
LASSCKSPQGMFGSIAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKMIKEAAIDL
PNLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNFTNVRGLKGIREASIDVDGTTVNVCIVNTLK
NARKIMDKVRSGECKYHIIEVMACPGGCVGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEP
NSDVAHKYLHTHYFDKSCVYGECPQECACEEAK

Sequences:

>Translated_593_residues
MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEIDKLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTN
SAKALNARRTIVELLLSDHPQDCFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETV
CNDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKLWDVLNKKEKTIVVQVAPAVRVA
IGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGADFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLN
LASSCKSPQGMFGSIAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKMIKEAAIDL
PNLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNFTNVRGLKGIREASIDVDGTTVNVCIVNTLK
NARKIMDKVRSGECKYHIIEVMACPGGCVGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEP
NSDVAHKYLHTHYFDKSCVYGECPQECACEEAK
>Mature_592_residues
SLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEIDKLDTCASCRVCMVETERGLVPACGTVIKEGMKVQTNS
AKALNARRTIVELLLSDHPQDCFVCEKNGDCELQTIAADLGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETVC
NDIQTVGALSGVNRGFNTLVSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKLWDVLNKKEKTIVVQVAPAVRVAI
GEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGADFTIMEEATEFIERIQKGENLPILTSCCPAWVNFLEHNYPDKLNL
ASSCKSPQGMFGSIAKNYYAPKILGINPEELYVVSVMPCVAKKYEASREELSESGILDVDLSITTRELAKMIKEAAIDLP
NLQDQDFDNPLGKSTGAASIFGASGGVLEAALRTSYEKITNKTLDNVNFTNVRGLKGIREASIDVDGTTVNVCIVNTLKN
ARKIMDKVRSGECKYHIIEVMACPGGCVGGAGQPYHHGNTEIVDRRANALYEIDRNKAIRKSHENPDLQAIYKDFFGEPN
SDVAHKYLHTHYFDKSCVYGECPQECACEEAK

Specific function: Ndh-1 Shuttles Electrons From NADH, Via Fmn And Iron- Sulfur (Fe-S) Centers, To Quinones In The Respiratory Chain. The Immediate Electron Acceptor For The Enzyme In This Species Is Believed To Be Ubiquinone. Couples The Redox Reaction To Proton Translocat

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI11968051, Length=403, Percent_Identity=28.287841191067, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI6912524, Length=438, Percent_Identity=27.8538812785388, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI134284357, Length=364, Percent_Identity=29.6703296703297, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI84452151, Length=382, Percent_Identity=29.3193717277487, Blast_Score=154, Evalue=3e-37,
Organism=Homo sapiens, GI14165461, Length=481, Percent_Identity=26.1954261954262, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI33519475, Length=212, Percent_Identity=32.5471698113208, Blast_Score=115, Evalue=2e-25,
Organism=Escherichia coli, GI145693161, Length=249, Percent_Identity=24.8995983935743, Blast_Score=83, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17565758, Length=218, Percent_Identity=33.9449541284404, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI32566231, Length=218, Percent_Identity=33.9449541284404, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193209088, Length=218, Percent_Identity=33.9449541284404, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI71995015, Length=361, Percent_Identity=27.7008310249307, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324089, Length=370, Percent_Identity=25.1351351351351, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI116007470, Length=413, Percent_Identity=28.8135593220339, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI116007466, Length=413, Percent_Identity=28.8135593220339, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI116007464, Length=413, Percent_Identity=28.8135593220339, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI116007468, Length=413, Percent_Identity=28.8135593220339, Blast_Score=153, Evalue=3e-37,
Organism=Drosophila melanogaster, GI116007462, Length=289, Percent_Identity=30.7958477508651, Blast_Score=122, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24640559, Length=214, Percent_Identity=32.7102803738318, Blast_Score=109, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24640557, Length=214, Percent_Identity=32.7102803738318, Blast_Score=109, Evalue=6e-24,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR003149
- InterPro:   IPR013352
- InterPro:   IPR001041 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF02256 Fe_hyd_SSU [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 64854; Mature: 64723

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEIDKLDTCASCRVCMVETE
CEEEEEEECCCEECCCCCCHHHHHHHHEEEEEHHEEEECHHHHHHHHHHHCCEEEEEECC
RGLVPACGTVIKEGMKVQTNSAKALNARRTIVELLLSDHPQDCFVCEKNGDCELQTIAAD
CCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHH
LGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETVCNDIQTVGALSGVNRGFNTL
HCHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKLWDVLNKKEKTIVVQVAPAVRVA
HHHHHCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHCCCCCEEEEEECCCEEEE
IGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGADFTIMEEATEFIERIQKGENLPIL
ECHHHCCCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCH
TSCCPAWVNFLEHNYPDKLNLASSCKSPQGMFGSIAKNYYAPKILGINPEELYVVSVMPC
HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCEEECCCHHHEEEEEHHHH
VAKKYEASREELSESGILDVDLSITTRELAKMIKEAAIDLPNLQDQDFDNPLGKSTGAAS
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
IFGASGGVLEAALRTSYEKITNKTLDNVNFTNVRGLKGIREASIDVDGTTVNVCIVNTLK
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEHHHH
NARKIMDKVRSGECKYHIIEVMACPGGCVGGAGQPYHHGNTEIVDRRANALYEIDRNKAI
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
RKSHENPDLQAIYKDFFGEPNSDVAHKYLHTHYFDKSCVYGECPQECACEEAK
HHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCC
>Mature Secondary Structure 
SLVNLTINGKHVSAPSGTSILDAAKLINIKIHNLCHLHMNEIDKLDTCASCRVCMVETE
EEEEEEECCCEECCCCCCHHHHHHHHEEEEEHHEEEECHHHHHHHHHHHCCEEEEEECC
RGLVPACGTVIKEGMKVQTNSAKALNARRTIVELLLSDHPQDCFVCEKNGDCELQTIAAD
CCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEEEHHHH
LGVRKIRYQGSKSFAGKDTSTKSLVKDHSKCILCRRCETVCNDIQTVGALSGVNRGFNTL
HCHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
VSTFFNSDMVETECTFCGQCISVCPTGALTEVDNVPKLWDVLNKKEKTIVVQVAPAVRVA
HHHHHCCCCCHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHCCCCCEEEEEECCCEEEE
IGEEFGLEPGSISTGKMVAALKALGFEHVFDTNFGADFTIMEEATEFIERIQKGENLPIL
ECHHHCCCCCCCCCHHHHHHHHHHCHHHHCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCH
TSCCPAWVNFLEHNYPDKLNLASSCKSPQGMFGSIAKNYYAPKILGINPEELYVVSVMPC
HHHHHHHHHHHHCCCCCCCCHHHHCCCCCCHHHHHHHHHCCCEEECCCHHHEEEEEHHHH
VAKKYEASREELSESGILDVDLSITTRELAKMIKEAAIDLPNLQDQDFDNPLGKSTGAAS
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
IFGASGGVLEAALRTSYEKITNKTLDNVNFTNVRGLKGIREASIDVDGTTVNVCIVNTLK
EECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEHHHH
NARKIMDKVRSGECKYHIIEVMACPGGCVGGAGQPYHHGNTEIVDRRANALYEIDRNKAI
HHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
RKSHENPDLQAIYKDFFGEPNSDVAHKYLHTHYFDKSCVYGECPQECACEEAK
HHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1911757; 9836629; 10529166 [H]