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The map label for this gene is adhB [H]

Identifier: 126700627

GI number: 126700627

Start: 3491474

End: 3492619

Strand: Direct

Name: adhB [H]

Synonym: CD3006

Alternate gene names: 126700627

Gene position: 3491474-3492619 (Clockwise)

Preceding gene: 126700626

Following gene: 126700637

Centisome position: 81.38

GC content: 32.11

Gene sequence:

>1146_bases
ATGAGCATTTATTATGTACCACCAATAAATTTACTTGGGAAAGGATGTCTTAATGAAGCTAAAGATTCAATTAAATCATT
AGGAACTAAAAAAGCATTTATTGTTAGTGATAAATTTCTAGTTTCAAATGGTACTGTAAAAAAAGTAACAGATATTTTAT
CTCAGATAGATATAGACTTTGTTGTTTATGATGAAGTTAAACAAAATCCAACTGTAACTAATGTGAATAAAGGACTTAAA
ATATTAAAATCAGAAAATTGCGACTTCGTTATAACTATAGGAGGTGGTTCTCCACAAGACTGTGGTAAAGCTATCTCTAT
ATTAGCCACTAATGGAGGAGATATTAGAGACTATGAAGGTATCAACAAAACTTCTAAAAAATGTCTTCCTATCATAGCTA
TAACTACTACTGCTGGTACATCTGCTGAAGTTACAATAAACTATGTTATAACTGATGAAGACAGACATGTAAAGATGATA
ATGGTTGATACCAATTCACTAGCCACAATGACAGTAAATGACCCAGAATTAATGATTAGCAAACCATCTAATTTAACAGC
AGCAACTGGTATGGATGCACTAACTCATGCTATAGAAGCTGTAGTAGCTAATGGTGCTTATGATGTTACAGATTCAACTG
CCTTATATGCTATAAAGCAGATATTTAAATACCTTCCAAGAGCTGTTAAAAATGGTAATGACATAGAAGCTAGAGAACAA
ATGTGTTATGCTTGTTTTTTAAATGGAATTGCCTTTAGTAATGCAGGTCTTGGAAATGTACATGCTATGGCTCATCAATT
AGGAGGTTTATATGATTTACCTCATGGAGTATGTAATGCCATGCTACTTCCAATAGTTGAGGAGGAAAATGCTAAATCAG
CCCCTGCCAAATTCCGACCAATAGCTGAAGTTATTGGAATGGATGTAAATAATAAATCAGATAAAGAGTGTGTTGACTTT
GTAATAGATAAGATAAAAGCTCTTTCTGAAGAGGTTGGAATCCCAAAATCTTTAAAAGATGTAGGTGTTGATAATCCTAA
TTTTGAATTGCTTGCAGAAAACTCTATGAAAGATGCTTGTGCTGGTGCTAATCCTGTTTTCTTTGATAAAGATAAGATTA
TAGAATTGTTTATGAAAATATCTTAA

Upstream 100 bases:

>100_bases
ATCTCAATCTAAGATACGATATATTATGAGTAAATTAGTGAAAATTGTTAGATATATATTTTTACATAAAAATCAATGAA
AATAAAAGGAGATTTTAGTT

Downstream 100 bases:

>100_bases
TTATGTATATTTATAAGAGAGTGCCTCAAAATATCTTTGTTTTGTTAATAGCACTCTCTTATTACACTTTTTAAATAGTA
CTCTTTATGAGAAGTTAATA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase II; ADH II [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNGTVKKVTDILSQIDIDFVVYDEVKQNPTVTNVNKGLK
ILKSENCDFVITIGGGSPQDCGKAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMI
MVDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAIKQIFKYLPRAVKNGNDIEAREQ
MCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHGVCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDF
VIDKIKALSEEVGIPKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS

Sequences:

>Translated_381_residues
MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNGTVKKVTDILSQIDIDFVVYDEVKQNPTVTNVNKGLK
ILKSENCDFVITIGGGSPQDCGKAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMI
MVDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAIKQIFKYLPRAVKNGNDIEAREQ
MCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHGVCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDF
VIDKIKALSEEVGIPKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS
>Mature_380_residues
SIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNGTVKKVTDILSQIDIDFVVYDEVKQNPTVTNVNKGLKI
LKSENCDFVITIGGGSPQDCGKAISILATNGGDIRDYEGINKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMIM
VDTNSLATMTVNDPELMISKPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAIKQIFKYLPRAVKNGNDIEAREQM
CYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHGVCNAMLLPIVEEENAKSAPAKFRPIAEVIGMDVNNKSDKECVDFV
IDKIKALSEEVGIPKSLKDVGVDNPNFELLAENSMKDACAGANPVFFDKDKIIELFMKIS

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=382, Percent_Identity=26.1780104712042, Blast_Score=118, Evalue=1e-26,
Organism=Escherichia coli, GI48994951, Length=376, Percent_Identity=48.1382978723404, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1789163, Length=369, Percent_Identity=43.360433604336, Blast_Score=300, Evalue=7e-83,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=37.4005305039788, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1787493, Length=400, Percent_Identity=33.5, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1789386, Length=363, Percent_Identity=23.4159779614325, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=382, Percent_Identity=26.7015706806283, Blast_Score=137, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6321181, Length=376, Percent_Identity=45.4787234042553, Blast_Score=341, Evalue=1e-94,
Organism=Drosophila melanogaster, GI24657991, Length=407, Percent_Identity=25.0614250614251, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41116; Mature: 40985

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNGTVKKVTDILSQIDIDF
CEEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEECCCCHHHHHHHHHHCCCEE
VVYDEVKQNPTVTNVNKGLKILKSENCDFVITIGGGSPQDCGKAISILATNGGDIRDYEG
EEEECCCCCCCEEEHHHCHHEEECCCCCEEEEECCCCCHHHHHEEEEEECCCCCCCCCCC
INKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMIMVDTNSLATMTVNDPELMIS
CCCCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCEEEEE
KPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAIKQIFKYLPRAVKNGNDIEAREQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHGVCNAMLLPIVEEENAKSAPAKFRP
HHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHEEEEEECCCCCCCCCHHHH
IAEVIGMDVNNKSDKECVDFVIDKIKALSEEVGIPKSLKDVGVDNPNFELLAENSMKDAC
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCHHHH
AGANPVFFDKDKIIELFMKIS
CCCCCEEECHHHHHHHHHHCC
>Mature Secondary Structure 
SIYYVPPINLLGKGCLNEAKDSIKSLGTKKAFIVSDKFLVSNGTVKKVTDILSQIDIDF
EEEEECCHHHHHHHHHHHHHHHHHHCCCCEEEEEECEEEECCCCHHHHHHHHHHCCCEE
VVYDEVKQNPTVTNVNKGLKILKSENCDFVITIGGGSPQDCGKAISILATNGGDIRDYEG
EEEECCCCCCCEEEHHHCHHEEECCCCCEEEEECCCCCHHHHHEEEEEECCCCCCCCCCC
INKTSKKCLPIIAITTTAGTSAEVTINYVITDEDRHVKMIMVDTNSLATMTVNDPELMIS
CCCCCCCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCEEEEE
KPSNLTAATGMDALTHAIEAVVANGAYDVTDSTALYAIKQIFKYLPRAVKNGNDIEAREQ
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHH
MCYACFLNGIAFSNAGLGNVHAMAHQLGGLYDLPHGVCNAMLLPIVEEENAKSAPAKFRP
HHHHHHHCCHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHEEEEEECCCCCCCCCHHHH
IAEVIGMDVNNKSDKECVDFVIDKIKALSEEVGIPKSLKDVGVDNPNFELLAENSMKDAC
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCEEEEECCCCHHHH
AGANPVFFDKDKIIELFMKIS
CCCCCEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3584063; 2308827; 2935393 [H]