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The map label for this gene is vanR [H]

Identifier: 126699934

GI number: 126699934

Start: 2677869

End: 2678585

Strand: Direct

Name: vanR [H]

Synonym: CD2316

Alternate gene names: 126699934

Gene position: 2677869-2678585 (Clockwise)

Preceding gene: 126699933

Following gene: 126699935

Centisome position: 62.42

GC content: 28.59

Gene sequence:

>717_bases
TTGAATCAAAATATATTGGTTGTAGATGATGATAGAGAGATAGTTGATGCTATAGAGTTCTATTTGAGACCTGATAACTT
TAATGTTTTAAAGGCATATGATGGACTTGAAGCATTGGACATACTAATCGAAAATGATATTAAGTTAATAATAATGGATG
TAATGATGCCCAATTTAGATGGGCTTAAAACTACACTTAAAATAAGAGAAAAAAGGAATATACCAATAATTCTCTTATCT
GCAAAATCAGAAGATATGGACAAAATTATAGGTCTTAATATGGGTGCTGATGACTATATAACTAAACCATTTAATCCACT
AGAACTTACTGCTCGAGTAAAATCTCAACTTAGAAGGTATATAAATTTAGGTGATTTTAGTAATACAAATAACTCAAATG
ATACTAATTATATTCTAAAAAGTGGTGGCCTAGAGCTAAATACAGATACAAAAATAGTTTCTTTAGATGGTGAAGAAATT
AAAATGACACCACTTGAATATAAAATACTTACACTTCTTATGTCACGAAAAGGTAAAATTTTCTCTTCTCATGAGATTTA
TGAAAATGTCTGGAATGAGGATGCTTATAGTTGTGAGAGAACTATTGCTGTTCATATTAGAAGAATTAGAGAAAAGATTG
AAATTAATCCAAAAGAACCAAAATATTTAAAGGTGGTGTGGGGCATTGGTTACAAAATTGAAAAACTTAATTATTAA

Upstream 100 bases:

>100_bases
AGTTTTTATTTCATAATGAATGGGCTTACTGTTTTCTAATACCTCTTTTTGGTATAAAATAAAAATTGGTTAAAAATAAA
ATTTCAAGGGGGTTAATAAG

Downstream 100 bases:

>100_bases
TGATTCTAAAGCAAAATTTATTTTATTATTATTACTGTTTCTATTAGTTTCTATATTATTTGAAGCAGTTTATGATTTGA
ATAATAACTTTTCTAATATT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIENDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLS
AKSEDMDKIIGLNMGADDYITKPFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPKEPKYLKVVWGIGYKIEKLNY

Sequences:

>Translated_238_residues
MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIENDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLS
AKSEDMDKIIGLNMGADDYITKPFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPKEPKYLKVVWGIGYKIEKLNY
>Mature_238_residues
MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIENDIKLIIMDVMMPNLDGLKTTLKIREKRNIPIILLS
AKSEDMDKIIGLNMGADDYITKPFNPLELTARVKSQLRRYINLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEI
KMTPLEYKILTLLMSRKGKIFSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPKEPKYLKVVWGIGYKIEKLNY

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=34.1991341991342, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=35.0649350649351, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=32.2033898305085, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=231, Percent_Identity=31.1688311688312, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=28.695652173913, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.2105263157895, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=31.4410480349345, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=237, Percent_Identity=28.6919831223629, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=30.8695652173913, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789402, Length=231, Percent_Identity=29.4372294372294, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1787229, Length=218, Percent_Identity=31.1926605504587, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=29.8701298701299, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.2576419213974, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787375, Length=232, Percent_Identity=28.8793103448276, Blast_Score=88, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27563; Mature: 27563

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIENDIKLIIMDVMMPNLD
CCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECCCHHHHHEEECCCCEEEEEEECCCCCC
GLKTTLKIREKRNIPIILLSAKSEDMDKIIGLNMGADDYITKPFNPLELTARVKSQLRRY
CHHHHEEEHHCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
INLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEIKMTPLEYKILTLLMSRKGKI
HCCCCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCEEEECCHHHHHHHHHHHCCCCE
FSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPKEPKYLKVVWGIGYKIEKLNY
ECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCC
>Mature Secondary Structure
MNQNILVVDDDREIVDAIEFYLRPDNFNVLKAYDGLEALDILIENDIKLIIMDVMMPNLD
CCCCEEEEECCHHHHHHHHHHCCCCCCEEEEECCCHHHHHEEECCCCEEEEEEECCCCCC
GLKTTLKIREKRNIPIILLSAKSEDMDKIIGLNMGADDYITKPFNPLELTARVKSQLRRY
CHHHHEEEHHCCCCCEEEEECCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
INLGDFSNTNNSNDTNYILKSGGLELNTDTKIVSLDGEEIKMTPLEYKILTLLMSRKGKI
HCCCCCCCCCCCCCCEEEEECCCEEECCCCEEEEECCCEEEECCHHHHHHHHHHHCCCCE
FSSHEIYENVWNEDAYSCERTIAVHIRRIREKIEINPKEPKYLKVVWGIGYKIEKLNY
ECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]