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The map label for this gene is yclK [H]

Identifier: 126699392

GI number: 126699392

Start: 2064344

End: 2065777

Strand: Direct

Name: yclK [H]

Synonym: CD1783

Alternate gene names: 126699392

Gene position: 2064344-2065777 (Clockwise)

Preceding gene: 126699391

Following gene: 126699393

Centisome position: 48.12

GC content: 26.92

Gene sequence:

>1434_bases
GTGTTACATTTTGAAGGTCTGAGAAAAAAAGTAATAAAAAACTATTTTATAATAATTATTATAATGGTTACTCTGTTTGA
AGGATTGTTCATGTTTTACATACAAAACTACTATTATGATTCTGTCAAACAGCTACTTGAATCTGAAATAAAATATGCTG
ATGAATATAATGCTATTACAATGGAAACTACAAGTTTTGAGAAAAAAGTAAAAAATATATTTGATAAACAACCCTTAACT
AAAAATTCAGAATTTGGAATTTCAATAATAGATAAAGATAAAAATATTATATTAGACCAATATGGTTTTAAAAGTAAAGA
AAAAGCAAACTATGAAGATGTTAACAATGCATTAAAAGATATAAAAACTAAAAATTTAACACCTTATACTTATAGAATAC
CAGATACAGGGGAGCATGTTATGAGTATCTCCTTACCACTTAAGGTAAATAATATAATAGAAGGTGTTGTTAGATATACA
GTATCATTAGATGCTATTGATAATGCAATATTAAAGCAAGCTACATGGCTTATATTAGCAGGAATATTTATACTTATTAT
AGCTATACTAATAAGTCTTAAATTTGCTGAGACTCTTATAAAACCATTACGAGAGCTAAAGAAATTTGCAAATGAATTGG
CTGTAGGAAATTATAATATAAAATTAGAAAAGATGAAGATTGTAGATGATGAAATTGGTGATTTAGCACAGACATTTGAA
CACATGGCACATGAGATTGACAAAAGTGAAAAATTAAAAGAGGAATTTATATCATCTGTATCTCATGAACTAAGGACTCC
TCTTACATCTATAAAGGGGTGGAGTGAAACCTTAGGTTATGAAAGTATAACAAGAGAAGAACTAGACTTAGGTTTAGGCA
TTATACAAGATGAAACAGAAAGACTTATAAAACTAGTTGAAGAATTATTAGACTTTTCAAGGCTTTCTTCAGACAGGATA
AAACTTCATGTTGATATAGTTGATGTTGAAGGTTTAATTGTAGGTGTTGTAAATCAACTTAAAGTTAAAGCAGCTGAAAA
AGATATATCACTTTTATTTGAATTTGAAAATGAATTTATAGAGAACATTCAAGGAGATAAAAATAGATTAAGACAGGTTC
TCATAAATTTAATACAAAATTCATTTAAATTTACGAGTCAAGGTGGTTACATAAAAGTTGTAGCTTCTCAAGATGAAGAG
ATAACAACCATATCAGTAGAGGATAATGGTTCAGGTATAGAAAAGCAAAATTTAAATAAAGTGTTAGATAAATTTTTCCA
AGAAGATTATAATAAGGCTGGTAGTGGATTAGGACTAGCAATTAGTAATGAAATTGTAAAACTTCATGGTGGAAGAATGA
AAATAGAAAGTGAAAAGAATGTTGGAACAAAAATAACTTTTAATATAAAAAATAAATTTGCTAAACAAGCATAA

Upstream 100 bases:

>100_bases
TAAGAAGGATAAGAAATAAAATAGAAGATGACCCATCAAAACCAAAATATATACAAACTATTTGGGGTTATGGATACTGT
TTTAGAAAGGAAGAATAATA

Downstream 100 bases:

>100_bases
ATTCTTAGAAAGAGGATTAAGATGAGAAACATAAAAATGATAGTAGCATACGATGGTTCAAGATATAAAGGATATCAAAA
ATTAGGTGACAATAATATGA

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQLLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLT
KNSEFGISIIDKDKNIILDQYGFKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNYNIKLEKMKIVDDEIGDLAQTFE
HMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSETLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRI
KLHVDIVDVEGLIVGVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIKVVASQDEE
ITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHGGRMKIESEKNVGTKITFNIKNKFAKQA

Sequences:

>Translated_477_residues
MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQLLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLT
KNSEFGISIIDKDKNIILDQYGFKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNYNIKLEKMKIVDDEIGDLAQTFE
HMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSETLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRI
KLHVDIVDVEGLIVGVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIKVVASQDEE
ITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHGGRMKIESEKNVGTKITFNIKNKFAKQA
>Mature_477_residues
MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQLLESEIKYADEYNAITMETTSFEKKVKNIFDKQPLT
KNSEFGISIIDKDKNIILDQYGFKSKEKANYEDVNNALKDIKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYT
VSLDAIDNAILKQATWLILAGIFILIIAILISLKFAETLIKPLRELKKFANELAVGNYNIKLEKMKIVDDEIGDLAQTFE
HMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSETLGYESITREELDLGLGIIQDETERLIKLVEELLDFSRLSSDRI
KLHVDIVDVEGLIVGVVNQLKVKAAEKDISLLFEFENEFIENIQGDKNRLRQVLINLIQNSFKFTSQGGYIKVVASQDEE
ITTISVEDNGSGIEKQNLNKVLDKFFQEDYNKAGSGLGLAISNEIVKLHGGRMKIESEKNVGTKITFNIKNKFAKQA

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=337, Percent_Identity=27.893175074184, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786600, Length=233, Percent_Identity=30.0429184549356, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=27.843137254902, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=27.5862068965517, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=27.9166666666667, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=32, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789149, Length=282, Percent_Identity=27.6595744680851, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790861, Length=396, Percent_Identity=25.5050505050505, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=30.1310043668122, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786783, Length=332, Percent_Identity=23.7951807228916, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=28.7610619469027, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1790551, Length=305, Percent_Identity=25.9016393442623, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=26.7657992565056, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788279, Length=276, Percent_Identity=25, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=27.4193548387097, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=22.4080267558528, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1789403, Length=287, Percent_Identity=26.8292682926829, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787894, Length=238, Percent_Identity=23.9495798319328, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54511; Mature: 54511

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQLLESEIKYADEYNAIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
METTSFEKKVKNIFDKQPLTKNSEFGISIIDKDKNIILDQYGFKSKEKANYEDVNNALKD
EEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHH
IKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYTVSLDAIDNAILKQATWLILA
HHCCCCCCEEEECCCCCCCEEEEEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFILIIAILISLKFAETLIKPLRELKKFANELAVGNYNIKLEKMKIVDDEIGDLAQTFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHHHHHHHHHH
HMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSETLGYESITREELDLGLGIIQDETE
HHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHHHHHHHHHHCCCCCHHHHH
RLIKLVEELLDFSRLSSDRIKLHVDIVDVEGLIVGVVNQLKVKAAEKDISLLFEFENEFI
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIQGDKNRLRQVLINLIQNSFKFTSQGGYIKVVASQDEEITTISVEDNGSGIEKQNLNK
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
VLDKFFQEDYNKAGSGLGLAISNEIVKLHGGRMKIESEKNVGTKITFNIKNKFAKQA
HHHHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCCCCEEEEEEHHHHCCCC
>Mature Secondary Structure
MLHFEGLRKKVIKNYFIIIIIMVTLFEGLFMFYIQNYYYDSVKQLLESEIKYADEYNAIT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
METTSFEKKVKNIFDKQPLTKNSEFGISIIDKDKNIILDQYGFKSKEKANYEDVNNALKD
EEHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHH
IKTKNLTPYTYRIPDTGEHVMSISLPLKVNNIIEGVVRYTVSLDAIDNAILKQATWLILA
HHCCCCCCEEEECCCCCCCEEEEEECEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GIFILIIAILISLKFAETLIKPLRELKKFANELAVGNYNIKLEKMKIVDDEIGDLAQTFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHHHHHHHHHH
HMAHEIDKSEKLKEEFISSVSHELRTPLTSIKGWSETLGYESITREELDLGLGIIQDETE
HHHHHHCHHHHHHHHHHHHHHHHHHCCHHHHCCHHHHCCHHHHHHHHHHHCCCCCHHHHH
RLIKLVEELLDFSRLSSDRIKLHVDIVDVEGLIVGVVNQLKVKAAEKDISLLFEFENEFI
HHHHHHHHHHHHHHCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENIQGDKNRLRQVLINLIQNSFKFTSQGGYIKVVASQDEEITTISVEDNGSGIEKQNLNK
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCHHHHHH
VLDKFFQEDYNKAGSGLGLAISNEIVKLHGGRMKIESEKNVGTKITFNIKNKFAKQA
HHHHHHHHHHHHCCCCCEEEECCCCCEECCCEEEEECCCCCCCEEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]