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The map label for this gene is grdG [H]

Identifier: 126699347

GI number: 126699347

Start: 2015960

End: 2017246

Strand: Direct

Name: grdG [H]

Synonym: CD1740

Alternate gene names: 126699347

Gene position: 2015960-2017246 (Clockwise)

Preceding gene: 126699346

Following gene: 126699348

Centisome position: 46.99

GC content: 33.49

Gene sequence:

>1287_bases
ATGAAGCTAGAGCTAGGGAATATATTTATAAAAAATGTTGAATTTGGAGAAAAGACAGAAGTAAAAGATGGAGTACTATA
TATTAGTAGCGAAGAAATAGAAAAGATAGTATTAGAAGATGAAAGGATTGTAAGTGTAAATGTTGAACTTGCAAGACCTG
GCGAATCAATAAGAATAGCTCCAGTTAAAGATGTAATAGAGCCTAGAGTTAAAATTGGAGATGAAAGCAAAATATTTCCT
GGAATTATAAATAAAGTGAAGACTGTAGGAAGTGGAAGAACCCATGTACTTTTAGGAGCTTGTGTTGTAACTTGTGGAAA
TATAGTTGGATTTCAAGAAGGCGTAATTGATATGAGTGGTCCTACTGCTAAATATACACCTTTTTCAAAAACAAATAATA
TATGTATTGTTATAAAAGCAAAGGATGGTATAGATACTCATGATTATGAAGAAGCAGCTAGAATTGCAGGATTAAAAATA
GGTGCATATGTAGGTGAGGCAGGAAGAGAAGTTGAGCCAGATGAAGTCATTGTATATGAGACAAAGCCATTATTAAAACA
AGTAAAAGAATATCCAGACCTGCCAACAGTAGCATATGTTCACATGTTACAATCACAAGGACTTTTACATGACACTTATT
ACTATGGGGTGGATGCTAAACAGATAGTGCCTACATTTATGTATCCAACTGAAATAATGGATGGAGCTATAATATCTGGA
AACTGTGTAGCACCATGTGATAAGGTTACAACATTCCATCATTTAAATAATCCAGTTATACATGACTTATATAAAAGACA
TGGAAAAGATTTAAACTTTATAGGAGTTATTTTGACTAATGAGAACGTATTCTTAGTCGATAAAGAGAGAAGCTCTGATA
TGGTAGCTAAATTAATAGAATTTTTAGGAGTTGATGGAGTTCTAGTGACAGAAGAAGGTTATGGGAATCCAGATACTGAC
CTAATGATGAATTGTAGAAAATGTAGTGAAGTTGGAGCAAATGTAGTTTTGATAACGGATGAATTTCCTGGAAAAGATGG
CAAGAGTCAATCTATAGCAGACGCTACTAAGGAAGCAGATGCAGTTGTTTCTTGTGGTCAAGGAAATCTAGTGGTTCATT
TCCCAGCAATGGAAAAAATTATAGGAACTTTAGATTATGTTGAAATGATGATAGGTGGGTATAAAGGATGCTTAAATGAA
GACGGAAGCATGGATGCAGAGCTACAAATTATAATAGCATCAACTATAGCAAATGGCTATAATCATTTGACAGCAAGATA
TTATTAA

Upstream 100 bases:

>100_bases
AATATATATTTTAAATAATTGGCATAGAAAATGCTTTATATATTAATAAACGTAATAAATACTTTTAATTGCGATTAAAT
ATATTAAGGGGGATTTTCAT

Downstream 100 bases:

>100_bases
ATAAGTATTTGAATATAAAGTTCTGTTGATGTAATCATTGGTCTAACTGATGTAATAACTATAAAGTGATTTGGAGGATT
AAGAGATGAGTAAAATCAGA

Product: sarcosine reductase complex component B subunit alpha

Products: NA

Alternate protein names: Selenoprotein PB alpha [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIVSVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFP
GIINKVKTVGSGRTHVLLGACVVTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVDAKQIVPTFMYPTEIMDGAIISG
NCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGVILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTD
LMMNCRKCSEVGANVVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIGGYKGCLNE
DGSMDAELQIIIASTIANGYNHLTARYY

Sequences:

>Translated_428_residues
MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIVSVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFP
GIINKVKTVGSGRTHVLLGACVVTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVDAKQIVPTFMYPTEIMDGAIISG
NCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGVILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTD
LMMNCRKCSEVGANVVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIGGYKGCLNE
DGSMDAELQIIIASTIANGYNHLTARYY
>Mature_428_residues
MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIVSVNVELARPGESIRIAPVKDVIEPRVKIGDESKIFP
GIINKVKTVGSGRTHVLLGACVVTCGNIVGFQEGVIDMSGPTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKI
GAYVGEAGREVEPDEVIVYETKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVDAKQIVPTFMYPTEIMDGAIISG
NCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGVILTNENVFLVDKERSSDMVAKLIEFLGVDGVLVTEEGYGNPDTD
LMMNCRKCSEVGANVVLITDEFPGKDGKSQSIADATKEADAVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIGGYKGCLNE
DGSMDAELQIIIASTIANGYNHLTARYY

Specific function: In the first step of sarcosine reductase, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selen

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016585
- InterPro:   IPR015417 [H]

Pfam domain/function: PF09338 Gly_reductase [H]

EC number: =1.21.4.3 [H]

Molecular weight: Translated: 46909; Mature: 46909

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIVSVNVELARPGESIRIA
CEEEECCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHCCCCEEEEEEEEEECCCCCEEEE
PVKDVIEPRVKIGDESKIFPGIINKVKTVGSGRTHVLLGACVVTCGNIVGFQEGVIDMSG
EHHHHHCCHHEECCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCEEECCC
PTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKIGAYVGEAGREVEPDEVIVYE
CCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCEEEEEEECCCCCCCCCCCEEEEC
TKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVDAKQIVPTFMYPTEIMDGAIISG
CCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHCCEEEEC
NCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGVILTNENVFLVDKERSSDMVAKLIE
CCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHH
FLGVDGVLVTEEGYGNPDTDLMMNCRKCSEVGANVVLITDEFPGKDGKSQSIADATKEAD
HHCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
AVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIGGYKGCLNEDGSMDAELQIIIASTIANGY
CEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEHHCCCC
NHLTARYY
CCEEEECC
>Mature Secondary Structure
MKLELGNIFIKNVEFGEKTEVKDGVLYISSEEIEKIVLEDERIVSVNVELARPGESIRIA
CEEEECCEEEEECCCCCCCCCCCCEEEEEHHHHHHHHCCCCEEEEEEEEEECCCCCEEEE
PVKDVIEPRVKIGDESKIFPGIINKVKTVGSGRTHVLLGACVVTCGNIVGFQEGVIDMSG
EHHHHHCCHHEECCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHCCCCCCCCCEEECCC
PTAKYTPFSKTNNICIVIKAKDGIDTHDYEEAARIAGLKIGAYVGEAGREVEPDEVIVYE
CCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCEEEEEEECCCCCCCCCCCEEEEC
TKPLLKQVKEYPDLPTVAYVHMLQSQGLLHDTYYYGVDAKQIVPTFMYPTEIMDGAIISG
CCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHCCHHHHHCCEEEEC
NCVAPCDKVTTFHHLNNPVIHDLYKRHGKDLNFIGVILTNENVFLVDKERSSDMVAKLIE
CCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCEEEEECCCCHHHHHHHHH
FLGVDGVLVTEEGYGNPDTDLMMNCRKCSEVGANVVLITDEFPGKDGKSQSIADATKEAD
HHCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCC
AVVSCGQGNLVVHFPAMEKIIGTLDYVEMMIGGYKGCLNEDGSMDAELQIIIASTIANGY
CEEECCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEEHHCCCC
NHLTARYY
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA