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The map label for this gene is zraR [H]

Identifier: 126699346

GI number: 126699346

Start: 2014359

End: 2015681

Strand: Direct

Name: zraR [H]

Synonym: CD1739

Alternate gene names: 126699346

Gene position: 2014359-2015681 (Clockwise)

Preceding gene: 126699345

Following gene: 126699347

Centisome position: 46.95

GC content: 26.0

Gene sequence:

>1323_bases
ATGAAAATACTATTAGTTGATGATGAGCTAGAATATGGAGTGGTAATGAAAAAAATTCTACAAAAGAAGGGCTATCTTGT
AGATATAGCACTAAGTGGTGAAGAAGCTATAAATATAATTAAAAAAGATAAAAATTATGATTTGGTTTTATCTGATGTTA
TGATGAAAAATATGGATGGAGTACAGCTATTAGATAGAATTAAATCTATTAATAGAGATATAGAGGTTATATTAGTTACA
GGATATGGAAGTATTGAAAATGCAGTTGATGCTATGAAAAGAGGAGCTTTATCTTATTTTATAAAAAGTAATCCCATTGA
AAATTTATTAGAAGAAGTTGAAAAGGTAAAGGCAAGTAAAATATCTGTTTCTGTACAAAAAAATAATTTTGAATTTACTT
TGGAATCTAAAAATAGAGATTTTAATAATATCATAAAAATAGCAAAAAAAGCTGCTTGTAAAGATGTTAATATATTAATC
TTGGGGGAATCTGGTGTAGGAAAAGATATATTAGCTAGATATATACATAGCATAAGTCCAAGAAAGAATGAGATATTTGT
ACCTGTAAATTGTTGTTCTTTTTCAGAAAATCTATTGGAGTCTGAGCTGTTTGGTCATGAAAAAGGTTCTTTTACAGGAG
CAGTAGATAGTAGAAAAGGTAGATTTGAACTTTCGAATAAAGGAACTCTATTTTTGGATGAAATAGGAGATATACCTCTA
AATGTTCAGGTAAAACTTTTGAGGACACTTGAGGACAAATCTATAGAGAGGATAGGAAGTAATAAATCTATTAAAGTTGA
CTTTAGGTTAATTTGTGCTATGAATAAAGAACCAAAAGTGGAAATATCAAATGGAAATATAAGAGAAGATTTTTTTTATA
GAATAAGTACAATAACAATAACTATACCACCACTAAGAAAGAGAAGAGAAGACTTAACTACTCTTATAGAATTTTTCTTA
AATAAGTACCAAATTGAACATGATAAAAAGATACACTCGATTGATAAGGAAGTAAAGGATTTTTTATTAAATTACAATTA
TCCAGGAAATATAAGAGAATTAAAAAATATAATAAATAGACTTGTAGTTTTAAGTGAAGAAGGTAATTTATCAAAAGACA
ATTTAAATTTAATATCAAATAATGTATACATAGATGATAAAATAAGTATTAGACCTTTAAGAGAAATAAGAAAAGAGTTT
GAATGTGAGTATATTGAAAAAGTTTTATCTTTGTGTGGAAATAATATTTCAAATACAGCTAAAAAATTGGAGATTAGTAG
AAGACAGTTAACCAATAAAATATCAGAGTATAATATTAAGTGA

Upstream 100 bases:

>100_bases
AGATTAAAAAGAATAATGGAGATATAAGTGTTGAAAGTAAATTGGGGGTTGGAACTTGTTTTCATATAAAAATTCCATTA
AATAAAGAGGTGACTATATA

Downstream 100 bases:

>100_bases
GAAAAAAACTTCTCATTAAGTGAGAAAAAAATTTCTCAAACTGTATTAAAAGATAAACAGAAAAAATCTGTTTATCTTTT
TTTATTATAATTTTAAAAAT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDKNYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVT
GYGSIENAVDAMKRGALSYFIKSNPIENLLEEVEKVKASKISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILI
LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSRKGRFELSNKGTLFLDEIGDIPL
NVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNKEPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFL
NKYQIEHDKKIHSIDKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRPLREIRKEF
ECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK

Sequences:

>Translated_440_residues
MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDKNYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVT
GYGSIENAVDAMKRGALSYFIKSNPIENLLEEVEKVKASKISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILI
LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSRKGRFELSNKGTLFLDEIGDIPL
NVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNKEPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFL
NKYQIEHDKKIHSIDKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRPLREIRKEF
ECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK
>Mature_440_residues
MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDKNYDLVLSDVMMKNMDGVQLLDRIKSINRDIEVILVT
GYGSIENAVDAMKRGALSYFIKSNPIENLLEEVEKVKASKISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILI
LGESGVGKDILARYIHSISPRKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSRKGRFELSNKGTLFLDEIGDIPL
NVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNKEPKVEISNGNIREDFFYRISTITITIPPLRKRREDLTTLIEFFL
NKYQIEHDKKIHSIDKEVKDFLLNYNYPGNIRELKNIINRLVVLSEEGNLSKDNLNLISNNVYIDDKISIRPLREIRKEF
ECEYIEKVLSLCGNNISNTAKKLEISRRQLTNKISEYNIK

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=38.8127853881278, Blast_Score=326, Evalue=1e-90,
Organism=Escherichia coli, GI1788550, Length=456, Percent_Identity=38.3771929824561, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI1788905, Length=437, Percent_Identity=32.7231121281465, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=31.3978494623656, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI87082117, Length=241, Percent_Identity=41.49377593361, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1789087, Length=228, Percent_Identity=46.0526315789474, Blast_Score=215, Evalue=4e-57,
Organism=Escherichia coli, GI87082152, Length=284, Percent_Identity=36.6197183098592, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1789233, Length=248, Percent_Identity=40.7258064516129, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI87081872, Length=225, Percent_Identity=40, Blast_Score=188, Evalue=8e-49,
Organism=Escherichia coli, GI1787583, Length=303, Percent_Identity=33.3333333333333, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1786524, Length=236, Percent_Identity=38.5593220338983, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1789828, Length=319, Percent_Identity=30.0940438871473, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081858, Length=335, Percent_Identity=26.2686567164179, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1786784, Length=128, Percent_Identity=28.125, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI87082012, Length=168, Percent_Identity=26.1904761904762, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50425; Mature: 50425

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDKNYDLVLSDVMMKNMDG
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCEEEHHHHHCCCCH
VQLLDRIKSINRDIEVILVTGYGSIENAVDAMKRGALSYFIKSNPIENLLEEVEKVKASK
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHE
ISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILILGESGVGKDILARYIHSISP
EEEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCC
RKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSRKGRFELSNKGTLFLDEIGDIPL
CCCEEEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCCCEEECCCCCEEEECCCCCCC
NVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNKEPKVEISNGNIREDFFYRISTITI
CEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEECCCCCCCCCEEEEEEEEE
TIPPLRKRREDLTTLIEFFLNKYQIEHDKKIHSIDKEVKDFLLNYNYPGNIRELKNIINR
EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVVLSEEGNLSKDNLNLISNNVYIDDKISIRPLREIRKEFECEYIEKVLSLCGNNISNTA
HEEEECCCCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHH
KKLEISRRQLTNKISEYNIK
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKILLVDDELEYGVVMKKILQKKGYLVDIALSGEEAINIIKKDKNYDLVLSDVMMKNMDG
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCCCCEEEHHHHHCCCCH
VQLLDRIKSINRDIEVILVTGYGSIENAVDAMKRGALSYFIKSNPIENLLEEVEKVKASK
HHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHE
ISVSVQKNNFEFTLESKNRDFNNIIKIAKKAACKDVNILILGESGVGKDILARYIHSISP
EEEEEEECCEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHCCC
RKNEIFVPVNCCSFSENLLESELFGHEKGSFTGAVDSRKGRFELSNKGTLFLDEIGDIPL
CCCEEEEEEECCCCHHHHHHHHHCCCCCCCEECCCCCCCCCEEECCCCCEEEECCCCCCC
NVQVKLLRTLEDKSIERIGSNKSIKVDFRLICAMNKEPKVEISNGNIREDFFYRISTITI
CEEHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEECCCCCCCCCEEEEEEEEE
TIPPLRKRREDLTTLIEFFLNKYQIEHDKKIHSIDKEVKDFLLNYNYPGNIRELKNIINR
EECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
LVVLSEEGNLSKDNLNLISNNVYIDDKISIRPLREIRKEFECEYIEKVLSLCGNNISNTA
HEEEECCCCCCCCCCEEEECCEEECCCCCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHH
KKLEISRRQLTNKISEYNIK
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]