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The map label for this gene is hisC [H]

Identifier: 126699153

GI number: 126699153

Start: 1797425

End: 1798474

Strand: Direct

Name: hisC [H]

Synonym: CD1549

Alternate gene names: 126699153

Gene position: 1797425-1798474 (Clockwise)

Preceding gene: 126699152

Following gene: 126699154

Centisome position: 41.9

GC content: 26.38

Gene sequence:

>1050_bases
TTGAGAGAAAAAGAAAGCATAAGAGAGTTAAGGGGATATGAACCAAATCACGTAAACTGTAAAGTAAAACTTGATGCAAA
TGAAGGAAGTAAGAGGTTGTTTAAATACCTTATTAAAGAAATTTCAGATAGTGATATAGATTTAAATTTATATCCTGAAG
ATTCTTATAGTGATTTGAAAGAATCTATAATAGATTACATAAATATTTCTGGAGTAAATAAGAAAAATCTTCTAGTAGGA
AACGGTTCAAGTGAAATAATTGATTTAATAATACATACTTTTGTAGATAAAGACGAAGTAATATTGAGTTTCTCTCCAAG
TTTTAGTATGTATTCTATATATAGTCAGATAAATGGGTCTAAATTTATAGGTGTTGAAAGTGATGAAAATTTAGTTATAA
ATATAGATAATGTGATTGAAAAAGTAAAGGAGAATAATCCTAAAATAGTAATTGTATGTAATCCTAATAATCCAACTGGA
ACAATATTAAAGAGGGAAGAGATAATAAAGCTTTTAGATTCAACTAATAGTCTAGTGGTTTTAGATGAAGCATATATGGA
TTTTGGAGAAGAAAGCATGTTAAGTGATGTTTTTAAGTATGATAATCTAATAGTTCTTAGAACTTTATCAAAGGCATTTG
GATTGGCTGGAATAAGAACAGGATATATGTTATCTAATAGTAGTTTAATAAATTCTGTTGAGAAAGTAAGACCTCCATAT
AATTTAAATTCATTATCAGACTTTATTGCTACAAGAGCACTTAGAAATAAAGATGTGGTAAAAGCTTATATAAAGGAAGT
AAAAGAGGAAAGAGAAGTTTTATATGAAGAAATGATTGGTATGGGAATTAAAGCATACAAATCACAAGCAAATTTTATAT
TATTTTATTCTGAAATCGAAAATTTATCACAAAAACTTATTGATAGAGGAGTTTTAATAAGAAAATTTGGTGGAAAGTTA
GAAAATTATTACAGAGTTACAATTGGTGATAAAGAAGAAAATTCTATGTTTGTTGGAGCTATAAGAGATATTTTGAAAAA
GGAGAAATAG

Upstream 100 bases:

>100_bases
TAGCTATAGATTTAAATATGAACAAATTCAGAATATAATTCGTTTATTTGAAGAACTTGATAATTAAAATATAATTGAGC
TTTATAAGGAGGGATTTAAG

Downstream 100 bases:

>100_bases
GTATGAGAATTTGGAAGGTAGAAAGAAATACTCTTGAAACACAGATTTTAGTAGAATTAAATATTGATGGTTCTGGTAAA
GCTGAAATAGATACTGGAAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDSDIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVG
NGSSEIIDLIIHTFVDKDEVILSFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGIRTGYMLSNSSLINSVEKVRPPY
NLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYEEMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKL
ENYYRVTIGDKEENSMFVGAIRDILKKEK

Sequences:

>Translated_349_residues
MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDSDIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVG
NGSSEIIDLIIHTFVDKDEVILSFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGIRTGYMLSNSSLINSVEKVRPPY
NLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYEEMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKL
ENYYRVTIGDKEENSMFVGAIRDILKKEK
>Mature_349_residues
MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDSDIDLNLYPEDSYSDLKESIIDYINISGVNKKNLLVG
NGSSEIIDLIIHTFVDKDEVILSFSPSFSMYSIYSQINGSKFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTG
TILKREEIIKLLDSTNSLVVLDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGIRTGYMLSNSSLINSVEKVRPPY
NLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYEEMIGMGIKAYKSQANFILFYSEIENLSQKLIDRGVLIRKFGGKL
ENYYRVTIGDKEENSMFVGAIRDILKKEK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=31.1614730878187, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788627, Length=202, Percent_Identity=25.2475247524752, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=355, Percent_Identity=31.830985915493, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39803; Mature: 39803

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDSDIDLNLYPEDSYSDLK
CCCHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
ESIIDYINISGVNKKNLLVGNGSSEIIDLIIHTFVDKDEVILSFSPSFSMYSIYSQINGS
HHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC
KFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTGTILKREEIIKLLDSTNSLVV
EEEEECCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCCCEEE
LDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGIRTGYMLSNSSLINSVEKVRPPY
EEHHHHCCCHHHHHHHHHHHCCEEEEEHHHHHHCCCHHCCCEEECCCHHHHHHHHHCCCC
NLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYEEMIGMGIKAYKSQANFILFYSEIE
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHH
NLSQKLIDRGVLIRKFGGKLENYYRVTIGDKEENSMFVGAIRDILKKEK
HHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MREKESIRELRGYEPNHVNCKVKLDANEGSKRLFKYLIKEISDSDIDLNLYPEDSYSDLK
CCCHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHH
ESIIDYINISGVNKKNLLVGNGSSEIIDLIIHTFVDKDEVILSFSPSFSMYSIYSQINGS
HHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCC
KFIGVESDENLVINIDNVIEKVKENNPKIVIVCNPNNPTGTILKREEIIKLLDSTNSLVV
EEEEECCCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHCCCCCEEE
LDEAYMDFGEESMLSDVFKYDNLIVLRTLSKAFGLAGIRTGYMLSNSSLINSVEKVRPPY
EEHHHHCCCHHHHHHHHHHHCCEEEEEHHHHHHCCCHHCCCEEECCCHHHHHHHHHCCCC
NLNSLSDFIATRALRNKDVVKAYIKEVKEEREVLYEEMIGMGIKAYKSQANFILFYSEIE
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCEEEEHHHHH
NLSQKLIDRGVLIRKFGGKLENYYRVTIGDKEENSMFVGAIRDILKKEK
HHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA