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The map label for this gene is hisG

Identifier: 126699152

GI number: 126699152

Start: 1796765

End: 1797391

Strand: Direct

Name: hisG

Synonym: CD1548

Alternate gene names: 126699152

Gene position: 1796765-1797391 (Clockwise)

Preceding gene: 126699151

Following gene: 126699153

Centisome position: 41.88

GC content: 28.07

Gene sequence:

>627_bases
TTGGATTATTTGACTATAGCACTAGCAAAAGGACGAATTGAAGGGGAATCATTTAAAAAATTTAAAAAAATGGGTCTAGG
AGATAGTATAGACACAGATACGAGAAAACTAATTTTTAAAGATGAAGAAAATAAAATTATATATATACATGTAAAGCCAT
CAGATGTAGTTACATATGTTGAAAAAGGAGTCGCTGACCTCGGTATAGCAGGTAAAGATACTATTTTAGAAAATGAGACA
GATGTATATGAAATATATGATTTAGGTTTTGGAAAATGTAAATTTGCTGTAGCAGGATTAAAGGGAGATAGCATATATAG
AGAAGATGAATATTTAAAAGTGGCAACAAAGTATCCCAATATAGCAAAAAAGTATTTTAAAGAGAAAGGTCAAAAAATTG
AAATAATAAAATTAAATGGTTCTGTAGAACTAGCTCCAATAGTAGGGTTGTCAGATGTAATTGTAGATATAGTTGAGACT
GGCAATACACTTAAAGCAAATGGTCTTGAAATATTAGAAGACATATGTAATATAAGTGCTAGAATTATATCAAATAGAGC
TAGCTATAGATTTAAATATGAACAAATTCAGAATATAATTCGTTTATTTGAAGAACTTGATAATTAA

Upstream 100 bases:

>100_bases
TAAAGAGTATGGAAAAGAAATTCCAGCCATTGGATTTACACTAAGTGTTGATGAGTTAATGAAGTATGTATATAAGTAAA
GTTTAGAAGGAGGGATTGCT

Downstream 100 bases:

>100_bases
AATATAATTGAGCTTTATAAGGAGGGATTTAAGTTGAGAGAAAAAGAAAGCATAAGAGAGTTAAGGGGATATGAACCAAA
TCACGTAAACTGTAAAGTAA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEENKIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENET
DVYEIYDLGFGKCKFAVAGLKGDSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN

Sequences:

>Translated_208_residues
MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEENKIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENET
DVYEIYDLGFGKCKFAVAGLKGDSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN
>Mature_208_residues
MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEENKIIYIHVKPSDVVTYVEKGVADLGIAGKDTILENET
DVYEIYDLGFGKCKFAVAGLKGDSIYREDEYLKVATKYPNIAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVET
GNTLKANGLEILEDICNISARIISNRASYRFKYEQIQNIIRLFEELDN

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=207, Percent_Identity=33.3333333333333, Blast_Score=93, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=151, Percent_Identity=33.112582781457, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CLOD6 (Q18C67)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001088049.1
- ProteinModelPortal:   Q18C67
- SMR:   Q18C67
- STRING:   Q18C67
- GeneID:   4916284
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1548
- NMPDR:   fig|1496.1.peg.3370
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- ProtClustDB:   CLSK2534930
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 23491; Mature: 23491

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEENKIIYIHVKPSDVVTYV
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHH
EKGVADLGIAGKDTILENETDVYEIYDLGFGKCKFAVAGLKGDSIYREDEYLKVATKYPN
HHCHHHCCCCCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCEECCCCEEEEEECCCH
IAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVETGNTLKANGLEILEDICNISA
HHHHHHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
RIISNRASYRFKYEQIQNIIRLFEELDN
HHHHCCCCEEEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDYLTIALAKGRIEGESFKKFKKMGLGDSIDTDTRKLIFKDEENKIIYIHVKPSDVVTYV
CCEEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHH
EKGVADLGIAGKDTILENETDVYEIYDLGFGKCKFAVAGLKGDSIYREDEYLKVATKYPN
HHCHHHCCCCCCCCEECCCCCEEEEEECCCCCEEEEEEECCCCCEECCCCEEEEEECCCH
IAKKYFKEKGQKIEIIKLNGSVELAPIVGLSDVIVDIVETGNTLKANGLEILEDICNISA
HHHHHHHHCCCEEEEEEECCCEEEEEECCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHH
RIISNRASYRFKYEQIQNIIRLFEELDN
HHHHCCCCEEEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA