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The map label for this gene is hisZ [H]

Identifier: 126699151

GI number: 126699151

Start: 1795799

End: 1796743

Strand: Direct

Name: hisZ [H]

Synonym: CD1547

Alternate gene names: 126699151

Gene position: 1795799-1796743 (Clockwise)

Preceding gene: 126699150

Following gene: 126699152

Centisome position: 41.86

GC content: 25.4

Gene sequence:

>945_bases
GTGAAATTTTTGAGGATTGAAGATGAGGTTATTTATTCTAAAAAAAGATATAAATTAAAAAGGGAAATAGATAAACTTTT
TTTGGATGAAGAATATTTTCAAATAGAACCACAATTATTTGAAGAATATGATGAATTTACAACTATAAATAATAAAATTC
CAGAAGAATCTATGGTAAAGGTTGTAAATGGAAAAGTAATGGTACTTAGAGCTGATATAACTACAAGTATAATAAAAAGC
CTTGTACCAAGATGGGAAGATGGTTTAAAGCTTAAGCTTTTTTATAATTCATCAATATATAAAAATAAAAATACAGTTGG
AATAAAAGAGATAAGACAAATAGGTTGTGAGTATCTAGGAGAAGCCTCTGTAGAAGCAGATAGAGAAGTAGTGAAATTAG
CTCTTAAGATACTTGAAAAATACAATAATAATTTTATTCTAGAGGTTGGGAGTAGCAAGTATATTCATGGTTTGTTAGAA
GAATTAAATTTAAATAAGAATTGTGAAAATCAAATTAAAAATTTACTATATACGAAGAACACTCATGAATTAAAAGTATA
TATTGAAGAATTGAAAATTAAGCATGAAGTAAAAGAGTTATTATCAAATATTTTAAGTTTACAAGGGAATTTATATAATG
TTATTGAAAAATCAAACAAGTTCTATTGTAATAATAAGATGAAGCAAGCTCTTGAAGAATTAAAGCAAGTAAATAATTTA
ATTGAGGAATGTAATTTTTTAGATAAGGCTAGATTTGATTTATCAATGATTACTATGCTTGACTATTATGAAGGAATTAT
GTTTAGAGGATACTACCCAAACTCATATAAAGAAATTCTTAGTGGTGGAAGATATGATTCTTTAACTAAAGAGTATGGAA
AAGAAATTCCAGCCATTGGATTTACACTAAGTGTTGATGAGTTAATGAAGTATGTATATAAGTAA

Upstream 100 bases:

>100_bases
TAAGAGAAAATTATAGCCATATAGGTATAAAGCCTATGTGGCTTTTTTATTGTTTTAAATTTGCAAATATAAGAGTAAAT
TTAATGAAGAGGGTGAGAAT

Downstream 100 bases:

>100_bases
AGTTTAGAAGGAGGGATTGCTTTGGATTATTTGACTATAGCACTAGCAAAAGGACGAATTGAAGGGGAATCATTTAAAAA
ATTTAAAAAAATGGGTCTAG

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYDEFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKS
LVPRWEDGLKLKLFYNSSIYKNKNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKHEVKELLSNILSLQGNLYNVIEKSNKFYCNNKMKQALEELKQVNNL
IEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSYKEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK

Sequences:

>Translated_314_residues
MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYDEFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKS
LVPRWEDGLKLKLFYNSSIYKNKNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKHEVKELLSNILSLQGNLYNVIEKSNKFYCNNKMKQALEELKQVNNL
IEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSYKEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK
>Mature_314_residues
MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYDEFTTINNKIPEESMVKVVNGKVMVLRADITTSIIKS
LVPRWEDGLKLKLFYNSSIYKNKNTVGIKEIRQIGCEYLGEASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLE
ELNLNKNCENQIKNLLYTKNTHELKVYIEELKIKHEVKELLSNILSLQGNLYNVIEKSNKFYCNNKMKQALEELKQVNNL
IEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSYKEILSGGRYDSLTKEYGKEIPAIGFTLSVDELMKYVYK

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004517
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 37059; Mature: 37059

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYDEFTTINNKIPEESMVK
CCCEEECHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
VVNGKVMVLRADITTSIIKSLVPRWEDGLKLKLFYNSSIYKNKNTVGIKEIRQIGCEYLG
HHCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHC
EASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLEELNLNKNCENQIKNLLYTKN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCC
THELKVYIEELKIKHEVKELLSNILSLQGNLYNVIEKSNKFYCNNKMKQALEELKQVNNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHH
IEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSYKEILSGGRYDSLTKEYGKEIPAIG
HHHCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHCCCCCCCE
FTLSVDELMKYVYK
EEECHHHHHHHHCC
>Mature Secondary Structure
MKFLRIEDEVIYSKKRYKLKREIDKLFLDEEYFQIEPQLFEEYDEFTTINNKIPEESMVK
CCCEEECHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHH
VVNGKVMVLRADITTSIIKSLVPRWEDGLKLKLFYNSSIYKNKNTVGIKEIRQIGCEYLG
HHCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHC
EASVEADREVVKLALKILEKYNNNFILEVGSSKYIHGLLEELNLNKNCENQIKNLLYTKN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHCCC
THELKVYIEELKIKHEVKELLSNILSLQGNLYNVIEKSNKFYCNNKMKQALEELKQVNNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEECHHHHHHHHHHHHHHHH
IEECNFLDKARFDLSMITMLDYYEGIMFRGYYPNSYKEILSGGRYDSLTKEYGKEIPAIG
HHHCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHCCCCCCHHHHHHCCCCCCCE
FTLSVDELMKYVYK
EEECHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]