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The map label for this gene is dxs

Identifier: 126698803

GI number: 126698803

Start: 1404562

End: 1406427

Strand: Direct

Name: dxs

Synonym: CD1207

Alternate gene names: 126698803

Gene position: 1404562-1406427 (Clockwise)

Preceding gene: 126698802

Following gene: 126698804

Centisome position: 32.74

GC content: 30.92

Gene sequence:

>1866_bases
ATGTATAAATATTTAGATAAAGTAAATTCTCCAAAGAATATAAAAAATATGAGTATAGAAGAAATGGATTTACTTGCAAA
GGATATAAGAAAGTTCTTAGTAAAATCTGTTTCAAAGACAGGAGGACACTTAGCTTCTAATCTAGGAGTGGTTGAGTTAA
CATTAGCACTTCATAAAGTATTTGATAGCCCTAAAGATAAGATTGTATGGGATGTAGGGCATCAATCTTATGTTCATAAA
ATAGTTACTGGAAGAAAAGATTGTTTTGTATCTTTGAGACAGTTTAATGGACTAAGTGGTTTTCCAAAGGAGAATGAAAG
TCCTCATGATATTTTTGATACAGGACATAGCAGTACATCTATTTCTATAGCTACAGGTATTGCCTGTGCTAGGGATATAA
AAAAAGAAAACTATAGTGTGATATCTGTGATAGGAGATGGTTCTATAACAGGAGGTATGGCACTTGAAGCTTTAAATCAA
TTAGGATATATAGATACCAATATGATAGTAATCCTTAATGATAATGAGATGTCCATAGATAAAAATGTTGGAGGAATGTC
TAAATATCTGTCAAGTATTATAAGAAACTCAACAGTTGAGAAAATGACAGATGAAGTTGATAAAATTTTAAATGTTACAC
AAACAGGTGAAATTTTATCTAAGACTGCACATAGATTTAAAGATAAACTAATGTATAGCTTTTCTCCTCAGGACTGTTCA
TTTTTTGATTCATTAGGTATAAGATATTATGGACCTATAGATGGCCATAATACTAAAGAACTAATAGATATATTGAGAAA
AGCTAAACACAAAAAAGGGCCTGTTCTTTTACATGTAATTACGAAAAAAGGAAAAGGGTACAGATTTGCAGAAGAACAAC
CCGATAAATATCATGGAGTATCAAAGTTTGATATAAAGACAGGTGTTACATCTGCAAAAGTTAAGTCTATGTCAATTAGT
GTTGGAGAAAAACTTGTTGATATGGCTAATAGTAATGAAAATATAGTAGCAATAACAGCTGCAATGCCATCTGGTACAGG
GCTAAACCTGTTTGAAAGTGCATATCCAAAAAGATATTATGATGTTGGTATAGCTGAACAACATGCAACAGGATTTGCAG
CAGGTCTTGCAAAAAATGGTATGAAACCTTACTTTGCTGTGTACTCATCATTTTTGCAAAGGGCATATGACCAAGTTATT
CATGATGTATGCATAACAAAAAAGCCAGTTACTTTTCTTATAGATAGAGCTGGATTAGTTGGAAATGATGGAGAAACTCA
TCATGGTATGTTTGATTTAAGTTACTTAAATTCTATTCCAAATATTGTAGTAATGGCTCCAAAAGACACAAGAGAGATGG
AGCTTATGATGGATTTGTCATTAAAATTAGATTGTCCACTAGCAATTAGATACCCAAGAGGAAGTAGTTATTACCTAGAT
AAGGGAGAGTATGGAGAGATTGTACTGGGTAAATATGAGGTATTAGATGACGGTCAAGATACAGTCATACTTTGTATTGG
AAGTATGGTAAAACATGCTTTAGAGGCTAAAGAAATATTATCAAGAGAAGGAATAAATCCGACAATAGTTAATGCTAGAT
TCTTAAAGCCAATTGATGAAGGTATGTTAAAAGCATTATTAAAAAATCATAAAAATGTAGTTACTATAGAGGATAATATT
GTAACTGGAGGATTTGGAAGTAGAATAAATAAGTTTATTATAGATAATGAATATAACGTAAATATACTTAATATAGCAAT
ACCAGAAGAATTTGTAAAACATGGCAATATAGATGAATTATATGATTTTGTAGGATTATCGCCAAAAAGTATTGCTGATA
AAATAAGGAAATTAGTTATTGAGTAA

Upstream 100 bases:

>100_bases
TCATACACCACTAGAAGTTTGGTTTGGAGCTTTACTTGGAATAGTAACAGCTTTAATATTGATGTAAATTGAAAATTTAC
AGAATAAAGGTGAGGATAAT

Downstream 100 bases:

>100_bases
AAATCTAATGTAGATATTGTAAATTAAAATTTATATAAAATATAGAATTTATCAATTAGAATAAATATCAAGTGTGTTAC
TTCAAGCTACTTTAGTTATC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MYKYLDKVNSPKNIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHLASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHK
IVTGRKDCFVSLRQFNGLSGFPKENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEILSKTAHRFKDKLMYSFSPQDCS
FFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVLLHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSIS
VGEKLVDMANSNENIVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFLQRAYDQVI
HDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDTREMELMMDLSLKLDCPLAIRYPRGSSYYLD
KGEYGEIVLGKYEVLDDGQDTVILCIGSMVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNI
VTGGFGSRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE

Sequences:

>Translated_621_residues
MYKYLDKVNSPKNIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHLASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHK
IVTGRKDCFVSLRQFNGLSGFPKENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEILSKTAHRFKDKLMYSFSPQDCS
FFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVLLHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSIS
VGEKLVDMANSNENIVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFLQRAYDQVI
HDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDTREMELMMDLSLKLDCPLAIRYPRGSSYYLD
KGEYGEIVLGKYEVLDDGQDTVILCIGSMVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNI
VTGGFGSRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE
>Mature_621_residues
MYKYLDKVNSPKNIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHLASNLGVVELTLALHKVFDSPKDKIVWDVGHQSYVHK
IVTGRKDCFVSLRQFNGLSGFPKENESPHDIFDTGHSSTSISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQ
LGYIDTNMIVILNDNEMSIDKNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEILSKTAHRFKDKLMYSFSPQDCS
FFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVLLHVITKKGKGYRFAEEQPDKYHGVSKFDIKTGVTSAKVKSMSIS
VGEKLVDMANSNENIVAITAAMPSGTGLNLFESAYPKRYYDVGIAEQHATGFAAGLAKNGMKPYFAVYSSFLQRAYDQVI
HDVCITKKPVTFLIDRAGLVGNDGETHHGMFDLSYLNSIPNIVVMAPKDTREMELMMDLSLKLDCPLAIRYPRGSSYYLD
KGEYGEIVLGKYEVLDDGQDTVILCIGSMVKHALEAKEILSREGINPTIVNARFLKPIDEGMLKALLKNHKNVVTIEDNI
VTGGFGSRINKFIIDNEYNVNILNIAIPEEFVKHGNIDELYDFVGLSPKSIADKIRKLVIE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=414, Percent_Identity=22.7053140096618, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI4507521, Length=414, Percent_Identity=22.7053140096618, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI225637463, Length=310, Percent_Identity=23.2258064516129, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI225637459, Length=310, Percent_Identity=23.2258064516129, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI225637461, Length=310, Percent_Identity=23.2258064516129, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI133778974, Length=296, Percent_Identity=23.9864864864865, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1786622, Length=623, Percent_Identity=41.7335473515249, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17539652, Length=579, Percent_Identity=23.6614853195164, Blast_Score=96, Evalue=8e-20,
Organism=Drosophila melanogaster, GI45551847, Length=631, Percent_Identity=20.4437400950872, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45550715, Length=631, Percent_Identity=20.4437400950872, Blast_Score=91, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24645119, Length=587, Percent_Identity=20.7836456558773, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24666278, Length=303, Percent_Identity=25.0825082508251, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_CLOD6 (Q18B68)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001087700.1
- ProteinModelPortal:   Q18B68
- SMR:   Q18B68
- STRING:   Q18B68
- GeneID:   4913267
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD1207
- NMPDR:   fig|1496.1.peg.188
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   CLSK2534741
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68942; Mature: 68942

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKYLDKVNSPKNIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHLASNLGVVELTLALHKV
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
FDSPKDKIVWDVGHQSYVHKIVTGRKDCFVSLRQFNGLSGFPKENESPHDIFDTGHSSTS
HCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCE
ISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQLGYIDTNMIVILNDNEMSID
EEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEC
KNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEILSKTAHRFKDKLMYSFSPQDCS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCCCCCC
FFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVLLHVITKKGKGYRFAEEQPDKYHGV
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHCCC
SKFDIKTGVTSAKVKSMSISVGEKLVDMANSNENIVAITAAMPSGTGLNLFESAYPKRYY
EEEEHHCCCCHHHHEEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEE
DVGIAEQHATGFAAGLAKNGMKPYFAVYSSFLQRAYDQVIHDVCITKKPVTFLIDRAGLV
ECCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GNDGETHHGMFDLSYLNSIPNIVVMAPKDTREMELMMDLSLKLDCPLAIRYPRGSSYYLD
CCCCCCCCCEEEHHHHHCCCCEEEECCCCCCHHHEEEECCEEECCCEEEECCCCCCEEEC
KGEYGEIVLGKYEVLDDGQDTVILCIGSMVKHALEAKEILSREGINPTIVNARFLKPIDE
CCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCHHHH
GMLKALLKNHKNVVTIEDNIVTGGFGSRINKFIIDNEYNVNILNIAIPEEFVKHGNIDEL
HHHHHHHHCCCCEEEEECCEEECCHHHHCCEEEECCCCCEEEEEEECCHHHHHCCCHHHH
YDFVGLSPKSIADKIRKLVIE
HHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYKYLDKVNSPKNIKNMSIEEMDLLAKDIRKFLVKSVSKTGGHLASNLGVVELTLALHKV
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
FDSPKDKIVWDVGHQSYVHKIVTGRKDCFVSLRQFNGLSGFPKENESPHDIFDTGHSSTS
HCCCCCCEEEECCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCE
ISIATGIACARDIKKENYSVISVIGDGSITGGMALEALNQLGYIDTNMIVILNDNEMSID
EEHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCEEEC
KNVGGMSKYLSSIIRNSTVEKMTDEVDKILNVTQTGEILSKTAHRFKDKLMYSFSPQDCS
CCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEEECCCCCCC
FFDSLGIRYYGPIDGHNTKELIDILRKAKHKKGPVLLHVITKKGKGYRFAEEQPDKYHGV
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCHHHCCC
SKFDIKTGVTSAKVKSMSISVGEKLVDMANSNENIVAITAAMPSGTGLNLFESAYPKRYY
EEEEHHCCCCHHHHEEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHCCCCEE
DVGIAEQHATGFAAGLAKNGMKPYFAVYSSFLQRAYDQVIHDVCITKKPVTFLIDRAGLV
ECCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCC
GNDGETHHGMFDLSYLNSIPNIVVMAPKDTREMELMMDLSLKLDCPLAIRYPRGSSYYLD
CCCCCCCCCEEEHHHHHCCCCEEEECCCCCCHHHEEEECCEEECCCEEEECCCCCCEEEC
KGEYGEIVLGKYEVLDDGQDTVILCIGSMVKHALEAKEILSREGINPTIVNARFLKPIDE
CCCCCCEEEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHCHHHH
GMLKALLKNHKNVVTIEDNIVTGGFGSRINKFIIDNEYNVNILNIAIPEEFVKHGNIDEL
HHHHHHHHCCCCEEEEECCEEECCHHHHCCEEEECCCCCEEEEEEECCHHHHHCCCHHHH
YDFVGLSPKSIADKIRKLVIE
HHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA