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The map label for this gene is gloA [H]

Identifier: 126698728

GI number: 126698728

Start: 1333408

End: 1333779

Strand: Direct

Name: gloA [H]

Synonym: CD1134

Alternate gene names: 126698728

Gene position: 1333408-1333779 (Clockwise)

Preceding gene: 126698727

Following gene: 126698729

Centisome position: 31.08

GC content: 28.76

Gene sequence:

>372_bases
ATGAAGTTTAATTTTTGTCATAACAATTTCAATGTTACTAATTTAGAAAAAAGTTTAGATTTTTATAAAAAAGCTTTAGG
GCTTAAAGAGGTAAAGCGCAAGGAAGCAGAAGATGGAAGTTTTATATTAGTTTATTTAGGAGATGGCATTACTAGTCATA
CATTAGAATTAACTTGGCTTAGAGATTGGGATAGACCATATAATTTAGGAGACAATGAATTTCATCTGGCTTTAGAAGTT
GAGGAGTTTGATGAGGCAAAAAAACTTCATAAAGATTTAGATTGCATATGTTTTGAAAATGAAAGTATGGGAATTTATTT
TATAGCGGACCCAGATAATTATTGGATTGAAATACTTCCTAAAAATCACTAA

Upstream 100 bases:

>100_bases
ATTGGTCATCATCATTCAAATTTTTAACTTAATATGATTTAAATAAATTTATAATAATGATATAATATAAAAAAAATAAA
AATTGGAGAGTGATTTCAAA

Downstream 100 bases:

>100_bases
TTTTAAGGATATGTTTATAATTTCTTTACAATTAATAAGAAAATAAGTTATCATTAAATTGTAGGGACTAAAAATGGATA
ATAATGTTATGAATTTATGA

Product: lactoylglutathione lyase

Products: NA

Alternate protein names: Aldoketomutase; Glyoxalase I; Glx I; Ketone-aldehyde mutase; Methylglyoxalase; S-D-lactoylglutathione methylglyoxal lyase [H]

Number of amino acids: Translated: 123; Mature: 123

Protein sequence:

>123_residues
MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILVYLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEV
EEFDEAKKLHKDLDCICFENESMGIYFIADPDNYWIEILPKNH

Sequences:

>Translated_123_residues
MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILVYLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEV
EEFDEAKKLHKDLDCICFENESMGIYFIADPDNYWIEILPKNH
>Mature_123_residues
MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILVYLGDGITSHTLELTWLRDWDRPYNLGDNEFHLALEV
EEFDEAKKLHKDLDCICFENESMGIYFIADPDNYWIEILPKNH

Specific function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione [H]

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glyoxalase I family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360
- InterPro:   IPR004361
- InterPro:   IPR018146 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: =4.4.1.5 [H]

Molecular weight: Translated: 14567; Mature: 14567

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILVYLGDGITSHTLELTWL
CEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEE
RDWDRPYNLGDNEFHLALEVEEFDEAKKLHKDLDCICFENESMGIYFIADPDNYWIEILP
ECCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCEEEEEEE
KNH
CCC
>Mature Secondary Structure
MKFNFCHNNFNVTNLEKSLDFYKKALGLKEVKRKEAEDGSFILVYLGDGITSHTLELTWL
CEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEE
RDWDRPYNLGDNEFHLALEVEEFDEAKKLHKDLDCICFENESMGIYFIADPDNYWIEILP
ECCCCCCCCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCEEEEEEE
KNH
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]