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The map label for this gene is kdpD [H]

Identifier: 126698101

GI number: 126698101

Start: 620661

End: 622268

Strand: Direct

Name: kdpD [H]

Synonym: CD0520

Alternate gene names: 126698101

Gene position: 620661-622268 (Clockwise)

Preceding gene: 126698100

Following gene: 126698102

Centisome position: 14.47

GC content: 29.29

Gene sequence:

>1608_bases
ATGAAAAAGGAACGACTACAACATGAAGACTTAAAAGAGTATGATTATGATGAAGATGGCTATCTCAGTAAAAAGATAAT
TATTAAGGACTTCATAAAAACTATATTGGTTATGACAATTGCTACTGGAATATCAGTAGTTTTTGAAAAGGTAGGTTTTA
ATGAATCTAATATTATACTAGTATACATATTAGGTGTACTATTTGCTACAAGTATAACCTATGGATATTTTTTTGGAATA
CTTTCTTCAGTAATAGGAGTGCTATCATTTAATTTTTTCTTTACGCATCCATTATATACTTTTTTAGCTTATAGAAAAGA
TTATCCTATGACCTTTTGTATTATGCTAATGGCAGCAATTATAACAAGTACTTTAACTTCTAGGATAAAAAGAGAAGTGA
GACTTTCTCATAAGAGAGAAAAAATGATAAGATTGCTCTATGAGAATAACAAAACGTTGCTTAAAGCAAAAAATAAAAAT
CAAATTATTGAATTTTGTGGGTCTAATTTAGTAAATATATTAAATAGAACTGTAATAGTGACTATTGCAGATGAGAATAA
TAATCTAGGTAAGCCAAGTATTTATATTTGTAACAATGATGGAAGTGAGAATATATTCCATTCAGTATTAGAAAAAGAAG
CTATAAAAGAAGCTTTTAGGACAGGTAACCCAGTTGGAATTGGGACAAAATATTGTAAAAACAGCAGTGCATATTATTTC
CCTATAAAAGGTCAAGAATCAAATGTTCTTGGTGTTATAGGTGTTGCGTGTTTTAAGATAGATATTATTACAGAAAATGA
AAAGATACTATTAGAAGCAGTTTCAACACAGGTTGCGTTGGCAATTGATAGAGAAAATTTATTTGAGAAAAATAAAAAAG
CAAATCTTGAGGCAGAGAGAGAGAGATTAAGAGGAAACTTGCTTAGGTCAATTTCTCATGATTTAAGAACTCCACTTACA
AGTATATTAGGTTCATCTTCAACAATACTTGAAAATGATGATGTGATAGATAAAGAAACTAGAGTAGAATTATTGAAAAA
TATATATGAAGATACGAGTTGGCTAACTCATTCTGTTGAGAATATACTTAGTATGACCAGAATAGATGAAGGAAAATTGG
ATATTGAAAAACGACCAGAAGTTGTTGATGAAATAATAGCTGAATCTATATTAAGAGTCAAAAAGTTTGCCAATAGTAGA
GACATAAAAACAAATATTCCAGATGAGATAATAATCGTTCATGTGGATGTATTATTAATAGAACAAGTGTTAGTAAATCT
AATTGATAATGCTATAAGGCATACACCTAAAAATTCTAAGATAGAACTAACTGTAAAAAAAGAGTCAAATCAAGTACTAT
TTGAAGTTGCAGATAATGGAAAAGGAATACCAAATGAAGATATCGGGAATATTTTTAATAGGTTTTATACTAAGAATAAG
TCTAGAAATCTTGAAAGAAGAGGTATTGGTCTTGGATTGGAGATATGTAAATCTATAGTAGAAGCTCATGGTGGAGAAAT
TGTCGCCTTTAATAATCCTTCTGGAGGAGCTACATTTAGATTTAGCATACCTATGTATGATGAGGAGGGGAAAGACAAGT
GGAAATAA

Upstream 100 bases:

>100_bases
GTACATTAATTAAATGTATTGATTGAATTTATTATGATAAAATTGTATTATATAAAATAGAGCCAATTTAAACAGTAACA
ATAAGGAGGAATTGTAGTAA

Downstream 100 bases:

>100_bases
AGCCATTAGTTCTAATTGTAGAAGATGATAAGCCAATTTGTAAATTTATAAAAGTATCTCTTGAAACTCAAAATTATAGG
TGTGTAGAGACAGATAATGG

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGISVVFEKVGFNESNIILVYILGVLFATSITYGYFFGI
LSSVIGVLSFNFFFTHPLYTFLAYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEAFRTGNPVGIGTKYCKNSSAYYF
PIKGQESNVLGVIGVACFKIDIITENEKILLEAVSTQVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLT
SILGSSSTILENDDVIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILRVKKFANSR
DIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESNQVLFEVADNGKGIPNEDIGNIFNRFYTKNK
SRNLERRGIGLGLEICKSIVEAHGGEIVAFNNPSGGATFRFSIPMYDEEGKDKWK

Sequences:

>Translated_535_residues
MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGISVVFEKVGFNESNIILVYILGVLFATSITYGYFFGI
LSSVIGVLSFNFFFTHPLYTFLAYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEAFRTGNPVGIGTKYCKNSSAYYF
PIKGQESNVLGVIGVACFKIDIITENEKILLEAVSTQVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLT
SILGSSSTILENDDVIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILRVKKFANSR
DIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESNQVLFEVADNGKGIPNEDIGNIFNRFYTKNK
SRNLERRGIGLGLEICKSIVEAHGGEIVAFNNPSGGATFRFSIPMYDEEGKDKWK
>Mature_535_residues
MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGISVVFEKVGFNESNIILVYILGVLFATSITYGYFFGI
LSSVIGVLSFNFFFTHPLYTFLAYRKDYPMTFCIMLMAAIITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKN
QIIEFCGSNLVNILNRTVIVTIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEAFRTGNPVGIGTKYCKNSSAYYF
PIKGQESNVLGVIGVACFKIDIITENEKILLEAVSTQVALAIDRENLFEKNKKANLEAERERLRGNLLRSISHDLRTPLT
SILGSSSTILENDDVIDKETRVELLKNIYEDTSWLTHSVENILSMTRIDEGKLDIEKRPEVVDEIIAESILRVKKFANSR
DIKTNIPDEIIIVHVDVLLIEQVLVNLIDNAIRHTPKNSKIELTVKKESNQVLFEVADNGKGIPNEDIGNIFNRFYTKNK
SRNLERRGIGLGLEICKSIVEAHGGEIVAFNNPSGGATFRFSIPMYDEEGKDKWK

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=475, Percent_Identity=30.3157894736842, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1788393, Length=239, Percent_Identity=29.7071129707113, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789149, Length=236, Percent_Identity=29.2372881355932, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI145693157, Length=266, Percent_Identity=27.4436090225564, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=242, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=29.4372294372294, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=27.6785714285714, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081816, Length=267, Percent_Identity=28.8389513108614, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=27.0742358078603, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=26.5217391304348, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790861, Length=242, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=27.6018099547511, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=225, Percent_Identity=28, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=27.8969957081545, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=26.3598326359833, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788279, Length=217, Percent_Identity=27.6497695852535, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1789403, Length=209, Percent_Identity=26.7942583732057, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082128, Length=230, Percent_Identity=25.2173913043478, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60804; Mature: 60804

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGISVVFEKVGFNESNIIL
CCCHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
VYILGVLFATSITYGYFFGILSSVIGVLSFNFFFTHPLYTFLAYRKDYPMTFCIMLMAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKNQIIEFCGSNLVNILNRTVIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEE
TIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEAFRTGNPVGIGTKYCKNSSAYYF
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEE
PIKGQESNVLGVIGVACFKIDIITENEKILLEAVSTQVALAIDRENLFEKNKKANLEAER
EECCCCCCCHHHEEEEEEEEEEEECCCCEEHHHHHHHEEEEECHHHHHHCCCCCCCHHHH
ERLRGNLLRSISHDLRTPLTSILGSSSTILENDDVIDKETRVELLKNIYEDTSWLTHSVE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NILSMTRIDEGKLDIEKRPEVVDEIIAESILRVKKFANSRDIKTNIPDEIIIVHVDVLLI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
EQVLVNLIDNAIRHTPKNSKIELTVKKESNQVLFEVADNGKGIPNEDIGNIFNRFYTKNK
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCC
SRNLERRGIGLGLEICKSIVEAHGGEIVAFNNPSGGATFRFSIPMYDEEGKDKWK
CCCCHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MKKERLQHEDLKEYDYDEDGYLSKKIIIKDFIKTILVMTIATGISVVFEKVGFNESNIIL
CCCHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEH
VYILGVLFATSITYGYFFGILSSVIGVLSFNFFFTHPLYTFLAYRKDYPMTFCIMLMAAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ITSTLTSRIKREVRLSHKREKMIRLLYENNKTLLKAKNKNQIIEFCGSNLVNILNRTVIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHCCEEEE
TIADENNNLGKPSIYICNNDGSENIFHSVLEKEAIKEAFRTGNPVGIGTKYCKNSSAYYF
EEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEE
PIKGQESNVLGVIGVACFKIDIITENEKILLEAVSTQVALAIDRENLFEKNKKANLEAER
EECCCCCCCHHHEEEEEEEEEEEECCCCEEHHHHHHHEEEEECHHHHHHCCCCCCCHHHH
ERLRGNLLRSISHDLRTPLTSILGSSSTILENDDVIDKETRVELLKNIYEDTSWLTHSVE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
NILSMTRIDEGKLDIEKRPEVVDEIIAESILRVKKFANSRDIKTNIPDEIIIVHVDVLLI
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
EQVLVNLIDNAIRHTPKNSKIELTVKKESNQVLFEVADNGKGIPNEDIGNIFNRFYTKNK
HHHHHHHHHHHHHCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCC
SRNLERRGIGLGLEICKSIVEAHGGEIVAFNNPSGGATFRFSIPMYDEEGKDKWK
CCCCHHHCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9226259; 11466286 [H]