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The map label for this gene is acdB [H]

Identifier: 126697968

GI number: 126697968

Start: 471487

End: 472620

Strand: Direct

Name: acdB [H]

Synonym: CD0399

Alternate gene names: 126697968

Gene position: 471487-472620 (Clockwise)

Preceding gene: 126697967

Following gene: 126697969

Centisome position: 10.99

GC content: 34.04

Gene sequence:

>1134_bases
ATGTTATATAACAAAGAACAAGAACTTTTAAGAAAAGCAGTAAGAGATTTTGTTAGTAAAGAATTAGATACTTTACCAGC
AGAAATGGATAAAACAGGTGTAATGCCTAAGGAATTAATCAAAAAATTAGCTGATGCAAAATTTATAAGCAGTAATATCC
CAGAAGAATATGGTGGTGGGGGAGCAGGATATGTTTCTTACGCTATAGTAATGGAAGAAATAGCTAGAAGATGTGCTTCA
ACAGCTACTTTTGTTACAGCTGGTTCTTCTCTTGCTTCATTACCAATACTTTACAATGGTACTGAAGAGCAAAAACAAAA
ATACTTAAAAGGTATAGCAACAGGTGAATTAATAGGAGCATTTGGTTTAACTGAGCCAGGAGCTGGTTCTGATGCAGGTG
GACAACAAACAACAGCAGAATTAGTTGGAGATCACTATATATTAAATGGTAGAAAAACTTTCATAACTAATGGACCATTC
TGTGATGTAGCTATAGTAATAGCAGTTACAGATAGAAGTAAAGGACTTAGAGGAACATCAGCGTTTATAGTAGAAAGTAA
ATGGGATGGTTTCTCAACAGGAGCTCATGAAGATAAGATGGGTATAAGAGGAACTGAAACTTCTGACTTAATATTTGAAA
ACGTTAAAGTTCCAAAAGAAAACTTACTTGGAAAAGAAGGTCAAGGATTTAAGATAGCAATGGGTACTCTAGAAGTTGGT
AGAATAGGTGTTGCTGCCTTAGCTCTAGGAATAGCTCAAGGTGCTTTAGATGAAGCTGTTAAATATACAAAACAAAGAGT
TCAATTTGGTAAGCCTATAGCTAAATTCCAAAATACTCAATTTACTATAGCTGACATGGAAACAAAAGTTTGTGCAGCTA
GAGGATTAGTTTATGATGCAGCACAAAAGAGAGATGCAGGAATGAGAGTTGCTCAAGAATCTGCTATGGCTAAATACTAT
GCATCAGAAATTGCAAATGAAGTTGCTTATAAAGCATTACAACTTCACGGTGGATATGGATTTATAAAAGATTATGAAAT
CGAAAGAATGTACAGAGATGCTAGAATCGTATCAATATACGAAGGAACATCAGAAGTTCAAAAAATGGTAATTTCATCAA
ACGTATTAAAATAA

Upstream 100 bases:

>100_bases
AACAAGCCAGAACTCGTATTCAAACTTTTGCTGAGATGATGAGTTTAGCGTAAGTTCATTAAAATAAATTTACTATAAAA
TATGAAAATTGGAGGAAGCT

Downstream 100 bases:

>100_bases
TAAATAATCTAATGAAATTGGAGGTATAGACTTTGAAAATATTAGTTTGCGTAAAACAAGTTCCAGATACTAACGAAGTA
AGAATAAATAAAGAAACAGG

Product: acyl-CoA dehydrogenase, short-chain specific

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLADAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCAS
TATFVTAGSSLASLPILYNGTEEQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENLLGKEGQGFKIAMGTLEVG
RIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYY
ASEIANEVAYKALQLHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK

Sequences:

>Translated_377_residues
MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLADAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCAS
TATFVTAGSSLASLPILYNGTEEQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENLLGKEGQGFKIAMGTLEVG
RIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYY
ASEIANEVAYKALQLHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK
>Mature_377_residues
MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLADAKFISSNIPEEYGGGGAGYVSYAIVMEEIARRCAS
TATFVTAGSSLASLPILYNGTEEQKQKYLKGIATGELIGAFGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPF
CDVAIVIAVTDRSKGLRGTSAFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENLLGKEGQGFKIAMGTLEVG
RIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQFTIADMETKVCAARGLVYDAAQKRDAGMRVAQESAMAKYY
ASEIANEVAYKALQLHGGYGFIKDYEIERMYRDARIVSIYEGTSEVQKMVISSNVLK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=371, Percent_Identity=46.3611859838275, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=40.2144772117962, Blast_Score=291, Evalue=5e-79,
Organism=Homo sapiens, GI226958412, Length=372, Percent_Identity=40.0537634408602, Blast_Score=271, Evalue=5e-73,
Organism=Homo sapiens, GI4557231, Length=373, Percent_Identity=39.9463806970509, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI187960098, Length=373, Percent_Identity=39.9463806970509, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI226958414, Length=368, Percent_Identity=40.4891304347826, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=37.1352785145889, Blast_Score=258, Evalue=6e-69,
Organism=Homo sapiens, GI7656849, Length=382, Percent_Identity=36.6492146596859, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI21361497, Length=367, Percent_Identity=38.1471389645777, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=34.6456692913386, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=34.6456692913386, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI4503943, Length=366, Percent_Identity=30.6010928961749, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=30.8988764044944, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI48976061, Length=337, Percent_Identity=29.673590504451, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI211971008, Length=337, Percent_Identity=29.673590504451, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI38505218, Length=345, Percent_Identity=27.2463768115942, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI218563752, Length=203, Percent_Identity=30.0492610837438, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=33.4210526315789, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=31.6622691292876, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI87081702, Length=356, Percent_Identity=25.8426966292135, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI87082384, Length=304, Percent_Identity=23.3552631578947, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=39.5161290322581, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17534899, Length=379, Percent_Identity=40.1055408970976, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=38.2749326145553, Blast_Score=261, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI17569725, Length=373, Percent_Identity=38.3378016085791, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=38.7700534759358, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17538396, Length=370, Percent_Identity=38.3783783783784, Blast_Score=256, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=36.5333333333333, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=350, Percent_Identity=39.7142857142857, Blast_Score=238, Evalue=4e-63,
Organism=Caenorhabditis elegans, GI71990804, Length=294, Percent_Identity=42.5170068027211, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71985192, Length=306, Percent_Identity=38.562091503268, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17534353, Length=372, Percent_Identity=32.258064516129, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=30.5039787798408, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=34.7985347985348, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=226, Percent_Identity=40.7079646017699, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=29.4117647058824, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17531909, Length=237, Percent_Identity=35.8649789029536, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17562446, Length=332, Percent_Identity=32.5301204819277, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17531913, Length=171, Percent_Identity=33.3333333333333, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563383, Length=277, Percent_Identity=27.7978339350181, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI86563381, Length=277, Percent_Identity=27.7978339350181, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=47.3262032085562, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=42.5133689839572, Blast_Score=297, Evalue=7e-81,
Organism=Drosophila melanogaster, GI24660351, Length=374, Percent_Identity=39.8395721925134, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=37.9032258064516, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21355753, Length=372, Percent_Identity=38.7096774193548, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI281363737, Length=328, Percent_Identity=36.890243902439, Blast_Score=211, Evalue=7e-55,
Organism=Drosophila melanogaster, GI19920834, Length=371, Percent_Identity=30.9973045822102, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24652780, Length=317, Percent_Identity=26.813880126183, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI221473076, Length=312, Percent_Identity=25, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI45550141, Length=312, Percent_Identity=25, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 40864; Mature: 40864

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLADAKFISSNIPEEYGGG
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCC
GAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTEEQKQKYLKGIATGELIGA
CHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHCCEEECCCHHHHHHHHHHCCHHHHHHH
FGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPFCDVAIVIAVTDRSKGLRGTS
CCCCCCCCCCCCCCCHHHHHHHCCEEEECCCEEEEECCCCCCEEEEEEEECCCCCCCCCE
AFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENLLGKEGQGFKIAMGTLEVG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCCCCCCCEEEEECCHHHH
RIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQFTIADMETKVCAARGLVYDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCHHHHHHHHHHHHHH
AQKRDAGMRVAQESAMAKYYASEIANEVAYKALQLHGGYGFIKDYEIERMYRDARIVSIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCEEEEEE
EGTSEVQKMVISSNVLK
CCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYNKEQELLRKAVRDFVSKELDTLPAEMDKTGVMPKELIKKLADAKFISSNIPEEYGGG
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCC
GAGYVSYAIVMEEIARRCASTATFVTAGSSLASLPILYNGTEEQKQKYLKGIATGELIGA
CHHHHHHHHHHHHHHHHHHCCHHEEECCCCHHHCCEEECCCHHHHHHHHHHCCHHHHHHH
FGLTEPGAGSDAGGQQTTAELVGDHYILNGRKTFITNGPFCDVAIVIAVTDRSKGLRGTS
CCCCCCCCCCCCCCCHHHHHHHCCEEEECCCEEEEECCCCCCEEEEEEEECCCCCCCCCE
AFIVESKWDGFSTGAHEDKMGIRGTETSDLIFENVKVPKENLLGKEGQGFKIAMGTLEVG
EEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHCCCCCCCEEEEECCHHHH
RIGVAALALGIAQGALDEAVKYTKQRVQFGKPIAKFQNTQFTIADMETKVCAARGLVYDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEECCHHHHHHHHHHHHHH
AQKRDAGMRVAQESAMAKYYASEIANEVAYKALQLHGGYGFIKDYEIERMYRDARIVSIY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCEEEEEE
EGTSEVQKMVISSNVLK
CCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]