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The map label for this gene is hadC [H]

Identifier: 126697967

GI number: 126697967

Start: 470312

End: 471439

Strand: Direct

Name: hadC [H]

Synonym: CD0398

Alternate gene names: 126697967

Gene position: 470312-471439 (Clockwise)

Preceding gene: 126697966

Following gene: 126697968

Centisome position: 10.96

GC content: 31.91

Gene sequence:

>1128_bases
ATGGAAGCTATTTTATCTAAAATGAAAGAAGTAGTTGAAAATCCAAATGCGGCTGTAAAAAAATATAAAAGTGAAACTGG
TAAAAAAGCTATAGGTTGTTTCCCAGTTTATTGCCCAGAAGAAATTATACATGCAGCTGGAATGCTTCCAGTTGGTATAT
GGGGAGGACAAACAGAATTAGATTTAGCTAAACAATATTTCCCTGCATTTGCATGTTCAATAATGCAATCATGTTTAGAA
TATGGATTAAAAGGTGCTTATGATGAATTATCTGGAGTTATTATACCAGGTATGTGTGATACACTAATTTGTTTAGGACA
AAACTGGAAATCAGCAGTACCTCATATAAAATATATATCATTAGTACACCCACAAAATAGAAAACTTGAAGCTGGTGTAA
AATACTTAATCAGTGAGTACAAAGGCGTAAAAAGAGAACTTGAAGAAATTTGTGGATATGAAATAGAAGAAGCAAAAATT
CATGAAAGTATAGAAGTTTACAATGAACATAGAAAAACTATGAGAGACTTTGTTGAAGTAGCTTATAAACATTCTAATAC
TATAAAACCATCAATAAGAAGCTTAGTAATTAAGAGTGGGTTCTTTATGAGAAAAGAAGAACATACTGAGCTAGTGAAAG
ATTTAATAGCAAAATTAAATGCTATGCCAGAAGAAGTCTGTTCTGGAAAGAAAGTTTTATTAACAGGTATATTAGCTGAT
TCTAAAGATATATTAGACATTTTAGAAGACAACAATATATCAGTTGTAGCTGACGATTTAGCACAAGAAACAAGACAATT
CAGAACAGATGTACCAGCAGGTGATGATGCGTTAGAGAGATTAGCAAGACAATGGTCAAACATAGAAGGATGTTCATTAG
CTTATGACCCTAAGAAAAAACGTGGGTCACTTATAGTAGATGAAGTTAAAAAGAAAGATATAGATGGTGTTATCTTCTGT
ATGATGAAATTCTGTGACCCAGAAGAATACGATTATCCTTTAGTTAGAAAAGATATAGAAGATAGTGGAATACCTACTTT
ATATGTTGAAATCGACCAACAAACTCAGAATAATGAACAAGCCAGAACTCGTATTCAAACTTTTGCTGAGATGATGAGTT
TAGCGTAA

Upstream 100 bases:

>100_bases
CAGACCCTAGAGCTTTCACTAATGCTCAATTTGAAACAAGAATTCAAGGTTTAGTTGAAGTAATGGAAGAAAGAAAAAAA
CTTAATAGAGGTGAGATATA

Downstream 100 bases:

>100_bases
GTTCATTAAAATAAATTTACTATAAAATATGAAAATTGGAGGAAGCTATGTTATATAACAAAGAACAAGAACTTTTAAGA
AAAGCAGTAAGAGATTTTGT

Product: subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIHAAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLE
YGLKGAYDELSGVIIPGMCDTLICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAMPEEVCSGKKVLLTGILAD
SKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFC
MMKFCDPEEYDYPLVRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA

Sequences:

>Translated_375_residues
MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIHAAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLE
YGLKGAYDELSGVIIPGMCDTLICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAMPEEVCSGKKVLLTGILAD
SKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFC
MMKFCDPEEYDYPLVRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA
>Mature_375_residues
MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIHAAGMLPVGIWGGQTELDLAKQYFPAFACSIMQSCLE
YGLKGAYDELSGVIIPGMCDTLICLGQNWKSAVPHIKYISLVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKI
HESIEVYNEHRKTMRDFVEVAYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAMPEEVCSGKKVLLTGILAD
SKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERLARQWSNIEGCSLAYDPKKKRGSLIVDEVKKKDIDGVIFC
MMKFCDPEEYDYPLVRKDIEDSGIPTLYVEIDQQTQNNEQARTRIQTFAEMMSLA

Specific function: Catalyzes the reversible dehydration of 2- hydroxyglutaryl-CoA to glutaconyl-CoA. This is a key step in the fermentation of glutamate [H]

COG id: COG1775

COG function: function code E; Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082427, Length=386, Percent_Identity=22.279792746114, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010327 [H]

Pfam domain/function: PF06050 HGD-D [H]

EC number: NA

Molecular weight: Translated: 42366; Mature: 42366

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIHAAGMLPVGIWGGQTEL
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHCCCCEEEECCCCHHH
DLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTLICLGQNWKSAVPHIKYIS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEECCCHHHHHHHHCCCHHHHCCCEEEEE
LVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKIHESIEVYNEHRKTMRDFVEV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAMPEEVCSGKKVLLTGILAD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHCC
SKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERLARQWSNIEGCSLAYDPKKK
CHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCHH
RGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPLVRKDIEDSGIPTLYVEIDQQTQNNEQ
CCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCHHH
ARTRIQTFAEMMSLA
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MEAILSKMKEVVENPNAAVKKYKSETGKKAIGCFPVYCPEEIIHAAGMLPVGIWGGQTEL
CHHHHHHHHHHHHCCCHHHHHHHHHCCCCEECCCCCCCHHHHHHHCCCCEEEECCCCHHH
DLAKQYFPAFACSIMQSCLEYGLKGAYDELSGVIIPGMCDTLICLGQNWKSAVPHIKYIS
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEECCCHHHHHHHHCCCHHHHCCCEEEEE
LVHPQNRKLEAGVKYLISEYKGVKRELEEICGYEIEEAKIHESIEVYNEHRKTMRDFVEV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AYKHSNTIKPSIRSLVIKSGFFMRKEEHTELVKDLIAKLNAMPEEVCSGKKVLLTGILAD
HHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEHHHCC
SKDILDILEDNNISVVADDLAQETRQFRTDVPAGDDALERLARQWSNIEGCSLAYDPKKK
CHHHHHHHCCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEECCCCCHH
RGSLIVDEVKKKDIDGVIFCMMKFCDPEEYDYPLVRKDIEDSGIPTLYVEIDQQTQNNEQ
CCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCHHH
ARTRIQTFAEMMSLA
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2659350; 3691501; 11106419 [H]