Click here to switch to the map view.

The map label for this gene is hadA [H]

Identifier: 126697964

GI number: 126697964

Start: 467033

End: 468232

Strand: Direct

Name: hadA [H]

Synonym: CD0395

Alternate gene names: 126697964

Gene position: 467033-468232 (Clockwise)

Preceding gene: 126697960

Following gene: 126697965

Centisome position: 10.89

GC content: 32.58

Gene sequence:

>1200_bases
ATGCTTTTAGAAGGAGTTAAAGTAGTAGAACTTTCAAGTTTCATCGCAGCACCATGTTGTGCAAAAATGTTAGGTGACTG
GGGTGCAGAGGTTATTAAGATTGAACCTATAGAAGGTGATGGAATAAGAGTTATGGGTGGAACATTTAAATCTCCAGCAT
CAGATGATGAAAACCCTATGTTTGAATTAGAAAATGGAAATAAAAAGGGTGTAAGTATTAATGTAAAATCAAAAGAAGGA
GTAGAAATATTACATAAATTATTATCAGAAGCAGACATATTTGTAACTAATGTTAGAGTTCAAGCATTAGAAAAAATGGG
TATAGCTTATGACCAAATAAAAGATAAGTATCCAGGATTAATATTCTCTCAAATATTAGGATATGGTGAAAAAGGACCTT
TAAAAGATAAACCAGGATTTGACTATACTGCATACTTCGCAAGAGGAGGAGTTAGCCAGTCTGTTATGGAAAAAGGAACA
TCTCCAGCAAATACAGCAGCAGGATTTGGTGACCACTATGCAGGTCTAGCACTAGCAGCAGGAAGTTTAGCAGCATTACA
TAAAAAAGCTCAAACTGGTAAAGGTGAGAGAGTAACAGTAAGTCTTTTCCATACAGCTATATATGGAATGGGAACAATGA
TAACAACAGCACAATACGGAAATGAAATGCCTTTATCAAGAGAAAATCCAAACAGCCCATTAATGACTACATATAAATGT
AAAGATGGAAGATGGATTCAATTAGCTTTAATACAATACAACAAGTGGTTAGGCAAATTCTGTAAGGTTATAAATAGAGA
ATATATATTAGAAGATGATAGATATAATAACATAGATTCAATGGTTAATCATGTTGAAGATTTAGTTAAGATAGTTGGAG
AAGCTATGTTAGAAAAAACATTAGACGAGTGGTCAGCTTTATTAGAAGAAGCAGACTTACCATTTGAAAAAATTCAAAGC
TGTGAAGATTTATTAGATGACGAACAAGCTTGGGCAAATGACTTCTTATTTAAGAAAACATACGATAGCGGAAATACAGG
TGTCTTAGTTAATACTCCAGTTATGTTTAGAAATGAAGGAATTAAAGAATATACACCAGCACCAAAAGTAGGTCAACATA
CTGTAGAAGTATTAAAATCTTTAGGCTACGATGAAGAGAAAATAAATAACTTTAAAGATAGTAAAGTTGTAAGATATTAA

Upstream 100 bases:

>100_bases
ATTAGGAACTTTGACATCAGACAGTTAATATCAGAAAAAAGTATTTTATGAGTGATTTAATCGAAATTTTATAATTGATA
CTATTAAGGAGGAAAACGTT

Downstream 100 bases:

>100_bases
TTAGTAATTCTAGATTTTTTAAAAGGAGAATGCTAAAGATGTACACAATGGGATTAGATATAGGTTCAACTGCATCAAAG
GGAGTAATCTTAAAGAATGG

Product: isocaprenoyl-CoA:2-hydroxyisocaproate CoA-transferase

Products: NA

Alternate protein names: Formyl-CoA transferase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVMGGTFKSPASDDENPMFELENGNKKGVSINVKSKEG
VEILHKLLSEADIFVTNVRVQALEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNEMPLSRENPNSPLMTTYKC
KDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQS
CEDLLDDEQAWANDFLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY

Sequences:

>Translated_399_residues
MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVMGGTFKSPASDDENPMFELENGNKKGVSINVKSKEG
VEILHKLLSEADIFVTNVRVQALEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNEMPLSRENPNSPLMTTYKC
KDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQS
CEDLLDDEQAWANDFLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY
>Mature_399_residues
MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVMGGTFKSPASDDENPMFELENGNKKGVSINVKSKEG
VEILHKLLSEADIFVTNVRVQALEKMGIAYDQIKDKYPGLIFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGT
SPANTAAGFGDHYAGLALAAGSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNEMPLSRENPNSPLMTTYKC
KDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSMVNHVEDLVKIVGEAMLEKTLDEWSALLEEADLPFEKIQS
CEDLLDDEQAWANDFLFKKTYDSGNTGVLVNTPVMFRNEGIKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY

Specific function: Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate [H]

COG id: COG1804

COG function: function code C; Predicted acyl-CoA transferases/carnitine dehydratase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CaiB/BaiF CoA-transferase family [H]

Homologues:

Organism=Homo sapiens, GI300863128, Length=399, Percent_Identity=27.3182957393484, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI300863124, Length=425, Percent_Identity=27.0588235294118, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI300863126, Length=397, Percent_Identity=26.1964735516373, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI266456254, Length=406, Percent_Identity=24.6305418719212, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI42794625, Length=406, Percent_Identity=24.6305418719212, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI13376042, Length=425, Percent_Identity=24.4705882352941, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI266458397, Length=269, Percent_Identity=26.3940520446097, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI266458393, Length=258, Percent_Identity=25.968992248062, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1788717, Length=423, Percent_Identity=27.4231678486998, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082093, Length=339, Percent_Identity=22.7138643067847, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786222, Length=406, Percent_Identity=25.1231527093596, Blast_Score=89, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115535051, Length=322, Percent_Identity=26.7080745341615, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI32564160, Length=320, Percent_Identity=24.6875, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24648431, Length=404, Percent_Identity=28.4653465346535, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24585488, Length=318, Percent_Identity=26.7295597484277, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003673
- InterPro:   IPR017659 [H]

Pfam domain/function: PF02515 CoA_transf_3 [H]

EC number: =2.8.3.16 [H]

Molecular weight: Translated: 44235; Mature: 44235

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVMGGTFKSPASDDENPM
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCE
FELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQALEKMGIAYDQIKDKYPGL
EEECCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCH
IFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGTSPANTAAGFGDHYAGLALAA
HHHHHHCCCCCCCCCCCCCCCEEHHHHCCCCCHHHHHCCCCCCCHHCCCCCHHHHHHHHH
GSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNEMPLSRENPNSPLMTTYKC
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEE
KDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSMVNHVEDLVKIVGEAMLEKT
CCCCEEEEEHHHHHHHHHHHHHHHCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDEWSALLEEADLPFEKIQSCEDLLDDEQAWANDFLFKKTYDSGNTGVLVNTPVMFRNEG
HHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCCEEEECCEEECCCC
IKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY
CHHCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLLEGVKVVELSSFIAAPCCAKMLGDWGAEVIKIEPIEGDGIRVMGGTFKSPASDDENPM
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCCE
FELENGNKKGVSINVKSKEGVEILHKLLSEADIFVTNVRVQALEKMGIAYDQIKDKYPGL
EEECCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHCCHHHHHHHHCCCH
IFSQILGYGEKGPLKDKPGFDYTAYFARGGVSQSVMEKGTSPANTAAGFGDHYAGLALAA
HHHHHHCCCCCCCCCCCCCCCEEHHHHCCCCCHHHHHCCCCCCCHHCCCCCHHHHHHHHH
GSLAALHKKAQTGKGERVTVSLFHTAIYGMGTMITTAQYGNEMPLSRENPNSPLMTTYKC
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEE
KDGRWIQLALIQYNKWLGKFCKVINREYILEDDRYNNIDSMVNHVEDLVKIVGEAMLEKT
CCCCEEEEEHHHHHHHHHHHHHHHCHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LDEWSALLEEADLPFEKIQSCEDLLDDEQAWANDFLFKKTYDSGNTGVLVNTPVMFRNEG
HHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHEEEECCCCCCCEEEECCEEECCCC
IKEYTPAPKVGQHTVEVLKSLGYDEEKINNFKDSKVVRY
CHHCCCCCCCHHHHHHHHHHCCCCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]