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The map label for this gene is purC [H]

Identifier: 126697790

GI number: 126697790

Start: 282205

End: 282903

Strand: Direct

Name: purC [H]

Synonym: CD0219

Alternate gene names: 126697790

Gene position: 282205-282903 (Clockwise)

Preceding gene: 126697789

Following gene: 126697791

Centisome position: 6.58

GC content: 27.47

Gene sequence:

>699_bases
ATGTTATTATATGAAGGAAAAGCAAAACAAGTATATTCTACAGATAATGAAAATGAATATGTTGTTTATTATAAAGATGA
TGCAACAGCATTTAATGGAGAAAAAAAAGCAGAAATATCTTCAAAAGGTATACTAAATAATAAGATATCAACAATAATCT
TTGAAATGTTAAAAGAAAATAATATAAATACTCACTTTATAAAAAGTTTATCAGATAGAGAAATGTTAGTTAAAAAAGTA
GAGATTTTACCATTAGAAGTAATAGTAAGAAATATTGCTGCTGGTTCTATCTGTAAAAGAGTTGGTCTTGAAGAAGGTGT
AGTTTTCGATGAGCCAATTTTTGAAATAAGCTACAAAAATGATGCTTATGGTGACCCAATGCTAAATGATGATTATGCAG
TGGCAATGAAGTTAGCAACTAGAGAAGAGTTAAAATTCTTAAGAGAAGAAACTTTAAAAATAAACGAGTTACTAAAAGCA
TTTTTCTTAAAATTAAACCTAAAGTTAGTTGACTTTAAAATAGAATTTGGTAAAGATTCTGAAGGAAATATAATATTGGC
AGATGAAGTATCACCAGACACTTGTAGACTTTGGGATGTAAATACAAATGAAAAGTTAGATAAGGACAGATTTAGAAAAG
ACCTTGGAGACCTTGTAGAAGGTTATACGGAAGTACTTTCAAGAATGAATAATAAATAG

Upstream 100 bases:

>100_bases
CTTTAAAATACCCAAAATTAAAAGAGGATTTGAAATCATATAGAGAAGAGATGGCACAAAAGGTGTTAGAAGACGACAAG
AATTTAAGGGGGTAGCAGAA

Downstream 100 bases:

>100_bases
GAGGCAAATGTATGTGTGGAGTTTTAGGGATTTACTCTAATAAAGATGTAACTAAAGAACTATATTATTCTTTATATTCT
ATGCAACACAGGGGGCAAGA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGILNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKV
EILPLEVIVRNIAAGSICKRVGLEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDLVEGYTEVLSRMNNK

Sequences:

>Translated_232_residues
MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGILNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKV
EILPLEVIVRNIAAGSICKRVGLEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDLVEGYTEVLSRMNNK
>Mature_232_residues
MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGILNNKISTIIFEMLKENNINTHFIKSLSDREMLVKKV
EILPLEVIVRNIAAGSICKRVGLEEGVVFDEPIFEISYKNDAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKA
FFLKLNLKLVDFKIEFGKDSEGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDLVEGYTEVLSRMNNK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=220, Percent_Identity=35, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI5453539, Length=220, Percent_Identity=35, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI119220559, Length=227, Percent_Identity=34.3612334801762, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1788820, Length=228, Percent_Identity=45.6140350877193, Blast_Score=203, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17531275, Length=242, Percent_Identity=35.5371900826446, Blast_Score=130, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6319326, Length=235, Percent_Identity=29.7872340425532, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=31.8181818181818, Blast_Score=120, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24583917, Length=205, Percent_Identity=31.219512195122, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 26703; Mature: 26703

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGILNNKISTIIFEMLKEN
CEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHC
NINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVGLEEGVVFDEPIFEISYKN
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEECC
DAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKAFFLKLNLKLVDFKIEFGKDS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCC
EGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDLVEGYTEVLSRMNNK
CCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLYEGKAKQVYSTDNENEYVVYYKDDATAFNGEKKAEISSKGILNNKISTIIFEMLKEN
CEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHC
NINTHFIKSLSDREMLVKKVEILPLEVIVRNIAAGSICKRVGLEEGVVFDEPIFEISYKN
CCCHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEECC
DAYGDPMLNDDYAVAMKLATREELKFLREETLKINELLKAFFLKLNLKLVDFKIEFGKDS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEECCCC
EGNIILADEVSPDTCRLWDVNTNEKLDKDRFRKDLGDLVEGYTEVLSRMNNK
CCCEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA