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The map label for this gene is purE [H]

Identifier: 126697789

GI number: 126697789

Start: 281723

End: 282199

Strand: Direct

Name: purE [H]

Synonym: CD0218

Alternate gene names: 126697789

Gene position: 281723-282199 (Clockwise)

Preceding gene: 126697787

Following gene: 126697790

Centisome position: 6.57

GC content: 33.54

Gene sequence:

>477_bases
ATGAAAGTAGCAGTAGTTATGGGTTCAAAATCAGATTATCCAAAATTAGAAGAAGGGATAAAACTGCTTGAAAAATATGG
AATAGAAGTTGTAGCAAGAGCATTATCAGCTCATAGAACACCAGAACAACTTTCAATATTCCTAAAAGAAATAGAAGATG
ATACTGATGTAATAATAGCAGCAGCAGGAAAAGCAGCACACTTACCAGGTGTAATAGCTTCACAAACATTAATTCCTGTA
ATAGGATTACCTATTAAATCATCAACTATGGATGGACTAGACTCACTTTTATCAATAGTTCAAATGCCAAAAGGAATCCC
AGTTGCAACAGTTACAATAGACTTAGGTTTAAACGCAGCTTTATTGGCATTACAAATAATGACTTTAAAATACCCAAAAT
TAAAAGAGGATTTGAAATCATATAGAGAAGAGATGGCACAAAAGGTGTTAGAAGACGACAAGAATTTAAGGGGGTAG

Upstream 100 bases:

>100_bases
AATATATGTATATTAATATAAAATTTAAGGTGTATAATTCGTATAATAATACGAATGATTTGTAGTGTAAAATAACTTAT
AAACGGAGAGGGGAAGTCTA

Downstream 100 bases:

>100_bases
CAGAAATGTTATTATATGAAGGAAAAGCAAAACAAGTATATTCTACAGATAATGAAAATGAATATGTTGTTTATTATAAA
GATGATGCAACAGCATTTAA

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQLSIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPV
IGLPIKSSTMDGLDSLLSIVQMPKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG

Sequences:

>Translated_158_residues
MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQLSIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPV
IGLPIKSSTMDGLDSLLSIVQMPKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG
>Mature_158_residues
MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQLSIFLKEIEDDTDVIIAAAGKAAHLPGVIASQTLIPV
IGLPIKSSTMDGLDSLLSIVQMPKGIPVATVTIDLGLNAALLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=111, Percent_Identity=49.5495495495495, Blast_Score=115, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6324702, Length=126, Percent_Identity=47.6190476190476, Blast_Score=124, Evalue=6e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17122; Mature: 17122

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQLSIFLKEIEDDTDVIIA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
AAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQMPKGIPVATVTIDLGLNAA
ECCCCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHH
LLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKVAVVMGSKSDYPKLEEGIKLLEKYGIEVVARALSAHRTPEQLSIFLKEIEDDTDVIIA
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEEE
AAGKAAHLPGVIASQTLIPVIGLPIKSSTMDGLDSLLSIVQMPKGIPVATVTIDLGLNAA
ECCCCHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHH
LLALQIMTLKYPKLKEDLKSYREEMAQKVLEDDKNLRG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]