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The map label for this gene is adk

Identifier: 126697661

GI number: 126697661

Start: 113228

End: 113878

Strand: Direct

Name: adk

Synonym: CD0091

Alternate gene names: 126697661

Gene position: 113228-113878 (Clockwise)

Preceding gene: 126697660

Following gene: 126697662

Centisome position: 2.64

GC content: 32.26

Gene sequence:

>651_bases
ATGAGAATAATATTACTTGGACCTCCAGGTGCTGGTAAAGGTACTCAGGCGGTAGGAATAGTAGAAAAATACAATATACC
TCATATATCAACAGGAGATATATTCAGAAAGAATATAAAAGAGGGAACAGAACTTGGAAAAAAAGCTAAAGAATACATGG
ACCAAGGTTTATTAGTACCAGATGAGTTAACTGTAGGTTTAGTTACTGATAGAATATCTCAAGAAGATTGTAAAAATGGA
TTTATGTTAGATGGATTTCCAAGAAATGTAGCACAAGGAGAACATTTAGATATCTTCTTAAAAAATGCTGGTATATCACT
AGATAAAGTTGTCAATATTGAAGTTGATAAGAGTATATTAGTGTCTAGAGCAGTTGGTAGAAGAATATGTAAGTCTTGTG
GAGCTACTTACCATGTTGAGTTTAATCCTCCTAAAGTAGAAGGTGTATGTGATGTATGCCAAGGAGAATTATATCAAAGA
GCTGATGATAATGAAGAAACTGTATCTAAGAGAATACAAGTTTATCTAGATGAAACTAAGCCTTTAGTAGATTATTATAG
CAAACAAGGTATAATAGCAGATATAAAAGGTGATCAAGCAATAGATAAAGTATTTGAAGATATTGTCGCAGCCTTAGGAA
GTGGAAAATAA

Upstream 100 bases:

>100_bases
ATCGTTGTTGGAGTTGCTTTGGAGCTTAAGAGACAGTTAGAGTCAAACTTAGTTATGAGAAGCTATCAAGGTTTCTTAAA
ATAAAATGGAGATGGATAAT

Downstream 100 bases:

>100_bases
ATGATTATCTTGAAATCAAAAAAAGAAATAGAACTTTTAAGAGAAGCAGGTAAAATAGTTGCTGACACTCATGAAGTTTT
AAGAAAAGCTATTTCTCCGG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MRIILLGPPGAGKGTQAVGIVEKYNIPHISTGDIFRKNIKEGTELGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNG
FMLDGFPRNVAQGEHLDIFLKNAGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK

Sequences:

>Translated_216_residues
MRIILLGPPGAGKGTQAVGIVEKYNIPHISTGDIFRKNIKEGTELGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNG
FMLDGFPRNVAQGEHLDIFLKNAGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK
>Mature_216_residues
MRIILLGPPGAGKGTQAVGIVEKYNIPHISTGDIFRKNIKEGTELGKKAKEYMDQGLLVPDELTVGLVTDRISQEDCKNG
FMLDGFPRNVAQGEHLDIFLKNAGISLDKVVNIEVDKSILVSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQR
ADDNEETVSKRIQVYLDETKPLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=44.6511627906977, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI4502013, Length=215, Percent_Identity=44.6511627906977, Blast_Score=195, Evalue=2e-50,
Organism=Homo sapiens, GI19923437, Length=218, Percent_Identity=37.1559633027523, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=35, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=35, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=35, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=35, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI4502011, Length=211, Percent_Identity=32.7014218009479, Blast_Score=121, Evalue=4e-28,
Organism=Homo sapiens, GI7706497, Length=212, Percent_Identity=31.6037735849057, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=29.3269230769231, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI28144897, Length=220, Percent_Identity=28.6363636363636, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI28144899, Length=220, Percent_Identity=28.6363636363636, Blast_Score=89, Evalue=4e-18,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=52.2935779816514, Blast_Score=217, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=42.9906542056075, Blast_Score=177, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17567503, Length=212, Percent_Identity=32.0754716981132, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17537943, Length=214, Percent_Identity=29.9065420560748, Blast_Score=110, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17533833, Length=207, Percent_Identity=28.5024154589372, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=25.5813953488372, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=214, Percent_Identity=45.3271028037383, Blast_Score=203, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6321018, Length=205, Percent_Identity=38.0487804878049, Blast_Score=145, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6322828, Length=213, Percent_Identity=25.8215962441315, Blast_Score=91, Evalue=1e-19,
Organism=Drosophila melanogaster, GI22026816, Length=205, Percent_Identity=45.3658536585366, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=40.5, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=40.5, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=27.0142180094787, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=27.0142180094787, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI221459597, Length=209, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356893, Length=209, Percent_Identity=27.2727272727273, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_CLOD6 (Q18CH9)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086558.1
- ProteinModelPortal:   Q18CH9
- SMR:   Q18CH9
- STRING:   Q18CH9
- GeneID:   4916513
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0091
- NMPDR:   fig|1496.1.peg.3631
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   CGEGYHD
- ProtClustDB:   PRK00279
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23700; Mature: 23700

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGPPGAGKGTQAVGIVEKYNIPHISTGDIFRKNIKEGTELGKKAKEYMDQGLLVP
CEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DELTVGLVTDRISQEDCKNGFMLDGFPRNVAQGEHLDIFLKNAGISLDKVVNIEVDKSIL
CCCEEEHHHHHCCHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCCCHHEEEEEECHHHH
VSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQRADDNEETVSKRIQVYLDETK
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCC
PLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK
HHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIILLGPPGAGKGTQAVGIVEKYNIPHISTGDIFRKNIKEGTELGKKAKEYMDQGLLVP
CEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DELTVGLVTDRISQEDCKNGFMLDGFPRNVAQGEHLDIFLKNAGISLDKVVNIEVDKSIL
CCCEEEHHHHHCCHHHHCCCCEECCCCCCCCCCCCEEEEEECCCCCCHHEEEEEECHHHH
VSRAVGRRICKSCGATYHVEFNPPKVEGVCDVCQGELYQRADDNEETVSKRIQVYLDETK
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCC
PLVDYYSKQGIIADIKGDQAIDKVFEDIVAALGSGK
HHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA