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The map label for this gene is map1 [H]

Identifier: 126697662

GI number: 126697662

Start: 113879

End: 114625

Strand: Direct

Name: map1 [H]

Synonym: CD0092

Alternate gene names: 126697662

Gene position: 113879-114625 (Clockwise)

Preceding gene: 126697661

Following gene: 126697663

Centisome position: 2.65

GC content: 35.07

Gene sequence:

>747_bases
ATGATTATCTTGAAATCAAAAAAAGAAATAGAACTTTTAAGAGAAGCAGGTAAAATAGTTGCTGACACTCATGAAGTTTT
AAGAAAAGCTATTTCTCCGGGAATATCTACTTTAGAATTAGATAAAATAGCTGAAGAGAATATAAGAAAATACAATGCAG
AACCTTCTTTTAAAGGATATGGAGGTTTTCCAGGAAGTATATGTGCTTCTATCAATAGAGAGGTAGTACATGGTATTCCA
GGAGAAACTATATTACAAGAAGGTGACATTGTAAGTTTGGATATAGGAGCCTATTATAAAGGATATCATGGTGATTCTGC
GAAAACTCACGGAGTAGGCATGATATCTGAAGAAGATAGGAAATTGATAGAAGTAACTAGAGAAAGCTTCTATGAAGGAA
TAAAATTTGCTAAATTAGGATATAGACTTTCAGATATCTCACACGCAGTACAAACACACGTTGAGAAACATGGTTTCTCG
GTAGTTAGAGATTTAGTGGGTCATGGAGTTGGAGCAAATCTTCATGAAGACCCACAAGTACCTAATTATGGACTCCCAGG
AAAAGGACCAAGACTTAGAGAAGGAATGGTTATTGCTATAGAGCCAATGGTTAATGCAGGTCGTTATCATGTAAAGACTC
TATCAGATGGGTGGACGACTGTTACAATAGATGGAAAAAAATCAGCTCATTATGAGCATACGATAGCAATTACTGAACAT
GAACCTTTGATATTGACAAAGTTGTAA

Upstream 100 bases:

>100_bases
TTATTATAGCAAACAAGGTATAATAGCAGATATAAAAGGTGATCAAGCAATAGATAAAGTATTTGAAGATATTGTCGCAG
CCTTAGGAAGTGGAAAATAA

Downstream 100 bases:

>100_bases
TTTAAAAAGTAGGTGAAAAAAGTGCTATCAGATAATTTAAGTATAGGTCAAGTTGTTAAAGTTTCATTAGGACGAGATAA
AGGAAATTTATTCTTTGTAG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP
GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH
EPLILTKL

Sequences:

>Translated_248_residues
MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP
GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH
EPLILTKL
>Mature_248_residues
MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGYGGFPGSICASINREVVHGIP
GETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDRKLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFS
VVRDLVGHGVGANLHEDPQVPNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH
EPLILTKL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=246, Percent_Identity=39.0243902439024, Blast_Score=183, Evalue=1e-46,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=37.246963562753, Blast_Score=180, Evalue=1e-45,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=42.1052631578947, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI1788728, Length=205, Percent_Identity=25.3658536585366, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71996291, Length=248, Percent_Identity=37.5, Blast_Score=179, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6323273, Length=246, Percent_Identity=39.4308943089431, Blast_Score=184, Evalue=9e-48,
Organism=Drosophila melanogaster, GI21355531, Length=240, Percent_Identity=38.75, Blast_Score=181, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=34.9593495934959, Blast_Score=171, Evalue=5e-43,
Organism=Drosophila melanogaster, GI19920384, Length=232, Percent_Identity=25, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27290; Mature: 27290

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGY
CEEECCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCC
GGFPGSICASINREVVHGIPGETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDR
CCCCHHHHHHHCHHHHHCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCHHHH
KLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLVGHGVGANLHEDPQV
HHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEEECC
EPLILTKL
CCEEEECC
>Mature Secondary Structure
MIILKSKKEIELLREAGKIVADTHEVLRKAISPGISTLELDKIAEENIRKYNAEPSFKGY
CEEECCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCCCCCCC
GGFPGSICASINREVVHGIPGETILQEGDIVSLDIGAYYKGYHGDSAKTHGVGMISEEDR
CCCCHHHHHHHCHHHHHCCCCHHHCCCCCEEEEECCCEECCCCCCCCCCCCCCCCCHHHH
KLIEVTRESFYEGIKFAKLGYRLSDISHAVQTHVEKHGFSVVRDLVGHGVGANLHEDPQV
HHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PNYGLPGKGPRLREGMVIAIEPMVNAGRYHVKTLSDGWTTVTIDGKKSAHYEHTIAITEH
CCCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEEEEEEECC
EPLILTKL
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]