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The map label for this gene is cysS

Identifier: 126697618

GI number: 126697618

Start: 78990

End: 80396

Strand: Direct

Name: cysS

Synonym: CD0052

Alternate gene names: 126697618

Gene position: 78990-80396 (Clockwise)

Preceding gene: 126697617

Following gene: 126697619

Centisome position: 1.84

GC content: 30.35

Gene sequence:

>1407_bases
GTGATGAGTGTGAAAGTTTATAATACATTGACTAGAACAAAAGAAGAATTTGTTCCATTAGAAGAAGGAAAGGTAAAAAT
GTATGTGTGTGGTCCAACAGTTTATAACTATATACACATAGGTAATGCAAGACCATTTATAATATTTGATACTCTAAGAA
GGTATTTAGAGTATAGAGGATATGATGTAACTTATGTACAAAACTTTACAGATGTTGATGATAAGATTATAAATAGAAGT
CATGAGGAGGGAATATCTCCTGAAGAAGTTGCGGCTAAGTATATAAAAGAATATTTTGTAGACTGTGATGGGCTAGGAAT
AAAAAGAGCTACTGTTCATCCTCAGGTTACAGATAATATACAACAGATTATAGAGTTTATAAAAGAGTTGGAAGATAAGG
GATATGCATATGCAGTAAATGGTGATGTATATTTTGATACAAATAAGTTTGAAGGTTATGGAAAACTTTCAGGTCAAAAA
CAAGAAGATTTAGAGGCAGGGGCTAGAATTGAGGTTAATGACCAAAAAAGACATCCTATGGACTTTGTTCTTTGGAAGGC
AAAAAAAGAAGGTGAGCCAGGATGGGATAGCCCTTGGGGAGAAGGTAGACCAGGATGGCATATAGAATGTTCTGTTATGT
CTAAGAGATATTTAGGTGAAACAATTGATATACATGCAGGTGGGCAAGATTTAACATTCCCACATCATGAAAATGAAATA
GCTCAAAGTGAAGCTAGAAGTGGAAAAACATTCTCAAAATACTGGATGCATAATGGATATATAAATATAAATGATGAAAA
GATGAGTAAATCAAAAGGTAATTTCTTTACAGTAAGAGATATATCAAAATTATATGATTTAGAGATAGTAAGATTTTTCA
TGTTATCAGCACATTATAGAAATCCAGTAAACTTTAGTGATGAGATGTTAAATCAAGCTAAAGCAGGTCTTGAAAGACTA
TATAATACTAAAGAAAAATTAGAATTTACGCTAAGTAATTTAGTAGAATCTCCTTTAACAGAAAAAGAAGTAGAGCTTGT
TAAAGAATTAGATGACTTTAGACAAAAATTCATAGATGCTATGGATGATGATGTTAATACAGCAGACGCAGTAAGTGTAA
TATTTGAATTAGCTAAGTTAATAAATTCTAATGTAGATGAAAATTCTTCTTTGGAGTTTGCTAAAAAATGCTTAGATGAA
TTTAATGAACTTACAGGAGTATTAAATATTGTAAATAAGAAAAAAGATACTGTATTAGATAAAGACATTGAAGAATTGAT
ACAAAAAAGAACTGATGCAAAGAAAAATAAAGAGTTTCAATTAGCTGATGATATTAGACAACAATTACTAGATATGGGAA
TTGTATTAGAAGACACAAGACAAGGTGTTAAGTGGAAAAGGATATAA

Upstream 100 bases:

>100_bases
AGATAGTACGAAAAATGATAGTAATACTATTATTTATTGCAATTTTCAACTATAATATAATATATAATGTTAAGAAGATA
ATTTATAAAAATACAGTGAG

Downstream 100 bases:

>100_bases
AAATGGAAAAAACTGAATTAGTTACTATGTCACCATTAGTTTTAGCATACTTAGGTGATACAGTGTATGAGACATATATA
AGAGAATATTTAATTAGACA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MMSVKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFIIFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRS
HEEGISPEEVAAKYIKEYFVDCDGLGIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQK
QEDLEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGETIDIHAGGQDLTFPHHENEI
AQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVRDISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERL
YNTKEKLEFTLSNLVESPLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAKKCLDE
FNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMGIVLEDTRQGVKWKRI

Sequences:

>Translated_468_residues
MMSVKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFIIFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRS
HEEGISPEEVAAKYIKEYFVDCDGLGIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQK
QEDLEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGETIDIHAGGQDLTFPHHENEI
AQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVRDISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERL
YNTKEKLEFTLSNLVESPLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAKKCLDE
FNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMGIVLEDTRQGVKWKRI
>Mature_468_residues
MMSVKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFIIFDTLRRYLEYRGYDVTYVQNFTDVDDKIINRS
HEEGISPEEVAAKYIKEYFVDCDGLGIKRATVHPQVTDNIQQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQK
QEDLEAGARIEVNDQKRHPMDFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGETIDIHAGGQDLTFPHHENEI
AQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVRDISKLYDLEIVRFFMLSAHYRNPVNFSDEMLNQAKAGLERL
YNTKEKLEFTLSNLVESPLTEKEVELVKELDDFRQKFIDAMDDDVNTADAVSVIFELAKLINSNVDENSSLEFAKKCLDE
FNELTGVLNIVNKKKDTVLDKDIEELIQKRTDAKKNKEFQLADDIRQQLLDMGIVLEDTRQGVKWKRI

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=483, Percent_Identity=36.0248447204969, Blast_Score=268, Evalue=9e-72,
Organism=Homo sapiens, GI303304987, Length=311, Percent_Identity=35.6913183279743, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI62240992, Length=311, Percent_Identity=35.6913183279743, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI21269877, Length=311, Percent_Identity=35.6913183279743, Blast_Score=188, Evalue=8e-48,
Organism=Homo sapiens, GI10835051, Length=311, Percent_Identity=35.6913183279743, Blast_Score=188, Evalue=9e-48,
Organism=Escherichia coli, GI1786737, Length=475, Percent_Identity=47.5789473684211, Blast_Score=430, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17509795, Length=359, Percent_Identity=34.2618384401114, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509797, Length=359, Percent_Identity=34.2618384401114, Blast_Score=183, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324082, Length=425, Percent_Identity=30.8235294117647, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI19922218, Length=505, Percent_Identity=33.2673267326733, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI19922364, Length=327, Percent_Identity=35.474006116208, Blast_Score=190, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_CLOD6 (Q18CD5)

Other databases:

- EMBL:   AM180355
- RefSeq:   YP_001086515.1
- ProteinModelPortal:   Q18CD5
- SMR:   Q18CD5
- STRING:   Q18CD5
- GeneID:   4916664
- GenomeReviews:   AM180355_GR
- KEGG:   cdf:CD0052
- NMPDR:   fig|1496.1.peg.97
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   DFDALNM
- ProtClustDB:   PRK00260
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 54237; Mature: 54237

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 270-270

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFIIFDTLRRYLEYRG
CCEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEHHHHHHHHHHCC
YDVTYVQNFTDVDDKIINRSHEEGISPEEVAAKYIKEYFVDCDGLGIKRATVHPQVTDNI
CCEEEECCCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
QQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQKQEDLEAGARIEVNDQKRHPM
HHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCC
DFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGETIDIHAGGQDLTFPHHENEI
CEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCCCCCCCCCHHH
AQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVRDISKLYDLEIVRFFMLSAHYR
HHHHHHCCCHHHHHHHCCCEEEECHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC
NPVNFSDEMLNQAKAGLERLYNTKEKLEFTLSNLVESPLTEKEVELVKELDDFRQKFIDA
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MDDDVNTADAVSVIFELAKLINSNVDENSSLEFAKKCLDEFNELTGVLNIVNKKKDTVLD
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KDIEELIQKRTDAKKNKEFQLADDIRQQLLDMGIVLEDTRQGVKWKRI
HHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHCCCEEEHHHCCCCCCCC
>Mature Secondary Structure
MMSVKVYNTLTRTKEEFVPLEEGKVKMYVCGPTVYNYIHIGNARPFIIFDTLRRYLEYRG
CCEEEEHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEECCCCCEEEHHHHHHHHHHCC
YDVTYVQNFTDVDDKIINRSHEEGISPEEVAAKYIKEYFVDCDGLGIKRATVHPQVTDNI
CCEEEECCCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHH
QQIIEFIKELEDKGYAYAVNGDVYFDTNKFEGYGKLSGQKQEDLEAGARIEVNDQKRHPM
HHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCCCCCCCCHHHHHCCCEEEECCCCCCCC
DFVLWKAKKEGEPGWDSPWGEGRPGWHIECSVMSKRYLGETIDIHAGGQDLTFPHHENEI
CEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHCCCEEEEECCCCCCCCCCCCHHH
AQSEARSGKTFSKYWMHNGYININDEKMSKSKGNFFTVRDISKLYDLEIVRFFMLSAHYR
HHHHHHCCCHHHHHHHCCCEEEECHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCC
NPVNFSDEMLNQAKAGLERLYNTKEKLEFTLSNLVESPLTEKEVELVKELDDFRQKFIDA
CCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
MDDDVNTADAVSVIFELAKLINSNVDENSSLEFAKKCLDEFNELTGVLNIVNKKKDTVLD
HCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHH
KDIEELIQKRTDAKKNKEFQLADDIRQQLLDMGIVLEDTRQGVKWKRI
HHHHHHHHHHHCHHCCCCCCHHHHHHHHHHHCCCEEEHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA