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The map label for this gene is eriC [H]

Identifier: 126697230

GI number: 126697230

Start: 1622022

End: 1623380

Strand: Direct

Name: eriC [H]

Synonym: P9301_18921

Alternate gene names: 126697230

Gene position: 1622022-1623380 (Clockwise)

Preceding gene: 126697229

Following gene: 126697232

Centisome position: 98.79

GC content: 34.29

Gene sequence:

>1359_bases
ATGCCAAACTTTATAAAAGATAATATTCAAAAAACAAGTAATAATTCTTCTCGTAGCATCAAAAAATTATTAAAACAAAG
ATCTCTAGTCGTTGCATTATCGCTCTTATTAACAGGTCTAGGGGCTTCAATTACAAGCATATCTTTTAAAACTGGAATCT
ATTTTTTTAATAATTGGAGATTAGCATTATTAGACCAATTCTCATCTATTGCGGTCTTACCTATTTTTGGAGCTCTTGGG
GGAGCTATTGCAGGATATTTGATCAAAAATATAGCACCTGCCGCAAAAGGTTCAGGTGTGAGTCAAATCATGGGTTTCTT
AAGACATAAAAAAGTTCCAATGAATTTAAAAGTAGGATTAGTAAAGCTCATATCAGGAATTATTGCGATTGGTAGCGGAT
TCCCTTTGGGTCCAGAAGGTCCATCAGTTCAAATGGGAGGATCAGTAGCTTGGCAAATGGCCAAGTGGCTCAAAGCTCCT
ACAGCTTTTAGAAGAGTAATAGTAGCAGCAGGTGGTGGTGCTGGGATAGCTGCAGTATTTAGCGCTCCATTAGGAGGGTT
TATCTATGCAATAGAGGAGTTATTAAACTCTGCTAGACCAGTAATTTTATTATTAGTAGTAATTACAACTTTTATTGCAG
ATTCGTCTGCTGATATTATTCAAGCATTGGGTTTAGATCCTAAAGCAGGAGGCTTTGATTTTAACCTCGGATTTTTGATT
CAAAAAGAATATGACCCATCAGTTTTTTTCTTACCTGTAGATTTTATTTACTTAGTTTTATTAGGAATAATTATTGGAAT
ATTTGCAGAATTGTACAGCAGATATGTTTTGTTAATGCAAAATCTTGGTAAAAAGTGGTACAAAAATAAATTTGTTTTAA
AAATGAGTATCTGTGGATTTATTTTAGGAAGTATCTACTCTTTTTTACCCAGTACATTTCATAATTTAGATGAATTACAG
AAAATAATAGCTGAACAAAATACAAGTATTGGAATTGCTTTATTAGCAGTTTTAGTGCTATTTATCACAACAGGTTTAGC
TGCAGCATCCGGAGCTCCTGGAGGATTATTCTACCCAATGCTTACTTTAGGAGGATCAATCGGACTAATAATGGGGAGCT
GGGTAGAAATTGCTACAGGACATGCACCGAGTACATACATTTTTGCGGGAATGGGAGCTTTCGTAGCAGGATGTTCTCGA
ACGCCAATAACAGCAATGTTTTTAGCTTTTGCTTTAACAAAAAATTTATTAATAATGAAACCTGTGTTAATCAGCTGCAT
TGCCAGTTTCTTGGTAGCAAGAGCTTTTAATGAAGAATCAATTTATGAAAGACAAATACAAATAGAATTAGAAGACTAA

Upstream 100 bases:

>100_bases
TATTACTAAAAATAAAATTAATCCATATTCAGATGAACTTTATCGCTATCTTCAATTTGATGAAATACACGATTTCAGCT
TGACAAAGTAATCATGGACC

Downstream 100 bases:

>100_bases
AAAACTATTTTCAATCAAAAACAGCAGTTTTGCTGTTATAGACAAATACTTGATGATTTAAGTGTAATCTAACTGCTCTT
GCTAAAGCTATTCTTTCAAT

Product: putative chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MPNFIKDNIQKTSNNSSRSIKKLLKQRSLVVALSLLLTGLGASITSISFKTGIYFFNNWRLALLDQFSSIAVLPIFGALG
GAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAP
TAFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGFILGSIYSFLPSTFHNLDELQ
KIIAEQNTSIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGSIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCIASFLVARAFNEESIYERQIQIELED

Sequences:

>Translated_452_residues
MPNFIKDNIQKTSNNSSRSIKKLLKQRSLVVALSLLLTGLGASITSISFKTGIYFFNNWRLALLDQFSSIAVLPIFGALG
GAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAP
TAFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGFILGSIYSFLPSTFHNLDELQ
KIIAEQNTSIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGSIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSR
TPITAMFLAFALTKNLLIMKPVLISCIASFLVARAFNEESIYERQIQIELED
>Mature_451_residues
PNFIKDNIQKTSNNSSRSIKKLLKQRSLVVALSLLLTGLGASITSISFKTGIYFFNNWRLALLDQFSSIAVLPIFGALGG
AIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGLVKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPT
AFRRVIVAAGGGAGIAAVFSAPLGGFIYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLIQ
KEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGFILGSIYSFLPSTFHNLDELQK
IIAEQNTSIGIALLAVLVLFITTGLAAASGAPGGLFYPMLTLGGSIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRT
PITAMFLAFALTKNLLIMKPVLISCIASFLVARAFNEESIYERQIQIELED

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=401, Percent_Identity=31.1720698254364, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71985148, Length=303, Percent_Identity=27.0627062706271, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71985141, Length=303, Percent_Identity=27.0627062706271, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322500, Length=408, Percent_Identity=24.5098039215686, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161078208, Length=400, Percent_Identity=23.5, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281361606, Length=400, Percent_Identity=23.5, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573073, Length=400, Percent_Identity=23.5, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI281361608, Length=400, Percent_Identity=23.5, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573075, Length=400, Percent_Identity=23.5, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28573071, Length=400, Percent_Identity=23.5, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 48385; Mature: 48254

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFIKDNIQKTSNNSSRSIKKLLKQRSLVVALSLLLTGLGASITSISFKTGIYFFNNWR
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHCCCEEEEECCH
LALLDQFSSIAVLPIFGALGGAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPTAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHHHH
SAPLGGFIYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEE
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGF
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
ILGSIYSFLPSTFHNLDELQKIIAEQNTSIGIALLAVLVLFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGSIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCIASFLVARAFNEESIYERQIQIELED
HHHHHHHHHHHHHHHCCHHHHEEEEEEEEECC
>Mature Secondary Structure 
PNFIKDNIQKTSNNSSRSIKKLLKQRSLVVALSLLLTGLGASITSISFKTGIYFFNNWR
CCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHCCCEEEEECCH
LALLDQFSSIAVLPIFGALGGAIAGYLIKNIAPAAKGSGVSQIMGFLRHKKVPMNLKVGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VKLISGIIAIGSGFPLGPEGPSVQMGGSVAWQMAKWLKAPTAFRRVIVAAGGGAGIAAVF
HHHHHHHHHHCCCCCCCCCCCCEECCCHHHHHHHHHHHCHHHHHHHHEECCCCCHHHHHH
SAPLGGFIYAIEELLNSARPVILLLVVITTFIADSSADIIQALGLDPKAGGFDFNLGFLI
HCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCEEEEEEEE
QKEYDPSVFFLPVDFIYLVLLGIIIGIFAELYSRYVLLMQNLGKKWYKNKFVLKMSICGF
EECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHH
ILGSIYSFLPSTFHNLDELQKIIAEQNTSIGIALLAVLVLFITTGLAAASGAPGGLFYPM
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
LTLGGSIGLIMGSWVEIATGHAPSTYIFAGMGAFVAGCSRTPITAMFLAFALTKNLLIMK
HHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHH
PVLISCIASFLVARAFNEESIYERQIQIELED
HHHHHHHHHHHHHHHCCHHHHEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA