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The map label for this gene is pgi

Identifier: 126696307

GI number: 126696307

Start: 836239

End: 837822

Strand: Direct

Name: pgi

Synonym: P9301_09691

Alternate gene names: 126696307

Gene position: 836239-837822 (Clockwise)

Preceding gene: 126696305

Following gene: 126696309

Centisome position: 50.93

GC content: 29.99

Gene sequence:

>1584_bases
ATGAATGGAGATTTAAACTCTTGGGATAAATTTTGTAATTATCTTTGGTTTGATAAAAAATTAAATATTTGGTTAGACAT
AAGCAAAATTAATTTCACAAGTAAAGAGATAAATAATTTAGAAGATAAATTTGTAGATGTTTTTTCATCAATGAAAGAAT
TAGAAAATGGTGCAATTTCAAATATTGATGAAAATAGACAAGTTGGACATTATTGGCTTAGAAATCCATCAATTTCACCC
TCTTCAAAAATAGCAGAGGAAATTAGAGCAGATATTAATGCAATCTCTGAATTTGGAAAACAAATTTTAAATGGAGATAT
TAAGAATAAGAATAATAAGCAGTATACTGATGTTCTATGGATAGGAATTGGTGGAAGTGGGTTAGGACCTTTACTTATTA
CAGAATCACTGCAGAAGTGTTCTAGAGGCTTAAATTTTTCTTATATCGATAATGTTGATCCTTTTTTAATTAGCGAAAAG
TTAGAAGAGTTATCTGAAAAATTATCAACAACATTATTTGTAGTAGTAAGCAAATCAGGTGGTACGCCTGAACCTAGAAT
TGCTATGGAAATTATTAAAAGTCACTGCGAAAAAAATTCTCTTGAATGGAATTCTAATGCTATAGCAATAACTATGAAAG
ATAGTAAGTTATTTAAAAAAGCCACTTCTGAATATTGGTTAAAAATATTTAATTTGCAAGATTGGGTTGGAGGAAGAACT
AGTATTACAAGCTCTGTGGGATTACTTCCATTAGCTCTTATTAATGAAAATATATCTGAATTTATTAAAGGTGCATCATT
AATGGATGAAGCCACACGTATAAGTGATTTTAAAAATAATCCAGCAGCACTATTGTCATCAGCATGGTATTTAACTGGTG
ATGGCACTGGAAAGAGAGATATGGTCGTATTACCTTATAGAGATAGGTTACAGGTATTTAGTAAATATCTTCAGCAATTA
GTAATGGAATCATTAGGAAAGAAATTTAATAGGAATGGTGAAGTAGTTAATCAAGGTATTTCCGTTTTTGGTAATAAAGG
ATCTACAGATCAACATGCTTATGTTCAGCAACTCAGAGATGGTATTGATAATTTCTTTTGTATTTTTATTGAATTATTAG
ATACTCCATCTACTAATATTTTTGATGATAAAGAGAATCCTAAAGAATATCTTTCTGGTTTTTTGCAAGGAACCAGATCA
GCACTCTCTAGTGAAAACAGACAAAGTATCACCATAACATTAGAAAAGTTAAATTGTTTTTCACTAGGTGCCTTAATCGC
TTTATTTGAGAGGGCTGTATCCTTCTACGCTGAATTGGTAAATATAAATGCATATGATCAACCTGGAGTTGAAGCTGGGA
AGAAAGCAGCCGCAAATATTATTGAGTATCAACAAAAAGTAAGTAATTTATTAGATGCAGGTGGAGAATATTCTATAAAT
GACATAACATCATTATTTGATAATTCAGTGAGTGAATCTATATTTTTCATACTCCGTGAAATGTGTTTCGGTAATGATAA
TTATTTGGTTAAGGGCGATTGGTCAAATCCAAATTCATTAGTTATTCAGAAACTAAATTCTTAA

Upstream 100 bases:

>100_bases
TTATTTGAAGATAATAATTTAAACAAATTTAAATGAATCAAATCTATGTACTATTCGTATAGATATAATTAAATAAAAAT
AAAAGAAACAAATATATAAA

Downstream 100 bases:

>100_bases
ACAACAATATTCATAATTTTTCCTTTAACAATAATTATTTTTCTTATTTCCTTATCTTTAGTCCATTTAAGTATGTTAGG
TCTTTTGAGAGTCAATTCTT

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNGDLNSWDKFCNYLWFDKKLNIWLDISKINFTSKEINNLEDKFVDVFSSMKELENGAISNIDENRQVGHYWLRNPSISP
SSKIAEEIRADINAISEFGKQILNGDIKNKNNKQYTDVLWIGIGGSGLGPLLITESLQKCSRGLNFSYIDNVDPFLISEK
LEELSEKLSTTLFVVVSKSGGTPEPRIAMEIIKSHCEKNSLEWNSNAIAITMKDSKLFKKATSEYWLKIFNLQDWVGGRT
SITSSVGLLPLALINENISEFIKGASLMDEATRISDFKNNPAALLSSAWYLTGDGTGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRNGEVVNQGISVFGNKGSTDQHAYVQQLRDGIDNFFCIFIELLDTPSTNIFDDKENPKEYLSGFLQGTRS
ALSSENRQSITITLEKLNCFSLGALIALFERAVSFYAELVNINAYDQPGVEAGKKAAANIIEYQQKVSNLLDAGGEYSIN
DITSLFDNSVSESIFFILREMCFGNDNYLVKGDWSNPNSLVIQKLNS

Sequences:

>Translated_527_residues
MNGDLNSWDKFCNYLWFDKKLNIWLDISKINFTSKEINNLEDKFVDVFSSMKELENGAISNIDENRQVGHYWLRNPSISP
SSKIAEEIRADINAISEFGKQILNGDIKNKNNKQYTDVLWIGIGGSGLGPLLITESLQKCSRGLNFSYIDNVDPFLISEK
LEELSEKLSTTLFVVVSKSGGTPEPRIAMEIIKSHCEKNSLEWNSNAIAITMKDSKLFKKATSEYWLKIFNLQDWVGGRT
SITSSVGLLPLALINENISEFIKGASLMDEATRISDFKNNPAALLSSAWYLTGDGTGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRNGEVVNQGISVFGNKGSTDQHAYVQQLRDGIDNFFCIFIELLDTPSTNIFDDKENPKEYLSGFLQGTRS
ALSSENRQSITITLEKLNCFSLGALIALFERAVSFYAELVNINAYDQPGVEAGKKAAANIIEYQQKVSNLLDAGGEYSIN
DITSLFDNSVSESIFFILREMCFGNDNYLVKGDWSNPNSLVIQKLNS
>Mature_527_residues
MNGDLNSWDKFCNYLWFDKKLNIWLDISKINFTSKEINNLEDKFVDVFSSMKELENGAISNIDENRQVGHYWLRNPSISP
SSKIAEEIRADINAISEFGKQILNGDIKNKNNKQYTDVLWIGIGGSGLGPLLITESLQKCSRGLNFSYIDNVDPFLISEK
LEELSEKLSTTLFVVVSKSGGTPEPRIAMEIIKSHCEKNSLEWNSNAIAITMKDSKLFKKATSEYWLKIFNLQDWVGGRT
SITSSVGLLPLALINENISEFIKGASLMDEATRISDFKNNPAALLSSAWYLTGDGTGKRDMVVLPYRDRLQVFSKYLQQL
VMESLGKKFNRNGEVVNQGISVFGNKGSTDQHAYVQQLRDGIDNFFCIFIELLDTPSTNIFDDKENPKEYLSGFLQGTRS
ALSSENRQSITITLEKLNCFSLGALIALFERAVSFYAELVNINAYDQPGVEAGKKAAANIIEYQQKVSNLLDAGGEYSIN
DITSLFDNSVSESIFFILREMCFGNDNYLVKGDWSNPNSLVIQKLNS

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=508, Percent_Identity=28.5433070866142, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI296080693, Length=504, Percent_Identity=25.9920634920635, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790457, Length=504, Percent_Identity=31.1507936507937, Blast_Score=189, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI71996708, Length=440, Percent_Identity=30, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71996703, Length=440, Percent_Identity=30, Blast_Score=157, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319673, Length=444, Percent_Identity=30.6306306306306, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24651916, Length=447, Percent_Identity=31.0961968680089, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24651914, Length=447, Percent_Identity=31.0961968680089, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI17737445, Length=447, Percent_Identity=31.0961968680089, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_PROM0 (A3PCW7)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001091193.1
- ProteinModelPortal:   A3PCW7
- SMR:   A3PCW7
- STRING:   A3PCW7
- GeneID:   4911692
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_09691
- eggNOG:   COG0166
- HOGENOM:   HBG285902
- OMA:   RTSITSA
- ProtClustDB:   PRK14096
- BioCyc:   PMAR167546:P9301ORF_0988-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 59167; Mature: 59167

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 323-323 ACT_SITE 352-352 ACT_SITE 454-454

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGDLNSWDKFCNYLWFDKKLNIWLDISKINFTSKEINNLEDKFVDVFSSMKELENGAIS
CCCCCCCHHHHHHHEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIDENRQVGHYWLRNPSISPSSKIAEEIRADINAISEFGKQILNGDIKNKNNKQYTDVLW
CCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
IGIGGSGLGPLLITESLQKCSRGLNFSYIDNVDPFLISEKLEELSEKLSTTLFVVVSKSG
EEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
GTPEPRIAMEIIKSHCEKNSLEWNSNAIAITMKDSKLFKKATSEYWLKIFNLQDWVGGRT
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCHHHHCCCCH
SITSSVGLLPLALINENISEFIKGASLMDEATRISDFKNNPAALLSSAWYLTGDGTGKRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCEEEECCCCCCCC
MVVLPYRDRLQVFSKYLQQLVMESLGKKFNRNGEVVNQGISVFGNKGSTDQHAYVQQLRD
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCCHHHHHHHHHHH
GIDNFFCIFIELLDTPSTNIFDDKENPKEYLSGFLQGTRSALSSENRQSITITLEKLNCF
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHH
SLGALIALFERAVSFYAELVNINAYDQPGVEAGKKAAANIIEYQQKVSNLLDAGGEYSIN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DITSLFDNSVSESIFFILREMCFGNDNYLVKGDWSNPNSLVIQKLNS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHEECCC
>Mature Secondary Structure
MNGDLNSWDKFCNYLWFDKKLNIWLDISKINFTSKEINNLEDKFVDVFSSMKELENGAIS
CCCCCCCHHHHHHHEEECCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
NIDENRQVGHYWLRNPSISPSSKIAEEIRADINAISEFGKQILNGDIKNKNNKQYTDVLW
CCCCCCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEE
IGIGGSGLGPLLITESLQKCSRGLNFSYIDNVDPFLISEKLEELSEKLSTTLFVVVSKSG
EEECCCCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHCCEEEEEEECCC
GTPEPRIAMEIIKSHCEKNSLEWNSNAIAITMKDSKLFKKATSEYWLKIFNLQDWVGGRT
CCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCHHHHCCCCH
SITSSVGLLPLALINENISEFIKGASLMDEATRISDFKNNPAALLSSAWYLTGDGTGKRD
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHCCEEEECCCCCCCC
MVVLPYRDRLQVFSKYLQQLVMESLGKKFNRNGEVVNQGISVFGNKGSTDQHAYVQQLRD
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCCCCCCCHHHHHHHHHHH
GIDNFFCIFIELLDTPSTNIFDDKENPKEYLSGFLQGTRSALSSENRQSITITLEKLNCF
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHH
SLGALIALFERAVSFYAELVNINAYDQPGVEAGKKAAANIIEYQQKVSNLLDAGGEYSIN
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
DITSLFDNSVSESIFFILREMCFGNDNYLVKGDWSNPNSLVIQKLNS
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA