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The map label for this gene is hemH

Identifier: 126695889

GI number: 126695889

Start: 480716

End: 481891

Strand: Direct

Name: hemH

Synonym: P9301_05511

Alternate gene names: 126695889

Gene position: 480716-481891 (Clockwise)

Preceding gene: 126695883

Following gene: 126695890

Centisome position: 29.28

GC content: 37.07

Gene sequence:

>1176_bases
ATGGTTAAAATAGGCGTCTTACTAATGAATTTAGGAGGGCCTGAACGCATTACTGATGTCGGCCCATTCTTATACAATCT
TTTTTCTGATCCAGAAATTATCAGGACACCTTTCCCTGTTTTTCAAAAGCCCCTAGCTTGGTTAATTAGCACGCTTAGGA
GTACTACATCACAACAGGCCTACCTTTCCATAGGTGGAGGTTCACCTATCAGAAGGATAACTGAACAACAAGCAAGAGAA
TTACAATCTAAATTAAGGGAAAAGGGATTTAATGCTACTACCTACATTGCTATGAGGTATTGGCATCCTTTTACCGAATC
AGCAATTGCTGATATGAAAGCAGATGGCATAGATCAAGTTGTTGTAATACCCTTGTATCCGCATTTTTCGATAAGTACTA
GTGGTTCGAGCTTTAGAGAATTAAAAAAATTGAGAGATTCTGATGATGAATTTAAGAAGGTTCCAATGAGATGTGTAAGG
AGTTGGTTCAGTCAATCAGGTTATTTAAAGTCTATGGTTGAATTAATTTCTGAACAAATTTCACTTTGTGAATCACCTTC
AAAAGCCCATATATTTTTCACTGCTCATGGAGTTCCTAAGAGTTACGTAGAGGAAGCTGGAGACCCTTACAAACAACAAA
TTGAAGATTGTTCCTTATTAATAATAAATGAGTTGGAAAAATGTTTAGGGTATAGTAACCCTCATACTCTCTCTTACCAG
AGTAGAGTTGGTCCTGTTGAATGGTTGAAACCTTATACAGAAGAGGTATTGGCGGATCTTGGAAGGTCAAATGTTAATGA
TCTAGTTGTGGTTCCTATAAGTTTCGTTGGAGAGCATATCGAAACGTTGCAAGAAATTGATATTGAATATAAAGAAATTG
CTGAAAAAGCTGGTATTAAAAACTTTCGGAGAGTTAAGGCTCTTAATACCCATCCTACTTTTATTGAAGGTCTTAGTGAT
CTAGTGATTTCCTGCTTGGAAGGGCCTCTAGTTAATATTGAGGAGGCTTCTCAGTTGCCTGAAAAAGTTAAACTTTATCC
TCAGGAGAAGTGGCAATGGGGTTGGAATAATAGTTCAGAGGTGTGGAACGGAAGGGTTGCAATGATTATTTTTCTTGTGC
TTTTTATTGAACTTATTTCAGGCTCTGGACCTCTACATAAATTAGGCATCTTATAA

Upstream 100 bases:

>100_bases
TCATTGACATTATTAATTTCCTGAATTACGTTCATTTACTTATATAATTGACCATATAATGACGTTTTTAATGTTGATTT
TCAATCTCCATAAATCTTAA

Downstream 100 bases:

>100_bases
GGAAAAATTGATATTCATTTGAAAATTTTAAATTTTTTAAAAGATTTTTTTTGAATATATTTCTGACATTACATTTCTAA
ATGAGGCAAAAGTATTTAAT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGFNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDSDDEFKKVPMRCVR
SWFSQSGYLKSMVELISEQISLCESPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGYSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLVVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPLVNIEEASQLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL

Sequences:

>Translated_391_residues
MVKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGFNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDSDDEFKKVPMRCVR
SWFSQSGYLKSMVELISEQISLCESPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGYSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLVVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPLVNIEEASQLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL
>Mature_391_residues
MVKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLREKGFNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDSDDEFKKVPMRCVR
SWFSQSGYLKSMVELISEQISLCESPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGYSNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLVVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPLVNIEEASQLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=35.3474320241692, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=35.3474320241692, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1786681, Length=328, Percent_Identity=30.7926829268293, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324750, Length=345, Percent_Identity=35.9420289855072, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI17864156, Length=331, Percent_Identity=32.02416918429, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=29.6153846153846, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI45552018, Length=139, Percent_Identity=39.568345323741, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_PROM0 (A3PBP9)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090775.1
- ProteinModelPortal:   A3PBP9
- SMR:   A3PBP9
- STRING:   A3PBP9
- GeneID:   4912160
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_05511
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   WLQKPLA
- ProtClustDB:   PRK00035
- BioCyc:   PMAR167546:P9301ORF_0564-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 44229; Mature: 44229

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQA
CEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLREKGFNATTYIAMRYWHPFTESAIADMKADGIDQV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHCCCCCCCE
VVIPLYPHFSISTSGSSFRELKKLRDSDDEFKKVPMRCVRSWFSQSGYLKSMVELISEQI
EEEEECCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCESPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGYSNPHTLSYQ
HHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
SRVGPVEWLKPYTEEVLADLGRSNVNDLVVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCH
NFRRVKALNTHPTFIEGLSDLVISCLEGPLVNIEEASQLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIIFLVLFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MVKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQA
CEEEEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLREKGFNATTYIAMRYWHPFTESAIADMKADGIDQV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHCCCCCCCE
VVIPLYPHFSISTSGSSFRELKKLRDSDDEFKKVPMRCVRSWFSQSGYLKSMVELISEQI
EEEEECCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCESPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGYSNPHTLSYQ
HHHCCCCCEEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
SRVGPVEWLKPYTEEVLADLGRSNVNDLVVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCH
NFRRVKALNTHPTFIEGLSDLVISCLEGPLVNIEEASQLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIIFLVLFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA