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The map label for this gene is ndhA

Identifier: 126695518

GI number: 126695518

Start: 165918

End: 167036

Strand: Reverse

Name: ndhA

Synonym: P9301_01801

Alternate gene names: 126695518

Gene position: 167036-165918 (Counterclockwise)

Preceding gene: 126695519

Following gene: 126695517

Centisome position: 10.17

GC content: 36.91

Gene sequence:

>1119_bases
TTGGAATACGGATTAGATCTCGAATATAGTTTTAATGAATTCTTAAAAGGTTTTGGCCTGTCCAGCGAAATTGCTCATAT
AATTTGGCTCCCTCTACCTATGCTTTTGGTTTTAGTAGCGGCAGTTGTTGGCGTTTTAGTAACAGTTTGGCTTGAAAGAA
AAATATCTGCTGCCGCTCAACAAAGAATAGGTCCCGAATATGCAGGTGCACTTGGCGTCCTTCAACCAATTGCAGATGGT
CTGAAGTTACTTGTTAAAGAGGATATTATTCCTGCTAAAGCGGATGGAATCCTCTTCACCGCAGGGCCCATATTAGTTCT
TGTTCCAGTGATTCTGTCCTGGCTGATCGTTCCCTTTGGACAAAACCTTTTAATAAGTAATGTAGGTATTGGAATTTTCC
TATGGATCGCTTTAAGCAGTATCCAGCCAATTGGACTTCTTATGAGCGGATATGCATCAAATAATAAATATTCATTGTTA
GGGGGATTAAGAGCAGCAGCTCAATCAATAAGTTATGAAATTCCTTTAGCTTTATCTGTACTGGCTATCGTACTAATGAC
AAATTCTCTAAGTACTATTGATATTGTTAATCAACAAAGTGGTGCTGGAATCCTAAGTTGGAATATATGGAGACAACCTG
TTGGTTTTATAGTCTTCTGGATTTGTGCACTTGCAGAATGTGAGAGACTTCCATTTGACTTACCTGAAGCTGAAGAAGAA
TTAGTTGCAGGATATCAAACTGAATATGCAGGGATGAAATTCGCACTGTTCTACCTTGGTAGTTACATAAATTTAATCCT
TTCAGCATTATTGGTATCAATACTTTATTTAGGAGGTTGGGGTTTTCCTATTCCAGTTGAATTAATAGCCAAGTTTCTAA
ATTTGCCCATTAATGCACCTTTAATACAAGTCTTTACTGCATCAATAGGAATTGTAATGACTGTATTGAAAGCTTATCTT
TTAGTTTTCATTGCAATATTATTACGTTGGACAACTCCTAGAGTCAGGATAGATCAACTATTGGATCTAGGATGGAAGTT
TCTTCTTCCAATTTCTCTTGCTAATCTTTTGATAACTGCAGGATTAAAACTTGCTTTTCCGCAATTCTTTGGAGGTTAA

Upstream 100 bases:

>100_bases
GATCAGCCTAGAAAACAGAAAATAATATTTGCAGCTTTTCATAAAAAACACACATATTGTTTGTGAAGAGTTAATCTATT
AAGTAAATAACATAAAAATT

Downstream 100 bases:

>100_bases
ACTTAAGTAAAAATACTTAAATTTAAATTTAATCCACTAAAATAAAATCACTGAGTAAATTCTTCAAAATGAAAAATTTC
CTTCAACAAATTAATAGCTA

Product: NADH dehydrogenase subunit H

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I subunit 1; NDH-1 subunit 1; NDH-A

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MEYGLDLEYSFNEFLKGFGLSSEIAHIIWLPLPMLLVLVAAVVGVLVTVWLERKISAAAQQRIGPEYAGALGVLQPIADG
LKLLVKEDIIPAKADGILFTAGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYASNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVLMTNSLSTIDIVNQQSGAGILSWNIWRQPVGFIVFWICALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYINLILSALLVSILYLGGWGFPIPVELIAKFLNLPINAPLIQVFTASIGIVMTVLKAYL
LVFIAILLRWTTPRVRIDQLLDLGWKFLLPISLANLLITAGLKLAFPQFFGG

Sequences:

>Translated_372_residues
MEYGLDLEYSFNEFLKGFGLSSEIAHIIWLPLPMLLVLVAAVVGVLVTVWLERKISAAAQQRIGPEYAGALGVLQPIADG
LKLLVKEDIIPAKADGILFTAGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYASNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVLMTNSLSTIDIVNQQSGAGILSWNIWRQPVGFIVFWICALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYINLILSALLVSILYLGGWGFPIPVELIAKFLNLPINAPLIQVFTASIGIVMTVLKAYL
LVFIAILLRWTTPRVRIDQLLDLGWKFLLPISLANLLITAGLKLAFPQFFGG
>Mature_372_residues
MEYGLDLEYSFNEFLKGFGLSSEIAHIIWLPLPMLLVLVAAVVGVLVTVWLERKISAAAQQRIGPEYAGALGVLQPIADG
LKLLVKEDIIPAKADGILFTAGPILVLVPVILSWLIVPFGQNLLISNVGIGIFLWIALSSIQPIGLLMSGYASNNKYSLL
GGLRAAAQSISYEIPLALSVLAIVLMTNSLSTIDIVNQQSGAGILSWNIWRQPVGFIVFWICALAECERLPFDLPEAEEE
LVAGYQTEYAGMKFALFYLGSYINLILSALLVSILYLGGWGFPIPVELIAKFLNLPINAPLIQVFTASIGIVMTVLKAYL
LVFIAILLRWTTPRVRIDQLLDLGWKFLLPISLANLLITAGLKLAFPQFFGG

Specific function: NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=306, Percent_Identity=35.6209150326797, Blast_Score=168, Evalue=7e-42,
Organism=Escherichia coli, GI1788618, Length=340, Percent_Identity=37.6470588235294, Blast_Score=224, Evalue=6e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NU1C_PROM0 (A3PAM8)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090404.1
- STRING:   A3PAM8
- GeneID:   4912857
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_01801
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   IFWICAL
- ProtClustDB:   PRK06076
- BioCyc:   PMAR167546:P9301ORF_0182-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: 1.6.5.3

Molecular weight: Translated: 40557; Mature: 40557

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1c3af3ac)-; HASH(0x1c7ed528)-; HASH(0x1b714dac)-; HASH(0x1b895858)-; HASH(0x1bc091c4)-; HASH(0x1c202578)-; HASH(0x1bf4a1fc)-; HASH(0x1c912958)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYGLDLEYSFNEFLKGFGLSSEIAHIIWLPLPMLLVLVAAVVGVLVTVWLERKISAAAQ
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYAGALGVLQPIADGLKLLVKEDIIPAKADGILFTAGPILVLVPVILSWLIVPFG
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCC
QNLLISNVGIGIFLWIALSSIQPIGLLMSGYASNNKYSLLGGLRAAAQSISYEIPLALSV
CCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
LAIVLMTNSLSTIDIVNQQSGAGILSWNIWRQPVGFIVFWICALAECERLPFDLPEAEEE
HHHHHHHCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVAGYQTEYAGMKFALFYLGSYINLILSALLVSILYLGGWGFPIPVELIAKFLNLPINAP
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
LIQVFTASIGIVMTVLKAYLLVFIAILLRWTTPRVRIDQLLDLGWKFLLPISLANLLITA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
GLKLAFPQFFGG
CHHHHCHHHHCH
>Mature Secondary Structure
MEYGLDLEYSFNEFLKGFGLSSEIAHIIWLPLPMLLVLVAAVVGVLVTVWLERKISAAAQ
CCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIGPEYAGALGVLQPIADGLKLLVKEDIIPAKADGILFTAGPILVLVPVILSWLIVPFG
HHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCC
QNLLISNVGIGIFLWIALSSIQPIGLLMSGYASNNKYSLLGGLRAAAQSISYEIPLALSV
CCHHHHHCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHH
LAIVLMTNSLSTIDIVNQQSGAGILSWNIWRQPVGFIVFWICALAECERLPFDLPEAEEE
HHHHHHHCCCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LVAGYQTEYAGMKFALFYLGSYINLILSALLVSILYLGGWGFPIPVELIAKFLNLPINAP
HHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCH
LIQVFTASIGIVMTVLKAYLLVFIAILLRWTTPRVRIDQLLDLGWKFLLPISLANLLITA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
GLKLAFPQFFGG
CHHHHCHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA