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The map label for this gene is gltA [H]

Identifier: 126695519

GI number: 126695519

Start: 167112

End: 168257

Strand: Reverse

Name: gltA [H]

Synonym: P9301_01811

Alternate gene names: 126695519

Gene position: 168257-167112 (Counterclockwise)

Preceding gene: 126695520

Following gene: 126695518

Centisome position: 10.25

GC content: 37.61

Gene sequence:

>1146_bases
TTGGATAGCAACAAACTAATTTTAAAACCAGGATTAGAAGGTGTCCCAGTTACTAATTCATCTATCTGTGATATTGACGG
GAACAAAGGTAAATTATTGTATAGGGGCTACTCCATTGAGGAACTATCCCAAAAAAGCAGTTTTTTAGAAACTGCTTACC
TATTGATTTGGGGTGAATTGCCCACAGCTATTCAACTAAGGGATTTTGAACAAGAAGTTCAAATGCATAGAAGGTTAAGT
TTTAGAGTCAGAGATATGATGAAATGTTTTCCTGCGACAGGTCATCCTATGGATGCTCTTCAATCTAGTGCAGCTTCTTT
AGGGCTTTTCTATTCACGTAGAGCAATAGATGATCCTAATTACATTTACAACGCAGTAATAAGACTTATAGCAAAAATAC
CTACTATGATTGCTGCGTTTCAACTTATAAGAAAAGGACAAGACCCTATTCAACCTCGTGACGATTTAACTTACTCATCA
AATTTTCTTTACATGCTGACAGAAAAAGAACAAGATCCAATAGCTGCAAAAGTTTTTGATAGGTGTTTAATCCTACATGC
CGAACATAGTTTAAACGCAAGTACATTTAGCGCTAGGGTTACTGCAAGCACTCTTACAGACCCATACGCTGTCATAGCCT
CTGCAGTAGGAACCCTGGCTGGTCCGCTGCATGGAGGAGCAAATGAGGATGTGATTGCAATGTTAGAAGAGATCAAAACT
CCAGAAAATGCTGCTTCTTTTTTGGATAACGCGATAAAAAATAAAAGTAAGATTATGGGCTTCGGTCATAGAGAATATAA
AGTCAAAGATCCAAGAGCAATAATTCTTCAAAAACTGGCAGAGGAGCTTTTTATTAGATTTGGAGCAGATGAAATGTATG
AAGTTGCAAAATCACTTGAAGCAGAAGCAATACCAAGACTTGGACCTAAGGGTATATTCCCTAACGTGGATTTTTATTCT
GGTCTTGTTTATAGAAAACTTGGTATTCCTCGTGATTTGTTTACTCCAATTTTTGCCATCTCTAGAGTCGCTGGTTGGTT
AGCTCATTGGAGAGAGCAACTTGGAGCAAATAGAATTTTTAGACCATCGCAAATCTATACTGGTTCAGCACCAAGAGATT
GGATCAGCCTAGAAAACAGAAAATAA

Upstream 100 bases:

>100_bases
AAAAATCAATTTAAATTCTCCGCCAAATTAATAACTTGTGGTTAATTAAAAATTATTTGACTATCTTTAATCTATAAGTA
TTTGATATTGAATTAAGCAA

Downstream 100 bases:

>100_bases
TATTTGCAGCTTTTCATAAAAAACACACATATTGTTTGTGAAGAGTTAATCTATTAAGTAAATAACATAAAAATTTTGGA
ATACGGATTAGATCTCGAAT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSQKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK

Sequences:

>Translated_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSQKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK
>Mature_381_residues
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSQKSSFLETAYLLIWGELPTAIQLRDFEQEVQMHRRLS
FRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPNYIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSS
NFLYMLTEKEQDPIAAKVFDRCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
PENAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLEAEAIPRLGPKGIFPNVDFYS
GLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIFRPSQIYTGSAPRDWISLENRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=380, Percent_Identity=27.3684210526316, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786939, Length=383, Percent_Identity=39.1644908616188, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI1786527, Length=386, Percent_Identity=33.6787564766839, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17555174, Length=376, Percent_Identity=27.6595744680851, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319850, Length=374, Percent_Identity=25.9358288770053, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325257, Length=374, Percent_Identity=25.668449197861, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=319, Percent_Identity=24.1379310344828, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356863, Length=389, Percent_Identity=26.7352185089974, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24640126, Length=395, Percent_Identity=27.3417721518987, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24640124, Length=395, Percent_Identity=27.3417721518987, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42767; Mature: 42767

Theoretical pI: Translated: 8.40; Mature: 8.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSQKSSFLETAYLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PENAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CHHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRK
CCCCEEECCCCHHHCCCCCCC
>Mature Secondary Structure
MDSNKLILKPGLEGVPVTNSSICDIDGNKGKLLYRGYSIEELSQKSSFLETAYLLIWGEL
CCCCCEEECCCCCCCCCCCCCEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCC
PTAIQLRDFEQEVQMHRRLSFRVRDMMKCFPATGHPMDALQSSAASLGLFYSRRAIDDPN
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCH
YIYNAVIRLIAKIPTMIAAFQLIRKGQDPIQPRDDLTYSSNFLYMLTEKEQDPIAAKVFD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHH
RCLILHAEHSLNASTFSARVTASTLTDPYAVIASAVGTLAGPLHGGANEDVIAMLEEIKT
HHHHEECCCCCCCCHHEEEEEHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCC
PENAASFLDNAIKNKSKIMGFGHREYKVKDPRAIILQKLAEELFIRFGADEMYEVAKSLE
CHHHHHHHHHHHHCHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
AEAIPRLGPKGIFPNVDFYSGLVYRKLGIPRDLFTPIFAISRVAGWLAHWREQLGANRIF
HHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RPSQIYTGSAPRDWISLENRK
CCCCEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]